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个人简介

靳明亮,博士,浙江大学百人计划研究员,加拿大阿尔伯塔大学访问学者。研究主要利用宏基因组学、代谢组学及转录组学等技术,开展早期断奶、高温应激等特殊条件及糖脂代谢异常等对肠道微生态结构和功能的影响研究,揭示肠道微生态中响应特殊条件的靶点微生物类群及内在免疫机制。同时,从肠道来源多糖高产菌株及特色中药入手,研发具有调控特殊环境及代谢异常条件下肠道微生态及免疫功能的富硒多糖、黄芪、白术及灵芝多糖产品并阐明其生物活性和作用机制,奠定肠道功能调控营养制剂的产业化基础。近年来,先后主持国家自然科学基金、国际科学基金、陕西省自然科学基金、中国博士后科学基金特别资助项目和面上项目及中央高校基本科研业务费科研资助项目等多个基金项目;在Carbohydrate Polymers及Frontiers in Physiology等期刊发表SCI论文40余篇。 1.教育经历 2006.09-2011.06:博士研究生,浙江大学,动物营养与饲料科学 2002.09-2006.06:学士,南京农业大学,动物科学 2.工作经历 2020.08-至今:百人计划研究员,浙江大学 2019.05-2020.07:特聘研究员,浙江大学 2014.05-2019.04:副教授,西北工业大学 2018.07-2018.08:访问学者,加拿大阿尔伯塔大学 2015.09-2017.02:访问学者,加拿大阿尔伯塔大学 2013.07-2014.04:讲师,西北工业大学 2011.07-2013.06:博士后,西北工业大学 2011.07-2011.08:访问学者,美国密苏里州立大学哥伦比亚分校 研究与成果 (1)国家自然科学基金(主持):白术多糖对断奶应激诱导肠粘膜屏障损伤的调控作用及机制研究(2018-2020) (2)陕西省自然科学基金面上项目(主持):基于微生物区系研究模拟失重对肠黏膜屏障功能的影响(2017-2018) (3)国际科学基金(主持):Preparation,structural characterization and antiviral activities of sulfated polysaccharides from Astragalus membranaceus(2012-2014) (4)中国博士后科学基金特别资助项目(主持):基于Toll样受体通路研究模拟失重对肠道免疫功能的影响(2013-2014) (5)中国博士后科学基金面上项目(主持):模拟微重力环境下灵芝多糖硫酸酯化衍生物对肠道免疫功能的调控及其机理研究(2011-2013) (6)中央高校基本科研业务费科研资助项目(主持):白术多糖对模拟失重诱导肠黏膜屏障功能障碍的调控作用及机制研究(2017-2018) (7)中央高校基本科研业务费科研资助项目(主持):肠道微生态在模拟失重诱导肠黏膜损伤中的作用及机制研究(2014-2016) 参编著作: [1].Deehan,E.C.,Duar,R.M.,Armet,A.M.,Perez-Muñoz,M.E.,Jin,M.,Walter,J.Chapter 20:Modulation of the gastrointestinal microbiome with nondigestible fermentable carbohydrates to improve human health.Bugs as Drugs:Therapeutic Microbes for the Prevention and Treatment of Disease.ASM Press,2018.

研究领域

肠道微生物与免疫

近期论文

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发表学术论文: [1].Jin,M.L.,Kalainy,S.,Baskota,N.,Chiang,D.,Deehan,E.D.,McDougall,C.,Tandon,P.,Martínez,I.,Cervera,C.,Walter,J.,Abraldes,J.G.Fecal microbiota from patients with cirrhosis has a low capacity to ferment non-digestible carbohydrates into short chain fatty acids.Liver International.2019. [2].Jin,M.L.,Zhang,H.,Wang,J.J.,Shao,D.Y.,Yang,H.,Huang,Q.S.,Shi,J.L.,Xu,C.L.,Zhao,K.Response of intestinal metabolome to polysaccharides from mycelia of Ganoderma lucidum.International Journal of Biological Macromolecules.2019,122:723-731. [3].Jin,M.L.,Zhang,H.,Zhao,K.,Xu,C.L.,Shao,D.Y.,Huang,Q.S.,Shi,J.L.,Yang,H.Responses of intestinal mucosal barrier functions of rats to simulated weightlessness.Frontiers in Physiology.2018,9:729. [4].Jin,M.L.,Zhu,Y.M.,Shao,D.Y.,Zhao,K.,Xu,C.L.,Li,Q.,Yang,H.,Huang,Q.S.,Shi,J.L.Effects of polysaccharide from mycelia of Ganoderma lucidumon intestinal barrier functions of rats.International Journal of Biological Macromolecules.2017,94:1-9. [5].Xu,C.L,Guo,Y.,Qiao,X.J.,Shang,X.Y.,Niu,W.N.,Jin,M.L.Design,recombinant fusion expression and biological evaluation of vasoactive intestinal peptide analogue as novel antimicrobial agent.Molecules.2017,22:1963. [6].Zhao,K.,Jin,M.L.,Chen,Q.,Zheng,P.S.Polysaccharides produced by Enterobacter cloacaeinduce apoptosis in cervical cancer cells.International Journal of Biological Macromolecules.2015,72:960-964.(Co-first Author) [7].Jin,M.L.,Wang,Y.M.,Huang,M.,Lu,Z.Q.,Wang,Y.Z.Sulphation can enhance the antioxidant activity of polysaccharides produced by Enterobacter cloacaeZ0206.Carbohydrate Polymers.2014,99:624-629. [8].Jin,M.L.,Zhao,K.,Huang,Q.S.,Shang,P.Structural features and biological activities of the polysaccharides from Astragalus membranaceus.International Journal of Biological Macromolecules.2014,64:257-266. [9].Jin,M.L.,Huang,Q.S.,Zhao,K.,Shang,P.Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarumL.International Journal of Biological Macromolecules.2013,54:16-23. [10].Jin,M.L.,Zhao,K.,Huang,Q.S.,Shang,P.Preparation,structure and biological activities of exopolysaccharides produced by Enterobacter cloacae.Asian Journal of Chemistry.2013,25:9101-9104. [11].Jin,M.L.,Zhao,K.,Huang,Q.S.,Xu,C.L.,Shang,P.Isolation,structure and bioactivities of the polysaccharides from Angelica sinensis(Oliv.)Diels:A review.Carbohydrate Polymers.2012,89:713-722. [12].Jin,M.L.,Lu,Z.Q.,Huang,M.,Wang,Y.M.,Wang,Y.Z.Effect of Se-enriched polysaccharides produced by Enterobacter cloacaeZ0206 on alloxan-induced diabetic mice.International Journal of Biological Macromolecules.2012,50:348-352. [13].Jin,M.L.,Lu,Z.Q.,Huang,M.,Wang,Y.M.,Wang,Y.Z.Sulfated modification and antioxidant activity of exopolysaccahrides produced by Enterobacter cloacaeZ0206.International Journal of Biological Macromolecules.2011,48:607-612. [14].Jin,M.L.,Wang,Y.M.,Huang,M.,Lu,Z.Q.,Wang,Y.Z.Optimization of culture medium for exo-polysaccharide production by Enterobacter cloacaeZ0206 using response surface methodology.Asian Journal of Chemistry.2011,23:3799-3802. [15].Jin,M.L.,Wang,Y.M.,Xu,C.L.,Lu,Z.Q.,Huang,M.,Wang,Y.Z.Preparation and biological activities of an exopolysaccharide produced by Enterobacter cloacaeZ0206.Carbohydrate Polymers.2010,81:607-611. [16].Arrieta,M.C.,Arevalo,A.,Stiemsma,L.,Dimitriu,P.,Chico,M.E.,Loor,S.,Vaca,M.,Boutin,R.C.T.,Morien,E.,Jin,M.,Turvey,S.E.,Walter,J.,Parfrey,L.W.,Cooper,P.J.,Finlay,B.Associations between infant fungal and bacterial dysbiosis and childhood atopic wheeze in a non-industrialized setting.Journal of Allergy and Clinical Immunology.2018,142,424-434. [17].Nieves-Ramírez,M.E.,Partida-Rodríguez,O.,Laforest-Lapointe,I.,Reynolds,L.A.,Brown,E.M.,Valdez-Salazar,A.,Morán-Silva,P.,Rojas-Velázquez,L.,Morien,E.,Parfrey,L.W.,Jin,M.,Walter,J.,Torres,J.,Arrieta,M.C.,Ximénez-García,C.,Finlay,B.B.Asymptomatic intestinal colonization with protist blastocystis is strongly associated with distinct microbiome ecological patterns.mSystems.2018,3:e00007-18. [18].Yan,L.,Zhao,H.,Zhao,X.,Xu,X.,Di,Y.,Jiang,C.,Shi,J.,Shao,D.,Huang,Q.,Yang,H.,Jin,M.Production of bioproducts by endophytic fungi:chemical ecology,biotechnological applications,bottlenecks,and solutions.Applied Microbiology and Biotechnology.2018,105:6279-6298. [19].Riaz Rajoka,M.S.,Jin,M.,Zhao,H.,Li,Q.,Shao,D.,Huang,Q.,Shi,J.Impact of dietary compounds on cancer-related gut microbiota and microRNA.Applied Microbiology and Biotechnology.2018,102:4291-4303. [20].Riaz Rajok,M.S.,Jin,M.,Zhao,H.,Li,Q.,Shao,D.,Jiang,C.,Huang,Q.,Yang,H.,Shi,J.,Hussain,N.Functional characterization and biotechnological potential of exopolysaccharide produced by Lactobacillus rhamnosusstrains isolated from human breast milk.LWT-Food Science and Technology.2018,89:638-647. [21].Riaz Rajoka,M.S.,Zhao,H.,Lu,Y.,Lian,Z.,Li,N.,Hussain,N.,Shao,D.,Jin,M.,Li,Q.,Shi,J.Anticancer potential against cervix cancer(HeLa)cell line of probiotic Lactobacillus casei and Lactobacillus paracasei strains isolated from human breast milk.Food and Function.2018,23:2705-2715. [22].Zhao,X.,Zhou,L.,Riaz Rajoka,M.S.,Yan,L.,Jiang,C.,Shao,D.,Zhu,J.,Shi,J.,Huang,Q.,Yang,H.,Jin,M.Fungal silver nanoparticles:synthesis,application and challenges.Critical Reviews in Biotechnology.2018,38:817-835. [23].Deehan,E.C.,Duar,R.M.,Armet,A.M.,Perez-Munoz,M.E.,Jin,M.,Walter,J.Modulation of the gastrointestinal microbiome with nondigestible fermentable carbohydrates to improve human health.Microbiology Spectrum.2017,5(5):BAD-0019-2017. [24].Li,J.,Rajoka,W.S.R.,Shao,D.,Jiang,C.,Jin,M.,Huang,Q.,Yang,H.,Shi,J.Strategies to increase the efficacy of using gut microbiota for the modulation of obesity.Obesity Reviews.2017,18:1260-1271. [25].Riaz Rajoka,M.S.,Shi,J.,Zhu,J.,Shao,D.,Huang,Q.,Yang,H.,Jin,M.Capacity of lactic acid bacteria in immunity enhancement and cancer prevention.Applied Microbiology and Biotechnology.2017,101:35-45. [26].Shao,D.,Yao,L.,Riaz,M.S.,Zhu,J.,Shi,J.,Jin,M.,Huang,Q.,Yang,H.Simulated microgravity affects some biological characteristics of Lactobacillus acidophilus.Applied Microbiology and Biotechnology.2017,101:3439-3449. [27].Zhao,H.,Shao,D.,Jiang,C.,Shi,J.,Li,Q.,Huang,Q.,Rajok,M.S.R.,Yang,H.,Jin,M.Biological activity of lipopeptides from Bacillus.Applied Microbiology and Biotechnology.2017,101:5951-5960. [28].Lu,Y.,Shao,D.,Shi,J.,Huang,Q.,Yang,H.,Jin,M.Strategies for enhancing resveratrol production and the expression of pathway enzymes.Applied Microbiology and Biotechnology.2016,100:7407-7421. [29].Xie,J.H.,Tang,W.,Jin,M.L.,Li,J.E.,Xie,M.Y.Recent advances in bioactive polysaccharides from Lycium barbarumL.,Zizyphus jujubaMill,Plantagospp.,and Morusspp.:Structures and functionalities.Food Hydrocolloid.2016,60:148-160. [30].Xie,J.H.,Jin,M.L.,Morris,G.A.,Zha,X.Q.,Chen,H.Q.,Yi,Y.,Li,J.E.,Wang,Z.J.,Gao,J.,Nie,S.P.,Shang,P.,Xie,M.Y.Advances on bioactive polysaccharides from medicinal plants.Critical Reviews in Food Science and Nutrition.2016,56(S1):S60-S84. [31].Huyan,T.,Li,Q.,Yang,H.,Jin,M.L.,Zhang,M.J.,Ye,L.J.,Li,J.,Huang,Q.S.,Yin,D.C.Protective effect of polysaccharides on simulated microgravity-induced functional inhibition of human NK cells.Carbohydrate Polymers.2014,101:819-827. [32].Lu,Z.Q.,Jin,M.L.,Huang,M.,Wang,Y.M.,Wang,Y.Z.Bioactivity of selenium-enriched exopolysaccharides produced by Enterobacter cloacaeZ0206 in broilers.Carbohydrate Polymers.2013,96:131-136. [33].Xu,C.L.,Wang,Y.Z.,Jin,M.L.,Yang,X.Q.Preparation,characterization and immunomodulatory activity of selenium-enriched exopolysaccharide produced by bacterium Enterobacter cloacaeZ0206.Bioresource Technology.2009,100:2095-2097. 发表会议论文: [1].Jin,M.L.,Shang,P.Effects of simulated weightlessness on the intestinal mucosal barrier functions of rats.Proceeding of the 19thInternational Academy of Astronautics(IAA)Humans in Space.Jul.2013.Cologne,Germany. [2].Jin,M.L.,Wang,Y.M.,Lu,Z.Q.,Huang,M.,Xu,C.L.,Wang,Y.Z.Isolation,characterization and antioxidant activity of an exopolysaccharide produced byEnterobacter cloacaeZ0206.Proceedings of ADSA-CSAS-ASAS Joint Annual Meeting.Jul.2010.Denver,USA. [3].Jin,M.L.,Wang,Y.Z.,Yang,X.Q.,Xu,C.L.,Lu,Z.Q.Protective effect of polysaccharide produced by Enterobacter cloacaeZ0206 on cyclophosphamide-induced suppression of immune functions in mice.Proceedings of ADSA-CSAS-ASAS Joint Annual Meeting.Jul.2009.Montreal,Canada. [4].Jin,M.L.,Wang,Y.Z.,Xu,C.L.,Yang,X.Q.Effect of enriched-Selenium exopolysaccharide and exopolysaccharide produced by Enterobacter cloacaeZ0206 on immune function of immunosuppressed mice.Proceeding of the 13th Animal Science Congress of the Asian-Australasian Association of Animal Production Societies.Sep.2008.Hanoi,Vietnam.

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