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个人简介

游恒志教授,博士生导师,博士毕业于英国牛津大学有机化学专业,师从 Prof. Stephen. Fletcher 教授,在不对称催化与合成领域具有多年的研究基础和工作经验。目前任职于哈尔滨工业大学(深圳),理学院化学学科副主任,同时兼任哈尔滨工业大学 (深圳)绿色制药工程研究院副院长,深圳市先进功能材料与综合应用重点实验室副主任。入选哈工大“青年拔尖人才计划”,深圳市“国家级领军人才计划”,深圳市南山区 A 类“领航人才计划”,深圳市南山区青联委员。 工作经历 2018.09 - 至今 中国 哈尔滨工业大学(深圳),教授、博导 2017.04 - 2018.09 美国/英国 Vertex Pharmaceuticals(VRTX),Vertex Fellow 教育经历 2012.10 - 2017.02 英国 牛津大学 有机化学,博士学位 2008.09 - 2012.07 中国 上海大学 应用化学,学士学位

研究领域

结合我国生物医药/制药行业的研发痛点和应用需求,探索研究更加绿色、高效、安全、智能化、自动化的应用型合成与生产技术。研究特色是非均相催化、Al+ 连续流动化学。具体包括:(1)新型非均相催化剂的设计、合成及其在连续流动合成中的应用研究;(2)基于高通量连续流反应系统平台,应用人工智能算法,在化学合成中的路线设计、反应预测、和参数自优化研究;(3)产业导向的药物中间体、功能分子的连续流动生产工艺研究

近期论文

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You, H., Rideau, E., Sidera, M. & Fletcher, S. P. Non-stabilized nucleophiles in Cu-catalysed dynamic kinetic asymmetric allylic alkylation. Nature. 517, 351–355 (2015).DOI: 10.1038/nature14089 Rideau, E., You, H., Sidera, M., Claridge, T. D. W. & Fletcher, S. P. Mechanistic studies on a Cu-catalyzed asymmetric allylic alkylation with cyclic racemic starting materials. J. Am. Chem. Soc. 139, 5614–5624 (2017).DOI: 10.1021/jacs.7b02440 Wang, J.,Li, J., Wang, Y., He, S., You, H. & Chen, F. Polymer-Supported Chiral Heterogeneous Copper Catalyst for Asymmetric Conjugate Addition of Ketones and Imines under Batch and Flow. ACS Catal. 9629–9637 (2022). DOI: 10.1021/acscatal.2c02056 Jun Li, Xiao Song, Yan Wang, Junrong Huang, Hengzhi You and Fen-Er Chen. Copper-Catalyzed Asymmetric Allylic Alkylation of Racemic Inert Cyclic Allylic Ethers under Batch and Flow. Chemical Science, 2023, 14, 4351 - 4356, DOI: 10.1039/D3SC00127J Chao Wang, Yan Wang, Xuelei Jia, Junrong Huang, Hengzhi You, Fen-Er Chen. Recyclable Silica-Support Taniaphos/Copper(Ⅰ) complex for asymmetric allylic alkylation reactions, Journal of Catalysis, 2023, 425, 50-56, DOI: https://doi.org/10.1016/j.jcat.2023.05.025 Ana Xu; Chaoyi Li; Junrong Huang; Heng Pang; Chengyao Zhao; Lijuan Song; Hengzhi You; Xumu Zhang; Fen-Er Chen. Highly enantioselective synthesis of both tetrahydroquinoxalines and dihydroquinoxalinones via Rh–thiourea catalyzed asymmetric hydrogenation. Chemical Science, 2023, 14, 9024 - 9032, DOI: 10.1039/D3SC00803G Ana Xu; Chaoyi Li; Junrong Huang; Heng Pang; Chengyao Zhao; Lijuan Song; Hengzhi You; Xumu Zhang; Fen-Er Chen. Highly enantioselective synthesis of both tetrahydroquinoxalines and dihydroquinoxalinones via Rh–thiourea catalyzed asymmetric hydrogenation. Chemical Science, 2023, 14, 9024 - 9032, DOI: 10.1039/D3SC00803G Lei Xu, Gang Wang, Nianxin Rong, Yang Gu, Le’an Hu, Hengzhi You and Qin Yin. Enantioselective and Step-Economic Synthesis of the Chiral Amine Fragment in the Tyrosine Kinase Inhibitor Repotrectinib by Direct Asymmetric Reductive Amination under Batch and Flow, Org. Process Res. Dev., 2023, DOI: 10.1021/acs.oprd.3c00152 Xiao Song, Jing Qing, Jun Li, Xuelei Jia, Fusong Wu, Junrong Huang, Jian Jin, Hengzhi You. Copper-catalyzed asymmetric allyl alkylation using Grignard reagents under flow, Chinese Journal of Organic Chemistry, 2023, DOI: 10.6023/cjoc202303027. Chao Wang, Yan Wang, Xuelei Jia, Junrong Huang, Hengzhi You, Fen-Er Chen. Recyclable Silica-Support Taniaphos/Copper(Ⅰ) complex for asymmetric allylic alkylation reactions, Journal of Catalysis, 2023, 425, 50-56, DOI: https://doi.org/10.1016/j.jcat.2023.05.025 卿晶,廖竞远,陈凯,代德胜,游恒志. 13C-尿素的合成工艺优化及连续流工艺研究 [J].当代化工研究,2023,(08):146-148. Jun Li, Xiao Song, Yan Wang, Junrong Huang, Hengzhi You and Fen-Er Chen. Copper-Catalyzed Asymmetric Allylic Alkylation of Racemic Inert Cyclic Allylic Ethers under Batch and Flow. Chemical Science, 2023, 14, 4351 - 4356, DOI: 10.1039/D3SC00127J Jingyuan Liao; Xuelei Jia; Fusong Wu; Junrong Huang; Guifu Shen; Hengzhi You; Fen-Er Chen. Rapid mild macrocyclization of depsipeptides under continuous flow: total syntheses of five cyclodepsipeptides. Org. Chem. Front., 2022, Advance Article, DOI: 10.1039/D2QO01577C Dongliang Zhang, Fusong Wu, Zhijian Wan, Yichun Wang, Xuan He, Bing Guo, Hengzhi You and Fen-Er Chen. Palladium Polyaniline Complex: A Simple and Efficient Catalyst for Batch and Flow Suzuki-Miyaura Cross-couplings. Chemical Communications, 2022, DOI: 10.1039/D2CC04051D Jun Li, Xiao Song, Fusong Wu, Hengzhi You, and Fen-Er Chen. Cu-Catalyzed Asymmetric Allylic Alkylation of Racemic CyclicAllyl Bromides with Organolithium Compounds. Eur. J. Org. Chem.2022, e202200860;DOI: 10.1002/ejoc.202200860 Wang, J.,Li, J., Wang, Y., He, S., You, H. & Chen, F. Polymer-Supported Chiral Heterogeneous Copper Catalyst for Asymmetric Conjugate Addition of Ketones and Imines under Batch and Flow. ACS Catal. 9629–9637 (2022). DOI: 10.1021/acscatal.2c02056 Xiaofei Sun,Jingyuan Zhu,Bin Chen ,Hengzhi You ,Huiqing Xu;A feature transferring workflow between data-poor compounds in various tasks;Pols one; 202204;DOI: 10.1371/journal.pone.0266088 Sun Xiaofei, Zhu Jingyuan, Chen Bin, You Hengzhi;融合多模态数据的药物合成反应的虚拟筛选;计算机应用;2022;DOI: 10.11772/j.issn.1001-9081.2021122228 Yufeng Xie; Huaying Liu; Zhong-Liang Li; Xin Zhang; Lijuan Song; Kang Zhou; Feng Yuan; Hengzhi You; Engui Zhao; Zikai He; Construction of chiral through-space luminophores via symmetry breaking triggered by sequenced chlorination; Science China Chemistry; 202305 ;DOI: 10.21203/rs.3.rs-2258314/v1 Jingyuan Liao, Shilong Zhang, Zesheng Wang, Xiao Song, Dongliang Zhang, Ravi Kumar, Jian Jin, Peng Ren, Hengzhi You, Fen-Er Chen;Transition-metal catalyzed asymmetric reactions under continuous flow from 2015 to early 2020;Green Synthesis and Catalysis;202008;DOI: 10.1016/j.gresc.2020.08.001 Brij Mohan; Zhiyu Tao; Sandeep Kumar; Tiantian Xing; Shixuan Ma; Wenbin Huang; Xueping Yang; Hengzhi You; Peng Ren; Water- and pH-Stable Methylthio-Containing Metal–Organic Frameworks as Luminescent Sensors for Metal-Ion Detection; Crystal Growth & Design; 2022; DOI: 10.1021/acs.cgd.2c00493 Mohan, B.,Kumar, S.,Xi, H.,Ma, S.,Tao, Z.,Xing, T.,You, H.,Zhang, Y.,Ren, P; Fabricated Metal-Organic Frameworks (MOFs) as luminescent and electrochemical biosensors for cancer biomarkers detection; Biosensors and Bioelectronics; 2022; DOI: 10.1016/j.bios.2021.113738 Mohan, B.,Modi, K.,Parikh, J.,Ma, S.,Kumar, S.,Kumar Manar, K.,Sun, F.,You, H.,Ren, P; Efficacy of 2-nitrobenzylidene-hydrazine-based selective and rapid sensor for Cu2 ions, histidine, and tyrosine: Spectral and computational stud; Journal of Photochemistry and Photobiology A: Chemistry; 2022; DOI: 10.1016/j.jphotochem.2021.113557 Kumar, S.,Mohan, B.,Tao, Z.,You, H.,Ren, P; Incorporation of homogeneous organometallic catalysts into metal-organic frameworks for advanced heterogenization: A review; Catalysis Science and Technology; 2021; DOI: 10.1039/d1cy00663k Wan, Z.,Tao, Y.,You, H.,Zhang, X.,Shao, J; Na-ZSM-5 Zeolite Nanocrystals Supported Nickel Nanoparticles for Efficient Hydrogen Production from Ammonia Decomposition; ChemCatChem; 2021; DOI: 10.1002/cctc.202100324 Wan, Z.,Tao, Y.,You, H.,Shao, J; Facile synthesis of a sintering-resistant zeolite confined Ni catalyst for efficient COx-free hydrogen generation from ammonia decomposition; Sustainable Energy and Fuels; 2021; DOI: 10.1039/d1se00417d Kumar, S.,Liu, S.,Mohan, B.,Zhang, M.,Tao, Z.,Wan, Z.,You, H.,Sun, F.,Li, M.,Ren, P; Fluorine-Containing Triazole-Decorated Silver(I)-Based Cationic Metal-Organic Framework for Separating Organic Dyes and Removing Oxoanions from Water; Inorganic Chemistry; 2021; DOI: 10.1021/acs.inorgchem.0c03688 Mohan, B.,Kumar, S.,Ma, S.,You, H.,Ren, P; Mechanistic Insight into Charge and Energy Transfers of Luminescent Metal–Organic Frameworks Based Sensors for Toxic Chemicals; Advanced Sustainable Systems; 2021; DOI: 10.1002/adsu.202000293 Mohan, B.,Modi, K.,Patel, C.,Kumar, S.,Zhiyu, T.,You, H.,Ren, P; A new N-methylhydrazinecarbothioamide incorporated “naked-eye” and “turn-off” chemosensor for selective and low detection of Cu2 ions and computation study; Journal of Photochemistry and Photobiology A: Chemistry; 2021; DOI: 10.1016/j.jphotochem.2020.113097 Wan, Z.,Tao, Y.,Shao, J.,Zhang, Y.,You, H; Ammonia as an effective hydrogen carrier and a clean fuel for solid oxide fuel cells; Energy Conversion and Management; 2021;DOI: 10.1016/j.enconman.2020.113729 Liu, F.,Kumar, S.,Li, S.,You, H.,Ren, P.,Zhao, L; Bifunctional design of stable metal-organic framework bearing triazole–carboxylate mixed ligand: Highly efficient heterogeneous catalyst for knoevenagel condensation reaction under mild conditions; Catalysis Communications; 2020; DOI: 10.1016/j.catcom.2020.106032 Rideau, E., You, H., Sidera, M., Claridge, T. D. W. & Fletcher, S. P. Mechanistic studies on a Cu-catalyzed asymmetric allylic alkylation with cyclic racemic starting materials. J. Am. Chem. Soc. 139, 5614–5624 (2017).DOI: 10.1021/jacs.7b02440 You, H., Rideau, E., Sidera, M. & Fletcher, S. P. Non-stabilized nucleophiles in Cu-catalysed dynamic kinetic asymmetric allylic alkylation. Nature. 517, 351–355 (2015).DOI: 10.1038/nature14089 Dai, Y.,Wu, F.,Zang, Z.,You, H.,Gong, H.;Ni-catalyzed reductive allylation of unactivated alkyl halides with allylic carbonates;Chemistry - A European Journal;2012;DOI: 10.1002/chem.201102984 Yin, H.,Zhao, C.,You, H.,Lin, K.,Gong, H.; Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides; Chemical Communications; 2012;DOI: 10.1039/c2cc33232a

学术兼职

2019-至今 哈尔滨工业大学(深圳)江苏省招生组成员,高考志愿咨询专家 2019-至今 深圳市科创委生物处重大项目评审专家 2020-至今 《Green Synthesis&Catalysis》 编委会青年编委 2020-至今 中国博士后科学基金评审专家 2020-至今《Chemical Science》《Organic Chemistry Frontiers》《Chemical Communications》《Journal of Flow Chemistry》等国际期刊审稿人 2021-至今 教育部学位中心-学位论文评审专家 2021-至今 深圳市南山区青年委员 2022-至今 《Chinese Chemical Letters》 编委会青年编委 2022-至今 《当代化工研究》 编委会编委

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