施回 - 浙江大学 - 动物科学学院

个人简介

施回博士，浙江大学“百人计划”研究员，博士生导师。2009年毕业于浙江大学动物科学学院动物医学专业，获农学学士学位。随后在浙江大学动物科学院直博，并于2014年获得农学博士学位。2014年-2020年在美国哈佛大学医学院Dana-Farber肿瘤研究所从事博士后研究工作，利用斑马鱼和人类细胞系作为疾病模型，对一些热点基因在神经母细胞瘤和节细胞神经瘤发病过程中的机理展开研究。在Nature、Cell Research、Science Advances、Nucleic Acids Research、Journal of Experimental Medicine、PNAS等国际重要学术期刊上发表SCI论文13篇，主持美国各类儿科肿瘤基金会项目共4项。

研究领域

动物消化器官发育与疾病

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

第一及共同第一作者论文 1.Shi H*,Tao T*,Abraham BJ,Durbin AD,Zimmerman MW,Kadoch C,Look AT.(2020).ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression.Sci.Adv.6(29),eaaz3440.*共同第一作者 2.Tao T*,Shi H*,Wang M,Perez-Atayde AR,London WB,Gutierrez A,Lemos B,Durbin AD,Look AT.(2020).Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors.J.Exp.Med.217(10),e20191871.*共同第一作者 3.Tao T*,Shi H*,Mariani L,Abraham BJ,Durbin AD,Zimmerman MW,Powers JT,Missios P,Ross KN,Perez-Atayde AR,Bulyk ML,Young RA,Daley GQ,Look AT.(2020).LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.Proc.Natl.Acad.Sci.U.S.A.117(28),16516-16526.*共同第一作者. 4.Tao T*,Sondalle SB*,Shi H*,Zhu S,Perez-Atayde AR,Peng J,Baserga SJ,Look AT.(2017).The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma.Oncogene 36(27),3852-3867.*共同第一作者 5.Shi H,Tao T,Huang D,Ou Z,Chen J,Peng J.(2015).A naturally occurring 4-bp deletion in the intron 4 of p53 creates a spectrum of novel p53 isoforms with anti-apoptosis function.Nucleic Acids Res.43(2),1035-1043.(F1000 Prime Recommended). 6.Tao T*,Shi H*,Guan Y,Huang D,Chen Y,Lane DP,Chen J,Peng J.(2013).Def defines a nucleolar pathway that leading p53 to proteasome-independent degradation.Cell Res.23(5),620-634.*共同第一作者.(Editor’s choice 2013,cover story and featured by a Research Highlight). 7.Tao T*,Shi H*,Huang D,Peng J.(2013).Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafish.PloS One 8(4),e58858.*共同第一作者. 其它论文 1.Tao T,Shi H,Durbin AD,Look AT.(2021).Targeting ganglioneuromas with mTOR inhibitors,Molecular&Cellular Oncology,DOI:10.1080/23723556.2020.1856621 2.Chen F,Huang D,Shi H,Wang Y,Peng J.(2020).Capn3 depletion causes Chk1 and Wee1 accumulation and disrupts synchronization of cell cycle reentry during liver regeneration after partial hepatectomy.Cell Regen.9(1),8. 3.Ma Z,Zhu P,Shi H,Guo L,Zhang Q,Chen Y,Chen S,Zhang Z,Peng J,Chen J.(2019).PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components.Nature 568(7751),259-263. 4.Oppel F*,Tao T*,Shi H,Ross KN,Zimmerman MW,He S,Tong G,Aster JC,Look AT.(2019).Loss of ATRX cooperates with p53-Deficiency to promote the development of sarcomas and other malignancies.PLoS Genet.15(4),e1008039.*共同第一作者. 5.Zhao S,Chen Y,Chen F,Huang D,Shi H,Lo LJ,Chen J,Peng J.(2019).Sas10 controls ribosome biogenesis by stabilizing Mpp10 and delivering the Mpp10-Imp3-Imp4 complex to nucleolus.Nucleic Acids Res.47(6),2996-3012. 6.Guan Y,Huang D,Chen F,Gao C,Tao T,Shi H,Zhao S,Liao Z,Lo L,Wang Y,Chen J,Peng J.(2016).Phosphorylation of Def regulates nucleolar p53 turnover and cell-cycle progression through Def recruitment of Calpain3.PLOS Biol.14(9),e1002555. 7.Niu X,Shi H,Peng J.(2010).The role of mesodermal signals during liver organogenesis in zebrafish.Sci China Life Sci 53(4),455–461.