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招生专业 083001-环境科学 071010-生物化学与分子生物学 071006-神经生物学 招生方向 二恶英,持久性有机污染物,神经毒理 信号通路,二恶英受体 乙酰胆碱酯酶,胆碱能神经传导,神经肌肉接头 教育背景 2002-09--2006-12 香港科技大学 理学博士 1995-09--2002-07 北京大学医学部 临床医学学士及硕士 工作简历 2008-01~2008-07,法国巴黎高师, 博士后 2007-03~2010-03,香港科技大学, 高级研究助理 2002-09~2006-12,香港科技大学, 理学博士 1995-09~2002-07,北京大学医学部, 临床医学学士及硕士 教授课程 环境分子毒理学 环境毒理学研究方法 现代生物学技术在环境健康研究中的应用 奖励信息 (1) 环境化学与生态毒理学“青年创新奖”, , 其他, 2011 (2) Biochemical Journal Young Investigator Award, , 其他, 2009 专利成果 ( 1 ) 用于二恶英类物质生物检测的重组载体, 2014, 第 3 作者, 专利号: 201410099508.1 ( 2 ) 用于二恶英类物质生物检测的重组载体, 2014, 第 3 作者, 专利号: 201410100210.8 ( 3 ) 用于二恶英类物质生物检测的重组载体和细胞, 2014, 第 3 作者, 专利号: 201410099506.2 ( 4 ) 用于二恶英类物质生物检测的重组载体, 2014, 第 3 作者, 专利号: 201410099507.7 ( 5 ) 用于二恶英类物质生物检测的重组载体和细胞, 2014, 第 3 作者, 专利号: 201410100554.9 ( 6 ) 用于二恶英类物质生物检测的重组载体和细胞, 2014, 第 3 作者, 专利号: 201410100654.1 科研项目 ( 1 ) 二恶英免疫毒理效应的分子作用靶点及机理研究, 参与, 国家级, 2013-01--2016-12 ( 2 ) 超高灵敏二恶英类生物检测方法的开发与应用, 参与, 国家级, 2013-01--2015-12 ( 3 ) 二恶英类污染物神经毒理作用新机制的研究, 参与, 国家级, 2012-01--2015-12 ( 4 ) 生活垃圾焚烧厂排放污染物生物检测传感器及生物活性检测技术, 参与, 国家级, 2012-01--2014-12 ( 5 ) 二恶英类污染物免疫毒性的分子机理研究, 参与, 部委级, 2011-01--2013-12 ( 6 ) 二恶英类污染物对神经胶质细胞分化和功能的影响及相关作用机制, 主持, 国家级, 2014-01--2017-12 ( 7 ) 典型污染物的生物作用典型污染物导致信号通路扰动与其生物效应的关联机制, 主持, 部委级, 2014-07--2019-06 ( 8 ) 细颗粒物与生物界面作用机制的系统探索, 参与, 国家级, 2016-01--2019-12 ( 9 ) 二恶英类污染物系统性神经毒理过程与机制研究, 参与, 国家级, 2019-01--2023-12 ( 10 ) 二恶英类污染物对肌肉发育与功能的干扰作用机制与生理代偿机制研究, 主持, 国家级, 2020-01--2023-12 ( 11 ) 高灵敏环境持久性有毒污染物感知与识别生物系统, 参与, 国家级, 2019-07--2024-06 参与会议 (1)New perspective on regulation of acetylcholinesterase via aryl hydrocarbon receptor 2020-12-08 (2)Dioxin suppresses AChE expression in neuron and muscle 2018-09-09 (3)A potential role of microRNA in alterations of AChE expression caused by dioxin 2015-09-26 (4)AN ALTERATION IN ENZYMATIC ACTIVITY OF NEURONAL ACETYLCHOLINESTERASE IN RESPONSE TO DIOXIN Xie HQ, Xu H-M, Hu Q, Tian W-J, Zhao B 2012-08-26 (5)A TRANSCRIPTIONAL REGULATION OF NEURONAL ACETYLCHOLINESTERASE BY DIOXIN Heidi Qunhui Xie, Bin Zhao 2012-06-04 (6)福寿螺胆碱酯酶特性的研究 中国化学会第27届学术年会 谢群慧, 查广才, 赵斌 2010-06-20

近期论文

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(1) Gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice: Neurobehavioral effects on female offspring, SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 通讯作者 (2) Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on spontaneous movement of human neuroblastoma cells, SCIENCE OF THE TOTAL ENVIRONMENT, 2020, 通讯作者 (3) 2,3,7,8-Tetrachlorodibenzo-p-dioxin and up-regulation of neurofilament expression in neuronal cells: Evaluation of AhR and MAPK pathways., Environment International, 2020, 第 2 作者 (4) Regulation of Aryl Hydrocarbon Receptor Signaling Pathway and Dioxin Toxicity byNovel Agonists and Antagonists., Chemical Research in Toxicology, 2020, 通讯作者 (5) Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on spontaneous movement of human neuroblastoma cells., Science of the Total Environment, 2020, 第 3 作者 (6) Effects of astrocyte conditioned medium on neuronal AChE expression upon 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure., Chem Biol Interact., 2019, 通讯作者 (7) Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on acetylcholinesterase during myogenic differentiation of contractile rat primary skeletal muscle cells., Chem Biol Interact., 2019, 通讯作者 (8) The toxic effects of in situ exposure of a native fish species (Anabas testudineus) to electronic waste pollution., Sci Total Environ., 2019, 第 2 作者 (9) Characterization of the Aryl Hydrocarbon Receptor (AhR) Pathway in Anabas testudineus and Mechanistic Exploration of the Reduced Sensitivity of AhR2a., Environ Sci Technol., 2019, 第 2 作者 (10) Type 3 innate lymphoid cells are altered in colons of C57BL/6 mice with dioxin exposure, Sci Total Environ., 2019, 第 2 作者 (11) Transcriptomic analysis of Anabas testudineus and its defensive mechanisms in response to persistent organic pollutants exposure, Sci Total Environ., 2019, 第 2 作者 (12) Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on acetylcholinesterase during myogenic differentiation of contractile rat primary skeletal muscle cells, Chem Biol Interact., 2019, 通讯作者 (13) Effects of astrocyte conditioned medium on neuronal AChE expression upon 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure, Chem Biol Interact., 2019, 通讯作者 (14) Aryl hydrocarbon receptor activity of polyhalogenated carbazoles and the molecular mechanism., Sci Total Environ., 2019, 第 2 作者 (15) 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces alterations in myogenic differentiation of C2C12 cells, Environ Pollut., 2018, 第 1 作者 (16) Development and Application of a Novel Bioassay System for Dioxin Determination and Aryl Hydrocarbon Receptor Activation Evaluation in Ambient-Air Samples., Environ Sci Technol., 2018, 通讯作者 (17) Dioxin induces expression of hsa-miR-146b-5p in human neuroblastoma cells., J Environ Sci (China), 2018, 通讯作者 (18) Acetylcholinesterase Is a Potential Biomarker for a Broad Spectrum of Organic Environmental Pollutants, Environ Sci Technol., 2018, 通讯作者 (19) Dioxins as potential risk factors for autism spectrum disorder, Environ Int., 2018, 第 2 作者 (20) Dioxins as potential risk factors for autism spectrum disorder, Environment International, 2018, 第 2 作者 (21) Acetylcholinesterase Is a Potential Biomarker for a Broad Spectrum of Organic Environmental Pollutants, Environmental Science & Technology, 2018, 通讯作者 (22) SLC6A19 is a novel putative gene, induced by dioxins via AhR in human hepatoma HepG2 cell, Environmental Pollution, 2018, 第 8 作者 (23) Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure, Journal of Environmental Sciences, 2017, 通讯作者 (24) CDC42 expression is altered by dioxin exposure and mediated by multilevel regulations via AhR in human neuroblastoma cells., Sci Rep., 2017, 第 2 作者 (25) New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins, Chem Biol Interact., 2016, 第 1 作者 (26) 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppress AChE activity in NGF treated PC12 cells., Chem Biol Interact., 2016, 通讯作者 (27) Development and characterization of monoclonal antibodies against human aryl hydrocarbon receptor., J Environ Sci, 2016, 通讯作者 (28) Effects of Acute Low-Dose Exposure to the Chlorinated Flame Retardant Dechlorane 602 and Th1 and Th2 Immune Responses in Adult Male Mice., Environ Health Perspect., 2016, 第 3 作者 (29) The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals and Physiological Functions, Environmental Science and Technology, 2015, 第 4 作者 (30) Characterizations of cholinesterases in golden apple snail (Pomacea canaliculata)., J Mol Neurosci., 2014, 第 2 作者 (31) Dioxin and dioxin-like compounds suppress acetylcholinesterase activity via transcriptional downregulations in vitro., J Mol Neurosci. , 2014, 通讯作者 (32) Functional analysis of the dioxin response elements (DREs) of the murine CYP1A1 gene promoter: beyond the core DRE sequence., Int J Mol Sci., 2014, 第 4 作者 (33) The role of AhR in autoimmune regulation and its potential as a therapeutic target against CD4 T cell mediated inflammatory disorder., Int J Mol Sci., 2014, 第 2 作者 (34) Dioxin suppresses the expression of neuronal acetylcholinesterase via aryl hydrocarbon receptor., Environ Health Perspect., 2013, 第 1 作者 (35) 二恶英类持久性有机污染物与老年痴呆可能存在相关性., 环境健康展望中文版, 2013, 第 2 作者 (36) Immuno-analysis Methods for the Detection of Dioxins and Related Chemicals., Sensors, 2012, 第 2 作者 (37) Expression of the IgSF protein Kirre in the rat central nervous system., Life Sci., 2011, 第 3 作者 (38) Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neurons., J Biol Chem., 2010, 第 1 作者 (39) PRiMA directs a restricted localization of tetrameric AChE at synapses., Chem Biol Interact., 2010, 第 1 作者 (40) The PRiMA-linked cholinesterase tetramers are assembled from homodimers: hybrid molecules composed of acetylcholinesterase and butyrylcholinesterase dimers are up-regulated during development of chicken brain., J Biol Chem., 2010, 第 2 作者 (41) An induction effect of heat shock on the transcript of globular acetylcholinesterase , Chem Biol Interact., 2010, 第 2 作者 (42) 二恶英对免疫系统影响的研究进展, 环境化学, 2010, 第 2 作者 (43) Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: an inductive effect of neuron differentiation., Brain Res., 2009, 第 1 作者 (44) Restricted localization of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions—contribution and expression from motor neurons., FEBS J., 2009, 第 2 作者

学术兼职

2018-07-02-2019-12-31,中华预防医学会卫生毒理分会青年委员会委员,

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