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个人简介

女,工学博士,教授,博士生导师。1998年7月于浙江农业大学获学士学位。2001年7月浙江大学获农学硕士学位。2001年10月-2005年3月,受日本政府资助在东京农工大学工学部生命工学科攻读博士课程,获工学博士学位。2005年4月-2007年8月为东京农工大学朝仓实验室博士后。2007年9月-2014年12月,浙江大学副研究员。并于2007年10月-2009年8月期间赴日本与日本京瓷公司对有关生物材料的应用进行了交流合作。2015年1月-至今,浙江大学教授,博士生导师。主持以及参与国家自然科学基金等9项。已发表SCI论文60篇,总影响因子达406.563。 教学与课程 学年 学期 课程名称 授课学时数 授课对象 2017-2018 冬 茧丝绸加工及质量检验学 6 20141721动物科学 2017-2018 夏 生物材料学 22 20151721动物科学 2016-2017 冬 茧丝绸加工及质量检验学 9 20131721动物科学 2016-2017 夏 生物材料学 22 20141721动物科学 2015-2016 冬 茧丝绸加工及质量检验学 5 20121721动物科学 2015-2016 夏 动物丝蛋白概论 31 20131721动物科学 2015-2016 夏 生物材料学 31 20131721动物科学 2014-2015 冬 茧丝绸加工及质量检验学 8 20111721动物科学 2014-2015 夏 生物材料学 32 20121721动物科学 2013-2014 夏 生物材料学 34 20111721动物科学 科研 (1)解明蚕丝蛋白生物矿化机理及其调控髓间充质干细胞向成骨细胞分化方面: 发明了将丝蛋白溶液置于人体模拟体液(SBF)中来研究丝蛋白自组装的方法,发现SBF溶液中的Ca2+与蚕丝蛋白中的-C00H结合,促使丝蛋白自组装成纳米纤维网络,启动针状纳米羟基磷灰石(HAp)沿着c-axis生长,在丝蛋白与羟基磷灰石晶体的氢键作用下,形成羟基磷灰石微球,首次阐明了丝蛋白调控生物矿化作用的机理,为丝蛋白作为生物模板提供了理论依据。 (2)结合多途径蛋白质加工技术,构建有效的蚕丝蛋白骨组织工程支架方面: 首次发现分子量决定静电纺丝膜的拓扑构造,分子量高的丝蛋白通过静电纺丝得到纳米纤维,而分子量低的丝蛋白得到微米球。而且通过细胞培养发现:纳米纤维静电纺丝膜促进细胞的增殖,而微米球静电纺丝膜促进骨髓间充质干细胞向成骨细胞定向分化。利用改变丝蛋白分子量构建静电纺丝膜的拓扑构造来调控细胞行为,为设计新型的骨组织工程支架材料提供路。 工作研究项目 1、十三五国家蚕桑产业技术体系岗位科学家:蚕茧贮运与加工,2017/01-2020/12,280万元,在研,主持。 2、863计划子课题,2013AA102507-1,家蚕驯化性状的功能基因组研究:茧丝性状功能基因,2013/01-2017/12,45万元,已结题,主持 3、国家自然科学基金面上项目,21172194,重组蜘蛛丝蛋白的设计及其分子自组装对生物矿化功能调控的研究,2012/01-2015/12,60万元,已结题,主持 4、浙江省自然科学基金重点项目,LZ12C17001,重组蜘蛛丝蛋白纳米支架的设计及其羟基磷灰石复合体的研究,2012/01-2014/12,30万元,已结题,主持 5、浙江省蚕桑产业科技创新团队项目,2011R50028-1,基于重组丝蛋白的骨修复材料开发,2013-2015,7万元,已结题,主持 6、重组丝蛋白纳米支架的研究,2010年浙江大学科研创新专项,已结题,主持 7、生物矿化功能蜘蛛丝蛋白的设计,2010年浙江大学科研创新专项,主持 8、水溶性重组丝蛋白的设计、结构特征及其对纳米纤维形成关系的研究,2008年国家自然科学基金,已结题,主持 9、水溶性重组丝蛋白的分子设计、表达及其结构特征,2008年高等学校博士学科点专项科研基金·新教师基金,已结题,主持 10、可控降解管型丝素蛋白尿道组织工程支架的研究,2008年国家自然科学基金,第二完成人

研究领域

生物高分子材料开发利用研究、结构解析及其作为组织工程用材料的应用基础研究,蚕茧收烘工艺条件对蚕丝蛋白结构形态及其茧丝品质的研究。

近期论文

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1.Hu,Doudou;Li,Ting;Xu,Zongpu;Liu,Di;Yang,Mingying;Zhu,Liangjun.Self-stabilized silk sericin-based nanoparticles:In vivo biocompatibility and reduced doxorubicin-induced toxicity.Acta biomaterialia,DOI:10.1016/j.actbio.2018.05.024.IF 6.383 2.Zhishang Li,Guanshan Zhou,Huang Dai,Mingying Yang*,YingchunFu*,Yibin YingandYanbin Li.Biomineralization-mimetic preparation of hybrid membranes with ultra-high loading of pristine metal–organic frameworks grown on silk nanofibers for hazard collection in water.Journal of Materials Chemistry A,2018,6,8,3402-3413.IF 9.931 3.Qifan Xie,Haiping Zhang,Mingying Yang*,and Liangjun Zhu*.Key Characteristics of a Novel Silk Yarn from Fresh Cocoons.Fibers and Polymers,2018,19(1),147-155.IF 1.353 4.Qing Zhang,Mingying Yang,Ye Zhu,Chuanbin Mao.Metallic nanoclusters for cancer imaging and therapy.Current medicinal chemistry,2018,25,12,1379-1396.IF 3.469 5.Mingying Yang.Silk-based materials.Microscopy research and technique,2017,80(3):269-271.IF 1.087 6.Chenlin Li,Mingying Yang*,Liangjun Zhu,Yongqiang Zhu.Honeysuckle flowers extract loaded Bombyx mori silk fibroin films for inducing apoptosis of HeLa cells.Microscopy research and technique,2017,80(12),1297-1303.IF 1.087 7.Mingying Yang,*Yajun Shuai,Kegan S.Sunderland,Chuanbin Mao*.Ice-Templated Protein Nanoridges Induce BoneTissue Formation.Advanced Functional Materials,2017,170376,1-9.IF 13.325 8.Jie Wang,ShuXu Yang,Chenlin Li,Yungen Miao,Liangjun Zhu,Chuanbin Mao,Mingying Yang.Nucleation and assembly of silica into protein-based nanocomposites as effective anti-cancer drug carriers using self-assembled silk protein nanostructures as biotemplates.ACS Applied Materials&Interfaces,2017,9(27):22259–22267,.IF 8.097 9.Yajun Shuai,Shuxu Yang,Chenlin Li,Liangjun Zha,Chuanbin Mao*,Mingying Yang*.In situ protein-templated porous protein–hydroxylapatite nanocomposite microspheres for pH-dependent sustained anticancer drug release.Journal of Materials Chemistry B,2017,5,3945-3954.IF4.776 10.Meng Wang*,Ming Li,Aoyang Yu,Ye Zhu,Mingying Yang*,Chuanbin Mao*.Fluorescent nanomaterials for the development of latent fingerprints in forensic sciences.Advanced Functional Materials,2017,27,1606243.IF13.325 11.Doudou Hu,Zongpu Xu,Zeyun Hu,Binhui Hu,Mingying Yang,Liangjun Zhu*.pH-triggered charge-reversal silk sericin-based nanoparticles for enhanced cellular uptake and doxorubicin delivery.ACS Sustainable Chemistry&Engineering,2017,5:1638-1647.IF 6.140 12.Penghe Qiu#,Mingying Yang#*,Xuewei Qu,Yanyan Huai,Ye Zhu,Chuanbin Mao*.Tuning photothermal properties of gold nanodendrites for in vivo cancer therapy within a wide near infrared range by simply controlling their degree of branching.Biomaterials,2016,104:138-144.IF 8.806 13.Shaohua Wang,Yuyu Zhang,Mingying Yang,Lupeng Ye,Lu Gong,Qiujie Qian,Yajun Shuai,Zhengying You,Yuyin Chen,Boxiong Zhong*.Characterization of transgenic silkworm yielded biomaterials with calcium-binding activity.Plos One,2016,11(7).IF 2.766 14.Zongpu Xu,Liyang Shi,Doudou Hu,Binhui Hu,Mingying Yang,Liangjun Zhu*.Formation of hierarchical bone-like apatites on silk microfiber templates via biomineralization.RSC Advances,2016,6:76426-76433.IF 2.936 15.Mingying Yang#*,Jie Wang#,Ye Zhu,Chuanbin Mao*.Bio-Templated growth of bone minerals from modified simulated body fluid on nanofibrous decellularized natural tissues.Journal of Biomedical Nanotechnology,2016,12(4):753-761.IF 5.068 16.Fatemeh Mottaghitalab,Hossein Hosseinkhani,Mohammad Ali Shokrgozar,Chuanbin Mao,Mingying Yang,Mehdi Farokhi*.Silk as a potential candidate for bone tissue engineering.Journal of Controlled Release,2015,215:112-128.IF 7.877 17.Zongpu Xu#,Liyang Shi#,Mingying Yang,Haiping Zhang,Liangjun Zhu*.Fabrication of a novel blended membrane with chitosan and silk microfibers for wound healing:characterization,in vitro and in vivo studies.Journal of Materials Chemistry B,2015,3:3634-3642.IF 4.776 18.Haiping Zhang,Xiaotian Liu,Mingying Yang,Liangjun Zhu*.Silk fibroin/sodium alginate composite nano-fibrous scaffold prepared through thermally induced phase separation method for biomedical applications.Materials Science and Engineering C,2015,55:8-13.IF 5.080 19.Mingying Yang#*,Guanshan Zhou#,Yajun Shuai,Jie Wang,Liangjun Zhu,Chunbin Mao*.Ca2+-induced self-assembly of Bombyx mori silk sericin into a nanofibrous network-like protein matrix for directing controlled nucleation of hydroxylapatite nano-needles.Journal of Materials Chemistry B,2015,3:2455-2462.IF 4.776 20.Mingying Yang#*,Guanshan Zhou#,Harold Castano-lzquierdo,Ye Zhu,Chuanbin Mao*.Biomineralization of natural collagenous nanofibrous membranes and their potential use in bone tissue engineering.Journal of Biomedical Nanotechnology,2015,11(3):447-456.IF 5.068 21.Caixia Pan,Qifan Xie,Zeyun Hu,Mingying Yang,Liangjun Zhu*.Mechanical and biological properties of silk Fibroin/carbon nanotube nanocomposite films.Fibers and Polymers,2015,16(8):1781-1787.IF 1.353 22.MengWang*,MingLi,MingyingYang*,XiaomeiZhang,AoyangYu,YeZhu,PengheQiu,Chunbin Mao*.NIR-induced highly sensitive detection of latent fingermarks by NaYF4:Yb,Er upconversion nanoparticles in a dry powderstate.Nano Research,2015,8(6):1800-1810.IF 7.994 23.Mingying Yang#*,Yajun Shuai#,Guanshan Zhou,Namita Mandal,Liangjun Zhu,Chanbin Mao*.Tuning molecular weights of Bombyx mori(B.mori)silk sericin to modify its assembly structures and materials formation.ACS Applied Materials&Interfaces,2014,6(16):13782-13789.IF 8.097 24.Binrui Cao#,Mingying Yang#*,Ye Zhu#,Xuewei Qu,Chuanbin Mao*.Stem cells loaded with nanoparticles as a drug carrier for in vivo breast cancer therapy.Advanced Materials,2014,26(27):4627-4631.IF 21.950 25.Mingying Yang#*,Yajun Shuai#,Can Zhang#,Yuyin Chen,Liangjun Zhu,Chuanbin Mao*,Hongwei OuYang.Biomimetic nucleation of hydroxyapatite crystals mediated by Antheraea pernyi(A.pernyi)silk sericin promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells.Biomacromolecules,2014,15(4):1185-1193.IF 5.738 26.Mingying Yang*,Namita Mandal,Yajun Shuai,Guanshan Zhou,Sijia Min,Liangjun Zhu.Mineralization and biocompatibility of Antheraea pernyi(A-pernyi)silk sericin film for potential bone tissue engineering.Bio-medical materials and engineering,2014,24(1):815-824.IF 0.872 27.Mingying Yang*,Yajun Shuai,Guanshn Zhou,Namita Mandal,Liangjun Zhu.Nucleation of hydroxyapatite on Antheraea pernyi(A-pernyi)silk fibroin film.Bio-medical materials and engineering,2014,24(1):731-740.IF 0.872 28.Lianxia Deng,Haiping Zhang,Mingying Yang,Namita Mandal,Liangjun Zhu*.Improving properties of superabsorbent composite induced by using alkaline protease hydrolyzed-sericin(Aph-sericin).Polymer composites,2014,35(3):509-515.IF 1.943 29.Haiping.Zhang,Xueyun.Wang,Sijia.Min,Namita.Mandal,Mingying.Yang,L.J.Zhu*.Hydroxyapatite/sericin composite film prepared through mineralization of flexible ethanol-treated sericin film with simulated body fluids.Ceramics International,2014,40(1):985-991.IF 3.057 30.Mingying Yang*,Wen He,Yajun Shuai,Sijia Min,Liangjun Zhu.Nucleation of hydroxyapatite crystals by self-assembled Bombyx mori silk fibroin.Journal of Polymer Science Part B-Polymer Physics,2013,51(9):742-748.IF 2.499 31.Mingying Yang*,Yajun Shuai,Wen He,Sijia Min,Liangjun Zhu.Preparation of porous scaffolds from silk fibroin extracted from the silk gland of Bombyx mori(B.mori).International Journal of Molecular Sciences,2012,13(6):7762-7765.IF 3.687 32.Sijia Min*,Xin Gao,Chunmao Han,Yuyin Chen,Mingying Yang,Liangjun Zhu,Haiping Zhang,Lin Liu,Juming Yao.Preparation of a silk fibroin spongy wound dressing and its therapeutic efficiency in skin defects.Journal of Biomaterials Science-Polymer Edition,2012,23(1-4):97-110.IF 1.911 33.Haiping Zhang,Lianxia Deng,Mingying Yang,Sijia Min,Lei Yang,Liangjun Zhu*.Enhancing effect of glycerol on the tensile properties of Bombyx mori cocoon sericin films.International Journal of Molecular Sciences,2011,12(5):3170-3181.IF 3.687 34.Yanhong Zhang,Yinsun Ma,Mingying Yang,Sijia Min,Juming Yao,Liangjun Zhu*.Expression,purification,and refolding of a recombinant human bone morphogenetic protein 2 in vitro.Protein Expression and Purification,2011,75(2):155-160.IF 1.388(344.201) 35.Mingying Yang,Junji Kawamura,Zhenghua Zhu,Kazuo Yamauchi,Tetsuo Asakura.Development of silk-like materials based on Bombyx mori and Nephila clavipes dragline silk fibroins.Polymer,2009,50(1):117-124.IF 3.483 36.Mingying Yang,Chikako Tanaka,Koji Yamauchi,Kotsuke.Ohgo,Tetsuo Asakura*,M.Kurokawa.Silk-like materials constructed from sequences of Bombyx mori silk fibroin,fibronectin and elastin.Journal of Biomedical Materials research:Part A,2008,84(2),53-363.IF 3.231 37.Mingying Yang,T.Muto,David Knight,A.M.Collins,Tetuso Asakura*.Synthesis and Characterization of Silklike Materials Containing the Calcium-Binding Sequence from Calbindin D9k or the Shell Nacreous Matrix Protein MSI60.Biomacromolecules 2008,9(1),416–420.IF 5.738 38.Haiping Zhang,Mingying Yang,Sijia Min,Qiang Feng,Xin Gao,Liangjun Zhu,Preparation and characterization of a novel spongy hydrogel from aqueous Bombyx mori sericin.E-Polymers,2008.IF 1.111 39.Mingying Yang,Kazuo Yamauchi.,M.Kurokawa,Tetuso Asakura*.Design of silk-like biomaterials inspired by mussel adhesive protein.Tissue Engineering,2007,13(12),2941-7.IF 3.508 40.Tetsuo Asakura*,Hirohiko Sato,Fumika Moro,Mingying Yang,Yasumoto Nakazawa,Andrew M.Collins,and David Knight,Solid-state NMR analysis of(GA)3S(AG)3D(GA)3S(AG)3D(GA)3S(AG)3,a peptide with a lamellar structure and a calcium binding site,and production of TS[(AG)3D(GA)3S](16)in Escherichia coli.Macromolecules,2007,40(25):8983-8990.IF 5.914 41.Tetsuo Asakura*,Juming Yao,Mingying Yang,Zhenghua Zhu,Haruko Hirose.Structure of the spinning apparatus of a wild silkworm Samia ynthia ricini and molecular dynamics calculation on the structure change of the silk fibroin.Polymer,2007,48(7):2064-2070.IF 3.483 42.Mingying Yang,Yasumoto Nakazawa,Kazuo Yamauchi,David Knight,Tetsuo Asakura*.Structure of model peptides based on Nephila clavipes dragline silk spidroin(MaSp1)studied by 13C cross polarization/magic angle spinning NMR.Biomacromolecules,2005,6(6):3220-3226.IF 5.738 43.Mingying Yang,Tetsuo Asakura*,Design,expression and solid-state NMR characterization of silk-like materials constructed from sequences of spider silk,Samia cynthia ricini and Bombyx mori silk fibroins.Journal of Biochemistry,2005,137(6):721-729.IF 2.350 44.Tetsuo Asakura*,Mingying Yang,Taiji Kawase,Yasumoto Nakazawa,C-13 solid-state NMR study of structure heterogeneity in peptides containing both polyalanine and repeated GGA sequences as a local structure model of Nephila clavipes dragline silk(Spidroin 1).Macromolecules,2005,38(8):3356-3363.IF 5.914 45.Mingying Yang,Juming Yao,Masashi Sonoyama,Tetsuo Asakura*.Spectroscopic characterization of heterogeneous structure of Samia cynthia ricini silk fibroin induced by stretching and molecular dynamics simulation.Macromolecules,2004,37(9):3497-3504.IF 5.914 46.Tetsuo Asakura*,Chikako Tanaka,Mingying Yang,Juming Yao,Masato Kurokawa.Production and characterization of a silk-like hybrid protein,based on the polyalanine region of Samin ynthia ricini silk fibroin and a cell adhesive region derived from fibronectin.Biomaterials,2004,25(4):617-624.IF 8.806 47.Tetsuo Asakura*,Mingying Yang,Taji Kawase.Structure of characteristic sequences in Nephila clavipes dragline silk(MaSp 1)studied with 13C solid state NMR.Journal of Polymer,2004,36(12):999-1003.IF 1.434 48.Tetsuo Asakura*,Koji Nitta,Mingying Yang,Juming Yao,Yasumoto Nakazawa,David L.Kaplan.Synthesis and characterization of chimeric silkworm silk.Biomacromolecules,2003,4(3):815-820.IF 5.738

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