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刘建新,浙江大学求是特聘教授,博士生导师,生物饲料安全与污染防控国家工程实验室主任;1982年毕业于浙江农业大学畜牧兽医系,1982年受国家公派赴日本北海道大学农学部攻读研究生学位,1985年获得硕士学位,1988年获博士学位后回国任教,1994年底晋升教授;1995-1996年,英国Rowett研究所从事博士后;1999-2000年,作为洪堡研究学者在德国基尔大学动物营养、生理与代谢研究所从事合作研究。1993-1998年,任浙江农业大学动物科学学院副院长、院长;2001-2013年历任浙江大学动物科学学院副院长、常务副院长、院长等。2000-2008年任中国畜牧兽医学会动物营养学分会副理事长,2008-2012年任中国畜牧兽医学会动物营养学分会理事长。 主要从事奶牛营养、泌乳生理、瘤胃微生物与发酵调控、饲料资源开发与利用等教学及科研工作;承担973课题、国家杰出青年基金、国家自然基金、支撑计划课题、国际合作重点项目等30多项国家、省部级科研项目。1999年获得德国著名的洪堡基金,2002年入选教育部“跨世纪优秀人才培养计划”,2003年获得国家杰出青年基金,曾获国际科学基金会Silver Jubilee Award。在Microbiome、Bioinformatics、Journal of Dairy Science、Journal of Animal Science&Biotechnology等刊物发表系列研究成果,出版科技专著6部;科研成果荣获国家和省部级科技进步奖6项,2009年被评为浙江省教学名师,2018年被评为浙江省优秀教师。现担任Journal of Animal Physiology and Animal Nutrition、Animal Bioscience、Journal of Animal Science and Biotechnology、Animal Nurition、《动物营养学报》、《中国畜牧杂志》等刊物编委,具有较高的国内知名度,在国际同行中也有一定影响。曾留学日本、英国、德国,与美、日、澳、德等众多国家的学者有密切合作与联系。 教学与课程 动物营养与饲料科学研究进展(博士研究生,主讲) 动物产品品质形成及其调控(博士研究生,参讲) 泌乳科学(硕士研究生,主讲) 动物营养学(普通高校本科生,主讲) 草食家畜生产学(普通高校本科生,参讲) 科研 承担的部分科研项目 Examples of Scientific Research Projects 基于系统生物学方法鉴定调节奶牛氮利用效率和牛奶品质的分子和代谢表征物。拟利用系统生物学技术,对日粮相同但乳蛋白产量不同的大群奶牛开展基因测序、表观遗传修饰和转录后调控系统研究,全面分析高或低乳蛋白产量奶牛的瘤胃微生物宏基因组、瘤胃液代谢组、血液转录组和代谢组,旨在验证影响乳蛋白产量的分子与代谢表征物,解析影响乳蛋白产量的生物学系统调节机制,为改善奶牛饲料效率和选育优质奶牛提供科学知识。(国家自然科学基金海外与港澳学者合作基金) System biology based approaches to identify molecular and metabolic markers for improvement of nitrogen utilization efficiency and milk quality in dairy cows,funded by The National Natural Science Foundation of China.The project is aimed to validate the identified molecular and metabolic biomarkers related to milk protein production from previous study in the commercial herd,and to characterize the biological systematic mechanism and regulation on the cows’milk protein production.It will provide implication to improve feed efficiency and contribute to scientific knowledge in the cow’s breeding in China dairy industry. 高产奶牛乳腺低氧应激成因的代谢与分子机制。通过在体奶牛和乳腺细胞试验,建立奶牛乳腺低氧应激模型;分析高产、热应激下奶牛泌乳性能、乳腺细胞形态与功能、关键代谢产物,揭示高产下奶牛低氧应激的诱发机制;施加抗应激制剂,研究其对奶牛血气参数、乳腺功能和低氧应激关键基因及核心分子网络的影响。揭示高产奶牛乳腺低氧应激成因的代谢与分子机制,为建立缓解高温高湿和高产下奶牛乳腺低氧应激、保障奶牛乳腺代谢稳态提供新的知见,丰富和发展高产奶牛健康养殖的理论与实践。(国家自然科学基金重点项目) Metabolic molecular mechanism involved in cause of hypoxia stress in mammary gland of lactating dairy cows,Funded by the National Natural Science Foundation of China.The individuals with hypoxia and normal status are screened from a large cohort of high-yielding lactating cows to investigate lactation performance,morphology and function of the mammary epithelial cells,and key metabolites,to verify the core molecular networks,and to reveal the mechanism with which hypoxia stress is induced by high production.Meanwhile,similar studies will be conducted in the high-yielding dairy cows under heat stress.Finally,anti-stress agents with different function modes are selected and used in high-yielding dairy cows and/or under heat stress to study their effects on blood gas parameters,mammary function,and key genes and core molecular network related to hypoxia stress.Based on the above results,we are to reveal the metabolic and molecular mechanism of hypoxia stress in mammary gland of high-yield dairy cows,which will provide new insights in relieving hypoxia stress in high-yielding dairy cows under heat stress,and ensuring the mammary metabolic homeostasis in dairy cows. 围产期和泌乳前期奶牛氧化应激发生机制及营养调控策略。针对围产期奶牛特殊代谢产生的生理异常,分析奶牛氧化应激的发生规律、应激指征物的变化,乳腺上皮细胞增殖与凋亡、细胞器应激蛋白变化和调控应激相关基因的表达变化等,探讨奶牛产前指标与产后泌乳性能和健康的关系;深入研究产犊前后的代谢网络变化,探究Keap1-Nrf2信号通路在乳腺代谢和抗氧化过程中的作用机制;筛选靶向的潜在抗氧化物质,通过应用示范,探究其最佳添加剂量及添加方式。分析不同抗氧化物质对奶牛机体健康、泌乳性能和对犊牛影响,确定2-3种高效抗应激制剂,明确作用机理和应用效果,以缓解奶牛因代谢变化和高精料日粮引起氧化应激,维持健康高产。(科技部中美国际合作项目) Oxidative stress mechanism and antioxidation strategies in dairy cows during transition period and early lactation,a China-USA Intergovernmental Collaborative Project funded by the Chinese Ministry of Science&Technology.Aiming at the physiological abnormalities caused by the special metabolism of dairy cows during the transition period,we are to study the occurrence of oxidative stress,changes in stress indicators,proliferation and apoptosis of mammary epithelial cell,changes in organelle stress proteins,and regulation of expression of stress-related genes,etc.Relationship will be analyzed between prepartum indicators and postpartum lactation performance and health of dairy cows.An in-depth study is also conducted of metabolic network changes before and after calving to explore the mechanism with which Keap1-Nrf2 signaling pathway is involved in mammary gland metabolism and antioxidant process.Potential antioxidants will then be screened through application demonstration to develop the best dosage and method of addition.The effects of different antioxidants will be investigated on cows’health,and lactation performance as well as calves,finally developing 2-3 high-efficient anti-stress preparations.Application of them will contribute to alleviate the oxidation stress of cows caused by metabolic changes and high-concentration diets and to maintain health andhigh productivity of early-lactation dairy cows. 国家奶牛产业体系岗位科学家(泌乳生理与调控),农业部,研究奶牛泌乳生理及营养、饲料调控,为奶牛产业寻求饲料资源高效利用、环境减排等技术,促进奶牛产业可持续发展。 Lactation biology and nutritional manipulation,Position Scientist in China Agriculture(Dairy)Research System funded by China Ministry of Agricuture and Rural Affairs,with aims at developments of nutritional strategies to improve the efficiency of nutrient utilization and reduce excretion of nitrogen and phosphorus to the environment,and promotion of the sustainability of the dairy production system in China. 研究与成果 2018年12月:获高等学校科学研究优秀成果奖(科学技术)自然科学奖二等奖(主持人) 2018年10月:获浙江省优秀教师称号 2014年01月:获湖南省科技进步奖一等奖(第四完成人) 2012年02月:获国家科技进步奖二等奖(第二完成人) 2009年12月:获浙江省第五届高等学校教学名师奖 2008年02月:获浙江省科技进步奖二等奖(主持人) 2006年02月:获浙江省科技进步奖二等奖(主持人) 2001年10月:获浙江省科技进步奖三等奖(第四) 2000年08月:获国际科学基金会银庆奖(IFS/Silver Jubilee Award) 2000年04月:被浙江省政府遴选为省高校中青年学科带头人 1999年07月:获德国洪堡基金会研究基金 1999年02月:入选浙江省“151人才工程”培养计划 1997年12月:获浙江省自然科学优秀论文一等奖(第一) 1998年10月:获国家科技进步奖二等奖(第七完成人) 1997年10月:获农业部科技进步奖一等奖(第四) 1997年10月:获浙江省科技进步奖三等奖(第三) 1996年04月:获第一届国际农业科技年会犁铧奖(Plowshare Award) 1995年10月:获浙江省科技进步奖三等奖(主持人) 1993年10月:获国务院特殊津贴 1992年05月:获霍英东教育基金会青年教师奖三等奖 1991年09月:获浙江省高校优秀青年教师称号 出版著作 论著 1)刘建新主编.2019.反刍动物营养生理.农业出版社,北京. 2)刘建新主编,2012.动物营养研究进展(2012).中国农业科技出版社 3)刘建新(副主编).2011.饲料添加剂学.农业出版社,北京. 4)刘建新主编.2004.浙江效益农业百科全书-奶牛.中国农业科技出版社,北京. 5)刘建新(参编).2004.反刍动物营养学(冯仰廉主编).中国科学出版社,北京. 6)陈代文,冯定远,刘建新.2003.饲料添加剂学.农业出版社,北京. 7)刘建新(参编).2003.配合饲料学(冯定远主编).上海科学技术出版社. 8)刘建新(参编).2003.饲料添加剂安全使用规范(蔡辉益、杨振海主编).中国农业出版社,北京. 9)刘建新,吴跃明,叶均安,周卫东,陈维虎.2002.干草秸秆青贮饲料加工技术.中国农业科技出版社,北京 10)刘建新(参译).2002.奶牛饲养标准,NRC(第10版)(孟庆翔主译).中国农业大学出版社,北京 11)刘建新,王恬,张宏福.2002.饲料营养研究进展-2002.畜牧与兽医杂志社,南京. 12)刘建新(参编).2002.秸秆养畜–中国的经验(郭庭双等编著).粮农组织家畜生产及卫生文集-149.FAO,罗马. 13)孟庆翔,王康宁,刘建新,单安山.2002.饲料学,中国农业大学出版社,北京. 14)戴旭明,刘建新,吕建涛.1999.山羊养殖与经营指南.浙江省科技出版社,杭州. 15)刘建新,张宏福,王康宁.1998.饲料营养研究进展-1998.亚洲中医药杂志社,澳门. 16)刘建新(参编).1996.秸秆畜牧业(郭庭双主编).上海科学技术出版社. 实验室介绍 奶业科学研究所 奶业科学研究所隶属国家重点(培育)学科-动物营养与饲料科学学科,是生物饲料安全与污染防控国家工程实验室、浙江大学动物分子营养学教育部重点实验室、农业部动物营养与饲料(华东)重点开放实验室、浙江省饲料与动物营养重点研究实验室和浙江省饲料产业科技创新服务平台的重要组成部分,设有浙江大学-阿尔伯塔大学动物功能基因组与微生物学联合实验室。 现有教授5人,副教授2人,百人计划研究员1人,特聘副研究员2人,讲座教授3人,技术员1人,博士后7人,在读博士生17人,硕士生43人。研究所主要从事奶牛营养与健康、消化道微生态与功能、泌乳生理与营养调控、饲料资源开发与利用、营养与污染控制等领域的研究。近年来,承担国家973计划课题、国家杰出青年基金、国家优秀青年基金、国家支撑计划、国家自然科学基金、科技部国际科技合作、国际原子能机构、省部级项目20多项,总经费4000多万元。获省部级科技进步奖6项,获授权国家发明专利13项。发表学术论文400余篇,其中SCI收录论文200多篇。 研究室主页:http://dairyscience.zju.edu.cn

研究领域

反刍动物营养及其调控、乳品质形成机理及其调控

近期论文

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2020 1.Xue MY,Sun HZ,Wu XH,Liu JX,Guan LL.2020.Multi-omics reveals that the rumen microbiome and its metabolome together with the host metabolome contribute to individualized dairy cow performance.Microbiome.8:64 https://doi.org/10.1186/s40168-020-00819-8 2.Sun HZ,Zhou M,Wang Ou,Wang DM,Liu JX,Guan LL.2020.Omics based nutrition:converting multi-omics based research to solutions for sustainable and environment friendly ruminant production.Bioinformatics.36(8):2530-2537https://doi.org/10.1093/bioinformatics/btz951 3.Cai J,Wang DM,Liang SL,Peng JR,Zhao FQ,Liu JX.2020.Excessive supply of glucose elicits an NF-κB2-dependent glycolysis in lactating goat mammary glands.FASEB J.34:8671-8685.https://doi.org/10.1096/fj.201903088R 4.Cai J,Wang DM,Zhao FQ,Liang SL,Lin SX,Liu JX.2020.AMPK-mTOR pathway is involved in glucose-modulated amino acid sensing and utilization in the mammary glands of lactating goats.J Anim Sci Biotechnol.11(1):32.https://doi.org/10.1186/s40104-020-0434-6 5.Guan RW,Wang DM,Wang BB,Jiang LY,Liu JX.2020.Prognostic potential of pre-partum blood biochemical and immune variables for postpartum mastitis risk in dairy cows.BMC Vet Res.16:136 https://doi.org/10.1186/s12917-020-02314-6 6.Yao KY,Wei ZH,Xie YY,Wang DM,Fang D,Ma MR,Liu JX.2020.Lactation performance and nitrogen utilization of dairy cows on diets including unfermented or fermented yellow wine lees mix.Livest Sci.236:104025.https://doi.org/10.1016/j.livsci.2020.104025 7.Yao KY,Gu FF,Liu JX.2020.In vitro rumen fermentation characteristics of substrate mixtures with soybean meal partially replaced by microbially-fermented yellow wine lees.Ital J Anim Sci.19(1):18-24.https://doi.org/10.1080/1828051X.2019.1686433 8.Wu JJ,Liu JX,Wang DM.2020.Effects of body condition on the insulin resistance,lipid metabolism and oxidative stress of lactating dairy cows.Lipids Health Dis.19(1):56 https://doi.org/10.1186/s12944-020-01233-7 9.Chen Q,Zhao FQ,Ren YF,Han JL,Liu JX,Li Y,Liu HY.2020.Parenterally delivered methionyl-methionine dipeptide during pregnancy enhances mammogenesis and lactation performance over free methionine by activating PI3K-AKT signaling in methionine-deficient mice.J Nutr.150(5):1186-1195https://doi.org/10.1093/jn/nxaa005 10.Wang CH,Zhao FQ,Liu JX,Liu HY.2020.The essential role of N-glycosylation in the transport activity of bovine PepT2.J Dairy Sci.103(07):6679-6683https://doi.org/10.3168/jds.2019-16858 11.Dai WT,Zhao FQ,Liu JX,Liu HY.2020.Seryl-tRNA synthetase is involved in methionine stimulation of beta-casein synthesis in bovine mammary epithelial cells.Br J Nutr.123(5):489-498https://doi.org/10.1017/S0007114519002885 12.Zhang WX,Zhang Y,Zhang XW,Deng ZX,Liu JX,He ML,Wang HF.2020.Effects of dietary supplementation with combination of tributyrin and essential oil on gut health and microbiota of weaned piglets.Animals.10:180.https://doi.org/doi:10.3390/ani10020180 13.Qi,SR,Cui YJ,Liu JX,Luo XM,Wang HF.2020.Lactobacillus rhamnosus GG components,SLP,gDNA and CpG,exert protective effects on mouse macrophages upon lipopolysaccharide challenge.Lett App Microbiol.70(2):118-127.https://doi.org/10.1111/lam.13255 14.Zheng ZY,Cao FF,Wang WJ,Yu J,Chen C,Chen Bo,Liu JX,Firrman J,Renye J,Ren DX.2020.Probiotic characteristics of lactobacillus plantarum e680 and its effect on hypercholesterolemic mice.BMC Microbiol.20:239https://doi.org/10.1186/s12866-020-01922-4 15.Li SS,Hu Q,Chen C,Liu JX,He GQ,Li L,Wu JP,Ren DX.2020.Formation of bioactive peptides during simulated gastrointestinal digestion is affected by as1-casein polymorphism in buffalo milk.Food Chem.313:126159.https://doi.org/10.1016/j.foodchem.2020.126159 16.Gu FF,Wang DM,Yang DT,Liu JX,Ren DX.2020.Short communication:Effect of dietary N-carbamoylglutamate supplementation on milk amino acid profile and mozzarella cheese quality in mid-lactating dairy cows.J Dairy Sci.103(6):6935-6940https://doi.org/10.3168/jds.2019-17385 17.Liu L,Jiang RL,Liu JX,Bo L.2020.The bovine Lactoferrin-Osteopontin complex increases proliferation of human intestinal epithelial cells by activating the PI3K/Akt signaling pathway.Food Chem.320:125919.https://doi.org/10.1016/j.foodchem.2019.125919 2019 18.Peng KL,Ren DX,Liu JX.2019.Diversity of Rumen microflora in dairy buffaloes at different ages.Chinese J Anim Nutr.31(11):5053-5064(in Chinese with English Summary) 19.Xie YY,Wu ZZ,Wang DM,Liu JX.2019.Nitrogen partition and microbial protein synthesis of lactating dairy cows in residual feed intake.J Anim Sci Biotechnol.10:54.https://doi.org/10.1186/s40104-019-0356-3 20.Wei ZH,Liang SL,Wang DM,Liu HY,Liu JX.2019.(Short Communication)Lactation performance and rumen fermentation in dairy cows fed corn stover based diet with molasses supplementation in comparison with alfalfa based diet.Asian Aust J Anim Sci 32(8):1122-1127 https://doi.org/10.5713/ajas.18.0735 21.Wang Li,Sun HZ,Guan LL,Liu JX.2019.SC:The relationship of blood DNA methylation rate and milk performance in dairy cows.J Dairy Sci.102:5208–5211.https://doi.org/10.3168/jds.2018-15869 22.Xue MY,Sun HZ,Wu XH,Guan LL,Liu JX.2019.Assessment of rumen bacteria in dairy cows with varied milk protein yield.J Dairy Sci.102:5031–5041.https://doi.org/10.3168/jds.2018-15974 23.Wu XH,Sun HZ,Xue MY,Guan LL,Liu JX.2019.Effects of day in milk and parity on serum biochemical and hormone profiles during mid-lactation of Holstein dairy cows.Animals 9:230 https://doi.org/10.3390/ani9050230 24.Xu QB,Liu HY,Zhao FQ,Wu YM,Huang XB,Liu ZX,Liu JX.2019 Mechanism of peptide absorption in the isolated forestomach epithelial cells of dairy cows.J Sci Food Agric 99:100-108 https://doi.org/10.1002/jsfa.9148 25.Wang DM,Cai Jie,Zhao FQ,Liu JX.2019.Low quality rice straw forage increases the permeability of mammary epithelial tight junctions in lactating dairy cows.J Sci Food Agric.99:2037-2041 https://doi.org/10.1002/jsfa.9330 26.Xu NN,Wang DM,Liu JX.2019.Variance of zein protein and starch granule morphology between corn and steam flaked 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学术兼职

兼任中国畜牧兽医学会理事、中国奶业协会饲养饲料与环境专业委员会副主任、全国饲料与饲料添加剂评审委员会委员、动物营养国家重点实验室学委会委员等。

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