Chen, Chun-Long - Pacific Northwest National Laboratory -

个人简介

Dr. Chun-Long Chen is currently a senior research scientist at Pacific Northwest National Laboratory (PNNL). His research focuses on developing sequence-defined synthetic polymers to mimic natural proteins for biomimetic mineralization and for assembly of porous materials with clean energy applications. He received his Ph.D. degree in physical inorganic chemistry from Sun Yat-Sen (Zhongshan) University in China. His doctoral research was focused on the design and assembly of metallo-supramolecules and the study of their formation mechanisms and structural dynamics. Since then, he has worked extensively on the applications of "bottom-up" assembly approaches, including the assembly of protein and protein-mimetic materials for biomimetic mineralization, and the assembly of complex nanoparticle superstructures by combining peptide self-assembly and peptide-directed mineralization. Throughout his career Dr. Chen has built extensive experience in both synthetic chemistry and materials science, developing a highly interdisciplinary approach to achieve the rational design and assembly of biomimetic materials. Dr. Chen has published more than 80 papers with three US patents. Education and Credentials PhD, Sun Yat-Sen(Zhongshan) University, 2005 BS, Nanchang University, 2000

研究领域

Peptoid synthesis and self-assembly Biomimetic mineralization In situ AFM imaging Chemical biology

近期论文

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Monahan M.C., B. Cai, T. Jian, S. Zhang, G. Zhu, C. Chen, and J.J. De Yoreo, et al. 2021. "Peptoid-Directed Assembly of CdSe Nanoparticles." Nanoscale 13, no. 2:1273-1282. PNNL-SA-158881. doi:10.1039/D0NR07509D Kim J., S.C. Kim, M.A. Kline, E.M. Grzincic, B.W. Tresca, J. Cardiel, and M. Karbaschi, et al. 2020. "Discovery of Stable and Selective Antibody Mimetics from Combinatorial Libraries of Polyvalent, Loop-Functionalized Peptoid Nanosheets." ACS Nano 14, no. 1:185-195. PNNL-SA-155692. doi:10.1021/acsnano.9b07498 Liu J., B. Cai, L. Cui, and C. Chen. 2020. "Peptoid-based hierarchically-structured biomimetic nanomaterials: synthesis, characterization and applications." Science China. Materials 63, no. 7:1099-1112. PNNL-SA-152798. doi:10.1007/s40843-020-1296-8 O'Callahan B.T., K. Park, I.V. Novikova, T. Jian, C. Chen, E.A. Muller, and P.Z. El-Khoury, et al. 2020. "In liquid infrared scattering scanning near-field optical microscopy for chemical and biological nanoimaging." Nano Letters 20, no. 6:4497-4504. PNNL-SA-152805. doi:10.1021/acs.nanolett.0c01291 Wang M., Y. Song, P. Mu, X. Cai, Y. Lin, and C. Chen. 2020. "Peptoid-Based Programmable 2D Nanomembranes Sensor for Selective and Sensitive Detection of H2S in Live Cells." ACS Applied Bio Materials 3, no. 9:6039-6048. PNNL-SA-152742. doi:10.1021/acsabm.0c00657 Zhang Q., C. Zhang, L. Cui, T. Jian, Y. Chen, X. Li, and C. Chen, et al. 2020. "Sequence-defined Peptoids with -OH and -COOH Groups as Binders to Reduce Cracks of Si Nanoparticles of Lithium-Ion Batteries." Advanced Science 7, no. 18:2000749. PNNL-SA-153025. doi:10.1002/advs.202000749 Zhao M., J. Sampath, S. Alamdari, G. Shen, C. Chen, C.J. Mundy, and J. Pfaendtner, et al. 2020. "MARTINI-Compatible Coarse-Grained Model for the Mesoscale Simulation of Peptoids." Journal of Physical Chemistry B 124, no. 36:7745-7764. PNNL-SA-153463. doi:10.1021/acs.jpcb.0c04567 Jiao F., X. Wu, T. Jian, S. Zhang, H. Jin, P. He, and C. Chen, et al. 2019. "Hierarchical Assembly of Peptoid-Based Cylindrical Micelles Exhibiting Efficient Resonance Energy Transfer in Aqueous Solution." Angewandte Chemie International Edition 58, no. 5:12223-12230. PNNL-SA-148211. doi:10.1002/anie.201904598 Jin H., T. Jian, Y. Ding, Y. Chen, P. Mu, L. Wang, and C. Chen. 2019. "Solid-Phase Synthesis of Three-Armed Star-Shaped Peptoids and Their Hierarchical Self-Assembly." Biopolymers 110, no. 4:e23258. PNNL-SA-140649. doi:10.1002/bip.23258 Luo Y., Y. Song, M. Wang, T. Jian, S. Ding, P. Mu, and Z. Liao, et al. 2019. "Bioinspired Peptoid Nanotubes for Targeted Tumor Cell Imaging and Chemo-Photodynamic Therapy." Small 15, no. 43:Article Number 1902485. PNNL-SA-147458. doi:10.1002/smll.201902485 Chen C. 2018. "Peptoid-based membrane-mimetic two dimensional nanomaterials." In Micro- and Nanotechnology Sensors, Systems, and Applications X, April 15-19, 2018,Orlando, Florida. Proceedings of the SPIE, edited by T George, AK Dutta and M Saif Islam, 10639, Aricle No. 106390X. Bellingham, Washington:SPIE. PNNL-SA-133246. doi:10.1117/12.2303685 Jin H., Y. Ding, M. Wang, Y. Song, Z. Liao, C.J. Newcomb, and X. Wu, et al. 2018. "Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids." Nature Communications 9. PNNL-SA-126066. doi:10.1038/s41467-017-02059-1 Merrill N.A., F. Yan, H. Jin, P. Mu, C. Chen, and M.R. Knecht. 2018. "Tunable Assembly of Biomimetic Peptoids as Templates to Control Nanostructure Catalytic Activity." Nanoscale 10, no. 26:12445-12452. PNNL-SA-135764. doi:10.1039/c8nr03852j Mu P., G. Zhou, and C. Chen. 2018. "2D nanomaterials assembled from sequence-defined molecules." Nano-Structures & Nano-Objects 15. PNNL-SA-129009. doi:10.1016/j.nanoso.2017.09.010 O'Callahan B.T., K.T. Crampton, I.V. Novikova, T. Jian, C. Chen, J.E. Evans, and M.M. Raschke, et al. 2018. "Imaging Nanoscale Heterogeneity in Ultrathin Biomimetic and Biological Crystals." Journal of Physical Chemistry C 122, no. 43:24891-24895. PNNL-SA-136203. doi:10.1021/acs.jpcc.8b06681 Song Y., M. Wang, S. Li, H. Jin, X. Cai, D. Du, and C. Chen, et al. 2018. "Efficient Cytosolic Delivery Using Crystalline Nanoflowers Assembled from Fluorinated Peptoids." Small 14, no. 52:Article Number: 1803544. PNNL-SA-139291. doi:10.1002/smll.201803544 Yan F., L. Liu, T.R. Walsh, Y. Gong, P.Z. El-Khoury, Y. Zhang, and Z. Zhu, et al. 2018. "Controlled synthesis of highly-branched plasmonic gold nanoparticles through peptoid engineering." Nature Communications 9. PNNL-SA-118537. doi:10.1038/s41467-018-04789-2 Chien Y., J. Tao, K. Saeki, A.F. Chin, J.L. Lau, C. Chen, and R. Zuckermann, et al. 2017. "Using biomimetic polymers in place of noncollagenous proteins to achieve functional remineralization of dentin tissues." ACS Biomaterials Science & Engineering 3, no. 12:3469-3479. PNNL-SA-125917. doi:10.1021/acsbiomaterials.7b00378 Ma X., S. Zhang, F. Jiao, C.J. Newcomb, Y. Zhang, A. Prakash, and Z. Liao, et al. 2017. "Tuning crystallization pathways through sequence-engineering of biomimetic polymers." Nature Materials 16, no. 7:767-774. PNNL-SA-123850. doi:10.1038/nmat4891 Chen C., R. Zuckermann, and J.J. De Yoreo. 2016. "Surface-Directed Assembly of Sequence-Defined Synthetic Polymers into Networks of Hexagonally Patterned Nanoribbons with Controlled Functionalities." ACS Nano 10, no. 5:5314-5320. PNNL-SA-116103. doi:10.1021/acsnano.6b01333