个人简介
在Nature, Developmental Cell, Molecular Psychiatry, Autophagy, Current Opinion in Neurobiology等国际生物学权威期刊上发表研究论文与应邀综述十余篇,引用1800余次。自闭症的非人灵长类动物模型工作入选科技部2016年“中国科学十大进展”,中国科协2016年“中国生命科学十大进展”。课题组长期收到中科院先导项目、科技部、国家基金委重大研究计划等项目资助。仇子龙研究员于2016年获中科院上海分院杰出青年科技创新人才奖,2016年获国家基金委“杰出青年”科学基金,2017年获药明康德生命化学研究奖,2017年任中科院特聘研究员,2018年晋升中科院神经所高级研究员。仇子龙研究员与复旦大学附属儿科医院,上海交大精神卫生中心,新华医院等建立了针对儿童自闭症的长期科研合作,积极开展中国自闭症的基础与临床的合作研究,并与上海多家三甲医院包括中山医院、仁济医院、五官科医院、瑞金医院、九院等建立了长期合作关系,积极推进基础科研的临床转化工作。仇子龙研究员还长期致力于自闭症与生命科学的科普工作,与果壳网,知识分子公众号等科普新媒体长期合作,撰写了大量自闭症与生命科学方面的科普文章,并积极参加在中科院科普SELF论坛,及“一席”论坛等,多次面对大众做针对自闭症与基因科学的科学普及报告,为普及科学知识做出了努力。
招生专业
071006-神经生物学
071008-发育生物学
招生方向
分子生物学
神经科学
分子遗传学
教育背景
1998-09--2003-06 中国科学院上海生物化学与细胞生物学研究所 博士学位
1994-09--1998-06 上海交通大学 学士学位
工作经历
1994-1998年 上海交通大学生物科学与技术系 学士
1998-2003年 中国科学院上海生物化学与细胞生物学研究所 博士
2003-2009年 加州大学圣迭戈分校(UCSD)神经生物学系 博士后
2009年-至今 中国科学院神经科学研究所高级研究员(二级)、博士生导师
工作简历
2009-07~现在, 中国科学院上海生命科学研究院, 研究员
2003-11~2009-07,美国加州大学圣迭戈分校神经生物学系, 博士后
教授课程
神经细胞与神经网络
精神疾病
神经生物学
科研项目
( 1 ) ****, 主持, 国家级, 2009-09--2011-08
( 2 ) 973, 参与, 国家级, 2011-01--2016-01
( 3 ) 基于CRISPR/Cas9方法构建孤独症谱系障碍的非人灵长类动物模型, 主持, 国家级, 2015-01--2017-12
近期论文
查看导师新发文章
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Ø Li X#, Yu B#, Sun Q, Zhang Y, Ren M, Zhang X, Li A, Yuan J, Madisen L, Luo Q, Zeng H, Gong H*, Qiu Z*(2018) Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons.Proc Natl Acad Sci USA.115(2):415-420
Ø Dang T, Duan W, Yu B, Tong DL, Cheng C, Zhang YF, Wu W, Ye K, Zhang WX, Wu M, Wu B, An Y, Qiu Z*, Wu BL* (2018) Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development. Molecular Psychiatry 23(3):747-758
Ø Qiu, Z*(2018) Deciphering MECP2- associated disorders: disrupted circuits and the hope for repair.Current Opinion in Neurobiology 48:30-36 (Invited review)
Ø Wen Z, Cheng TL, Li GZ, Sun SB, Yu SY, Zhang Y*, Du YS*, Qiu Z*(2017) Identification of Autism-Related MECP2 Mutations by Whole-Exome Sequencing and Functional Validation. Molecular Autism8:43
Ø Yang K, Yu B, Cheng C, Cheng TL, Yuan B, Li K, Xiao JH, Qiu Z*, Zhou YX* (2017) Mir505-3p regulates axonal development via inhibiting autophagy pathway by targeting Atg12. Autophagy13:1679-1696
Ø Liu, Z.#, Li, X.#, Zhang, J., Cai, Y., Cheng, T., Cheng, C., Wang, Y., Zhang, C., Nie, Yan., Chen, Z., Bian, W., Zhang, L., Xiao, J., Lu, B., Zhang, Y., Zhang., X., Sang, X., Wu, J., Xu, X., Xiong, Z., Zhang, F., Yu, X., Gong, N., Zhou, W., Sun, Q.*, Qiu, Z.* (2016) Autism-like behaviors and germline transmission in transgenic monkeys overexpressing MeCP2. Nature. 530:98-102
Ø Cheng, T., Wang, Z., Liao, Q., Zhu, Y., Zhou, W., Xu, W., Qiu, Z.*(2014) MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex. Developmental Cell28:547-560
(1) Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors., Journal of Genetics and Genomics., 2017, 通讯作者
(2) Scientific Reports, Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome, 2017, 通讯作者
(3) Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain, Scientific Reports, 2017, 通讯作者
(4) Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development., Molecular Psychiatry, 2017, 通讯作者
(5) L2hgdh deficiency accumulates L-2-hydroxyglutarate with progressive leukoencephalopathy and neurodegeneration., Mol Cell Biol., 2017, 通讯作者
(6) Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2, Nature, 2016, 通讯作者
(7) MeCP2 plays an analgesic role in pain transmission through regulating CREB / miR-132 pathway, Molecular Pain, 2015, 通讯作者
(8) Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress, Scientific Reports, 2015, 通讯作者
(9) Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis, Neurosci Bull, 2015, 第 3 作者
(10) SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development, Journal of Neurochemistry, 2014, 通讯作者
(11) Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders, Molecular Brain, 2014, 通讯作者
(12) MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex, Developmental Cell, 2014, 通讯作者
(13) Generation of a monkey with MECP2 mutations by TALEN-based gene targeting, Neurosci Bull, 2014, 通讯作者
(14) MeCP2: multifaceted roles in gene regulation and neural development, Neurosci Bull, 2014, 第 2 作者
(15) The Epigenetic Switches for Neural Development and Psychiatric Disorders, Journal of Genetics and Genomics, 2013, 通讯作者
(16) Role of the PTEN signaling pathway in autism spectrum disorder, Neuroscience Bulletin, 2013, 第 3 作者
(17) The Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling, Journal of Neuroscience, 2012, 第 1 作者
(18) Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques, Genome Research, 2012, 通讯作者
(19) The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond. , Neurosignals, 2010, 通讯作者
(20) Histone modifier, the gatekeeper of good memory., Cell Research, 2009, 通讯作者
(21) A Calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression., Neuron, 2008, 第 1 作者
(22) A brief history of neuronal gene regulation: regulatory mechanisms and cellular consequences. , Neuron, 2008, 第 1 作者
(23) Tox3: a CREB- and CBP-interacted protein that regulates calcium-dependent transcription in neurons., Proc. Natl. Acad. Sci. USA, 2008, 第 2 作者
(24) Regulation of dendritic development by neuron-specific chromatin remodeling complexes, Neuron, 2007, 第 4 作者
(25) Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. , Journal of Neuroscience, 2006, 第 2 作者