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Xingwen Wang, Dong Zhao, Hui Xie, Ying Hu*. Interplay of long non-coding RNAs and HIF-1α: A new dimension to understanding hypoxia-regulated tumor growth and metastasis. Cancer Lett. 2021 Feb 28;499:49-59.
Kunming Zhao, Ying Hu*. Microbiome harbored within tumors: a new chance to revisit our understanding of cancer pathogenesis and treatment. Signal Transduct Target Ther. 2020 Jul 29;5(1):136.
Xingwen Wang, Yudong Wang, Li Li, Xuting Xue, Hui Xie, Huaxing Shi and Ying Hu*. A lncRNA coordinates with Ezh2 to inhibit HIF-1α transcription and suppress cancer cell adaption to hypoxia. Oncogene. 2020 Feb;39(9):1860-1874. Epub 2019 Nov 29.
Kunming Zhao, Xingwen Wang, Xuting Xue, Li Li, Ying Hu*. A long non-coding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers. PLos Biol. 2020 Mar 23;18(3):e3000666.
Huayi Li#, Wenxin Zhang#, Kunming Zhao, Dong Zhao, Shanliang Zheng, Ying Hu*. A previously identified apoptosis inhibitor iASPP confers resistance to chemotherapeutic drugs by suppressing senescence in cancer cells. J Biol Chem. 2020 Mar 20;295(12):4049-4063. Epub 2020 Jan 31.
Xingwen Wang, Li Li, Kunming Zhao, Qingyu Lin, Xuting Xue, Wenjie Ge, Hongjuan He, Dong Liu, Qiong Wu, Ying Hu*. A novel LncRNA HITT forms a regulatory loop with HIF-1α to modulate angiogenesis and tumor growth. Cell Death Differ. 2020 Apr;27(4):1431-1446. Epub 2019 Nov 7. CDDPress Monthly Top Picks
Huyi Li#, Xingwen Wang#, Cheng Zhang, Yiwei Cheng, Miao Yu, Wenjie Ge, Anyong Cai, Yao Zhang, Fengtong Han, Hu Ying*. HDAC1-induced epigenetic silencing of ASPP2 promotes cell motility, tumour growth and drug resistance in renal cell carcinoma. Cancer Lett. 2018 Jun 8;432:121-131.
Wenjie Ge#, Kunming Zhao#, Xingwen Wang, Huayi Li, Miao Yu, Mengmeng He, Xuting Xue, Yifu Zhu, Cheng Zhang, Yiwei Cheng, Shijian Jiang, Ying Hu*. iASPP is an antioxidative factor and drives cancer growth and drug resistance by competing with Nrf2 for Keap1 binding. Cancer Cell. 2017 Nov 13;32(5):561-573. Epub 2017 Oct 12. Featured article
Qingyu Lin, Tong Liu, Xingwen Wang, Guixue Hou, Zhiyuan Xiang, Wenxin Zhang, Shanliang Zheng, Dong Zhao, Qibin Leng, Xiaoshi Zhang, Minqiao Lu, Tianqi Guan, Hao Liu, Ying Hu* Long noncoding RNA HITT coordinates with RGS2 to inhibit PD-L1 translation in T cell immunity. J Clin Invest. 2023 Apr 4;e162951. doi: 10.1172/JCI162951. Online ahead of print.
Zheng S, Zhao D, Hou G, Zhao S, Zhang W, Wang X, Li L, Lin L, Tang TS, Ying Hu*. iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca2%2B homeostasis and control tumor growth and drug resistance. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2111380119. doi: 10.1073/pnas.2111380119.
Zheng S, Wang X, Zhao D, Liu H, Ying Hu*.Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications. Trends Cell Biol. 2022 Jul 29:S0962-8924(22)00174-X. doi: 10.1016/j.tcb.2022.07.004. Online ahead of print.
Zheng S, Wang X, Liu H, Zhao D, Lin Q, Jiang Q, Li L, Ying Hu*. iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers. Cell Death Differ. Epub 2022 Nov 15.
Xingwen Wang, Li Li, Kunming Zhao, Qingyu Lin, Xuting Xue, Wenjie Ge, Hongjuan He, Dong Liu, Qiong Wu, Ying Hu*. A novel LncRNA HITT forms a regulatory loop with HIF-1α to modulate angiogenesis and tumor growth. Cell Death Differ. 2020 Apr;27(4):1431-1446. Epub 2019 Nov 7. CDDPress Monthly Top Picks
Kunming Zhao, Xingwen Wang, Xuting Xue, Li Li, Ying Hu*. A long non-coding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers. PLos Biol. 2020 Mar 23;18(3):e3000666.
Wang X, Zheng S, Yang F, Zhang W, Zhao D, Xue X, Lin Q, He Y, Hu G, Ying Hu*. LncRNA HITT inhibits metastasis by attenuating Rab5-mediated endocytosis in lung adenocarcinoma. Mol Ther. 2022 Jan 8:S1525-0016(22)00014-4. doi: 0.1016/j.ymthe.2022.01.014. Online ahead of print.
Zhao D, Zheng S, Wang X, Liu H, Zhao K, Li L,Ying Hu*. iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation. Oncogene. 2022 Feb 15.
Xingwen Wang, Yudong Wang, Li Li, Xuting Xue, Hui Xie, Huaxing Shi and Ying Hu*. A lncRNA coordinates with Ezh2 to inhibit HIF-1α transcription and suppress cancer cell adaption to hypoxia. Oncogene. 2020 Feb;39(9):1860-1874. Epub 2019 Nov 29.
Huayi Li#, Wenxin Zhang#, Kunming Zhao, Dong Zhao, Shanliang Zheng, Ying Hu*. A previously identified apoptosis inhibitor iASPP confers resistance to chemotherapeutic drugs by suppressing senescence in cancer cells. J Biol Chem. 2020 Mar 20;295(12):4049-4063. Epub 2020 Jan 31.
Xingwen Wang, Yi Zhang, Qingyu Lin, Kunming Zhao, Dantong Zhu, Ying Hu*. Mitochondria-localized lncRNA HITT inhibits fusion by attenuating formation of mitofusin-2 homotypic or heterotypic complexes. J Biol Chem. 2023 Feb;299(2):102825. doi: 10.1016/j.jbc.2022.102825. Epub 2022 Dec 23.
Other Publicaitons
Zhao K, Wang X, Zhao D, Lin Q, Zhang Y, Hu Ying*. lncRNA HITT Inhibits Lactate Production by Repressing PKM2 Oligomerization to Reduce Tumor Growth and Macrophage Polarization. Research (Wash D C). 2022 Jul 5;2022:9854904. doi: 10.34133/2022/9854904. eCollection 2022.
Huyi Li#, Xingwen Wang#, Cheng Zhang, Yiwei Cheng, Miao Yu, Wenjie Ge, Anyong Cai, Yao Zhang, Fengtong Han, Hu Ying*. HDAC1-induced epigenetic silencing of ASPP2 promotes cell motility, tumour growth and drug resistance in renal cell carcinoma. Cancer Lett. 2018 Jun 8;432:121-131. doi: 10.1016/j.canlet. 2018.06.009.
Wang Xingwen, Cheng Yiwei, Zhu Yifu, Li Huayi, Ge Wenjie, Wu Xiaoliang, Zhao Kunming, Yuan J, Li Z, Jiang S, Han Zhengbin, Jiang Qinghua, Wu Qiong, Liu Tao, Zhang Cheng*, Yu Miao*, Hu Ying*. Epigenetic Silencing of ASPP1 confers 5-FU resistance in Clear Cell Renal Cell Carcinoma by preventing p53 activation.Int J Cancer. 2017 Oct 1;141(7):1422-1433. doi: 10.1002/ijc.30852. Epub 2017 Jul 10.
Kunming Zhao, Miao Yu, Yifu Zhu, Dong Liu, Qiong Wu, and Ying Hu*. EGR-1/ASPP1 inter-regulatory loop promotes apoptosis by inhibiting cyto-protective autophagy. Cell Death Dis. 2017 Jun 8;8(6):e2869. doi: 10.1038/cddis.2017.268.
Xingwen Wang, Miao Yu,Kunming Zhao, Mengmeng He,Wenjie Ge,Yuhui Sun,Yihua Wang, Haizhu Sun, Ying Hu*. Upregulation of MiR-205 under hypoxia promotes epithelial-mesenchymal transition by targeting ASPP2. Cell Death Dis. 2016 Dec 8;7(12):e2517. doi: 10.1038/cddis.2016.412.
Di J, Zhao G, Wang H, Wu Y, Zhao Z, Zhu B, Zhang Y, Zheng J, Liu Y, Ying Hu*. A p53/CPEB2 negative feedback loop regulates renal cancer cell proliferation and migration. J Genet Genomics. 2021 Jul 20;48(7):606-617. doi: 10.1016/j.jgg.2021.05.011. Epub 2021 Jul 2.
Ge W, Wang Y, Zheng S, Zhao D, Wang X, Zhang X, Ying Hu*. Nuclear iASPP determines cell fate by selectively inhibiting either p53 or NF-κB. Cell Death Discov. 2021 Jul 26;7(1):195. doi: 10.1038/s41420-021-00582-1.
Zhu D, Han F, Sun L, Agnihotri SK, Ying Hu*, Büeler H*. Loss of PTEN-Induced Kinase 1 Regulates Oncogenic Ras-Driven Tumor Growth By Inhibiting Mitochondrial Fission. Front Oncol. 2022 May 5;12:893396. doi: 10.3389/fonc.2022.893396. eCollection 2022.PMID: 35600352
Zhao K, Wang X, Ying Hu*. Identification of lncRNA-Protein Interactions by CLIP and RNA Pull-Down Assays. Methods Mol Biol. 2021;2348:231-242. doi: 10.1007/978-1-0716-1581-2_16.
Zinaida Dedeic#, Gopinath Sutendra#, Ying Hu#, Kathryn Ho Ki Chung, Elizabeth A. Slee, Michael J. White, Felix Zhou, Robert D. Goldin, David J. P. Ferguson, Debra McAndrew, Jurgen E. Schneider and Xin Lu. Cell autonomous role of iASPP deficiency in causing cardiocutaneous disorders. Cell death and differentiation, 2018 Jul;25(7):1289-1303.
Mario Notari#，Ying Hu#，Sofia Koch，Min Lu， Indrika Ratnayaka，Shan Zhong，Caroline Baer，Anna Pagotto，Robert Goldin，Victoria Salter，Eleonora Candi，Gerry Melino，and Xin Lu*. iASPP prevents premature cellular senescence and is required for normal epithelial stratification. Proc Natl Acad Sci. 2011. 108(40): 16645–16650.
Mario Notari，Ying Hu，Gopinath Sutendra, Zinaida Dedeic, Min Lu, Laurent Dupays, Arash Yavari, Carolyn Carr, Shan Zhong, Aaisha Opel, Andrew Tinker, Kieran Clarke, Hugh Watkins, David Ferguson, David Kelsell, Sofia de Noronha, Mary Sheppard, Mike Hollinshead, Timothy J Mohun and Xin Lu*. iASPP: A Novel Desmosome Regulator and its Deficiency Causes Arrhythmogenic Right Ventricular Cardiomyopathy. Proc Natl Acad Sci. 2015 Mar 3;112(9):E973-81. doi: 10.1073/pnas.1408111112. Epub 2015 Feb 17.
Min Lu, Hilde Breyssens，Victoria Salter，Shan Zhong，Ying Hu，Caroline Baer，Indrika Ratnayaka，Alex Sullivan，Nicholas R Brown，Stefan Knapp，Benedikt Kessler,Mark R Middleton，Christian Siebold，Yvonne Jones，Elena V Sviderskaya，Jonathan Cebon，Tom John，Otavia Caballero，Colin R Goding and Xin Lu*. Restoring p53 function in human melanoma cells by inhibiting mdm2 and cyclinB1/cdk1 phosphorylated nuclear iASPP. Cancer cell. 2013. 23(5):618-33.
Chong Chen, Hongqian Sang, Pengcheng Ding, Ye Sun, Manuela Mura, Ying Hu, Lev N. Kantorovich,* Flemming Besenbacher*, Miao Yu*, Xanthine quartets on Au(111), J. Am. Chem. Soc., 2018, 140, 54–57.
Zhenglin Li, Ying Hu, Zhaohua Miao, Han Xu, Chunxiao Li, Yan Zhao, Zhuo Li, Manli Chang, Zhuo Ma, Ye Sun,* Flemming Besenbacher,* Peng Huang,* and Miao Yu*, Dual-Stimuli Responsive Bismuth Nanoraspberries for Multimodal Imaging and Combined Cancer Therapy, Nano Letters, 2018, DOI: 10.1021/acs.nanolett.8b02639. (ACS Highlight).
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