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汪海峰,研究员,博士生导师,国家万人计划科技创新领军人才 浙江大学动物科学学院/新农村发展研究院 主要从事动物消化道微生物、营养代谢、粘膜免疫与生物饲料开发研究 招收动物营养与饲料科学专业科学硕士/博士,畜牧专业硕士,欢迎加入! 学习工作经历 2017.01-今浙江大学研究员 2007.07-2016.12浙江农林大学副教授、教授 2006.06-2007.06西班牙乐达Lucta S.A.饲料技术研发 2001.09-2006.06浙江大学博士研究生 1995.09-2001.07安徽农业大学畜牧、农业自动化专业本科 期间 2018.06-2018.08美国康涅狄格大学访问学者 2012.06-2013.07美国弗吉尼亚理工大学博士后 2011.02-2012.02科技部农村中心挂职科技管理 2009.06-2012.05浙江大学博士后 荣誉与主要奖励 2018年,国家万人计划科技创新领军人才 2016年,科技部中青年科技创新领军人才 2012年,浙江省151人才第二层次人选 科研项目 主持项目 1)AI-2/LuxS群体感应对仔猪肠道乳酸杆菌生物被膜调控作用及机制,国家自然科学基金面上项目(31672430),2017-2020 2)低值原料发酵生物饲料及生态健康养殖技术集成与示范,科技部国家星火计划重点项目(2015GA700001),2015-2016 3)乳酸杆菌对仔猪肠上皮细胞免疫调节效应及NF-κB信号靶点解析,国家自然科学基金面上项目(31172221),2012-2015 4)仔猪肠壁优势乳酸杆菌黏附相关S蛋白功能与结构域解析,国家自然科学基金青年基金项目(30901043),2010-2012 5)嘉兴黑猪种质资源培育与创新利用,国家科技支撑计划子课题(2015BAD03B01-09),2015-2019 6)以AI-2为切入点研究群体感应调控仔猪肠道乳酸杆菌生物膜的分子机制,浙江省自然科学基金重点项目(Z19C170001),2019-2022 7)乳酸杆菌对仔猪肠上皮细胞自噬调控作用及其信号靶点解析,浙江省自然科学基金(Y14C170018),2014-2016 8)乳酸杆菌对猪肠上皮细胞的免疫调节作用及信号分子机制研究,动物营养学国家重点实验室开放课题,2014-2016 9)基于表面蛋白分子结构的高效乳酸杆菌益生菌的筛选与应用,浙江省重点科技创新团队(2011R50025),2012-2015 10)乳仔猪肠道健康功能饲料关键技术中试与示范,浙江省农业成果转化基金项目,2012-2014 11)仔猪肠壁优势乳酸杆菌黏附相关表面蛋白功能与结构域解析,浙江省自然科学基金(Y3090050),2010-2011 12)仔猪肠道优势乳酸杆菌与肠上皮作用的表面相关蛋白位点解析,中国博士后科学基金(20090461387),2009-2011 13)乳仔猪诱食与肠道调理组合饲料添加剂的研制与应用,浙江省科技厅重大农业科技专项(2008C12047),2008-2011 14)新型猪用饲料调味剂开发利用的关键技术研究,企业横向项目,2017-2021 参与项目 1)国家重点研发计划课题《畜禽肠道健康与消化道微生物互作机制研究》(2017YFD0500502),2017-2021,项目骨干 2)乳酸杆菌持家蛋白GAPDH兼职肠道粘附和锚定功能的机制,国家自然科学基金青年基金项目(31601951),2017-2019,排名第二 3)畜禽健康养殖通用技术标准及营养调控关键技术研究,国家科技支撑计划课题(2012BAD39B01),2012-2016,参与 4)奶牛高效健康养殖关键技术集成与示范,国家星火计划重点项目(2013GA700002),2013-2014,参与 5)除抗营养因子和毒素的麻疯树浓缩蛋白与饼粕制备以及他们在单胃动物、鱼类和反刍动物营养中的应用,科技部国际科技合作项目(2009DFA32260),2009-2011,排名第二 6)奶业发展重大关键技术研究与示范(课题3奶牛高效饲养关键技术研究及开发),浙江省科技厅重大招标项目(2008C02002-3),2008-2010,排名第二 7)南方地区犊牛生长规律研究及日粮中经济作物副产物营养价值评定,农业部公益性行业专项子课题(201303143-02-01),2013-2017,参与 8)奶牛乳蛋白稳定与提升关键技术研究示范,浙江省公益技术研究农业项目(2013C32069),2013-2015,参与 著作、专利、奖励 著作 1)汪海峰(主编1/8).《畜禽标准化设施养殖技术》,ISBN:978-7-5045-9520-1,中国劳动社会保障出版社.北京,2012年3月. 2)汪海峰(副主编).2019《营养学导论》,ISBN:978-7-122-33846-4,化学工业出版社.北京,2019年3月. 3)汪海峰(副主编3/9).2016《饲料学导论》(普通高等教育“十三五”规划教材).ISBN:978-7-122-25912-7,化学工业出版社.北京,2016年3月. 4)汪海峰(副主编3/11).2014.动物营养学教程(普通高等教育“十二五”规划教材),ISBN:978-7-122-19268-4,化学工业出版社.北京,2014年5月. 5)汪海峰(副主编6/16).2010《饲料学》(第二版),ISBN:978-7-5337-3867-9,安徽科学技术出版社.安徽合肥,2010年10月. 授权专利 1)汪海峰,王永侠,王翀.一种猪乳仿生饲料香味剂及其使用方法,专利号:ZL201210558733.8 2)汪海峰.一种饲料酸化剂及其使用方法,专利号:ZL201010179755.4 3)刘建新,汪海峰.一种麻疯树蛋白的生产方法,专利号:ZL 201010300007.7 4)刘建新,汪海峰.利用麻疯树饼粕制备的猪饲料,专利号:ZL 201010300012.8 5)王翀,朱启,汪海峰,周圻,任大喜,王永侠,赵阿勇.一种湖羊TMR饲料及湖羊养殖方法,专利号:ZL 201210234519.7 6)王翀,汪海峰,茅慧玲,刘建新,刁其玉,屠焰,刘红云,杨金勇,许英蕾,任大喜.一种过瘤胃保护叶酸、含有该过瘤胃保护叶酸的牛用饲料及其应用,专利号:ZL201510289697.3 7)王翀,汪海峰,茅慧玲,刘建新,刁其玉,金佩华,屠焰,杨金勇,许英蕾,任大喜,周圻,陈伟健.一种基于笋壳的牛饲料.专利号:ZL201510385860.6 8)王翀,汪海峰,茅慧玲,刘建新,刁其玉,屠焰,杨金勇,许英蕾,刘红云,任大喜,金佩华,夏月峰.一种幼龄反刍动物早期断奶促进剂及其饲喂方法.专利号:ZL201710093776.6 9)姚凯勇,汪海峰,刘建新.提高瘤胃蛋白利用率的微生物发酵黄酒糟饲料及制备方法.专利号:ZL201710889380.2 申请专利 1)汪海峰,毛江笛,章亭洲,刘建新.一种提高酸溶蛋白含量的发酵饲料生产工艺,2017年9月21日,申请号:201710860250.6 2)汪海峰,张文馨,刘建新,何茂龙,王翀,崔艳军.一种用于脂溶性物质的抑菌特性检验方法,中国,申请号:201810301443.2 3)刘建新,赵一诺,汪海峰.一株高效降解佛波酯菌株及其在麻疯树饼粕发酵脱毒中的应用,中国,申请号:201711341340.0 4)汪海峰,唐仁龙,刘建新,王翀,崔艳军.耐热性乳酸菌微胶囊的制备方法,中国,2018年10月14日,申请号:201811193285.X 获奖 汪海峰,王翀,代兵,赵阿勇,周圻,朱祖阳,游卫云,王井亮.2012.乳仔猪诱食与肠道调理组合饲料添加剂的研制与应用,浙江省科学技术奖三等奖,证书号:1203216-1 教学与课程 研究生课程《饲料资源开发与利用》

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动物消化道微生物与营养代谢

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1)Zhaoxi Deng,Tian Dai,Wenming Zhang,Junli Zhu,Xin M.Luo,Dongyan Fu,Jianxin Liu,Haifeng Wang*.Glyceraldehyde-3-phosphate dehydrogenase increases the adhesion of Lactobacillus reuteri to host mucin to enhance probiotic.International Journal of Molecular Sciences,2020,21,24:9756.doi:10.3390/ijms21249756. 2)Zhaoxi Deng,Xin M.Luo,Jianxin Liu,Haifeng Wang*.Quorum Sensing,Biofilm and Intestinal Mucosal Barrier:Involvement the Role of Probiotic.Frontiers in Cellular and Infection Microbiology.doi:10.3389/fcimb.2020.538077 3)Jiangdi Mao,Siri Qi,Yanjun Cui,Xiaoxiao Dou,Xin M.Luo,Jianxin Liu,Tao Zhu,Yanfei Ma,Haifeng Wang*.Lactobacillus rhamnosus GG attenuates lipopolysaccharide-induced inflammation and barrier dysfunction by regulating MAPK/NF-κB signaling and modulating metabolome in the piglet intestine.The Journal of Nutrition,2020,150:1313-1323.doi:https://doi.org/10.1093/jn/nxaa009 4)Chong Wang,Junhong Wang,Sirui Qi,Cunzhu Xu,Yanming Wang,Haifeng Wang*.Effect of dietary inclusion with antioxidants and organic trace minerals on growth performance,carcass characteristics and meat quality of finishing pigs with pre-slaughter transportation.Canadian Journal of Animal Science,2020,100:577-585.http://dx.doi.org/10.1139/cjas-2019-0177 5)Wenxin Zhang,Yu Zhang,Xiaowei Zhang,Zhaoxi Deng,Jianxin Liu,Maolong He,Haifeng Wang*.Effects of dietary supplementation with combination of tributyrin and essential oil on gut health and microbiota of weaned piglets.Animals,2020,10,180.doi:10.3390/ani10020180 6)Sirui Qi,Yanjun Cui,Jianxin Liu,Xin Luo,Haifeng Wang*.Lactobacillus rhamnosus GG components,SLP,gDNA and CpG,exert protective effects on mouse macrophages upon lipopolysaccharide challenge.Letter in Applied Microbiology.2020,70(2):118-127. 7)Qinghui Mu,Xavier Cabana-Puig,Jiangdi Mao,Brianna Swartwout,Leila Abdelhamid,Thomas E.Cecere,Haifeng Wang,Christopher M.Reilly,Xin M.Luo*.Pregnancy and lactation interfere with the response of autoimmunity to modulation of gut microbiota.Microbiome,2019,7:105.https://doi.org/10.1186/s40168-019-0720-8 8)Yanjun Cui,Sirui Qi,Wenming Zhang,Jiangdi Mao,Renlong Tang,Chong Wang,Jianxin Liu,Xin M.Luo,Haifeng Wang*.Lactobacillus reuteri ZJ617 culture supernatant attenuates acute liver injury induced in mice by lipopolysaccharide.The Journal of Nutrition,2019,149:2046-2055. 9)Yanjun Cui,Chong Wang,Yue Hao,Xianhong Gu*,Haifeng Wang*.Chronic heat stress induces acute phase responses and serum metabolome changes in finishing pigs.Animals,2019,9:395.doi:10.3390/ani9070395 10)Wang,H.,Wang,C.,Wang,X.,He,M.Dietary flavors and rumen bioactive additives increased feed intake and lactation performance of high-yield Holstein cows during early lactation period.Journal of Animal Science,2018,96:427-428. 11)Wang H.,Wang C.,Wang X.,He M.Supplementation of a fennel herbaceous flavor to total mixed rations containing cottonseed or flaxseed increased dry matter intake of high-yield Holstein cows during early lactation period.Journal of Animal Science,2018,96:426. 12)Cui Yanjun,Liu Li,Dou Xiaoxiao,Wang Chong,Zhang Wenming,Gao Kan,Liu Jianxin,Wang Haifeng*.Lactobacillus reuteri ZJ617 maintains intestinal integrity via regulating tight junction,autophagy and apoptosis in mice challenged with lipopolysaccharide.Oncotarget,2017,8(44):77489-77499. 13)Gao Kan,Wang Chong,Liu Li,Dou Xiaoxiao,Liu Jianxin,Yuan Lijuan,Zhang Wenming,Wang Haifeng*.Immunomodulation and signalling mechanism of Lactobacillus rhamnosus GG and its components on porcine intestinal epithelial cells stimulated by lipopolysaccharide.Journal of Microbiology,Immunology and Infection,2017(50):700-713.(IF5=2.460) 14)Gao Kan,Liu Li,Dou Xiaoxiao,Wang Chong,Liu Jianxin,Zhang Wenming,Wang Haifeng*.Doses Lactobacillus reuteri depend on adhesive ability to modulate the intestinal immune response and metabolism in mice challenged with lipopolysaccharide.Scientific Reports,2016,6,28332.doi:10.1038/srep28332. 15)Wang Haifeng*,Gao Kan,Wen Ke,Allen Irving Coy,Li Guohua,Zhang Wenming,Jacob Kocher,Yang Xingdong,Giri-Rachman Ernawati,Li Guanhong,Clark-Deener Kocher Sherrie,Yuan Lijuan.Lactobacillus rhamnosus GG modulates innate signaling pathway and cytokine responses to rotavirus vaccine in intestinal mononuclear cells of gnotobiotic pigs transplanted with human gut microbiota.BMC Microbiology,2016,16:109.doi:10.1186/s12866-016-0727-2 16)Zhang Wenming,Wang Haifeng*,Gao Kan,Wang Cong,Liu Li,Liu Jianxin*.Lactobacillus reuteri glyceraldehyde-3-phosphate dehydrogenase functions as an adhesion to intestinal epithelial cells.Canadian Journal of Microbiology.2015,61(5):373-80 17)Wang C,Dong CJ,Wang ZQ,Yang F,Mao HL,Wu Z,Zhou Q*,Wang HF*.Effect of cysteamine hydrochloride supplementation on the milk performance of dairy cow.Livestock Science,2015,178:94–99 18)Zhan XA#,Wang HF#,Yuan D,Wang YX,Zhu F.Comparison of different forms of dietary selenium supplementation on gene expression of cytoplasmic thioredoxin reductase,selenoprotein P,and selenoprotein W in broilers.Czech J.Anim.Sci.,2014,59,(12):571-578. 19)Zhang H,Wang HF,Shepherd M,Li GH,Yang XD,Kocher J,Giri-Rachman E,Dickerman A,Settlage R,Yuan LJ.2014.Probiotics and virulent human rotavirus modulate the transplanted human gut microbiota in gnotobiotic pigs.Gut Pathogens,2014,6:39 20)Xu CZ,Wang HF,Wang JH,Duan ZY,Wang C,Liu JX,Lao Y.2014 Effects of feeding lutein on production performance,antioxidative status and milk quality of high-yielding dairy cows.Journal of Dairy Science.97(11):7144–7150 21)Zhang WM,Wang HF*,Liu JX*,Zhao YH,Gao K,Zhang J.Adhesive ability means inhibition activities for lactobacillus against pathogens and S-layer protein plays an important role in adhesion.Anaerobe,2013,22:97-103. 22)Wang HF,Gao K,Wang C,Zhang WM,Liu JX.Effects of feeding bamboo vinegar and acidifier as an antibiotic substitute on the growth performance and intestinal bacterial communities of weaned piglets.Acta Agriculturae Scandinavica,Section A-Animal Science,2013,63(3):143-150. 23)Wang HF*,Wang JL,Wang C,Zhang WM,Liu JX,Dai B.2012.Effect of bamboo vinegar as an antibiotic alternative on growth performance and fecal bacterial communities of weaned piglets.Livest.Sci.,144,1-2:173-180. 24)Wang HF,Chen Y,Zhao YN,Liu HY,Liu JX,Makkar HPS,Becker K.2011.Effects of replacing soybean meal by detoxified Jatropha curcas kernel meal in the diet of growing pigs on their growth,serum biochemical parameters and visceral organs.Anim Feed Sci Technol.170,1:141-146 25)Wang HF,Ye JA,Li CY,Liu JX,Wu YM,2011.Effects of feeding whole crop rice combined with soybean oil on growth performance,carcass quality characteristics,and fatty acids profile of Longissimus muscle and adipose tissue of pigs.Livestock Science,136,2-3:64-71 26)Wang HF,Zhu WY,YAO W,Liu JX,2007.DGGE and 16S rDNA sequencing analysis of bacterial communities in colon content and feces of pigs fed whole crop rice.Anaerobe.13(3-4):127-133 27)Wang HF,Wu YM,Liu JX,Qian Q,2006.Morphological fractions,chemical compositions and in vitro gas production of rice straw from wild and brittle culm1 variety harvested at different growth stages.Anim Feed Sci Technol.129,1-2:159-171 28)Wang HF,Liu JX,Qian Q,Wu YM,2006.Feeding brittle culm1 whole crop rice replacing wheat by-product to growing-finishing pigs.Acta Agric.Scand.,Sect.A,Animal Sci.56,3-4:155-160. 29)Zhao YN,Wang HF,Liu JX.2018.Detoxification of Jatropha curcas seed cake by a new soil-borne Enterobacter cloacae strain.Letters in Applied Microbiology 67,197-204. 30)Zhao YN,Wang YB,Wang HF,Wu YM,Harinder P.Makkar,Liu JX*.2018.Nutritional value of detoxified Jatropha curcas seed cake protein isolates using rats as an animal model.Animal Nutrition,4,429-434. 31)Yao KY,Zhang TZ,Wang HF,Liu JX.2018.Upgrading of by-product from beverage industry through solid-state fermentation with Candida utilis and Bacillus subtilis.Letters in Applied Microbiology,67,557-563. 32)Wang YX,Wang HF,Zhan XA.2016.Effects of different DL-selenomethionine and sodium selenite levels on growth performance,immune functions and serum thyroid hormones concentrations in broilers.Journal of Animal Physiology and Animal Nutrition,100,431-439 33)Wen K,Tin C,Wang HF,Yang XD,Li GH,Giri-Rachman E,Kocher J,Bui T,Clark-Deener S,Yuan LJ.2014.Probiotic Lactobacillus rhamnosus GG enhanced Th1 cellular immunity but did not affect antibody responses in a human gut microbiota transplanted neonatal gnotobiotic pig model.Plos One,9(4):e94504 34)Wen K,Liu F,Li G,Bai M,Kocher J.Yang X,Wang H,Clark-Deener S,Yuan L*.2015.Lactobacillus rhamnosus GG dosage affects the adjuvanticity and protection against rotavirus diarrhea in gnotobiotic pigs.J Pediatr Gastroenterol Nutr.60(6):834-843.(doi:10.1097/MPG.0000000000000694). 35)Yang X.D,Wen K.,Tin C,Li GH,Wang HF,Kocher J,Pelzer K,Ryan E,Yuan LJ.2014.Dietary Rice Bran Protects against Rotavirus Diarrhea and Promotes Th1-Type Immune Responses to Human Rotavirus Vaccine in Gnotobiotic Pigs.Clin.Vaccine Immunol.21:10 1396-1403. 36)Ye JA,Wang C,Wang HF,Liu HY,Wang YM,Chen B,Liu JX.2010.Effects of pelletizing and supplementary methionine,lysine,and choline on the performance of periparturient dairy cows.Acta Agriculturae Scandinavica,Section A-Animal Science,60:4,230-238. 37)Ye JA,Wang C,Wang HF,Ye HW,Wang BX,Liu HY,Wang YM,Yang ZQ,Liu JX.2009.Milk production and fatty acid profile of dairy cows supplemented with flaxseed oil,soybean oil,or extruded soybeans.Acta Agriculturae Scandinavica,Section A-Animal Science,59:2,121-129. 38)Zhao Yinuo,Wang Yubao,Wang Haifeng,Wu Yueming*,Harinder P.Makkar,Liu Jianxin*.Nutritional value of detoxified Jatropha curcas seed cake protein isolates using rats as an animal model.Animal Nutrition,2018,1,6 39)Jiahuan Rong,Wenhao Su,Xiaofan Guan,Wei Shi,Shanjie Zha,Maolong He,Haifeng Wang,Guangxu Liu*.Ocean acidification impairs foraging behavior by interfering with olfactory neural signal transduction in the black sea bream,Acanthopagrus schlegelii.Frontiers in Physiology,2018,DOI:10.3389/fphys.2018.01592. 40)Yinglei Xu,Huiling Mao,Caimei Yang,Huahua Du,Haifeng Wang,Jue Tu.Effects of chitosan nanoparticle supplementation on growth performance,humoral immunity,gut microbiota and immune responses after lipopolysaccharide challenge in weaned pigs.J Anim Physiol Anim Nutr.2020,104:597-605.DOI:10.1111/jpn.13283. 41)Leila Abdelhamid,Xavier Cabana-Puig,Brianna Swartwout,Jiyoung Lee,Song Li,Sha Sun,Yaqi Li,A.Catharine Ross,Thomas E.Cecere,Tanya LeRoith,Stephen R.Werre,Haifeng Wang,Christopher M.Reilly,Xin M.Luo.Retinoic acid exerts disease stage-dependent effects on pristane-induced lupus.Frontiers in Immunology,2020,doi.org/10.3389/fimmu.2020.00408 42)毛江笛,唐仁龙,王翀,汪海峰*.低氮、低磷饲粮添加复合酶对生长猪生长性能、养分消化率和血清生化指标的影响,动物营养学报,2019,31(6):1-8 43)戴甜,章文明*,王翀,崔艳军,杨彩梅,汪海峰*.乳酸菌益生特性及其在畜禽养殖中的应用,中国畜牧杂志,2019,55(7):49-53 44)唐仁龙,王翀,汪海峰*.微囊化包被技术在饲用益生菌上应用的研究进展.2018,54(11):5-11 45)邓曌曦,音建华,汪海峰*.乳酸菌群体感应与其肠道生物膜形成的研究进展.微生物学报,2018,58(11):1970-1978 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学术兼职

中国畜牧兽医学会动物营养学分会理事 国家生猪产业技术创新战略联盟理事 浙江省畜牧产业技术创新与推广服务团队生猪组专家 美国微生物学会会员 国际粘膜免疫学会会员 《世界华人消化杂志》编委

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