Wang, Changning - Harvard Medical School - Massachusetts General Hospital

个人简介

Changning Wang, PhD, has a unique and broad background in molecular imaging, medicinal chemistry, pharmaceutical sciences and neuroscience. After finishing his doctoral studies, he joined Martinos Center for Biomedical Imaging as a research fellow and later as a trainee in the Harvard/MGH Nuclear Medicine Training Program, to expand his research skills in clinical imaging research. He is now an assistant professor at Harvard Medical School. In the past few years, he has developed [11C]Martinostat as a robustly brain penetrant imaging agent with selectivity for class I HDACs. [11C]Martinostat is the first and only-to-date PET imaging probe for epigenetic research. He designed this probe in only a half year, an extremely short time. The exploratory IND for [11C]Martinostat was approved by the FDA for first-in-human trials and is the first tool of its kind available to characterize HDAC expression in the living human brain. Dr. Wang is leading the project of [11C]Martinostat clinical imaging in several patient groups. He is also working on developing new PET imaging probes targeting other epigenetic enzymes and using these tools for new drug discovery.

研究领域

Aging, Alzheimer's Disease, Brain, Chemistry, Clinical, Molecular Imaging, PET, PET-MRI, Positron Emission Tomography, Preclinical, Probe Development

近期论文

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Zhipei Sang, Keren Wang, Ping Bai, Anguo Wu, Jian Shi, Wenmin Liu, Gaofeng Zhu, Yiling Wang, Yu Lan, Zude Chen, Yiyang Zhao, Zhanpin Qiao, Changning Wang, and Zhenghuai Tan. 5/2020. “Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer’s disease.” European Journal of Medicinal Chemistry, 194, Pp. 112265. Publisher's Version Ping Bai, Xiaoxia Lu, Yu Lan, Zude Chen, Debasis Patnaik, Stephanie Fiedler, Robin Striar, Stephen J. Haggarty, and Changning Wang. 4/2020. “Radiosynthesis and in vivo evaluation of a new positron emission tomography radiotracer targeting bromodomain and extra-terminal domain (BET) family proteins.” Nuclear Medicine and Biology, 84-85, Pp. 96-101. Publisher's Version Ping Bai, Sha Bai, Michael S. Placzek, Xiaoxia Lu, Stephanie Fiedler, Brenda Ntaganda, Hsiao-Ying Wey, and Changning Wang. 3/2020. “A New Positron Emission Tomography Probe for Orexin Receptors Neuroimaging.” Molecules, 25, 5, Pp. 1018. Publisher's Version Yiwei Zhu, Stephanie A. Fiedler, Matthew L. Hibert, and Changning Wang. 1/2020. “Synthesis of a carbon-11 radiolabeled BACE1 inhibitor.” Medicinal Chemistry Research. Publisher's Version Ping Bai, Yu Lan, Hao Wang, Zude Chen, Stephanie Fiedler, Robin Striar, Xiaoxia Lu, and Changning Wang. 2020. “Development of a Novel Positron Emission Tomography (PET) Radiotracer Targeting Bromodomain and Extra-Terminal Domain (BET) Family Proteins.” Front. Mol. Biosci. . Publisher's Version Zude Chen, Xiashuang Wang, Xiaoshuang Yang, Yulong Xu, Yu Yang, Hao Wang, Tao Li, Ping Bai, Gengyang Yuan, Huabiao Chen, Jing Yang, Stephanie A. Fiedler, Robin Striar, Daniela R. Bernales, Robert E. Koegel, Qi Cao, Chongzhao Ran, Bo Xiang, Hong Li, and Changning Wang. 2020. “Imaging assisted evaluation of antitumor efficacy of a new histone deacetylase inhibitor in the castration-resistant prostate cancer.” European Journal of Nuclear Medicine and Molecular Imaging. Publisher's Version Chieh-En J. Tseng, Tonya M. Gilbert, Mary C. Catanese, Baileigh G. Hightower, Amy T. Peters, Anjali J. Parmar, Minhae Kim, Changning Wang, Joshua L. Roffman, Hannah E. Brown, Roy H. Perlis, Nicole R. Zürcher, and Jacob M. Hooker. 2020. “In vivo human brain expression of histone deacetylases in bipolar disorder.” Transl Psychiatry. Publisher's Version Yulong Xu, Changning Wang, Hsiao-Ying Wey, Yingxia Liang, Zude Chen, Se Hoon Choi, Chongzhao Ran, Kevin D. Rynearson, Daniela R. Bernales, Robert E. Koegel, Stephanie A. Fiedler, Robin Striar, Steven L. Wagner, Rudolph Tanzi, and Can Zhang. 2020. “Molecular imaging of Alzheimer’s disease-related gamma-secretase.” Journal of Experimental Medicine. 2019 Yu Lan, Ping Bai, Zude Chen, Ramesh Neelamegam, Michael S. Placzek, Hao Wang, Stephanie A. Fiedler, Jing Yang, Gengyang Yuan, Xiying Qu, Hayden R. Schmidt, Jinchun Song, Marc D. Normandin, Chongzhao Ran, and Changning Wang. 2019. “Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET).” Acta Pharmaceutica Sinica B, 9, 6, Pp. 1204-1215. Publisher's Version Dong Yang, Hao Wang, Shenglin Luo, Changning Wang, Sheng Zhang, and Shiqi Guo. 2019. “Paper-Cut Flexible Multifunctional Electronics Using MoS2 Nanosheet.” Nanomaterials, 9, 7, Pp. 922. Publisher's Version Tonya M. Gilbert, Nicole R. Zürcher, Christine J. Wu, Anisha Bhanot, Baileigh G. Hightower, Minhae Kim, Daniel S. Albrecht, Hsiao-Ying Wey, Frederick A. Schroeder, Anais Rodriguez-Thompson, Thomas M. Morin, Kamber L. Hart, Amelia M. Pellegrini, Misha M. Riley, Changning Wang, Steven M. Stufflebeam, Stephen J. Haggarty, Daphne J. Holt, Marco L. Loggia, Roy H. Perlis, Hannah E. Brown, Joshua L. Roffman, and Jacob M. Hooker. 2019. “PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.” The Journal of Clinical Investigation, 129, 1, Pp. 364-372. Publisher's VersionAbstract Ping Bai, Hsiao-Ying Wey, Debasis Patnaik, Xiaoxia Lu, Yu Lan, Johanna Rokka, Fiedler Stephanie, Stephen J. Haggarty, and Changning Wang. 2019. “Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging.” Chemical Communications, 55, 86, Pp. 12932-12935. Publisher's Version Zude Chen, Xiashuang Wang, Yulong Xu, and Changning Wang. 2019. “Synthesis of 11C-labeled DNA polymerase-β inhibitor 5-methoxyflavone and PET/CT imaging thereof.” Nuclear Medicine and Biology, 78-79, Pp. 17-22. Publisher's Version Michael S. Placzek, Frederick A. Schroeder, Tao Che, Hsiao-Ying Wey, Ramesh Neelamegam, Changning Wang, Bryan L. Roth, and Jacob Hooker. 2019. “Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging.” ACS Chem. Neurosci., 10, Pp. 1384-395. Publisher's Version Tonya M. Gilbert, Nicole R. Zürcher, Mary C. Catanese, Chieh-En J. Tseng, Maria A. Di Biase, Amanda E. Lyall, Baileigh G. Hightower, Anjali J. Parmar, Anisha Bhanot, Christine J. Wu, Matthew L. Hibert, Minhae Kim, Umar Mahmood, Steven M. Stufflebeam, Frederick A. Schroeder, Changning Wang, Joshua L. Roffman, Daphne J. Holt, Douglas N. Greve, Ofer Pasternak, Marek Kubicki, Hsiao-Ying Wey, and Jacob M. Hooker. 2019. “Neuroepigenetic signatures of age and sex in the living human brain.” Nature Communications, 10, 2945. Publisher's Version Genevieve C. Van de Bittner, Misha M. Riley, Luxiang Cao, Janina Ehses, Scott P. Herrick, Emily L. Ricq, Hsiao-Ying Wey, Michael J. O’Neill, Zeshan Ahmed, Tracey K. Murray, Jaclyn E. Smith, Changning Wang, Frederick A. Schroeder, Mark W. Albers, and Jacob M. Hooker. 2018. “Nasal neuron PET imaging quantifies neuron generation and degeneration.” The Journal of Clinical Investigation, 127, 2, Pp. 681-694. Publisher's Version Changning Wang*, Frederick A. Schroeder, and Jacob M. Hooker. 1/2017. “Development of New Positron Emission Tomography Radiotracer for BET Imaging.” ACS Chem. Neurosci., 8, 1, Pp. 17-21. Publisher's Version Martin G. Strebl, Changning Wang, Frederick A. Schroeder, Michael S. Placzek, Hsiao-Ying Wey, Genevieve C. Van de Bittner, Ramesh Neelamegam, and Jacob M. Hooker*. 2016. “Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance. .” ACS Chem Neurosci. , 7, 5, Pp. 528–533. Publisher's Version Benjamin H. Rotstein, Michael S. Placzek, Hema S. Krishnan, Aleksandra Pekosak, Thomas Lee Collier, Changning Wang, Steven H. Liang, Ethan S. Burstein, Jacob M. Hooker, and Neil Vasdev*. 2016. “Preclinical PET neuroimaging of [11C]bexarotene. .” Molecular Imaging., 15, Pp. 1-5. Publisher's Version Hsiao-Ying Wey, Tonya M. Gilbert, Nicole R. Zürcher, Angela She, Anisha Bhanot, Brendan D. Taillon, Fredrick A. Schroeder, Changning Wang, Stephen J. Haggarty, and Jacob M. Hooker*. 2016. “Insights into neuroepigenetics through human histone deacetylase PET imaging.” Science Translational Medicine. , 8, 351, Pp. 351ra106. Publisher's Version Changning Wang*, Michael S. Placzek, Genevieve C. Van de Bittner, Frederick A. Schroeder, and Jacob M. Hooker. 12/22/2015. “A Novel Radiotracer for Imaging Monoacylglycerol Lipase in the Brain Using Positron Emission Tomography.” ACS Chem. Neurosci., 7, 4, Pp. 484-489. Publisher's Version Hsiao-Ying Wey*, Changning Wang, Frederick A. Schroeder, Jean Logan, Julie C. Price, and Jacob M. Hooker*. 2015. “Kinetic Analysis and Quantification of [11C]Martinostat for in Vivo HDAC Imaging of the Brain. .” ACS Chem Neurosci. , 6, 5, Pp. 708–715. Publisher's Version Changning Wang, Thomas E Eessalu, Vanessa N Barth, Charles H Mitch, Florence F Wagner, Yijia Hong, Ramesh Neelamegam, Frederick A Schroeder, Edward B Holson, Stephen J Haggarty, and Jacob M Hooker*. 2014. “Design, Synthesis, and Evaluation of Hydroxamic Acid-Based Molecular Probes for Imaging of Histone Deacetylase (HDAC). .” Am J Nucl Med Mol Imaging. , 4, 1, Pp. 29–38. Publisher's Version Ramesh Neelamegam, Tim Hellenbrand, Frederick A. Schroeder, Changning Wang, and Jacob M. Hooker*. 2014. “Imaging evaluation of 5-HT2C agonists, [11C]WAY-163909 and [11C]vabicaserin, formed by Pictet-Spengler cyclization. .” J Med Chem. , 57, 4, Pp. 1488–1494. Publisher's Version Changning Wang, Frederick A. Schroeder, Hsiao-Ying Wey, Ronald Borra, Florence F. Wagner, Surya Reis, Sungwon Kim, Edward B. Holson, Stephen J. Haggarty, and Jacob M. Hooker*. 2014. “In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. .” J Med Chem. , 57, 19, Pp. 7999–8009. Publisher's Version F. A. Schroeder, C. Wang, G. C. Van de Bittner, R. Neelamegam, W. R. Takakura, A. Karunakaran, H. Y. Wey, S. A. Reis, J. Gale, Y. L. Zhang, E. B. Holson, S. J. Haggarty, and J. M. Hooker*. 2014. “PET imaging demonstrates HDAC target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat. .” ACS Chem Neurosci. , 5, 10, Pp. 1055–1062. Publisher's Version C. Wang, F. A. Schroeder, and J. M. Hooker*. 2014. “Visualizing epigenetics: Current advances and advantages in HDAC PET imaging techniques. .” Neuroscience. , 264, Pp. 186–197. Publisher's Version Changning Wang, Colin M. Wilson, Christian K. Moseley, Stephen M. Carlin, Shirley Hsu, Frederick A. Schroeder, Christin Y. Sander, and Jacob M. Hooker*. 2013. “Evaluation of Potential PET Imaging Probes for the Orexin 2 Receptors. .” Nucl Med Biol. , 40, 8, Pp. 1000–1005. Publisher's Version Changning Wang, Christian K. Moseley, Stephen M. Carlin, Colin M. Wilson, Ramesh Neelamegam, and Jacob M. Hooker*. 2013. “Radiosynthesis and Evaluation of [11C]EMPA as a potential PET Tracer for Orexin 2 Receptors. .” Bioorg Med Chem Lett., 23, 11, Pp. 3389–3392. Publisher's Version Luca Frullano, Junqing Zhu, Changning Wang, Chunying Wu, Robert H. Miller, and Yanming Wang*. 2012. “Myelin Imaging Compound (MIC) Enhanced Magnetic Resonance Imaging of Myelination. .” J Med Chem. , 55, 1, Pp. 94–105. Publisher's Version