黄亮 - 浙江工业大学 - 化学工程学院

个人简介

2017.05-至今，浙江工业大学，化学工程学院，副研究员 2016.01-2017.05，中国科学院深圳先进技术研究院，生物医药与技术研究所，副研究员 2013.07-2015.12，中国科学院深圳先进技术研究院，生物医药与技术研究所，博士后 2008.09-2013.06，华中农业大学，理学院，博士 2004.09-2008.06，河南科技学院，化学化工学院，学士

研究领域

1.量子点超敏荧光免疫传感荧光免疫层析技术是当前应用于即时诊断（POCT）领域的重要平台，而开发高性能荧光标记探针则是提升免疫层析技术检测性能的关键所在。为解决荧光标记探针发光单元强度弱、荧光团负载量低等缺陷，我们发展了基于金属-配基亲和驱动组装策略的新型纳米结构调控方法，将高色纯度以及高亮度的油溶性量子点紧密、均匀封装于胶体二氧化硅微球基质。基于该探针的荧光免疫层析检测卡可与便携式荧光扫描仪配合使用，在10~15min内可直接检出血液、尿液等样本中的特定生物标志物（如炎症标志物、肿瘤标志物、心肌标志物等），具有高灵敏及特异性优势。利用类似原理，该技术同样应用于毒品检测（如冰毒）、传染病诊断以及食品安全检测（如毒素）等领域的超敏即时诊断。 2.纳米磁珠生物纯化技术与产业化应用我们基于功能单元的控制合成及其组装过程优化的多维材料设计理念，结合纳米模板与亲和驱动策略，实现了对磁性及光学等纳米原件的可控组装及功能集成与协同。力求解决当前磁分离纯化过程中，分离单元磁响应性弱、多分散、液相分散性差等制约体外诊断与生物纯化性能的关键问题。成功制备了单分散、快速磁响应、低沉降、重悬性好（超顺磁）的系列纳米生物磁珠。目前已成功应用的领域包括：在特定条件下吸附/脱附核酸，用于全血、组织、细菌、病毒、植物等DNA/RNA的提取纯化；基于自动化磁分离平台与分子诊断技术（PCR）的血液病毒筛查（乙肝、丙肝、艾滋多重检测）、刑侦司法用痕量样本（指纹、毛发、皮肤等）DNA提取及检测；用于医院及第三方检验机构磁珠法化学发光平台对血液中生物标志物的高通量自动化检测，并与上市公司宁波美康生物开展合作共同推进化学发光用免疫磁珠国产化。

近期论文

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Liang Huang, Tao Liao, Jing Wang, Lijiao Ao, Wu Su*, Jun Hu*. Brilliant Pitaya-Type Silica Colloids with Central–Radial and High-Density Quantum Dots Incorporation for Ultrasensitive Fluorescence Immunoassays. Adv. Funct. Mater. （IF~15.621）, 2018, 28(4): 1705380. Liang Huang, Lijiao Ao, Dehong Hu, Wei Wang, Zonghai Sheng, Wu Su*. Magneto-Plasmonic Nanocapsules for Multimodal-Imaging and Magnetically Guided Combination Cancer Therapy. Chem. Mater.（IF~10.159）, 2016, 28(16): 5896-5904. Liang Huang, Jiening Jin, Jing Wang, Chenxing Jiang, Meng Xu, Huimin Wen, Tao Liao*, Jun Hu*. Homogeneous and high-density gold unit implanted optical labels for robust and sensitive point-of-care drug detection. Nanoscale（IF~6.970）, 2019, 11, 16026–16035. Liang Huang, Lijiao Ao, Xiaobin Xie, Guanhui Gao, Mohamed F. Foda, Wu Su*. Iron Oxide Nanoparticle Layer Templated by Polydopamine Spheres: a Novel Scaﬀold toward Hollow-Mesoporous Magnetic Nanoreactors. Nanoscale（IF~6.970）, 2015, 7(2): 806-813. Liang Huang, Lijiao Ao, Wei Wang, Dehong Hu, Zonghai Sheng, Wu Su*. Multifunctional Magnetic Silica Nanotubes for MR Imaging and Targeted Drug Delivery. Chem. Commun.（IF~6.164）, 2015, 51(18): 3923-3926. Liang Huang, Qiong Wu, Jing Wang, Mohamed Foda, Jiawei Liu, Kai Cai, Heyou Han*. A Brilliant Sandwich Type Fluorescent Nanostructure Incorporating a Compact Quantum Dot Layer and Versatile Silica Substrates. Chem. Commun.（IF~6.164）, 2014, 50(22): 2896-2899. Liang Huang, Zhihui Luo, Heyou Han*. Organosilane Micellization for Direct Encapsulation of Hydrophobic Quantum Dots into Silica Beads with Highly Preserved Fluorescence. Chem. Commun.（IF~6.164）, 2012, 48(49): 6145-6147. Liang Huang, Heyou Han*. One-Step Synthesis of Water-Soluble ZnSe Quantum Dots via Microwave Irradiation. Mater. Lett.（IF~3.019）, 2010, 64(19): 1099-1101. Chi Chen, Lijiao Ao, Yu-Tang Wu, Vjona Cifliku, Marcelina Cardoso Dos Santos, Emmanuel Bourrier, Martina Delbianco, David Parker, Jurriaan M. Zwier, Liang Huang*, Niko Hildebrandt*. Single-Nanoparticle Cell Barcoding by Tunable FRET from Lanthanides to Quantum Dots. Angew. Chem. Int. Ed（IF~12.257）, 2018, 57, 13686-13690. Lijiao Ao, Chunlei Wu, Ke Liu, Wei Wang, Lijing Fang, Liang Huang*, Wu Su*，Polydopamine Derivated Hierarchical Nanoplatform for Efficient Dual-Modal Imaging Guided Combination In Vivo Cancer Therapy. ACS Appl. Mater. Interfaces（IF~8.456）, 2018, 10, 12544-12552. Mohamed F. Foda, Liang Huang, Feng Shao, Heyou Han*. Biocompatible and highly luminescent near-infrared CuInS2/ZnS quantum dots embedded silica beads for cancer cell Imaging. ACS Appl. Mater. Interfaces（IF~8.456）, 2014, 6, 2011-2017. Zeshan Leng, Liang Huang, Feng Shao, Zhicheng Lv, Tingting Li, Xiaoxu Gu, Heyou Han*. Facile synthesis of Cu-In-Zn-S alloyed nanocrystals with temperature-dependent photoluminescence spectra. Mater. Lett.（IF~3.019）, 2014, 119, 100-103. Chi Chen, Ben Corry, Liang Huang, Niko Hildebrandt*. FRET-Modulated Multihybrid Nanoparticles for Brightness-Equalized Single-Wavelength Barcoding. J. Am. Chem. Soc.（IF~14.695）, 2019, 141, 11123−11141. Qiong Wu, Lu Chen, Liang Huang, Jing Wang, Jiawei Liu, Chao Hu, Heyou Han*. Quantum dots decorated gold nanorod as ﬂuorescent-plasmonic dual-modal contrasts agent for cancer imaging. Biosens. Bioelectron.（IF~9.518）, 2015, 74, 16–23. Jing Wang, Zhili Zuo, Liang Huang, Muhammad Asif Warsi, John Q. Xiao*, Jun Hu*. Novel gradient-diameter magnetic nanowire arrays with unconventional magnetic anisotropy behaviors. Chem. Commun.（IF~6.164）, 2018, 54, 7515-7518. Xuepu Li, Kun Chen, Liang Huang, Donglian Lu, Jiangong Liang, Heyou Han*. Sensitive immunoassay for porcine pseudorabies antibody based on fluorescence signal amplification induced by cation exchange in CdSe nanocrystals. Microchim. Acta（IF~5.705）, 2013, 180, 303-310. Kai Cai, Zhicheng Lv, Kun Chen, Liang Huang, Jing Wang, Feng Shao, Yanjun Wang, Heyou Han*. Aqueous synthesis of porous platinum nanotubes at room temperature and their intrinsic peroxidase-like activity. Chem. Commun.（IF~6.164）, 2013, 49, 6024-6026. Jing Wang, Heyou Han*, Xiaochun Jiang, Liang Huang, Lina Chen, Na Li. Quantum Dot-Based Near-Infrared Electrochemiluminescent Immunosensor with Gold Nanoparticle-Graphene Nanosheet Hybrids and Silica Nanospheres Double-Assisted Signal Amplification. Anal. Chem. （IF~6.042）, 2012, 84, 4893-4899. Lijiao Ao, Bi Wang, Peng Liu, Liang Huang, Caixia Yue, Duyang Gao, Chunlei Wua, Wu Su*. A folate-integrated magnetic polymer micelle for MRI and dual targeted drug delivery. Nanoscale（IF~6.970）, 2014, 6, 10710-10716. Na Li, Jing Wang, Heyou Han*, Liang Huang, Feng Shao, Xuepu Li. Intravital imaging of Bacillus thuringiensis Cry1A toxin binding sites in the midgut of silkworm. Anal. Biochem. （IF~2.275）2014, 447, 90-97.