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博士,教授,兽医学一级学科负责人。主要从事动物寄生虫病学、兽医公共卫生学及寄生虫分子免疫学等方面的教学和研究工作。先后主持承担“十三五”国家重点研发计划课题、国家自然科学基金项目(5项)、“973”课题、“863”课题、公益性行业(农业)科研专项课题、浙江省重大专项、省自然科学基金、重大横向等研究课题30多项。在国内外学术期刊发表学术论文200余篇,其中以一作或通讯作者发表SCI论文80多篇。获浙江省科学技术进步奖二等奖1项,三等奖4项。主编、副主编、参编国内专著、教材6部。授权国家发明专利11件。 教学与课程 本科生课程: 1.兽医公共卫生学 2.兽医寄生虫病学 硕士研究生课程: 1.动物病原生物学 2.预防兽医学进展 3.动物疫病诊断技术 4.动物源性疫病控制与检疫 6.分子寄生虫病学专题 博士研究生课程: 1.预防兽医学学术讨论 2.兽医分子病理生物学 成人教育本专科生课程: 1.兽医公共卫生 2.家畜寄生虫病学 远程教育本专科生课程: 1.兽医卫生检验 2.动物寄生虫病学 科研 1) “十三五”国家重点研发计划课题,2017YFD0501203,牛羊捻转血矛线虫检测与防控技术研究,2017/01-2020/12 2) 国家自然科学基金面上项目,31672543,TgROPs介导Raf/MEK/ERK信号通路诱导细胞自噬促进弓形虫增殖的分子机制,2017/01-2020/12,在研,主持 3) 国家重点基础研究计划(973计划)子课题,2015CB150302-2,捻转血矛线虫侵入的关键分子与功能(“牛羊重要寄生虫致病机制的分子基础”,2015CB150300),2015/01-2019/12,在研,主持 4) 国家自然科学基金面上项目,31372426,捻转血矛线虫Hc-dhs-28基因调控虫体发育的作用机制,2014/01-2017/12,在研,主持 5) 国家高技术研究发展计划(863计划)子课题,2012AA101602-3橘青霉毒素霉素和展青霉毒素精准检技术研究(食品中微生物毒素精准检测技术,2012AA101602),2012/01-2015/12,已结题 6) 浙江省重大科技专项重点农业项目,2012C12009-2,重要人畜共患寄生虫病检测关键技术研究与安全控制,2012/07-2015/12,已结题,主持 7) 国家自然科学基金面上项目,30972174,捻转血矛线虫感染诱导宿主T淋巴细胞基因表达谱的差异分析,2010/01-2012/12,已结题,主持 8) 浙江省重大科技专项重点农业项目,2009C12029、主要食源性寄生虫病预警支撑技术研究与示范应用,2009/01-2011/12,已结题,主持 9) 国家自然科学基金面上项目,30771618,捻转血矛线虫滞育期幼虫差异表达基因的研究,2008/01-2010/12,28万元,已结题,主持 10) 国家公益性行业(农业)科研专项子课题,动物弓形虫病PCR检测技术的研究及应用(“动物源性人兽共患弓形虫病防控技术体系研究”课题,200803017),2008/05-2010/12,,已结题,主持 11) 国家自然科学基金项目,30571395,利用转基因秀丽线虫研究H11蛋白的生物学功能,2006.01-2008.12,已结题,主持 12) 浙江省重点科研农业项目,2006C22043,猪弓形虫病快速检测与免疫防制技术研究,2006.01-2008.07,已结题,主持 研究与成果 省部级成果奖 1)潘炳龙,刘建新,杜爱芳,王建军,王清华,楼程富.实验教学-生产实习-科研训练三结合的动物科学本科生实践能力培养模式探索,获2014年度浙江省教学成果奖二等奖 2)杜爱芳,曲道峰,叶秀娟,林纯洁,张娟敏,项玉燕,鲍伟华.猪弓形虫病快速检测与疫防制技术研究.获2009年度浙江省科学技术奖三等奖 3)蔡渭明,杜爱芳,王志刚,何永强,许赢升,高翔,邬生力.动物附红细胞体病检疫技术研究及进口动物附红细胞体病流行病学调查.获2008年度浙江省科学技术奖三等奖 4)杜爱芳参与.集约化猪场猪链球菌病防治技术研究.获浙江省人民政府科技进步奖三等奖(2003)(排名10/11) 5)杜爱芳参与.鸡传染性法氏囊病病毒变异株分离及弱毒疫苗研究.获浙江省人民政府科技进步奖二等奖(2000)(排名6/10) 6)杜爱芳参与.肉鸡用中草药饲料添加剂研究.获浙江省人民政府科技进步奖三等奖(1998)(排名3/7) 出版著作 1)杜爱芳(参编),杨光友主编.兽医寄生虫病学,中国农业大学出版社(普通高等教育农业部“十二五”规划教材,全国高等农林“十二五”规划教材),ISBN978-7-109-22538-1,2017.01 2)杜爱芳(副主编),李国清主编。兽医寄生虫学(中英双语),ISBN978-7-5655-1084-7,2015.1,中国农业大学出版社(普通高等教育“十一五”国家级规划教材、普通高等教育农业部“十二五”规划教材国家级规划教材)第二版 3)杜爱芳(参编),《兽医寄生虫学》,ISBN 978-7-03-025535-8,2009,科学出版社 4)杜爱芳(参编),《高级寄生虫学》,ISBN978-7-04-021594-6,2007,高等教育出版社 5)杜爱芳(参编),兽医寄生虫学(双语版),ISBN97-81117-026-4,2006,中国农业大学出版社 6)杜爱芳(参编),《动物寄生虫病学》(高等农业院校“十五”规划教材)四川科学技术出版社2005.01第1版 7)杜爱芳(参编),《水生动物疾病学》,中国农业大学出版社2005.06第1版 8)杜爱芳(参编),《安全优质生猪的生产与加工》,中国农业出版社2005.05第1版 9)杜爱芳(参编),《安全优质肉品的选择与消费》,中国农业出版社2005.04第1版 专利成果 1)杜爱芳,李闵薇,陈海卫,郭筱璐。授权日期:2016.02.05.羊肝片吸虫的荧光定量PCR检测试剂盒及应用。专利号:ZL 201410267699.8。 2)杜爱芳,潘辰,杨怡,张红丽。授权日期:2016.03.28.一种检测猪华支睾吸虫的试剂盒及应用。专利号:ZL 201410266750.3 3)杜爱芳,俞颖超,卓洵辉,阳毅敏。授权日期:2016.04.06。一种检测细粒棘球蚴的试剂盒及应用。专利号:ZL 201410268876.4 4)杜爱芳,俞颖超,闫宝龙,蓝丽华。授权日期:2016.05.05。基于18SrRNA基因的猪旋毛虫检测试剂盒及应用.专利号:ZL 201410268877.9 5)杜爱芳,张德福,周前进,王素华.授权日期:2012.12.26.一种检测猪囊尾蚴、猪旋毛虫、猪弓形虫的多重PCR方法.专利号:ZL2011102508768 6)杜爱芳,王素华,李群.授权日期:2012.07.25.一种牛巴贝斯虫LAMP检测方法.专利号:ZL 201010285586.2 7)杜爱芳,王素华,曲道峰,孔得翔.授权日期:2012.05.09.一种检测弓形虫的半巢式PCR方法.专利号:ZL2008100612322 8)杜爱芳,侯玉慧,赵现锋.授权日期:2008.02.27.猪附红细胞体PCR检测方法.专利号:ZL200610050193.7 9)杜爱芳,高翔.授权日期:2009.12.16.球虫卵囊的分离纯化及子孢子制备方法.专利号:ZL200610049619.7

研究领域

分子寄生虫学与免疫学 病原与宿主的互作机制 动物疫病检疫与控制

近期论文

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英文文章(*Corresponding author) 1)Chunqun Wang,Fangfang Li,Zongze Zhang,Xin Yang,Awais A.Ahmad,Xiangrui Li,Aifang Du,and Min Hu.Recent Research Progress in China on Haemonchus contortus.Front Microbiol.2017;8:1509. 2)Xu W,Guan R,Shi F,Du A,Hu S.Structural analysis and immunomodulatory effect of polysaccharide from Atractylodis macrocephalae Koidz.on bovine lymphocytes.Carbohydr Polym.2017,174:1213-1223.doi:10.1016/j.carbpol.2017.07.041. 3)Zhuo X,Sun H,Zhang Z,Luo J,Shan Y,Du A*.Development and Application of an Indirect Enzyme-Linked Immunosorbent Assay Using Recombinant Mag1 for Serodiagnosis of Toxoplasma gondii In Dogs.J.Parasitol.,103(3),2017,pp.237–242 4)Yang Y,Guo X,Zhang H,Huang Y,Chen X,Du A*.Characterization of the development of Haemonchus contortus ZJ strain from gerbils.Parasit Vectors.2017;10(1):505.doi:10.1186/s13071-017-2465-1 5)HongchaoSun,SuhuaWang,Xianfeng Zhao,ChaoqunYao,Haohan Zhuang,Yechuan Huang,Xueqiu Chen,YiYang,Aifang Du*.The heat shock protein 90 of Toxoplasma gondii is essential for invasion of host cells and tachyzoite growth.VETERINARY PARASITOLOGY.2017,243,248-255 6)Sun H,Zhuo X,Zhao X,Yang Y,Chen X,Yao C,Du A*.Targeted overexpression of cyclic AMP-dependent protein kinase subunit in Toxoplasma gondii promotes replication and virulence in host cells.Parasite.2017;24:22.doi:10.1051/parasite/2017023. 7)Xunhui Zhuo,Sun H,Wang S,Guo X,Ding H,Yang Y,Shan Y,Du A*.Ginseng Stem-and-Leaf Saponin(GSLS)-Enhanced Protective Immune Responses Induced by Toxoplasma gondii Heat Shocked Protein 70(HSP70)Against Toxoplasmosis in Mice.J Parasitol.2017,103(1):111-117. 8)Zhuo X,Yu Y,Chen X,Zhang Z,Yang Y,Du A*.Development of a colloidal gold immunochromatographic strip based on HSP70 for the rapid detection of Echinococcus granulosus in sheep.Vet Parasitol.2017;240:34-38 9)Haojie Ding,Hengzhi Shi,Shi,Yu,Aifang Du*Characterization and function analysis of a novel gene,Hc-maoc-1,in the parasitic nematode Haemonochus contortus.Parasites and Vector,2017;10(1):67 10)Yimin Yang,Qun Li,Suhua Wang,Xueqiu Chen,Aifang Du*.Rapid and sensitive detection of Babesia bovis and Babesia bigemina by loop-mediated isothermal amplification combined with a lateralflow dipstick.Veterinary Parasitology,2016,219,71–76 11)Xiaolu Guo,Hongli Zhang,Xiuping Zheng,Qianjin Zhou,Yi Yang,Xueqiu Chen and Aifang Du*.Structural and functional characterization of a novel gene,Hc-daf-22,from the strongylid nematode Haemonchus contortus.Parasites and Vector,2016,9:422-435 12)Li-Hua Lan,Bao-Xing-Zi Zuo,Hao-Jie Ding,Yan Huang,Xue-Qiu Chen,Ai-Fang Du*.Anticoccidial evaluation of a traditional Chinese medicine-Brucea javanica-in broilers.POULTRY SCIENCE,2016,95(4):811-818 13)Yimin Yang;Xue Xue;Yi Yang;Xueqiu Chen;Ai-Fang Du*.Efficacy of a potential DNA vaccine encoding Cryptosporidium baileyi rhomboid protein against homologous challenge in chickens.VETERINARY PARASITOLOGY,2016,225,5-11 14)Haiwei Cheng,Yifei Chen,Yi Yang,Xueqiu Chen,Xiaolu Guo,Aifang Du*.Characterization of Anti-Citrinin Specific ScFvs Selected from Non-Immunized Mouse Splenocytes by Eukaryotic Ribosome Display.Plos One,2015,10(7):1-16 15)Yi Yang,Qianjin Zhou,Xueqiu Chen,Baolong Yan,Xiaolu Guo,Hongli Zhang,Aifang Du*.Profiling of differentially expressed genes in sheep T lymphocytes response to an artificial primary Haemonchus contortus infection.Parasites and Vector,2015,8:235-246 16)Yi Yang,Yujie Ma,Xueqiu Chen,Xiaolu Guo,Baolong Yanb,Aifang Du*.Screening and analysis of Hc-ubq and Hc-gst related todesiccation survival of infective Haemonchus contortus larvae.Veterinary Parasitology,2015,210,179-185 17)Zhuo X,Huang B,Luo J,Yu H,Yan B,Yang Y,Du A*.Development and application of loop-mediated isothermal amplification assays based on ITS-1 for rapid detection of Toxoplasma gondii in pork.Veterinary Parasitology,2015,208,246–249 18)Lengmei Wang,Xue Xue,Jianqiu Li,Qianjin Zhou,Yingchao Yu,Aifang Du*.Cryptosporidiosis in broiler chickens in Zhejiang Province,China:molecular characterization of oocysts detected in fecal samples.Parasite,2014,21,36-40 19)Baolong Yan,Xiaolu Guo,Qianjin Zhou,Yi Yang,Xueqiu Chen,Weiwei Sun,Aifang Du*.Hc-fau,a novel gene regulating diapause in the nematode parasite Haemonchus contortus.International Journal for Parasitology,2014,44 775–786 20)Qian-Jin Zhou,Yi Yang,Xiao-Lu Guo,Li-Jun Duan,Xue-Qiu Chen,Bao-Long Yan,Hong-Li Zhang,Aifang Du*.Expression of Caenorhabditis elegans-expressed Trans-HPS,partial aminopeptidase H11 fromHaemonchus contortus.Experimental Parasitology,2014,145,87–98 21)Daofeng Qu,Huaiyu Zhou,Jianzhong Han,Siyue Tao,Bailing Zheng,Na Chia,Chunlei Su*,Aifang Du*.Development of reverse transcription loop-mediated isothermal amplification(RT-LAMP)as a diagnostic tool of Toxoplasma gondii in pork.Veterinary Parasitology.2013,192(1-3):98-103 22)Haijie Yu,Bin Huang,Xunhui Zhuo,Chen X,Aifang Du*.Evaluation of a real-time PCR assay based on the single-copy SAG1 gene for the detection of Toxoplasma gondii.Veterinary Parasitology.2013,(13),00364-6 23)Qu Daofeng,Han Jianzhong,Du Aifang.Evaluation of protective effect of multiantigenic DNA vaccine encoding MIC3 and ROP18 antigen segments of Toxoplasma gondii in mice.Parasitology Research.2013,112(7):2593-2599 24)Qu,Daofeng,Han,Jianzhong,Du,Aifang.Enhancement of protective immune response to recombinant Toxoplasma gondii ROP18 antigen by ginsenoside Re.EXPERIMENTAL PARASITOLOGY.2013,135(2):234-239 25)Hongli Zhang,Qianjin Zhou,YiYang,Xueqiu Chen,Baolong Yan,Aifang Du*.Characterization of heat shock protein 70 gene from Haemonchus contortus and its expression and promoter analysis in Caenorhabditis elegans.Parasitology.2013,140,683–694 26)De-Fu Zhang,Hui Xu,Bing-Bing Sun,Jian-Qiu Li,Qian-Jin Zhou,Hong-Li Zhang,Ai-Fang Du*.Adjuvant effect of ginsenoside-based nanoparticles(ginsomes)on the recombinant vaccine against Eimeria tenella in chickens.Parasitol Res,2012,110:2445–2453 27)De-Fu Zhang,Bing-Bing Sun,Ying-Ying Yue,Hai-Jie Yu,Hong-Li Zhang,Qian-Jin Zhou,Ai-Fang Du*.Anticoccidial effect of halofuginone hydrobromide against Eimeria tenella with associated histology.Parasitol Res,2012,111:695–701 28)De-Fu Zhang,Bing-Bing Sun,Ying-Ying Yue,Qian-Jin Zhou,Ai-Fang Du*.Anticoccidial activity of traditional Chinese herbal Dichroa febrifuga Lour extract against Eimeria tenella infection in chickens,Parasitol Res,2012,111:2229-2233 29)Daofeng QU,Hai-Jie YU,Zhao LIU,De-Fu ZHANG,Qian-Jin ZHOU,Hong-Li ZHANG,Ai-Fang Du*.Ginsenoside Rg1 enhances Immune response induced by recombinant Toxoplasma gondii SAG1 antigen.Veterinary parasitology.2011,179,28-34 30)Hai-jie Yu,Zhi Zhang,Zhao Liu,Dao-feng Qu,De-fu Zhang,Hong-li Zhang,Qian-jin Zhou and Ai-fang Du*.Seroprevalence of Toxoplasma gondii infection in pigs,in Zhejiang province,China.Journal of Parasitology,2011,97(4):748-749 31)Qian-Jin Zhou&Hong-Li Zhang&Xiao-Lei Jiang&Ai-Fang Du*.The gene structure and promoter region of the vaccine target aminopeptidase H11 from the blood-sucking nematode parasite of ruminants,Haemonchus contortus.Funct Integr Genomics.2010,10:589–601(IF 3.825) 32)Qu D,Yu H,Wang S,Cai W,Du A*.Induction of protective immunity by multiantigenic DNA vaccine delivered in attenuated Salmonella typhimurium against Toxoplasma gondii infection in mice.Veterinary Parasitology.2009,166(3-4):220-7 33)Qu,D.,Wang,S.,Cai,W.,Du,A*.Protective effect of a DNA vaccine delivered in attenuated Salmonella typhimurium against Toxoplasma gondii infection in mice.Vaccine.2008,26(35):4541-8 34)Zhou,Q.,Chu,W.,Gao,X.,Qu,D.Zhang,H.,Du,A*.Combined immunization of an oral DNA vaccine with adjuvant IL2 delivered in attenuated salmonella typhimurium against Eimeria tenella infection in chickens.Inflammatory bowel diseases.2008,14:S39 35)Li,X.,Du,A*.Cai.W.Evaluation of a recombinant excretory secretory Haemonchus contortus protein for use in a diagnostic enzyme-linked immunosorbent assay.Experimental parasitology.2007,115,242-246 36)Du A*.and Wang S.Efficacy of a DNA vaccine delivered in attenuated Salmonella typhimurium against Eimeria tenella infection in chickens.International Journal for Parasitology,2005,35(7):777-85 37)Aifang Du*,Songhua Hu,Suhua Wang.Eimeria tenella:Ginsenosides-enhanced immune response to the immunization with recombinant 5401 antigen in chickens.Experimental parasitology,2005,111(3):191-197 中文文章(*通讯作者) 1)郑秀平.捻转血矛线虫Hc-daf-22基因的原核表达及重组蛋白酶活性测定.中国农业科学.08,2017 2)邬迎辉,曾若雪,于婧怡,杜爱芳*.宠物进口食品的种类及检验检疫规程与风险分析.浙江畜牧兽医,2016,05, 3)程海卫,陈一飞,陈学秋,杨怡,卓洵辉,蓝丽华,杜爱芳*.大容量天然鼠源核糖体展示单链抗体文库的构建与鉴定.中国兽医学报,2016,36(05):763-767+777 4)李闵薇,陈学秋,杨怡,杜爱芳*,基于重组蛋白TPx的羊肝片吸虫感染Dot-ELISA检测方法的建立,中国兽医学报,2016,36(1):79-84+89 5)潘辰,杨怡,陈学秋,杜爱芳*,华支睾吸虫间接ELISA检测方法的建立及初步应用,中国兽医学报,2015,35(11):1792-1798 6)闫宝龙,杨怡,郭筱璐,陈学秋,杜爱芳*,捻转血矛线虫ZJ株滞育虫体的获得及其形态特征,中国兽医学报,2015,35(2):225-228 7)马羽洁,陈学秋,闫宝龙,杨怡,郭筱璐,杜爱芳*,捻转血矛线虫感染性三期幼虫gst基因的筛选及抗干燥功能分析,中国兽医学报,2015,35(3):401-405 8)段丽君,周前进,张红丽,杨怡,闫宝龙,杜爱芳*.捻转血矛线虫ZJ株疫苗候选抗原H11亚型基因H11-4的克隆及序列分析.中国兽医学报,2013,33(3)381-385 9)陈学秋,马羽洁,周前进,张红丽,杨怡,闫宝龙,杜爱芳*.利用mRNA差异显示技术分离捻转血矛线虫感染性三期幼虫抗干燥相关基因.中国兽医学报,2013,33(8):1212-1216 10)郑柏玲,张红丽,周前进,陈学秋,杜爱芳*.利用mRNA差异显示技术克隆分析捻转血矛线虫滞育相关基因.中国兽医学报,2012,32(5),675-681 11)周前进,张红丽,姜小磊,杜爱芳*.Act-1核心启动子转录的EGFP基因在秀丽隐杆线虫体内的表达.生物工程学报,2009,25(3):336-340

学术兼职

曾兼任教育部高等学校动物医学教学指导委员会委员;国务院学位办第四届兽医专业学位研究生教育指导委员会委员;中国畜牧兽医学会兽医寄生虫学分会常务理事;浙江省动物预防医学重点实验室主任。

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