个人简介
教育经历(Academic Qualification)
2009/09-2011/08 香港大学(University of Hong Kong)，巴斯德研究中心(HKU-Pasteur Research Center)，硕士(M.Phil.)
2012/04-2015/08 剑桥大学(University of Cambridge)，病理系(Department of Pathology)，博士(Ph.D.)
研究经历(Working Experience)
2011/09-2012/03 香港大学李嘉诚医学院/University of Hong Kong，研究助理 Research Assistant
2015/09-2020/12 哈尔滨工业大学（深圳）/Harbin Institute of Technology (Shenzhen)，助理教授 Assistant Professor
2021/01-Present 哈尔滨工业大学（深圳）/Harbin Institute of Technology (Shenzhen)，副教授 Associate Professor
Associate editor: BMC Biology; Frontiers in Microbiology
Guest editor: Trends in Analytical Chemistry. Special Issue: AI in analytical chemistry: from methodology to applications
Grants
深圳市基础研究（自由探索）项目/Shenzhen Basic Research (Free Exploration) Project
深圳市高层次人才启动项目/Oversea Talent Startup Fund by Shenzhen City
中央高校基本科研业务费项目（哈尔滨工业大学科研创新基金）/Fundamental Research Funds for the Central Universities
广东省基础与应用基础研究基金, 省企联合基金-面上项目/Natural Science Foundation of Guangdong Province
广东省教育厅普通高校特色创新类项目/Project of Educational Commission of Guangdong Province of China
国家自然科学基金面上项目/National Natural Science Foundation of China
中国科学院基础医学与肿瘤研究所开放课题/Opening Project of Zhejiang Province Key Laboratory for Aptamer and Theranostics, The Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
研究领域
My research interest combines computational and experimental approaches for pathogen and cancer research. On the computational side, my group is both developing and applying the latest deep learning technologies to analyze a wide range of biological and biochemical data, including (i) developing Artificial Intelligence (AI)-powered smart microscopic imaging to accelerate disease diagnostic and drug discovery. (ii) enabling deep learning techniques to be applied to omics data, (e.g. modeling of proteins, DNAs, miRNAs, LncRNAs, and mRNAs and their interactions, structures and/or dynamics in molecular, cellular and tissue level), for the discovery of novel diagnostic biomarkers and therapeutic targets. (iii) the use of deep learning in cheminformatics and chemical biology in guiding drug discovery to target those therapeutic targets and fight against disease. On the experimental side, my group combines imaging, high-throughput sequencing, mass spectrometry, and chemical biology to mechanistically understand diseases at the molecular level by addressing the fundamental question of how those molecules shape the disease systematically.
近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
Predicting RNA structures and functions by artificial intelligence Trends in Genetics 2023-10 | Journal article DOI: 10.1016/j.tig.2023.10.001 CONTRIBUTORS: Jun Zhang; Mei Lang; Yaoqi Zhou; Yang Zhang
Clinical Translation of Aptamers for COVID-19 Journal of Medicinal Chemistry 2023-10-25 | Journal article DOI: 10.1021/acs.jmedchem.3c01607 CONTRIBUTORS: Yang Zhang; Yongen Li
A knowledge-integrated deep learning framework for cellular image analysis in parasite microbiology STAR Protocols 2023-09 | Journal article DOI: 10.1016/j.xpro.2023.102452 CONTRIBUTORS: Ruijun Feng; Sen Li; Yang Zhang
Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19 Trends in Biotechnology 2023-04 | Journal article DOI: 10.1016/j.tibtech.2022.07.012 CONTRIBUTORS: Yang Zhang; Mario Juhas; Chun Kit Kwok
Discovery of novel multi-functional peptides by using protein language models and graph-based deep learning 2023-04-17 | Preprint DOI: 10.1101/2023.04.14.536982 CONTRIBUTORS: Jiawei Luo; Kejuan Zhao; Junjie Chen; Caihua Yang; Fuchuan Qu; Ke Yan; Yang Zhang; Bin Liu
Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation Nature Communications 2023-03-27 | Journal article DOI: 10.1038/s41467-023-37398-9 CONTRIBUTORS: An Xu; Mo Liu; Mo-Fan Huang; Yang Zhang; Ruifeng Hu; Julian A. Gingold; Ying Liu; Dandan Zhu; Chian-Shiu Chien; Wei-Chen Wang et al.
Correction of out-of-focus microscopic images by deep learning Computational and Structural Biotechnology Journal 2022 | Journal article DOI: 10.1016/j.csbj.2022.04.003 Part of ISSN: 2001-0370 CONTRIBUTORS: Yang Zhang
Fluorescence detection of the human angiotensinogen protein by the G-quadruplex aptamer The Analyst 2022 | Journal article DOI: 10.1039/D2AN01057G CONTRIBUTORS: Hui Xi; Hanlin Jiang; Mario Juhas; Yang Zhang
DRBin: metagenomic binning based on deep representation learning Journal of Genetics and Genomics 2022-07 | Journal article DOI: 10.1016/j.jgg.2021.12.005 CONTRIBUTORS: Gang Mao; Yulin Wu; Yang Zhang; Xuan Wang; Yan Zhu; Bo Liu; Yadong Wang; Junyi Li
Fabricated Metal-Organic Frameworks (MOFs) as luminescent and electrochemical biosensors for cancer biomarkers detection Biosensors and Bioelectronics 2022-02 | Journal article DOI: 10.1016/j.bios.2021.113738 CONTRIBUTORS: Brij Mohan; Sandeep Kumar; Hui Xi; Shixuan Ma; Zhiyu Tao; Tiantian Xing; Hengzhi You; Yang Zhang; Peng Ren
A span-based joint model for extracting entities and relations of bacteria biotopes Bioinformatics 2021-12-22 | Journal article DOI: 10.1093/bioinformatics/btab593 CONTRIBUTORS: Mei Zuo; Yang Zhang; Jonathan Wren
Deep Learning Driven Drug Discovery: Tackling Severe Acute Respiratory Syndrome Coronavirus 2 Frontiers in Microbiology 2021-10-28 | Journal article DOI: 10.3389/fmicb.2021.739684 Part of ISSN: 1664-302X
Multiplex Biosensing for Simultaneous Detection of Mutations in SARS-CoV-2 ACS Omega 2021-10-12 | Journal article DOI: 10.1021/acsomega.1c04024 CONTRIBUTORS: Hui Xi; Hanlin Jiang; Mario Juhas; Yang Zhang
Deep Learning for Imaging and Detection of Microorganisms Trends in Microbiology 2021-07 | Journal article DOI: 10.1016/j.tim.2021.01.006 CONTRIBUTORS: Yang Zhang; Hao Jiang; Taoyu Ye; Mario Juhas
Multi-stage malaria parasite recognition by deep learning GigaScience 2021-06-17 | Journal article DOI: 10.1093/gigascience/giab040 CONTRIBUTORS: Sen Li; Zeyu Du; Xiangjie Meng; Yang Zhang
Biosensing Detection of the SARS-CoV-2 D614G Mutation Trends in Genetics 2021-04 | Journal article DOI: 10.1016/j.tig.2020.12.004 CONTRIBUTORS: Yang Zhang; Hui Xi; Mario Juhas
Analytical Chemistry 2021-04-13 | Journal article DOI: 10.1021/acs.analchem.0c04862 CONTRIBUTORS: Yang Zhang; Yang Wu; Hongjin Zheng; Hui Xi; Taoyu Ye; Chun-Yin Chan; Chun Kit Kwok
Deep learning for COVID-19 chest CT (computed tomography) image analysis: a lesson from lung cancer. Computational and structural biotechnology journal 2021-03 | Journal article DOI: 10.1016/j.csbj.2021.02.016 PMID: 33680351 PMC: PMC7923948 CONTRIBUTORS: Jiang H; Tang S; Liu W; Zhang Y
Yang Zhang via Europe PubMed Central Discovery of G-quadruplex-forming sequences in SARS-CoV-2 Briefings in Bioinformatics 2021-03-22 | Journal article DOI: 10.1093/bib/bbaa114 CONTRIBUTORS: Danyang Ji; Mario Juhas; Chi Man Tsang; Chun Kit Kwok; Yongshu Li; Yang Zhang
Genomic pan-cancer classification using image-based deep learning. Computational and structural biotechnology journal 2021-01-15 | Journal article DOI: 10.1016/j.csbj.2021.01.010 PMID: 33598099 PMC: PMC7848437
Deactivation and mislocalization of Toxoplasma gondii rhoptry protein 18 induced by a single amino acid mutation on the proton transport catalytic aspartic acid Microbiological Research 2020 | Journal article DOI: 10.1016/j.micres.2019.126352 EID: 2-s2.0-85073330530 Part of ISBN: 09445013 CONTRIBUTORS: Zhang, Y.; Lai, B.S.; Juhas, M.
Yang Zhang via Scopus - Elsevier G-quadruplex based biosensor: A potential tool for SARS-CoV-2 detection Biosensors and Bioelectronics 2020 | Journal article DOI: 10.1016/j.bios.2020.112494 EID: 2-s2.0-85089200535 Part of ISBN: 18734235 09565663 CONTRIBUTORS: Xi, H.; Juhas, M.; Zhang, Y.
Enzyme-Linked Aptamer Assay (ELAA) for Detection of Toxoplasma ROP18 Protein in Human Serum Frontiers in Cellular and Infection Microbiology 2019 | Journal article DOI: 10.3389/fcimb.2019.00386 EID: 2-s2.0-85076012235 Part of ISBN: 22352988 CONTRIBUTORS: Vargas-Montes, M.; Cardona, N.; Moncada, D.M.; Molina, D.A.; Zhang, Y.; Gómez-Marín, J.E.
MXene-Enabled Electrochemical Microfluidic Biosensor: Applications toward Multicomponent Continuous Monitoring in Whole Blood Advanced Functional Materials 2019 | Journal article DOI: 10.1002/adfm.201807326 EID: 2-s2.0-85056770092 Part of ISBN: 16163028 1616301X CONTRIBUTORS: Liu, J.; Jiang, X.; Zhang, R.; Zhang, Y.; Wu, L.; Lu, W.; Li, J.; Li, Y.; Zhang, H.
Novel electrochemical sensing platform based on integration of molecularly imprinted polymer with Au@Ag hollow nanoshell for determination of resveratrol Talanta 2019 | Journal article DOI: 10.1016/j.talanta.2018.12.063 EID: 2-s2.0-85059457745 Part of ISBN: 00399140 CONTRIBUTORS: Wang, D.; Wang, J.; Zhang, J.; Li, Y.; Zhang, Y.; Li, Y.; Ye, B.-C.
Rapid Colorimetric Determination of Procalcitonin Using Magnetic Separation and Enzymatic Catalysis Analytical Letters 2019 | Journal article DOI: 10.1080/00032719.2018.1482312 EID: 2-s2.0-85049782207 Part of ISBN: 1532236X 00032719 CONTRIBUTORS: Zhang, Y.; Si, X.; Zhang, M.; Yang, X.; Yuan, H.; Wang, X.; Zhang, Y.; Wang, H.
Toxoplasma gondii secretory proteins and their role in invasion and pathogenesis Microbiological Research 2019 | Journal article DOI: 10.1016/j.micres.2019.06.003 EID: 2-s2.0-85067600899 Part of ISBN: 09445013 CONTRIBUTORS: Zhang, Y.; Lai, B.S.; Juhas, M.; Zhang, Y.
Ultrasensitive and selective detection of Staphylococcus aureus using a novel IgY-based colorimetric platform Biosensors and Bioelectronics 2019 | Journal article DOI: 10.1016/j.bios.2019.111570 EID: 2-s2.0-85070236062 Part of ISBN: 18734235 09565663 CONTRIBUTORS: Zhang, Y.; Tan, W.; Zhang, Y.; Mao, H.; Shi, S.; Duan, L.; Wang, H.; Yu, J.
Novel molecularly imprinted polymer (MIP) multiple sensors for endogenous redox couples determination and their applications in lung cancer diagnosis Talanta 2019-07 | Journal article DOI: 10.1016/j.talanta.2019.03.018 CONTRIBUTORS: Jie Liu; Yuli Wang; Xiaoxue Liu; Qunhui Yuan; Yang Zhang; Yingchun Li
Multilayer network analysis of miRNA and protein expression profiles in breast cancer patients PLOS ONE 2019-04-04 | Journal article DOI: 10.1371/journal.pone.0202311 Part of ISSN: 1932-6203
Recent Advances in Aptamer Discovery and Applications Molecules 2019-03-07 | Journal article DOI: 10.3390/molecules24050941 CONTRIBUTORS: Yang Zhang; Bo Lai; Mario Juhas
Microfluidic chip coupled with optical biosensors for simultaneous detection of multiple analytes: A review Biosensors and Bioelectronics 2019-02 | Journal article DOI: 10.1016/j.bios.2018.11.032 CONTRIBUTORS: Zerong Liao; Yang Zhang; Yongrui Li; Yunfei Miao; Shimeng Gao; Fankai Lin; Yulin Deng; Lina Geng
Ruyue Zhang#, Yang Zhang#, Xiling Deng, Shiguo Sun, Yingchun Li, A novel dual-signal electrochemical sensor for bisphenol A determination by coupling nanoporous gold leaf and self-assembled cyclodextrin. Electrochimica Acta. 2018.
Dongyang Wang, Bintong Huang, Jie Liu, Xia Guo, Guzailinur Abudukeyoumu, Yang Zhang*, Bang-Ce Ye*, Yingchun Li*. A novel electrochemical sensor based on Cu@Ni/MWCNTs nanocomposite for simultaneous determination of guanine and adenine. Biosens. Bioelectron., 2018(102): 389-395 (IF: 7.476)
Yu Zhang, Bintong Huang, Feng Yu, Qunhui Yuan, Meng Gu, Junyi Ji, Yang Zhang*, Yingchun Li*. 3D nitrogen-doped graphite foam@Prussian blue: an electrochemical sensing platform for highly sensitive determination of H2O2 and glucose. Microchimica Acta. 2018 (185): 86 (IF: 4.58)
Yangguang Li, Jiang Liu, Yang Zhang, Meng Gu, Dongyang Wang, Yan-yan Dang*, Bang-Ce Ye*, Yingchun Li*. A robust electrochemical sensing platform using carbon paste electrode modified with molecularly imprinted microsphere and its application on methyl parathion detection. Biosens. Bioelectron., 2018(106): 71-77. (IF: 7.476)
Lu Zhang, Gang Wang, Feng Yu, Yang Zhang, Bang-Ce Ye, Yingchun Li*. Facile synthesis of hollow MnFe2O4 nanoboxes based on galvanic replacement reaction for fast and sensitive VOCs sensor. Sens. Actuators B: Chem., 2018(258): 589-596 (IF: 5.401)
Junjie Zhang, Jiang Liu, Yang Zhang, Feng Yu, Fu Wang, Zhengchun Peng*, Yingchun Li*. Voltammetric lidocaine sensor by using a glassy carbon electrode modified with porous carbon prepared from a MOF, and with a molecularly imprinted polymer. Microchimica Acta. 2018 (185): 78(IF: 4.58 )
Ying Fan, Chris Ka-Pun Mok, Michael Chi Wai Chan, Yang Zhang, Béatrice Nal-Rogier, Fran？ois Kien, Roberto Bruzzone and Sumana Sanyal*. Cell Cycle Independent Role of Cyclin D3 in Host Restriction of Influenza Virus Infection, The Journal of Biological Chemistry, 2017, 292, 5070-5088. (IF: 4.125)
Ma, H. #*, Kien, F., Manière, M., Zhang, Yang, Lagarde, N., Tse, KS., Poon, LL. and Nal, B. *. Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection, J Virol, 2012, 86 (3): 1789- 1801 (IF: 4.663)
Huailiang Ma, Francois Kien, Yang Zhang, Leo Lit Man Poon, Beatrice Nal-Rogier*. Identification of human annexin A6 as a novel cellular interactant of influenza A M2 protein: implications for influenza life cycle, Influenza and Other Respiratory Viruses, 2011, 5 (1):269~293(IF: 2.677)
京公网安备 11010802027423号