葛高翔 - 中国科学院大学

个人简介

招生专业 071010-生物化学与分子生物学招生方向细胞微环境对肿瘤发生及转移的调控教育背景 1996-09--2001-08 中国科学院生物化学研究所博士 1992-08--1996-08 南京大学理学学士学位工作简历 2007-12~现在, 中科院上海生化细胞所, 研究员 2002-10~2007-11,美国威斯康星大学麦迪逊分校, Scientist/博士后 2001-12~2002-09,美国田纳西大学健康科学中心, 博士后 2001-09~2001-11,中科院上海生化细胞所, 助理研究员 1996-09~2001-08,中国科学院生物化学研究所, 博士 1992-08~1996-08,南京大学, 理学学士学位教授课程分子肿瘤学细胞生物学科研项目（ 1 ）细胞生长过程细胞骨架可塑性的调控机制, 参与, 国家级, 2010-01--2014-12 （ 2 ） Lysyl Oxidase在肿瘤转移中的作用机制研究, 主持, 国家级, 2010-01--2012-12 （ 3 ）癌症重大科学问题及防治新策略的研究, 参与, 国家级, 2009-12--2011-07 （ 4 ） ****, 主持, 国家级, 2010-01--2012-12 （ 5 ）赖氨酸氧化酶的调控与功能研究, 主持, 国家级, 2014-01--2017-12 （ 6 ） IV型胶原蛋白在肿瘤发生发展中的功能与机制研究, 主持, 国家级, 2015-01--2019-12 （ 7 ）分子病理表型分析, 主持, 部委级, 2015-10--2020-09 参与会议（1）FSP1-positive fibroblasts: adipogenic niche in adult adipose homeostasis 第11届亚洲及泛太平洋结缔组织学术研讨会 2018-11-16 （2）Extracellular matrix remodeling in lung fibrosis and cancer 第15届海峡两岸生物医学学术研讨会 2016-10-17 （3）Minor type IV collagen α5 chain promotes cancer progression through collagen receptor DDR1 2013-11-29 （4）Minor Type IV Collagen a5 Chain Promotes Cancer Progression through Collagen Receptor DDR1 2013-11-05 （5）Lysyl Oxidase in Lung Fibrosis and Cancer 第一届中-欧个体化肿瘤免疫标志物专家学术论坛 2013-09-06 （6）Lysyl Oxidase in Lung Fibrosis and Cancer 2013-07-21 （7）Cancer- An Overhealing Wound: Lysyl Oxidase in Lung Fibrosis and Cancer 第一届肿瘤新生血管和肿瘤微环境国际研讨会 Gaoxiang Ge 2011-05-30 （8）LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular Gaoxiang Ge 2010-11-12 （9）Activation of TGF-？ Family Growth Factors by BMP-1/Tolloid-like Metalloproteinases Gaoxiang Ge 2009-10-27 （10）Activation of TGF-β family growth factors by BMP-1/Tolloid-like metalloproteinases Gaoxiang Ge 2009-09-12 （11）GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cells Gaoxiang Ge 2004-10-11 （12）Activation mechanism of solubilized epidermal growth factor tyrosine kinase. 1 2000-10-21

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

（1） The Micropeptide LEMP Plays an Evolutionarily Conserved Role in Myogenesis, Cell Death Dis, 2020, 其他（合作组作者）（2） A Mutation That Blocks Integrin α 4 β 7 Activation Prevents Adaptive Immune-Mediated Colitis Without Increasing Susceptibility to Innate Colitis, BMC Biol, 2020, 其他（合作组作者）（3） Progress of Extracellular Matrix., Chin J Cell Biol, 2019, 通讯作者（4） Complexity of type IV collagens: from network assembly to function., Biol Chem, 2019, 通讯作者（5） Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers., Cell Res, 2019, 其他（合作组作者）（6） Dual function of VGLL4 in muscle regeneration., EMBO J, 2019, 其他（合作组作者）（7） Integrin α4β7 switches its ligand specificity via distinct conformer-specific activation., J Cell Biol, 2018, 其他（合作组作者）（8） FSP1-positive fibroblasts are adipogenic niche and regulate adipose homeostasis., PLOS Biol, 2018, 通讯作者（9） Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins., Immunity, 2018, 其他（合作组作者）（10） Th-POK regulates mammary gland lactation through mTOR-SREBP pathway, PLOS Genetics, 2018, 通讯作者（11）细胞外基质与肿瘤相关成纤维细, 生物化学与生物物理进展, 2017, 通讯作者（12） C/EBPβ mediates TNF-α-induced cancer cell migration by inducing MMP expression dependent on p38 MAPK., J Cell Biochem., 2015, 通讯作者（13） Minor type IV collagen 5 chain promotes cancer progression through discoidin domain receptor-1., PLOS Genet., 2015, 通讯作者（14） Targeting Type Iγ phosphatidylinositol phosphate kinase inhibits breast cancer metastasis, Oncogene, 2014, 其他（合作组作者）（15） Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma, Nat Commun, 2014, 其他（合作组作者）（16） Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition., J Mol Cell Biol., 2014, 通讯作者（17） Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation., J Mol Cell Biol., 2014, 通讯作者（18） Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1, Proc Natl Acad Sci U S A, 2012, 其他（合作组作者）（19） Lysyl Oxidase, Extracellular Matrix Remodeling and Cancer Metastasis., Cancer Microenviron., 2012, 通讯作者（20） LKB1 in Lung Cancerigenesis: A Serine/Threonine Kinase as Tumor Suppressor., Protein and Cell., 2011, 通讯作者（21） α3(V) Collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues., J Clin Invest., 2011, 第 1 作者（22） The CC and DE loops in Ig domains 1 and 2 of MAdCAM-1 play different roles in MAdCAM-1 binding to low- and high-affinity integrin a4b7., J Biol Chem., 2011, 通讯作者（23） LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling., Proc Natl Acad Sci U S A., 2010, 通讯作者（24） Fibronectin binds and enhances the activity of bone morphogenetic protein 1., J Biol Chem., 2009, 第 4 作者（25） Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. , Nat Cell Biol., 2009, 通讯作者（26） ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation., Nat Genet., 2008, 通讯作者（27） Two domains of the epidermal growth factor receptor are involved in cytoskeletal interactions., Biochem Biophys Res Commun. , 2008, 第 3 作者（28） Bone Morphogenetic Protein 1 Processes Prolactin to a 17kDa Anti-Angiogenic Form., Proc Natl Acad Sci U S A., 2007, 第 1 作者（29） Bone Morphogenetic Protein 1 Prodomain Specifically Binds, Localizes and Regulates Signaling of Bone Morphogenetic Proteins 2 and 4., J Biol Chem, 2007, 第 2 作者（30） Inhibition of bone morphogenetic protein 1 by native and altered forms of ？2-macroglobulin., J Biol Chem, 2006, 第 1 作者（31） ., BMP1 controls TGF？1 activation via cleavage of latent TGF？-binding protein, J Cell Biol., 2006, 第 1 作者（32） bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis., Mech Dev., 2006, 第 2 作者（33） TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2., Biochem J., 2006, 第 4 作者（34） Developmental roles of the BMP1/TLD metalloproteinases., Birth Defects Res C Embryo Today, 2006, 第 1 作者（35） Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains., J Biol Chem., 2006, 第 1 作者（36） GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cells., Mol Cell Biol., 2005, 第 1 作者（37） Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis., J Biol Chem., 2004, 第 1 作者（38） Activation mechanism of solubilized epidermal growth factor tyrosine kinase., Biochem Biophys Res Commun, 2002, 第 1 作者（39） Effect of membrane fluidity on tyrosine kinase activity of reconstituted Epidermal Growth Factor Receptor., Biochem Biophys Res Commun., 2001, 第 1 作者

学术兼职

2020-01-01-今,中国细胞生物学学会细胞结构和行为专业分会, 委员 2019-09-01-今,上海市生物化学与分子生物学学会, 常务理事 2019-06-01-今,中国生理学会基质生物学专业委员会, 副主任委员 2017-04-01-今,中国细胞生物学学会肿瘤细胞生物学分会, 委员 2014-03-01-今,Acta Biochimica et Biophysica Sinica, 编委