个人简介
招生专业
071005-微生物学
071007-遗传学
071022-基因组学
招生方向
合成生物学,基因合成,基因线路,代谢工程,蛋白质和酶工程
表观遗传性,组蛋白修饰
教育背景
2000-08--2006-08 美国爱荷华州立大学 研究生/博士
1997-09--2000-07 清华大学生物科学与技术系 研究生/硕士
1993-09--1997-07 南京大学基础学科教学强化部 本科/学士
工作简历
2017-05~现在, 中国科学院深圳先进技术研究院, 研究员
2011-03~2017-04,清华大学生命科学学院, 研究员
2006-09~2011-02,美国约翰霍普金斯大学医学院, 博士后
教授课程
Molecular Biology
奖励信息
(1) 首批青年“****”, , 国家级, 2011
(2) Albert Lehninger研究奖, , 研究所(学校), 2011
(3) 爱荷华州立大学优秀研究奖, , 研究所(学校), 2006
专利成果
( 1 ) 一种利用短链引物阻遏提高DNA克隆及组装效率的方法, 发明, 2015, 第 1 作者, 专利号: 201510849165
( 2 ) 酿酒酵母标准化生物元件的构建及体外快速组装代谢途径的方法与应用, 发明, 2015, 第 1 作者, 专利号: 201510138132
( 3 ) 一种用于多元蛋白复合物表达的成套载体及其应用, 发明, 2015, 第 1 作者, 专利号: 201510847331
科研项目
( 1 ) 酿酒酵母rDNA区的合成与功能分析, 主持, 国家级, 2015-01--2018-12
( 2 ) 酿酒酵母高维度蛋白质修饰组动态变化规律研究, 主持, 国家级, 2017-07--2022-06
( 3 ) 微生物合成生物学, 主持, 国家级, 2018-01--2022-12
( 4 ) 酿酒酵母第17条染色体的合成, 主持, 部委级, 2018-01--2019-12
( 5 ) 酿酒酵母中标准化生物元件的设计与构建, 主持, 部委级, 2018-01--2021-12
参与会议
(1)Assemble, characterize and apply the yeast synthetic chromosome XII 第7届国际合成生物学会议 戴俊彪 2017-06-13
(2)Synthetic yeast XII 2017-05-09
(3)Genome Engineering: From biological parts to whole genome synthesis 冷泉港苏州合成生物学会议 2016-12-28
(4)Decode and reprogram the yeast genome 2016-10-20
(5)Development of a “selector” system to identify strains with increased genetic variation after SCRaMbLEing 2016-10-16
近期论文
查看导师新发文章
(温馨提示:请注意重名现象,建议点开原文通过作者单位确认)
(1) Landscape of the Regulatory Elements for Lysine 2-Hydroxyisobutyrylation Pathway, Cell Research, 2018, 通讯作者
(2) Wicket: A Versatile Tool for the Integration and Optimization of Exogenous Pathways in Saccharomyces cerevisiae, ACS Synthetic Biology, 2018, 通讯作者
(3) MiYA, an efficient machine-learning workflow in conjunction with the YeastFab assembly strategy for combinatorial optimization of heterologous metabolic pathways in Saccharomyces cerevisiae, Metabolic Engineering, 2018, 通讯作者
(4) Identifing and characterizing SCRaMbLEd synthetic yeast using ReSCuES, Nature communications, 2018, 通讯作者
(5) Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods, Nature communications, 2018, 通讯作者
(6) 2-hydroxyisobutyrylation on histone H4K8 is regulated by glucose homeostasis in Saccharomyces cerevisiae, PNAS, 2017, 通讯作者
(7) Dissecting Nucleosome Function with a Comprehensive Histone H2A and H2B Mutant Library, G3, 2017, 通讯作者
(8) Construction of comprehensive dosage-matching core histone mutant libraries for Saccharomyces cerevisiae, Genetics, 2017, 通讯作者
(9) Engineering the ribosomal DNA in a megabase synthetic chromosome, Science, 2017, 通讯作者
(10) Synthesis, debugging and consolidation of synthetic chromosomes in yeast: synVI and beyond, Science, 2017, 第 10 作者
(11) Deep functional analysis of synII, a 770 kb synthetic yeast chromosome, Science, 2017, 第 10 作者
(12) Bug mapping and fitness testing of chemically synthesized chromosome X, Science, 2017, 第 10 作者
(13) 3D organization of synthetic and scrambled chromosomes, Science, 2017, 第 10 作者
(14) Construction, characterization and application of genome-wide promoter part library in Saccharomyces cerevisiae, Front Chem Sci Eng, 2017, 通讯作者
(15) EcoExpress—Highly Efficient Construction and Expression of Multicomponent Protein Complexes in Escherichia coli, ACS Synth Biol., 2016, 通讯作者
(16) Identification of Sporopollenin as the Outer Layer of Cell Wall in Microalga Chlorella protothecoides, Front Microbiol., 2016, 通讯作者
(17) Kinetic flux profiling dissects nitrogen utilization pathways in the oleaginous green alga Chlorella protothecoides, J. Phycol, 2016, 通讯作者
(18) YeastFab: the design and construction of standard biological parts for metabolic engineering in Saccharomyces cerevisiae, Nucleic Acids Res, 2015, 通讯作者
(19) Genome-based metabolic mapping and 13C flux analysis reveal systematic properties of an oleaginous microalga Chlorella protothecoides, Plant Physiol, 2015, 通讯作者
(20) Auxenochlorella protothecoides and Prototheca wickerhamii plastid genome sequences give insight into the origins of non-photosynthetic algae, Sci Rep., 2015, 通讯作者
(21) Autophagy-like processes are involved in lipid droplet degradation in Auxenochlorella protothecoides during the heterotrophy-autotrophy transition, Front Plant Sci, 2014, 通讯作者
(22) Oil accumulation mechanisms of the oleaginous microalga Chlorella protothecoides revealed through its genome, transcriptomes, and proteomes, BMC Genomics, 2014, 通讯作者
(23) Engineered TAL Effector modulators for the large-scale gain-of-function screening, Nucleic Acids Res, 2014, 通讯作者