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主要论文清单(*通讯作者):
1.Weiche Wu,Sisi Wang,Qing Liu,Tizhong Shan*,Yizhen Wang*.Metformin protects against LPS-induced intestinal barrier dysfunction by activating AMPK pathway.Molecular Pharmaceutics.2018 Jul 3.doi:10.1021/acs.molpharmaceut.8b00332.[Epub ahead of print]
2.Liu Jiaqi,You Wenjing,Xu Ziye,Chen Bide,Wang Yizhen,Shan Tizhong*.Rapid Communication:Porcine CRTC3 gene clone,expression pattern,and its regulatory role in intestinal epithelial cells.Journal of Animal Science.2018,96(7):2622-2628.
3.Xiong Yan,Xu Ziye,Wang Yizhen,Kuang Shihuan*,Shan Tizhong*.Adipocyte-specific DKO of Lkb1 and mTOR protects mice against HFD-induced obesity,but results in insulin resistance.Journal of Lipid Research.2018,59(6):974-981.
4.Weiche Wu,Ziye Xu,Ling Zhang,Jiaqi Liu,Jie Feng,Xinxia Wang,Tizhong Shan*,Yizhen Wang*.Muscle-specific deletion of Prkaa1 enhances skeletal muscle lipid accumulation in mice fed a high-fat diet.Journal of Physiology and Biochemistry.2018,74(2):195-205.
5.Jiaqi Liu,Ziye Xu,Weiche Wu,Yizhen Wang,Tizhong Shan*.Regulation role of CRTC3 in skeletal muscle and adipose tissue.Journal of Cellular Physiology.2018,233(2):818-821.
6.Weiche Wu,Sisi Wang,Ziye Xu,Xinxia Wang,Jie Feng,Tizhong Shan,Yizhen Wang.Betaine promotes lipid accumulation in adipogenic-differentiated skeletal muscle cells through ERK/PPARγsignalling pathway.Molecular and Cellular Biochemistry.2018 Jan 30.doi:10.1007/s11010-018-3299-7.
7.Tizhong Shan*,Ziye Xu,Jiaqi Liu,Weiche Wu,Yizhen Wang.Lkb1 regulation of skeletal muscle development,metabolism and muscle progenitor cell homeostasis.Journal of Cellular Physiology.2017,232(10):2653-2656.
8.Weiche Wu,Jie Feng,Denghu Jiang,Xihong Zhou,Qin Jiang,Min Cai,Xinxia Wang,Tizhong Shan*,Yizhen Wang*.AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosine.Scientific Reports.2017,7:41606.
9.Feng Yue,Pengpeng Bi,Chao Wang,Tizhong Shan,Yaohui Nie,Timothy L.Ratliff,Timothy Gavin.Shihuan Kuang.Pten is Necessary for the Quiescence and Maintenance of Adult Muscle Stem Cells.Nature Communications.2017,8:14328.
10.Chao Wang,Min Wang,Justine Arrington,Tizhong Shan,Feng Yue,Yaohui Nie,Weiguo Tao,Shihuan Kuang.Ascl2 inhibits myogenesis by antagonizing the transcriptional activity of myogenic regulatory factors.Development.2017,144(2):235-247.
11.Tizhong Shan*,Ziye Xu,Weiche Wu,Jiaqi Liu,Yizhen Wang.Roles of Notch1 Signaling in Regulating Satellite Cell Fates Choices and Postnatal Skeletal Myogenesis.Journal of Cellular Physiology.2017,232(11):2964-2967.
12.Tizhong Shan*,Jiaqi Liu,Weiche Wu,Ziye Xu,Yizhen Wang.Roles of Notch Signaling in Adipocyte Progenitor Cells and Mature Adipocytes.Journal of Cellular Physiology.2017,232(6):1258-1261.
13.Jiaqi Liu,Ziye Xu,Weiche Wu,Yizhen Wang,Tizhong Shan*.Cre Recombinase Strains Used For the Study of Adipose Tissue and Adipocyte Progenitors.Journal of Cellular Physiology.2017,232(10):2698-2703.
14.Ziye Xu,Jiaqi Liu,Tizhong Shan*.New Roles of Lkb1 in Regulating Adipose Tissue Development and Thermogenesis.Journal of Cellular Physiology.2017,232(9):2296-2298.
15.Tizhong Shan*,Yan Xiong,Shihuan Kuang*.Deletion of Lkb1 in adult mice results in body weight reduction and lethality.Scientific Reports.2016 Nov 8;6:36561.doi:10.1038/srep36561.
16.Pengpeng Bi,Feng Yue,Sato Y,Wirbisky S,Liu W,Tizhong Shan,Wen Y,Zhou D,Freeman J,Shihuan Kuang*.Stage-specific effects of Notch activation during skeletal myogenesis.Elife.2016,5.pii:e17355.
17.Tizhong Shan,Yan Xiong,Pengpeng Zhang,Zhiguo Li,Qingyang Jiang,Pengpeng Bi,Feng Yue,Gongshe Yang,Yizhen Wang,Shihuan Kuang*.Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3.Nature Communications.2016,7:12205.
18.Tizhong Shan*,Pengpeng Zhang,Qingyang Jiang,Yan Xiong,Yizhen Wang,Shihuan Kuang*.Adipocyte-specific deletion of mTOR inhibits adipose tissue development and causes insulin resistance in mice.Diabetologia.2016 59(9):1995-2004.
19.Tizhong Shan*,Pengpeng Zhang,Yan Xiong,Yizhen Wang,Shihuan Kuang*.Lkb1 deletion upregulates Pax7 expression through activating Notch signaling pathway in myoblasts.International Journal of Biochemistry and Cell Biology.2016,76:31-8.
20.Tizhong Shan*,Pengpeng Zhang,Pengpeng Bi,Shihuan Kuang*.Lkb1 deletion promotes ectopic lipid accumulation in muscle progenitor cells and mature muscles.Journal of Cellular Physiology.2015,230(5):1033-1041.
21.Zhang Pengpeng,Liang Xinrong,Shan Tizhong,Jiang Qingyang,Deng Changyan,Zheng Rong,Kuang Shihuan.mTOR is necessary for proper satellite cell activity and skeletal muscle regeneration.Biochemical and Biophysical Research Communications.2015,463(1-2):102-108.
22.Pengpeng Bi,Tizhong Shan,Weiyi Liu,Feng Yue,Xin Yang,Xinrong Liang,Jinghua Wang,Jie Li,Nadia Carlesso,Xiaoqi Liu,Shihuan Kuang.Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity.Nature Medicine.2014,20(8):911-918.
23.Tizhong Shan,Pengpeng Zhang,Xinrong Liang,Pengpeng Bi,Feng Yue,Shihuan Kuang.Lkb1 is indispensable for skeletal muscle development,regeneration and satellite cell homeostasis.Stem Cells.2014,32:2893-2907.
24.Pengpeng Zhang,Tizhong Shan,Xinrong Liang,Changyan Deng,Shihuan Kuang.Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice.Biochemical and Biophysical Research Communications.2014,452(1):53-59.
25.Tizhong Shan,Xinrong Liang,Pengpeng Bi,Shihuan Kuang.Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle.FASEB Journal.2013,27(5):1981-1989.
26.Tizhong Shan,Weiyi Liu,Kuang Shihuan.Fatty acid binding protein 4 expression marks a population of adipocyte progenitors in white and brown adipose tissues.FASEB Journal.2013,27(1):277-287.
27.Tizhong Shan,Xinrong Liang,Pengpeng Bi,Pengpeng Zhang,Weiyi Liu,Shihuan Kuang.Distinct populations of adipogenic and myogenic Myf5-lineage progenitors in white adipose tissues.Journal of Lipid Research.2013,54(8):2214-2224.
28.Tizhong Shan,Yang Ren,Yizhen Wang.Sirtuin1 affects the transcriptional expression of adipose triglyceride lipase in porcine adipocytes.Journal of Animal Science.2013,91(3):1247-54.
29.Yang Ren,Jing Huang,Xiufeng Yu,Tizhong Shan,Xihong Zhou,Xinxia Wang,Yizhen Wang.Breed difference of porcine Sirtuin 1,adipose triglyceride lipase(ATGL)and hormone sensitive lipase(HSL).Livestock Science.2013,158(1-3):199-205.
30.Yang Ren#,Tizhong Shan#,Lingna Zhu,Ting Wu,Jia Guo,Yizhen Wang.Effect of breed on the expression of Sirtuins(Sirt1-7)and antioxidant capacity in porcine brain.Animal.2013,7(12):1994-1998(#contributed equally to this work).
31.Weiyi Liu,Tizhong Shan,Xin Yang,Xinrong Liang,Pengpeng Zhang,Yaqin Liu,Xiaoqi Liu,Shihua Kuang.A heterogeneous lineage origin underlies the phenotypic and molecular differences of white and beige adipocytes.Journal of Cell Science.2013,126:3527-3532.
32.Weiyi Liu,Pengpeng Bi,Tizhong Shan,Xin Yang,Hang Yin,Yongxu Wang,Ning Liu,Rudnicki MA,Shihuan Kuang.miR-133a regulates adipocyte browning in vivo.PLoS Genetics.2013,9(7):e1003626.
33.Jia Guo,Tizhong Shan,Ting Wu,Lingna Zhu,Yang Ren,Sha An,Yizhen Wang.Comparisons of Different Muscle Metabolic Enzymes and Muscle Fiber Types in Jinhua and Landrace Pigs.Journal of Animal Science.2011,89(1):185-191.
34.Tizhong Shan,Yang Ren,Yan Liu,Linna Zhu,Yizhen Wang.Breed difference and regulation of the porcine Sirtuin 1(Sirt1)by insulin.Journal of Animal Science.2010,88(12):3909-3917.
35.Youming Wang,Qingping Meng,Yuming Guo,Yizhen Wang,Zhong Wang,Zhonglei Yao,Tizhong Shan.Effect of Atmospheric Ammonia on Growth Performance and Immunological Response of Broiler Chickens.Journal of Animal and Veterinary Advances.2010,22:2802-2806.
36.Tizhong Shan,Yang Ren,Ting Wu,Chenxin Liu,Yizhen Wang.Regulatory role of Sirt1 on the gene expression of fatty acid binding protein 3 in cultured porcine adipocytes.Journal of Cellular Biochemistry.2009,107:984-991.
37.Tizhong Shan,Ting Wu,Yang Reng,Yizhen Wang,Chenxi Liu.Breed difference and regulation of the porcine adipose triglyceride lipase and hormone sensitive lipase by TNFα.Animal Genetics.2009,40:863-870.
38.Tizhong Shan,Yizhen Wang,Ting Wu,Chenxi Liu,Jia Guo,Yanfang Zhang,Jianxin Liu,Zirong Xu.Porcine sirtuin 1 gene clone,expression pattern,and regulation by resveratrol.Journal of Animal Science.2009,87:895-904.
39.Tizhong Shan,Yizhen Wang,Ting Wu,Jia Guo,Jianxin Liu,Jie Feng,Zirong Xu.Porcine adipose triglyceride lipase complementary deoxyribonucleic acid clone,expression pattern and regulation by resveratrol(RES).Journal of Animal Science.2008.86:1781-1788.
40.Tizhong Shan,Yizhen Wang,Jia Guo,Xiaona Chu,Jianxin Liu and Zirong Xu.The body weight-related differences of leptin and neuropeptide Y(NPY)gene expression in pigs.Asian-Australasian Journal of Animal Sciences,2008.21:161-166.
41.Yanjie Liu,Yizhen Wang,Tizhong Shan,Jia Guo,Chunlan Xu,Jianxin Liu.The tissue-specific and developmental expression patterns of the forkhead transcription factor FoxO1 gene in pigs.Journal of Animal and Feed Sciences.2008.17:182-190.
42.Tizhong Shan,Yizhen Wang,Jianxin Liu,Zirong Xu.Effect of dietary lactoferrin on the immune functions and serum iron level of weanling piglets.Journal of Animal Science.2007,85:2140-2146.
43.Yizhen Wang,Tizhong Shan,Zirong Xu,Jie Feng,Zhongqiang Wang.Effects of the lactoferrin(LF)on the growth performance,intestinal microflora and morphology of weanling pigs.Journal of Animal Science and Technology.2007,135:263-272.
44.Tizhong Shan,Yizhen Wang,Guangfu Liu,Haiqing Huang.Expression of recombinant porcine lactoferrin N-lobe in Pichia methanolica and its antibacterial activity.Journal of Animal and Feed Sciences.2007,16:283-292.
45.Tizhong Shan,Yizhen Wang,Yanjie Liu,Jianxin Liu,Jie Feng,Zirong Xu.Developmental expression of the lipoprotein lipase gene in porcine subcutaneous adipose tissue.Journal of Animal and Feed Sciences.2006,15:621-629.
46.Yizhen Wang,Tizhong Shan,Zirong Xu,Jianxin Liu,Jie Feng.Effect of lactoferrin on the growth performance,intestinal morphology and gene expression of PR-39 and protegrin-1 in weaned piglets.Journal of Animal Science,2006,84:2636-2641.
47.Youjin Tu,Chunlan Xu,Yizhen Wang,Guojia Yao,Tizhong Shan.Effect of Astragalus and Astragalus Polysaccharide on Antimicrobial Peptides PR-39 and Protegrin-1 Gene Expression in Pigs.Turkish Journal of Veterinary&Animal Sciences.2006,30:325-330.
48.徐子叶，吴纬澈，单体中*.调控肌内脂肪沉积的分子机制研究进展.中国畜牧杂志.2018,54(5):1-5.
49.张艳芳，任阳，朱琳娜，单体中，汪以真.猪肌内前体脂肪细胞的体外培养.农业生物技术学报.2011,19(1):116-121.
50.单体中，任阳，伍婷，汪以真.猪甘油三酯脂酶（ATGL）基因特异性siRNA表达载体的构建及鉴定.农业生物技术学报，2009，17(5):763-766.
51.羊雪芹，靳明亮，徐春兰，单体中，汪以真.Z0206细菌富硒多糖对小鼠的免疫调节作用.农业生物技术学报.2009，17(5):815-819.
52.王燕，汪以真，姚国佳，单体中，徐春兰.牛乳铁蛋白对断奶仔猪抗菌肽PMAP-37 mRNA表达的影响.农业生物技术学报.2007，15(5):757-761.
53.刘延杰，汪以真，单体中.猪SOCS3基因克隆及其在不同生长阶段表达差异.农业生物技术学报，2007，15（4）：713-714.
54.单体中，汪以真，刘建新，许梓荣，冯杰.不同日龄猪腹脂中脂肪酸合成酶（FAS）基因表达规律的研究.畜牧兽医学报，2006，37（7）：662-666.
55.单体中，汪以真，李民.猪脂蛋白脂酶基因片段的克隆及不同体重的表达差异.农业生物技术学报，2006，14(2):151-155.
56.单体中，汪以真.猪不同生长阶段脂肪酸合成酶基因的表达差异.农业生物技术学报，2006，14(2):293-294.
57.单体中，汪以真.β-酪啡肽在仔猪营养中的生理功能研究进展.中国畜牧杂志，2006，42(3):59-60.
58.姚国佳，单体中，汪以真，王燕.脂肪酸合成酶基因在皮下脂肪中表达及其与血清Leptin的关系.农业生物技术学报，2006,14(5)：818-819.
59.黄玉海，汪以真，单体中，刘建新，冯杰.猪心型脂肪酸结合蛋白基因的克隆及不同生长阶段表达的差异.农业生物技术学报.2006，14（5）：657-661.
60.屠友金，汪以真，单体中.影响猪肉安全的饲料因素分析.中国畜牧杂志，2004，40(8):29-31.
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