个人简介

Ph.D., Stanford University B.S., New College

研究领域

Biochemistry/Molecular Biology

We investigate Drosophila CNS development. Current interests are (1) how stem cell-like neural precursors (neuroblasts) establish cell polarity and divide asymmetrically; (2) how neuroblasts maintain stem cell-like features as they divide to produce differentiating progeny; (3) how transcription factors regulate temporal identity within neuroblast lineages; and (4) the genetic program governing the production of motoneurons, serotonergic interneurons, or glia.

近期论文

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Lai SL, Doe CQ. Transient nuclear Prospero induces neural progenitor quiescence. eLIFE October 29, 2014;3:e03363 Joy T, Hirono K, Doe CQ. The RanGEF Bj1 Promotes Prospero Nuclear Export and Neuroblast Self-Renewal. Developmental Neurobiology. 2014 October 14 Heckscher ES, Long F, Layden MJ, Chuang C-H, Manning L, Richart J, Pearson JC, Crews ST, Peng H, Myers E, Doe CQ. Atlas-builder software and the eNeuro atlas: resources for developmental biology and neuroscience. Development. 2014 June; 141(12):2524-2532 PMCID: PMC4050700 Gay L, Karfilis KV, Miller MR, Doe CQ, Stankunas K. Applying thiouracil tagging to mouse transcriptome analysis. Nature Protocols. 2014 Feb;9(2):410-20. PMCID: PMC4112099 Kohwi M, Doe CQ. Temporal fate specification and neural progenitor competence during development. Nature Reviews Neuroscience. 2013 Dec;14(2):823-38. Review PMCID: PMC3951856 Cabernard C, Doe CQ. Live Imaging of Neuroblase Lineages within Intact Larval Brains in Drosophila. Cold Spring Harbor Protocols. 2013 October 1;2013(10). PMID: 24086057 Carney TD, Struck AJ, Doe CQ. midlife crisis encodes a conserved zinc-finger protein required to maintain neuronal differentiation in Drosophila. Development. 2013 Oct;140(20):4155-64. PMCID: PMC3787755 Johnston CA, Manning L, Lu MS, Golub O, Doe CQ, Prehoda KE. Formamin-mediated actin polymerization cooperates with Mud/Dynein during Frizzled/Dishevlled spindle orientation. Journal of Cell Science. 2013 Oct 1;126(jpt 19):4436-44 PMCID: PMC3784822 Bayraktar OA, Doe CQ. Combinatorial temporal patterning in progenitors expands neural diversity. Nature. 2013 June 27:498(7455):449-55 PMCID: PMC3941985 Kohwi M, Lupton JR, Lai S-L, Miller MR, Doe CQ. Developmentally Regulated Subnuclear Genome Reorganization Restricts Neural Progenitor Competence in Drosophila. Cell. 2013 Jan 17;152(1-2):197-108. PMCID: PMC3670710 Gay L, Miller MR, Ventura PB, Devasthali V, Vue Z, Thompson HL, Temple S, Zong H, Cleary MD, Stankunas K, Doe CQ. Mouse TU tagging: a chemical/genetic intersectional method for purifying cell type-specific nascent RNA. Genes and Development. 2013 January 1;27(1):98-115. PMCID: PMC3553287 Lai S-L, Miller MR, Robinson KJ, Doe CQ. The snail family member worniu is continuously required in neuroblasts to prevent elav-induced premature differentiation. Developmental Cell, October 16, 2012; 23 (4) 849-57 PMCID: PMC3509944 Manning L, Heckscher ES, Purice MD, Roberts J, Bennett AL, Kroll JR, Pollard JL, Strader ME, Lupton JR, Dyukareva AV, Doan PN, Bauer DM, Wilbur AN, Tanner S, Kelly JJ, Lai S-L, Tran KD, Kohwi M, Laverty TR, Pearson JC, Crews ST, Rubin GM, Doe CQ. A Resource for Manipulating Gene Expression and Analyzing cis-Regulatory Modules in the Drosophila CNS. Cell Reports October 21, 2012; 2(4):1002-13 PMCID: PMC3523218 Heckscher ES, Lockery SR, Doe CQ. Characterization of Drosophila larval crawling at the level of organism, segment, and somatic body wall musculature. Journal of Neuroscience September 5, 2012; 32(36:12461-71 PMCID: PMC3711835 Johnston CA, Doe CQ, Prehoda KE. Structure of an enzyme-derived phosphoprotein recognition domain. PLoS One Vol. 7(4) e36014 PMCID: PMC3335814 Miller MR, Brunelli JP, Wheeler PA, Liu S, Rexroad III CE, Palti, Y., Doe, C.Q., Thorgaard, G.H. A conserved haplotype controls parallel adaptation in geographically distant salmonid populations. Molecular Ecology 21, 237-249. PMCID: PMC3664428 Andersen, R.O., Turnbull, D.W., Johnson, E.A., Doe, C.Q., (2012) Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts. Developmental Biology 363, 258-265. PMID: 22248825 Sun, K., Westholm, J.O., Tsurudome, K., Hagen, J.W., Lu, Y., Kohwi, M., Betel, D., Gao, F-B., Haghighi, A.P., Doe, C.Q., Lai, E.C. (2012) Neurophysiological Defects and Neuronal Gene Deregulation inDrosophila mir-124 Mutants. PLos Genetics V8 (2) e1002515. PMCID: PMC3276548 Carney, T.D., Miller, M.R., Robinson, K.J., Bayraktar, O.A., Osterhout, J.A., Doe, C.Q. (2012) Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis. Developmental Biology 361, 137-146. PMID:22061480 Connell, M., Cabernard, C., Ricketson, D., Doe, C.Q. Prehoda, K.E. (2011) Asymmetric cortical extension shifts cleavage furrow position in Drosophila neuroblasts. Molecular Biology of the Cell V22, 4220-4226. PMCID: PMC3216648