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浙江大学动物科学学院动物医学系教授,承担8项国家自然科学基金、3项浙江省自然科学基金和2项浙江省科技厅项目的研究。研究禽类卵泡发育和闭锁及产蛋机能调节的分子机理、性分化和生殖干细胞发育的调控及其信号转导机理、禽类生物反应器平台的建立等。入选教育部新世纪优秀人才支持计划、浙江省“新世纪151人才工程”第二层次培养人员、浙江省自然科学基金杰出青年基金获得者。在国内外刊物上发表了近100篇论文,其中SCI收录论文70余篇(通讯作者)。指导的博士生获全国优博提名论文和省优秀博士论文。 教学与课程 本课生课程: 1.动物生理学(必修课,省级精品课程,3学分) 2.动物细胞生物学(选修课,2学分) 研究生课程: 1.动物细胞与发育生物学(博士生学位课,校核心课,2学分) 2.兽医科学进展(硕士生学位课,2学分) 3.动物分子细胞生物学实验技术(硕士生学位课,2学分) 4.动物生物化学专题(硕士生学位课,2学分) 5.高级动物生理及病理学(硕士生学位课,2学分) 6.基础兽医学专题(全日制专业学位硕士生学位课,3学分) 7.基础兽医学专题(非全日制专业学位硕士生学位课,3学分) 8.实验设计与科技写作(专业学位硕士生学位课,2学分) 科研 研究内容: 1.生殖干细胞发育调控机理的研究 2.禽类卵泡发育和闭锁及产蛋机能调节 3.内分泌干扰物生殖毒性作用及其分子机理的研究 4.禽类生物反应器平台的研究机制和防治措施的研究 主持的科研项目: 1.项目名称:母鸡卵巢内细胞间互作对原始卵泡发生及其发育的调节作用,国家自然科学基金(31772693),2018.01.-2022.12. 2.项目名称:母鸡小黄卵泡库动态变化调节机理的研究,国家自然科学基金(31472160),2015.01.-2018.12. 3.项目名称:蛋鸡卵泡再生和闭锁调控机理的研究,国家自然科学基金(31272525),2013.01.-2016.12. 4.项目名称:雌激素通过膜受体GPR30调节鸡胚PGC发育及其机理的研究.高等学校博士学科点专项科研基金(20110101110099),2012.01-2014.12. 5.项目名称:家禽肝-卵巢轴对卵黄沉积和胚胎发育调控作用的研究.浙江省自然科学基金重点项目(Z3110115),2011.01-2013.12. 6.项目名称:作物新品种培育及动物消化系统研究.浙江大学校长基金子课题(2011XZZX006),2011.01-2013.12. 7.项目名称:间充质干细胞移植对小鼠肝硬化修复作用的研究.传染病诊治国家重点实验室开放基金(2010KF03),2010.06-2012.12. 8.项目名称:家禽卵泡内局部信号通讯对等级前卵泡发育调控机理的研究,国家自然科学基金(30871843),2009.01.-2011.12. 9.项目名称:原始生殖细胞介导的家禽生物反应器的构建,浙江省科技支撑和引导计划面上项目(2008C22040),2008.01-2009.12. 10.项目名称:禽类生殖干细胞为载体的生物反应器平台的研究,教育部“新世纪优秀人才支持计划”(NCET-05-0514),2006.01-2008.12. 11.项目名称:体细胞诱导的胚胎生殖干细胞增殖和分化机制的研究,国家自然科学基金(30471245),2005.01.-2007.12. 12.项目名称:下丘脑和腺垂体细胞联合移植对家鸡繁殖机能的影响及其机理的研究,国家自然科学基金(30371051),2004.01.-2006.12. 13.项目名称:母鸡性行为反转机制的研究,国家自然科学基金(39970535),2000.1.-2002.12. 研究与成果 承担8项国家自然科学基金的研究,在家禽繁殖生理和毒理及生物技术方面取得了一系列新成果,发表论文100余篇,申报专利1项。 出版著作 教材: 1.张才乔主译.《Avian Physiology 6th edition》,中国农业出版社,“十二五”国家重点图书出版规划项目世界兽医经典著作译丛 2.张才乔主编.《动物生理学实验》,第二版,科学出版社,全国高等农林院校规划教材,2014年,ISBN 978-7-03-040968-3 3.张才乔副主译.《Dukes′Physiology of Domestic Animals》,第十二版,中国农业出版社,“十二五”国家重点图书出版规划项目世界兽医经典著作译丛,2014.5,ISBN 978-7-109-17675-1 4.张才乔副主编.《动物生理学》,第二版,科学出版社,全国高等农林院校规划教材,2012年1月,普通高等教育“十二五”规划教材,978-7-03-033315-5 5.张才乔副主编.《动物生理学》,第五版,中国农业出版社,普通高等教育“十一五”国家级规划教材、全国高等农业院校“十一五”规划教材,2011.7出版,ISBN 978-7-10-915809-2 奖励荣誉 获奖情况: 1.浙江省“新世纪151人才工程”第二层次培养人员,2010 2.2010年校级先进工作者 3.《产蛋鸡卵泡发育的组织学结构的研究》,中国畜牧兽医学会动物解剖与组织胚胎学分会第十六次学术研讨会优秀论文奖,青海西宁,2010 4.2009年度浙江大学本科生百篇特优毕业论文(设计)优秀指导教师 5.浙江大学“圣雄学生工作管理奖教金”获得者,2009年 6.《动物生理学》省级精品课程,2009年 7.全国优秀博士学位论文提名论文,黄酮类化合物缓解内分泌干扰物引起的雄性鸡胚生殖毒性机理的研究,教育部,博士生:米玉玲,导师:张才乔,2008年 8.浙江大学教学成果二等奖,“农科“动物生理学”课程教学体系的改革”,2008 9.入选“浙江大学首届教学名师培养对象”,2008年 10.2008年度奖教金获得者 11.浙江省自然科学优秀论文一等奖,“槲皮素对多氯联苯引起的鸡胚精原细胞氧化损伤的缓解作用”,2007 12.2007年院级、校级先进工作者 13.教育部“新世纪优秀人才支持计划”获得者,2006-2008 14.浙江省自然科学基金人才培养项目获得者,2006-2008 15.浙江省“新世纪151人才工程”第三层次培养人员,2005年 16.浙江省高校优秀科研成果二等奖,“环境内分泌干扰物生物活性评价细胞模型的建立及其应用”,2005 17.浙江省自然科学优秀论文二等奖,“多氯联苯对培养的鸡胚卵巢生殖细胞增殖的雌激素和毒性作用”2005 18.浙江大学优秀教师奖,2004 19.浙江大学教学成果二等奖,“动物生理学实验教学创新体系构建”,2004年,排名1/3 20.浙江省自然科学优秀论文二等奖,“多氯联苯对鸡胚性腺发育和生殖功能的干扰作用”,2003

研究领域

动物生理生化 繁殖生理学

近期论文

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1.Xingting Liu,Xin Lin,Siyu Zhang,Changquan Guo,Jian Li,Yuling Mi*,Caiqiao Zhang*Lycopene ameliorates oxidative stress via activation of Nrf2/HO-1 pathway in the aging chicken ovary.Aging-US.2018,10(8):2016-2036.https://doi.org/10.18632/aging.101526 2.Lijuan Liu;Siyu Zhang;Jiayang Bao;Xiaowen He;Danni Tong;Cong Chen;Qingxiang Ying;Qing Zhang;Caiqiao Zhang*;Jian Li*.Melatonin improve hens laying performance by regulating intestinal amino acids transportation.Frontiers in Endocrinology,section Experimental Endocrinology.2018 Manuscript ID:384996 3.Min Xiao;Yuling Mi;Caifeng Lv;Weidong Zeng;Caiqiao Zhang*;Jian Li*.Taurine regulate mucosal renewal to alleviate LPS-induced duodenal inflammation.Amino Acids.2018,50(11):1637-1646 4.Xin Lin,Xingting Liu,Yanfen Ma,Yuling Mi,Weidong Zeng,Jian Li*and Caiqiao Zhang*.Coherent Apoptotic and autophagic activities involved in regression of chicken postovulatory follicles.Aging-US.2018,10(4):819-832.doi:https://doi.org/10.18632/aging.101436 5.Xin Lin,Xingting Liu,Changquan Guo,Mengqi Liu,Yuling Mi,Caiqiao Zhang*.Promotion of the prehierarchical follicle growth by postovulatory follicles involving PGE2-EP2 signaling in chickens.Journal of Cellular Physiology.2018,1-12.https://doi.org/10.1002/jcp.26844 6.Xingting Liu,Xin Lin,Yuling Mi,Jian Li,Caiqiao Zhang*,Grape seed proanthocyanidin extract prevents ovarian aging by inhibiting oxidative stress in the hens.Oxidative Medicine and Cellular Longevity.Vol.2018,Article ID 9390810,16 pages,2018.doi:10.1155/2018/9390810. 7.R.X.Li,J.Li,S.Y.Zhang,Y.L.Mi,C.Q.Zhang*.Attenuating effect of melatonin on lipopolysaccharide-induced chicken small intestine inflammation.Poultry Science.2018,97(7):2295–2302(SCI,IF 2.216)https://doi.org/10.3382/ps/pey084 8.Dan Zhao,Imdad Hussain Leghari,Jian Li,Yuling Mi and Caiqiao Zhang*.Isolation and culture of chicken growing follicles in 2-and 3-dimensional models.Theriogenology.2018,111:43-51.DOI:https://doi.org/10.1016/j.theriogenology.2018.01.012 9.J.Li,J.Li Jr,S.Y.Zhang,R.X.Li,X.Lin,Y.L.Mi,C.Q.Zhang*.Culture and characterization of chicken small intestinal crypts.Poultry Science.2018,97(5):1536–1543. 10.Xing-ting Liu,Xin Lin,Yu-ling Mi,Wei-dong Zeng,Caiqiao Zhang*.Age-related changes of yolk precursor formation in the liver of laying hens.Journal of Zhejiang University-SCIENCE B(Biomedicine&Biotechnology).2018,19(5):390-399. 11.J.Li,R.X.Li,G.Liu,C.F.Lv,Y.L.Mi,and C.Q.Zhang*.Effect of melatonin on renewal of chicken small intestinal mucosa.Poultry Science.2017,96(8):2942-2949.DOI:10.3382/ps/pex085 12.Dan Zhao,Caifeng Lv,Guang Liu,Yuling Mi*and Caiqiao Zhang*Effect of estrogen on chick primordial follicle development and activation.Cell Biology International.2017,630–638. 13.G Liu,R Li,C Guo,D Zhao,Y Mi,J Li*and C Zhang*.Inhibitory effect of melatonin on formation of the chicken primordial follicles.Pakistan Veterinary Journal.2017,37(3):263-268. 14.L.Wang,J.Li,J.Li Jr.,R.X.Li,C.F.Lv,S.Li,Y.L.Mi,and C.Q.Zhang*.Identification of the Paneth cells in chicken small intestine.Poultry Science.2016,95:1631–1635.doi:http://dx.doi.org/10.3382/ps/pew079 15.Jun Li,Dan Zhao,Changquan Guo,Jian Li,Yuling Mi*,Caiqiao Zhang*.Involvement of Notch signaling in early chick ovarian follicle development.Cell Biology International.2016,40(1):65-73 DOI:10.1002/cbin.10538. 16.Fuyin Hou,Min Xiao,Jian Li,Weidong Zeng,Caiqiao Zhang,Yuling Mi*.Ameliorative effect of grape seed proanthocyanidin extract on cadmium-induced meiosis inhibition during oogenesis in chicken embryos.The Anatomical Record.2016,299(4):450-460. 17.Kai Jin,Xin Ye,Sha Li,Bo Li,Caiqiao Zhang,Changyou Gao,Juan Ye.A biomimetic collagen/heparin multi-layered porous hydroxyapatite orbital implant for in vivo vascularization studies on the chicken chorioallantoic membrane.Graefes Arch Clin Exp Ophthalmol,2016,254(1):83-89.DOI 10.1007/s00417-015-3144-6 18.Imdad Hussain Leghari,Dan Zhao,Yuling Mi and Caiqiao Zhang*.Isolation and culture of chicken primordial follicles.Poultry Science.2015,94:2576-2580. 19.I.H.Leghari,J.Li,W.Zeng,Y.Mi*and C.Zhang*.Comparative study of reproductive organs and egg quality characteristics in Hyline and domestic layer breeds.Pakistan Veterinary Journal.2015,35(3):315-320. 20.侯福银,宓君鹏,刘兴廷,李剑,米玉玲*,张才乔.原花青素对镉引起的鸡胚睾丸氧化损伤的缓解作用。生态毒理学报,2015,10(4):138-145,2015 21.赵丹,刘广,郭长权,李剑,米玉玲,张才乔*.雌激素对鸡早期卵巢发育的影响。2015,中国科技论文在线.http://www.paper.edu.cn/releasepaper/content/201512-641. 22.俞萍,李剑,米玉玲,张才乔*.鸡早期卵泡发育的研究。2015,中国科技论文在线.http://www.paper.edu.cn/releasepaper/content/201512-649. 23.Yuling Mi,Bin He,Jian Li,Caiqiao Zhang*.Progesterone regulates chicken embryonic germ cell meiotic initiation independent of retinoic acid signaling.Theriogenology.2014,82(2):195–203. 24.Jun Li,Imdad Hussain Leghari,Bin He,Weidong Zeng,Yuling Mi,Caiqiao Zhang*.Estrogen stimulates expression of chicken hepatic vitellogenin II and very low density apolipoprotein II through ERα.Theriogenology.2014,82(3):517-524. 25.H.Wang,C.Zhang,Y.Mi,M*.T.Kidd.Copper and lysine-amino acid density responses in commercial broilers.Journal of Applied Poultry Research.2014,23(3):470-477. 26.Bin He,Yuling Mi*,Caiqiao Zhang*.Gonadotropins regulate ovarian germ cell mitosis/meiosis decision in the embryonic chicken.Molecular and Cellular Endocrinology.2013,370(1-2):32-41.DOI:10.1016/j.mce.2013.02.010 27.Minli Yu,Ping Yu,Imdad Hussain Leghari,Chutian Ge,Yuling Mi,Caiqiao Zhang*.Raldh2,the enzyme for retinoic acid synthesis,mediates meiosis initiation in germ cells of the female embryonic chickens.Amino Acids.2013,44(2):405-412. 28.Yudong Jia,Jinxing Lin,Yuling Mi,Caiqiao Zhang*.Prostaglandin E2 and insulin-like growth factor I interact to enhance proliferation of theca externa cells from chicken prehierarchical follicles.Prostaglandins and Other Lipid Mediators.2013,106:91-98. 29.Yuling Mi,Longlong Tu,Huimin Wang,Weidong Zeng,Caiqiao Zhang*Supplementation with quercetin attenuates 4-nitrophenol-induced testicular toxicity in adult male mice.The Anatomical Record.296(10):1650-1657,2013. 30.Lin Jinxing,Yunjie Mao,Yuling Mi,Caiqiao Zhang*.Effect of Ghrelin on development of chicken prehierarchical follicles.Chinese Journal of Animal and Veterinary Sciences.43:22-28,2013 31.Jie Li,Jun Li,Sha Li,Bin He,Yuling Mi,Hongcui Cao,Caiqiao Zhang*,Lanjuan Li*.Ameliorative effect of grape seed proanthocyanidin extract on thioacetamide-induced mouse hepatic fibrosis.Toxicology Letters.2012,213(3):353–360. 32.Chutian Ge,Minli Yu,Caiqiao Zhang*.G protein-coupled receptor 30 mediates estrogen-induced proliferation of primordial germ cells via EGFR/Akt/β-catenin signaling pathway.Endocrinology.2012,153(7):3504-3516.doi:10.1210/en.2012-1200 33.Bin He,Jinxing Lin,Jie Li,Yuling Mi,Weidong Zeng,Caiqiao Zhang*.Basic fibroblast growth factor suppresses meiosis and promotes mitosis of ovarian germ cells in embryonic chickens.General and Comparative Endocrinology.2012,176(2):173-181.DOI:10.1016/j.ygcen.2012.01.012 34.Chutian Ge,Jian Ye,Qin Wang,Caiqiao Zhang*,Jun-Mo Yang,Guoying Qian.Polycyclic aromatic hydrocarbons suppress meiosis in primordial germ cells via the AHR signaling pathway.Toxicology Letters.2012,210(3):285-92. 35.Minli Yu,Chutian Ge,Weidong Zeng,Yuling Mi and Caiqiao Zhang*.Retinoic acid promotes proliferation of chicken primordial germ cells via activation of PI3K/Akt-mediated NF-κB signaling cascade.Cell Biology International.2012,36(8):705-712. 36.Jinxing Lin,Yudong Jia,Weidong Zeng,Yuling Mi,Caiqiao Zhang*.Basic FGF promotes proliferation of ovarian granulosa cells in the laying chickens via FGFR1 and PKC pathway.Reproduction in Domestic Animals.2012,47(1):135-142(SCI,IF 1.400)DOI:10.1111/j.1439-0531.2011.01813.x. 37.Tongliang Bu,Yudong Jia,Jinxing Lin,Yuling Mi*,Caiqiao Zhang*.Alleviative effects of quercetin on germ cells intoxicated by 3-methyl-4-nitrophenol from diesel exhaust particles.Journal of Zhejiang University-SCIENCE B(Biomed&Biotechnol).2012,13(4):318-326. 38.Minli Yu,Kun Guan,Caiqiao Zhang*.The promoting effect of retinoic acid on proliferation of chicken primordial germ cells by increased expression of cadherin and catenins.Amino Acids.2011,40(3):933-941. 39.Yudong Jia,Jinxing Lin,Yuling Mi,Caiqiao Zhang*.Quercetin attenuates cadmium-induced oxidative damage and apoptosis in granulosa cells from chicken ovarian follicles.Reproductive Toxicology.2011,31(4):477-485. 40.Tongliang Bu,Yuling Mi*,Weidong Zeng and Caiqiao Zhang*.Protective effect of quercetin on cadmium-induced oxidative toxicity on germ cells in male mice.Anatomical Record.2011,294(3):520-526. 41.Jinxing Lin,Yudong Jia,Caiqiao Zhang*.Effect of epidermal growth factor on follicle-stimulating hormone-induced proliferation of granulosa cells from chicken prehierarchical follicles.Journal of Zhejiang University-SCIENCE B(Biomed&Biotechnol).2011,12(11):875-883. 42.贾玉东,颜菲菲,曾卫东,张才乔*.胰岛素样生长因子-I对鸡等级前卵泡发育的促进作用.中国农业科学.2011,44(20):4295-4301 43.林金杏,毛赟杰,米玉玲,张才乔*.Ghrelin对鸡等级前卵泡发育的影响.畜牧兽医学报.2011,42(9):1220-1226 44.曾卫东,张才乔,米玉玲,蒋振东.开设自主性实验培养学生的创新能力.实验科学与技术.2011,9(5):114-115,124 45.Yanqun Wu,Chutian Ge,Weidong Zeng and Caiqiao Zhang*.Induced multilineage differentiation of chicken embryonic germ cells via embryoid body formation.Stem Cells and Development.2010,19(2):195-202. 46.Yudong Jia,Jinxing Lin,Weidong Zeng,Caiqiao Zhang*.Effect of prostaglandin on luteinizing hormone-stimulated proliferation of theca externa cells from chicken prehierarchical follicles.Prostaglandins and Other Lipid Mediators.2010,92:77-84. 47.Tu Quang Tan,Chutian Ge,Yuling Mi,Yanmei Jin and Caiqiao Zhang*.Ginsenosides promote proliferation of granulosa cells from chicken prehierarchical follicles through PKC activation and upregulated cyclin gene expression.Cell Biology International.2010,34(7):769-775. 48.Yuling Mi,Caiqiao Zhang*,Chunmei Li,Shinji Taneda,Gen Watanabe,Akira K Suzuki,Kazuyoshi Taya.Protective effect of quercetin on the reproductive toxicity of 4-nitrophenol in diesel exhaust particles on male embryonic chickens.Journal of Reproduction and Development.2010,56(2):195-199. 49.Yuling Mi,Caiqiao Zhang*,Chunmei Li,Shinji Taneda,Gen Watanabe,Akira K Suzuki,Kazuyoshi Taya.Quercetin attenuates oxidative damage induced by treatment of embryonic chicken spermatogonial cells with 4-nitro-3-phenylphenol in diesel exhaust particles.Bioscience,Biotechnology,and Biochemistry.2010,74(5):934-938. 50.Hongyun Liu,Weidong Zeng,Ailing Cao,Caiqiao Zhang*.Follicle-stimulating hormone promotes proliferation of cultured chicken ovarian germ cells through protein kinase A and C activation.Journal of Zhejiang University SCIENCE B.2010,11(12):952-957.

学术兼职

担任中国畜牧兽医学会动物生理生化分会副理事长、动物解剖学与组织胚胎学分会常务理事。受邀担任Aging-US、Amino Acids、Anatomical Record、Biomaterials、Biology of Reproduction、Bioresourse Technology、DNA and Cell Biology、Cytokine、Drug and Chemical Toxicology、Journal of Agricultural and Food Chemistry、PlosOne、Poultry Science、Stem Cells and Development、Theriogenology等60余种SCI杂志评议人,参与国家基金(一审和二审)、国家留学基金、多个省区自然科学基金的评议。

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