Ji, Ru-Rong - Duke University - School of Medicine

个人简介

Ru-Rong Ji, PhD, is the chief of pain research within Duke Anesthesiology, co-director of the Center for Translational Pain Medicine, and a professor of anesthesiology and neurobiology. As director of the Sensory Plasticity and Pain Research Laboratory at Duke, his research focuses on molecular and cellular mechanisms of chronic pain, such as inflammatory pain, neuropathic pain, and cancer pain. He is internationally-recognized for his contributions to demonstrating critical roles of MAP kinase signaling pathways and glial cells in the pathogenesis of chronic pain. His recent work has demonstrated powerful antinociceptive actions of pro-resolution lipid mediators (e.g., resolvins). Ji lectures internationally and reviews papers for numerous international journals. He also serves on National Institutes of Health review panels and the editorial boards of Pain, Neuroscience, and Neuroscience Bulletin. He previously was an associate professor at Brigham and Women’s Hospital, Harvard Medical School, before joining the Duke faculty in 2012. He earned a PhD in neurobiology at Shanghai Institute of Physiology and completed postdoctoral training at Peking (Beijing) University Medical School, Karolinska Institute, and Johns Hopkins University School of Medicine.

研究领域

(1) How do neuroinflammation and activation of glial cells (microglia and astrocytes) regulate pain and spinal cord synaptic plasticity via neuro-glial and neuro-immune interactions? (2) How do secreted miRNAs regulate neuronal signaling and synaptic transmission and pain as novel neuromodulators and pain mediators? (3) How do pro-resolution lipid mediators such as resolvins and protectin control pain via GPCR and arrestin signaling? (4) Do pain and itch share similar mechanisms? (5) How does Toll-like receptor (TLR) signaling in primary sensory neurons regulate pain and itch? (6) How can bone marrow stem cells produce long-term pain relief via secreting anti-inflammatory and trophic factors? We employ a multidisciplinary approach that covers in vitro, ex vivo, and in vivo electrophysiology, neuronal and glial cell biology, transgenic mice, and behaviors.

近期论文

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Bang, Sangsu, Christopher R. Donnelly, Xin Luo, Maria Toro-Moreno, Xueshu Tao, Zilong Wang, Sharat Chandra, Andrey V. Bortsov, Emily R. Derbyshire, and Ru-Rong Ji. “Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice.” Nature Communications 12, no. 1 (March 17, 2021): 1704. https://doi.org/10.1038/s41467-021-21940-8. Deerhake, M Elizabeth, Keiko Danzaki, Makoto Inoue, Emre D. Cardakli, Toshiaki Nonaka, Nupur Aggarwal, William E. Barclay, Ru-Rong Ji, and Mari L. Shinohara. “Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M.” Immunity 54, no. 3 (March 9, 2021): 484-498.e8. https://doi.org/10.1016/j.immuni.2021.01.004. Wang, Zilong, Changyu Jiang, Hongyu Yao, Ouyang Chen, Sreya Rahman, Yun Gu, Junli Zhao, Yul Huh, and Ru-Rong Ji. “Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition.” Brain 144, no. 2 (March 3, 2021): 665–81. https://doi.org/10.1093/brain/awaa430. Brigham, Natasha C., Ru-Rong Ji, and Matthew L. Becker. “Degradable polymeric vehicles for postoperative pain management.” Nat Commun 12, no. 1 (March 1, 2021): 1367. https://doi.org/10.1038/s41467-021-21438-3. Donnelly, Christopher R., Changyu Jiang, Amanda S. Andriessen, Kaiyuan Wang, Zilong Wang, Huiping Ding, Junli Zhao, et al. “STING controls nociception via type I interferon signalling in sensory neurons.” Nature 591, no. 7849 (March 2021): 275–80. https://doi.org/10.1038/s41586-020-03151-1. Brigham, Natasha C., Rebecca Nofsinger, Xin Luo, Nathan Z. Dreger, Alexandra K. Abel, Tiffany P. Gustafson, Seth P. Forster, Andre Hermans, Ru-Rong Ji, and Matthew L. Becker. “Controlled release of etoricoxib from poly(ester urea) films for post-operative pain management.” J Control Release 329 (January 10, 2021): 316–27. https://doi.org/10.1016/j.jconrel.2020.11.052. Mwirigi, Juliet, Moeno Kume, Shayne N. Hassler, Ayesha Ahmad, Pradipta R. Ray, Changyu Jiang, Alexander Chamessian, et al. “A Role for Protease Activated Receptor Type 3 (PAR3) in Nociception Demonstrated Through Development of a Novel Peptide Agonist.” J Pain, January 9, 2021. https://doi.org/10.1016/j.jpain.2020.12.006. Rimola, Vittoria, Lisa Hahnefeld, Junli Zhao, Changyu Jiang, Carlo Angioni, Yannick Schreiber, Tabea Osthues, et al. “Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain.” J Neurosci 40, no. 49 (December 2, 2020): 9519–32. https://doi.org/10.1523/JNEUROSCI.1223-20.2020. Jiang, Changyu, Zilong Wang, Christopher R. Donnelly, Kaiyuan Wang, Amanda S. Andriessen, Xueshu Tao, Megumi Matsuda, Junli Zhao, and Ru-Rong Ji. “PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia.” Iscience 23, no. 10 (October 23, 2020): 101570. https://doi.org/10.1016/j.isci.2020.101570. Donnelly, Christopher R., Ouyang Chen, and Ru-Rong Ji. “How Do Sensory Neurons Sense Danger Signals?” Trends Neurosci 43, no. 10 (October 2020): 822–38. https://doi.org/10.1016/j.tins.2020.07.008. Chandra, Sharat, Zilong Wang, Xueshu Tao, Ouyang Chen, Xin Luo, Ru-Rong Ji, and Andrey V. Bortsov. “Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch.” Anesthesiology 133, no. 3 (September 1, 2020): 611–27. https://doi.org/10.1097/ALN.0000000000003427. Chandra, Sharat, Zilong Wang, Xueshu Tao, Ouyang Chen, Xin Luo, Ru-Rong Ji, and Andrey V. Bortsov. “Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch.” Anesthesiology 133, no. 3 (September 2020): 611–27. https://doi.org/10.1097/ALN.0000000000003427. Wang, Kaiyuan, Yun Gu, Yihan Liao, Sangsu Bang, Christopher R. Donnelly, Ouyang Chen, Xueshu Tao, Anthony J. Mirando, Matthew J. Hilton, and Ru-Rong Ji. “PD-1 blockade inhibits osteoclast formation and murine bone cancer pain.” J Clin Invest 130, no. 7 (July 1, 2020): 3603–20. https://doi.org/10.1172/JCI133334. Tao, Xueshu, Michael S. Lee, Christopher R. Donnelly, and Ru-Rong Ji. “Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain.” Neurotherapeutics 17, no. 3 (July 2020): 886–99. https://doi.org/10.1007/s13311-020-00892-9. Donnelly, Christopher R., Amanda S. Andriessen, Gang Chen, Kaiyuan Wang, Changyu Jiang, William Maixner, and Ru-Rong Ji. “Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain.” Neurotherapeutics 17, no. 3 (July 2020): 846–60. https://doi.org/10.1007/s13311-020-00905-7. Lee, Jun-Ho, Chul-Kyu Park, Gang Chen, Qingjian Han, Rou-Gang Xie, Tong Liu, Ru-Rong Ji, and Seok-Yong Lee. “Retraction Notice to: A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief.” Cell 181, no. 7 (June 25, 2020): 1695. https://doi.org/10.1016/j.cell.2020.06.019. Chen, Ouyang, Christopher R. Donnelly, and Ru-Rong Ji. “Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons.” Curr Opin Neurobiol 62 (June 2020): 17–25. https://doi.org/10.1016/j.conb.2019.11.006. Buchheit, Thomas, Yul Huh, William Maixner, Jianguo Cheng, and Ru-Rong Ji. “Neuroimmune modulation of pain and regenerative pain medicine.” J Clin Invest 130, no. 5 (May 1, 2020): 2164–76. https://doi.org/10.1172/JCI134439. Mishra, Santosh K., Joshua J. Wheeler, Saumitra Pitake, Huiping Ding, Changyu Jiang, Tomoki Fukuyama, Judy S. Paps, et al. “Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch.” Cell Rep 31, no. 1 (April 7, 2020): 107472. https://doi.org/10.1016/j.celrep.2020.03.036. Suo, Yang, Zilong Wang, Lejla Zubcevic, Allen L. Hsu, Qianru He, Mario J. Borgnia, Ru-Rong Ji, and Seok-Yong Lee. “Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.” Neuron 105, no. 5 (March 4, 2020): 882-894.e5. https://doi.org/10.1016/j.neuron.2019.11.023.