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研究领域

statistical genetics; epigenetics; genomic data integration.

近期论文

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Adams HHH, Hibar DP, Chouraki V, Stein JL, Nyquist P, Renteria ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivières S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis KA, Aribisala BS, Armstrong NJ, Athanasiu L et al. Novel genetic loci underlying human intracranial volume identified through genome-wide association. Accepted, Nature Neuroscience, 31/08/2016. Stirzaker C, Song J, Ng W, Du Q, Armstrong NJ, Locke W, Statham A, Pidsley R, Valdes-Mora F, French F, Zotenko E, Clark S. Methyl-CpG-Binding Protein MBD2 plays a key role in maintenance and spread of DNA methylation of CpG islands and shores in cancer. Accepted, Oncogene, 18/07/16. Tran DN, Smith SABC, Brown DA, Parker AJC, Joseph JE, Armstrong NJ, Sewell WA. Polychromatic flow cytometry is more sensitive than microscopy in detecting small monoclonal plasma cell populations. Accepted, Cytometry: Part B – Clinical Cytometry, 13/07/16. Mather K, Thalamuthu A, Oldmeadow C, Song F, Armstrong N, Poljak A, Holliday E, McEvoy M, Kwok JBJ, Assareh A, Reppermund S, Kochan N, Lee T, Ames D, Wright M, Trollor J, Schofield P, Brodaty H, Scott R, Schofield PR, Attia J, Sachdev P. Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults. Scientific Reports, 2016 6:23675. Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJ, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P, McMahon FJ, Meyer-Lindenberg A, Mattheisen M, Andreassen OA, Gruber O, Sachdev PS, Roiz-Santiañez R, Saykin AJ, Ehrlich S, Mather KA, Turner JA, Schwarz E, Thalamuthu A, Yao Y, Ho YY, Martin NG, Wright MJ; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Psychosis Endophenotypes International Consortium; Wellcome Trust Case Control Consortium 2; Enigma Consortium, O’Donovan MC, Thompson PM, Neale BM, Medland SE, Sullivan PF. Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nature Neuroscience, 2016 19(3):420-31. Lupton MK, Strike L, Hansell NK, Wen W, Mather KA, Armstrong NJ, Thalamuthu A et al. The effect of increased genetic risk for Alzheimer’s disease on hippocampal and amygdala volume. Neurobiology of Aging, 2016 40:68-77. Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, Davies G, Trompet S, Smith JA, Wolf C, Chibnik LB, Liu Y, Vitart V, Kirin M, Petrovic K, Polasek O, Zgaga L, Fawns-Ritchie C, Hoffmann P, Karjalainen J, Lahti J, Llewellyn DJ, Schmidt CO, Mather KA, Chouraki V, Sun Q, Resnick SM, Rose LM, Oldmeadow C, Stewart M, Smith BH, Gudnason V, Yang Q, Mirza SS, Jukema JW, deJager PL, Harris TB, Liewald DC, Amin N, Coker LH, Stegle O, Lopez OL, Schmidt R, Teumer A, Ford I, Karbalai N, Becker JT, Jonsdottir MK, Au R, Fehrmann RSN, Herms S, Nalls M, Zhao W, Turner ST, Yaffe K, Lohman K, van Swieten JC, Kardia SLR, Knopman DS, Meeks WM, Heiss G, Holliday EG, Schofield PW, Tanaka T, Stott DJ, Wang J, Ridker P, Gow AJ, Pattie A, Starr JM, Hocking LJ, Armstrong NJ, et al. GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Molecular Psychiatry, 2016 21(2):189-97. Tan J, Armstrong NJ, Yuan FF, Flower RL, Dyer WB. Identification of genetic polymorphisms that predict responder/non-responder profiles to the RhD antigen. Molecular Immunology, 2015 68(2 Pt C):628-33. Boraxbekk CJ, Ames D, Kochan NA, Lee T, Thalamuthu A, Wen W, Armstrong NJ, Kwok JB, Schofield PR, Reppermund S, Wright MJ, Trollor JN, Brodaty H, Sachdev P, Mather KA. Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals. Neuropsychologia 2015 78:10-7. Wu HZY, Ong KL, Seeher K, Armstrong NJ, Thalamuthu A, Brodaty H, Sachdev P, Mather K. Circulating microRNAs as biomarkers of Alzheimer’s disease – a systematic review. Journal of Alzheimer’s Disease 2015 49(3):755-66 Matuszek MA, Anton A, Thillainathan S, Armstrong NJ. Increased insulin following an oral glucose load, genetic variation near the melatonin receptor MTNR1B, but no biochemical evidence of endothelial dysfunction in young Asian men and women. PLoS ONE, 2015 10(7):e0133611. Hibar D, Stein J, Renteria M, Arias-Vasquez A, Desrivieres S, Jahanshad N, Toro R, Wittfeld K, Andersson M, Aribisala B, Armstrong N et al. Common genetic variants influence human subcortical brain structures. Nature, 2015 520(7546):224-9 Stirzaker C, Zotenko E, Song J, Qu W, Nair S, Locke WJ, Stone A, Armstrong N, Robinson M, Dobrovic A, Avery-Kiejda K, Peters K, French J, Stein S, Korbie D, Trau M, Forbes J, Scott R, Brown MA, Francis G, Clark S. Methylome sequencing in triple negative breast cancer reveals distinct methylation clusters with prognostic value. Nature Communications, 2015 6:5899. Debette S, Ibrahim Verbaas CA, Bressler J, Schuur M, Smith A, Bis JC, Davies G, Wolf C, Gudnason V, Chibnik LB, Yang Q, DeStefano AL, de Quervain DJF, Srikanth V, Lahti J, Grabe HJ, Smith JA, Priebe L, Yu L, Karbalai N, Hayward C, Wilson JF, Campbell H, Petrovic K, Fornage M, Chauhan G, Yeo R, Boxall R, Becker J, Stegle O, Mather KA, Chouraki V, Sun Q, Rose LM, Resnick S, Oldmeadow C, Kirin M, Wright AF, Jonsdottir MK, Au R, Becker A, Amin N, Nalls MA, Turner ST, Kardia SLR, Oostra B, Windham G, Coker LH, Zhao W, Knopman DS, Heiss G, Griswold ME, Gottesman RF, Vitart V, Hastie ND, Zgaga L, Rudan I, Polasek O, Holliday EG, Schofield P, Choi SH, Tanaka T, An Y, Perry RT, Kennedy RE, Sale MM, Wang J, Wadley VG, Liewald DC, Ridker PM, Gow AJ, Pattie A, Starr JM, Porteous D, Liu X, Thomson R, Armstrong NJ, et al. Genome-wide studies of verbal declarative memory in non-demented older people: the CHARGE consortium. Biol Psychiatry, 2015 77(8):749-63. Eslam M, Hashem AM, Leung R, Romero-Gomez M, Berg T, Dore GJ, Chan HLY, Irving WL, Sheridan D, Abate ML, Adams LA, Mangia A, Weltman M, Bugianesi E, Spengler U, Shaker O, Fischer J, Mollison L, Cheng W, Powell E, Nattermann J, Riordan S, McLeod D, Armstrong NJ, Douglas MW, Liddle C, Booth DR, George J, Ahlenstiel G for the International Hepatitis C Genetics Consortium (IHCGC). Interferon lambda rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease. Nature Communications, 2015 6:6422. Chan JPL, Thalamuthu A, Oldmeadow C, Armstrong NJ, Holliday EG, McEvoy M, Kwok JB, Assareh AA, Peel R, Hancock SJ, Reppermund S, Menant J, Trollor JN, Brodaty H, Schofield PR, Attia JR, Sachdev PS, Scott RJ, Mather KA. Genetics of Hand Grip Strength in Mid to Late Life. AGE, 2015 37(1):9745. Lazarus J,Mather KA, Armstrong NJ, Song F, Poljak A, Thalamuthu A,Lee T, Kochan NA, Brodaty H, Wright MJ, Ames D, Sachdev PS, Kwok JBJ. DNA Methylation in the Apolipoprotein-A1 Gene is Associated with Episodic Memory Performance in Healthy Older Individuals. Journal of Alzheimer’s Disease, 2015 44(1):175-82. Zhou J, Belov L, Chapuis P, Chan C, Armstrong NJ, Kaufman KL, Solomon MJ, Clarke SJ, Christopherson R. Surface profiles of live colorectal cancer cells and tumour infiltrating lymphocytes from surgical samples correspond to prognostic categories. Journal of Immunological Methods, 2015 416:59-68. Mather KA, Armstrong NJ, Wen W, Kwok JB, Assareh A, Thalamuthu A, Reppermund S, Duesing K, Wright MJ, Ames D, Trollor JN, Brodaty H, Schofield PR, Sachdev PS. Investigating the genetics of hippocampal volume in older adults. PLoS ONE, 2015 10(1):e0116920. Davies G, Armstrong N, Bis J, Bressler J et al. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE Consortium (N = 53 949). Molecular Psychiatry, 2015 20(2):183-92

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