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个人简介

陈华英,副教授,博士生导师,本科毕业于山东大学材料科学与工程学院,于2012年在澳大利亚新南威尔士大学生物医学工程学院获博士学位。他自2012到2016年分别在昆士兰大学澳大利亚生物工程和纳米技术研究所和澳大利亚联邦科学与工业研究组织从事博士后研究,并于2016年6月作为副教授入职哈尔滨工业大学(深圳)机电学院。陈华英博士主要从事微流控芯片在细胞分析和疾病快速检测领域的研究。主要研究兴趣包括:单细胞分析、类器官芯片、疾病快速检测芯片、纸芯片等。现主持国家自然基金面上项目和青年项目各一项,深圳市自由探索项目三项。已授权发明专利7项,PCT专利1项,申请发明专利9项。在包括Analytical Chemistry, Trends in Analytical Chemistry, Nanoscale和 Lab on a Chip等的SCI刊物上发表论文三十多篇。此外,陈华英博士是广东省珠江计划青年拔尖人才,深圳市和珠海香洲区高层次人才,中国微纳协会高级会员,深圳微纳协会理事,中国生物医学工程学会高级会员。 教育经历 2008-2012 澳大利亚新南威尔士大学 博士 2006-2008 山东大学材料科学与工程学院 硕士研究生 2000-2004 山东大学材料科学与工程学院 本科 研究与工作经历 2016- 哈尔滨工业大学(深圳)机电工程与自动化学院 副教授 2014-2016 澳大利亚联邦科学与工业研究组织 博士后 2012-2014 澳大利亚昆士兰大学 澳大利亚生物工程与纳米技术研究所 博士后 2004-2006 山东大学材料科学与工程学院 辅导员 科研项目 2023-2025 广东省自然基金面上项目:自动化、高速、多通道纸基生物芯片微滴点样技术和机理研究 (主持) 2022-2024 国家自然科学基金面上项目:基于谱系追踪和逐代子细胞分离测序技术的干细胞命运研究 (主持) 2021-2022 深圳市高等院校稳定支持计划项目:基于微流控芯片的高通量单细胞克隆培养和谱系追踪 (主持) 2019-2020 深圳市基础研究自由探索项目:用于药物筛选和个性化医疗的血栓芯片的研发(主持) 2018-2020 国家自然科学基金青年项目:单细胞筛选和回收机理及干细胞克隆扩增动力学研究(主持) 2018-2019 深圳市基础研究自由探索项目:面向液体活检和个性化医疗的单个循环肿瘤细胞筛选芯片的研发(主持) 2017-2019 深圳市启动项目:面向单个干细胞研究的微流控芯片平台研发(主持) 2016-2019 哈工大(深圳)新教师科研启动项目:单个微球在磁性阵列和微流中的高通量捕获研究(主持)

研究领域

基于纸芯片的即时检测(Point of care testing based on paper microfluidics) 基于芯片实验室装置的细胞分析 (Lab on a chip for cell analysis) 微流控芯片在辅助生殖中的应用研究 (Microfluidics for Artificial Reproduction) 微尺度流体力学(Micro Fluid Mechanics)

近期论文

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Huaying Chen*, Haixu Meng, Zhenlin Chen, Tong Wang, Chuanpin Chen, Yonggang Zhu, and Jing Jin* Size-Based Sorting and In Situ Clonal Expansion of Single Cells using Microfluidics. Biosensors 2022, 12, 1100. (JCR一区,影响因子:5.743) Chang Chen, Haixu Meng, Tianruo Guo, Siddharth Deshpande, and Huaying Chen*. Development of Paper Microfluidics with 3D-Printed PDMS Barriers for Flow Control. ACS Applied Materials & Interfaces, 2022.(中科院一区Top期刊,影响因子:10.383) Chang Chen, Panpan Li, Tianruo Guo, Siyuan Chen, Dong Xu, Huaying Chen*,Generation of Dynamic Concentration Profile Using A Microfluidic Device Integrating Pneumatic Microvalves. Biosensors, 2022, 13;12(10):868.(JCR一区,影响因子:5.743) Haixu Meng, Chang Chen, Yonggang Zhu, Zhengtu Li, Feng Ye, Joshua W.K. Ho, and Huaying Chen*. Automatic flow delay through passive wax valves for paper-based analytical devices. Lab on a Chip, 2021. (中科院一区Top期刊,影响因子:7.517) Zhenlin Chen, Yonggang Zhu, Dong Xu, Md.Mahbub Alam, Lingling Shui, and Huaying Chen*. Cell elasticity measurement using a microfluidic device with real-time pressure feedback. Lab on a Chip, 2020.(中科院一区Top期刊,影响因子:7.517) Chang Chen, Dong Xu, Siwei Bai, Zhihang Yu, Yonggang Zhu, Xiao Xing and Huaying Chen*. Dynamic screening and printing of single cells using a microfluidic chip with dual microvalves. Lab on a Chip, 2020. (中科院一区Top期刊,影响因子:7.517) Chaozhan Chen, Bin Ran, Zhenxing Wang, Hongli Zhao, Minbo Lan, Huaying Chen* and Yonggang Zhu*. Development of micropillar array electrodes for highly sensitive detection of biomarkers. RSC Advances. 2020. (JCR二区,影响因子:4.036) Huaying Chen*, Zhihang Yu, Siwei Bai, Huaxiu Lu, Dong Xu, Chang Chen, Di Liu, Yonggang Zhu. Microfluidic models of physiological or pathological flow shear stress for cell biology, disease modeling and drug development. Trends in Analytical Chemistry, 2019. (中科院一区Top期刊,影响因子:14.908) Chang Chen, Litao Zhao, Han Zhang, Xiaoshuang Shen, Yonggang Zhu and Huaying Chen*. Novel wax valves to improve distance-based analyte quantification in paper microfluidics. Analytical Chemistry, 2019. (中科院一区Top期刊,影响因子:8.008) Huaying Chen, Chang Chen, Siwei Bai, Yuan Gao, Guy Metcalfe, Wenlong Cheng and Yonggang Zhu*. Multiplexed detection of cancer biomarkers using a microfluidic platform integrating single bead trapping and acoustic mixing techniques. Nanoscale, 2018,43.(JCR一区,影响因子:8.307) Huaying Chen, Yuan Gao, Petkovic Karolina, Yan Sheng, Best Michael, Yanping Du and Yonggang Zhu*, Reproducible bubble-induced acoustic microstreaming for bead disaggregation and immunoassay in microfluidics. Microfluidics and Nanofluidics, 2017,21(3):30.(JCR 二区,影响因子:3.090) Huaying Chen, Jane Sun, Ernst J. Wolvtang and Justin J. Cooper-White*, High-throughput, deterministic single cell trapping and long-term cell culture in microfluidic devices, Lab On a Chip, 2015, 15, 1072–1083.(中科院一区Top期刊,影响因子:7.517) Huaying Chen, James Cornwell, Han Zhang, Tse Lim, Rena Resurreccion, Timothy Port, Gary Rosengarten, and Robert E Nordon*, Cardiac-like flow generator for long-term imaging of endothelial cell responses to circulatory pulsatile flow at microscale, Lab On a Chip, 2013, 13 15: 2999-3007. (中科院一区Top期刊,影响因子:7.517) Huaying Chen, Gary Rosengarten, Musen Li, and Robert E. Nordon*, Design of microdevices for long-term live cell imaging, Journal of Micromechanics and Microengineering, 2012, 22 6: 065033.1-065033.10. (JCR 三区,影响因子:2.282) Huaying Chen, Jingjing Li, Han Zhang, Musen Li, Gary Rosengarten, and Robert E. Nordon*, Microwell perfusion array for high-throughput, long-term imaging of clonal growth. Biomicrofluidics, 2011, 5 4: 044117.1-044117.12. (JCR 二区,影响因子:3.258) Menghua Lyu, Xuyang Shi, Xiaopan Liu, Yang Liu, Xijun Zhu, Lijuan Liao, Hongyan Zhao, Na Sun, Shiyu Wang, Linzhe Chen, Linyuan Fan, Qumiao Xu, Qianqian Zhu, Kai Gao, Huaying Chen, Yonggang Zhu, Zida Li, Weijin Guo, Yue Zheng, Ying Gu, LongqiLiu*, Meiniang Wang*, and Ya Liu*. Generation and Screening of Antigen-Specific Nanobodies from Mammalian Cells Expressing the BCR Repertoire Library Using Droplet-Based Microfluidics. Analytical Chemistry, 2022.(中科院一区Top期刊,影响因子: 8.008) Yong Wang, Xiaoxia Liu, Chang Chen, Yuduo Chen, Yang Li, Heng Ye, Bo Wang, Huaying Chen, Jinhong Guo and Xing Ma*. Magnetic Nanorobots as Maneuverable Immunoassay Probes for Automated and Efficient Enzyme Linked Immunosorbent Assay. ASC Nano, 2022.(中科院一区Top期刊, 影响因子:18.027) Bo Liu, Bin Ran, Chaozhan Chen, Liuyong Shi, Ya Liu, Huaying Chen and Yonggang Zhu*. A low-cost and high-performance 3D micromixer over a wide working range and its application for high-sensitivity biomarker detection. Reaction Chemistry & Engineering, 2022.(JCR二区,影响因子:5.200) Bin Ran, Chaozhan Chen, Bo Liu, Minbo Lan, Huaying Chen, Yonggang Zhu*. A Ti3C2TX/Pt–Pd based amperometric biosensor for sensitive cancer biomarker detection. Electrophoresis, 2022.(JCR二区,影响因子:3.595) Zhihang Yu, Jing Jin, Lingling Shui, Huaying Chen, Yonggang Zhu*. Recent advances in microdroplet techniques for single-cell protein analysis. Trends in Analytical Chemistry, 2021, 143, 116411. (中科院一区Top期刊,影响因子:14.908) Penghui Guo, Wenxin Zeng, Sanping Tian, Huaying Chen, Wenfang Liu, Chuanpin Chen*. Quantitative detection of nanomolar drug using surface-enhanced Raman scattering combined with internal standard method and two-step centrifugation method. Microchemical Journal. 2020. (JCR一区,影响因子:5.304) Bo Liu, Chuanwen Lv, Chaozhan Chen, Bin Ran, Minbo Lan, Huaying Chen and Yonggang Zhu*. Electrochemical Performance of Micropillar Array Electrodes in Microflows. Micromachines. 2020. (JCR二区,影响因子:3.523) Xiao Xing, Litao Zhao, Wenjie Zhang, Zhuo Wang, Huimin Su, Huaying Chen, Guohong Ma, Junfeng Dai and Wenjing Zhang*. Influence of a substrate on ultrafast interfacial charge transfer and dynamical interlayer excitons in monolayer WSe2/graphene heterostructures. Nanoscale. 2020. (JCR一区,影响因子:8.307) Jiaming Shi, Lei Tong, Wenqiang Tong, Huaying Chen, Minbo Lan, Xiaoxi Sun and Yonggang Zhu*. Current progress in long-term and continuous cell metabolite detection using microfluidics. Trends in Analytical Chemistry. 2019. (中科院一区Top期刊,影响因子:14.908) Lim Wei Yap, Huaying Chen, Yuan Gao, Karolina Petkovic, Yan Liang, Kae Jye Si, Huanting Wang, Zhiyong Tang, Yonggang Zhu and Wenlong Cheng*. Bifunctional plasmonic-magnetic particles for an enhanced microfluidic SERS immunoassay. Nanoscale. 2017;9(23), 7822-7829.(JCR一区,影响因子:8.307) Karolina Petkovic, Guy Metcalfe, Huaying Chen, Yuan Gao, Michael Best, D. Lester and Yonggang Zhu*, Rapid Detection of Hendra Virus Antibodies: An Integrated Device with Nanoparticle Assay and Chaotic Micromixing, Lab on a chip ,2016. (中科院一区Top期刊,影响因子:7.517) Yanping Du, Nam Le, Dong Chen, Huaying Chen and Yonggang Zhu*, Thermal management of solar cells using a nanocoated heat pipe plate: an indoor experimental study, International Journal of Energy Research ,2016. (中科院一区,影响因子:4.672) Huihui Yuan, Bin Qian, Huaying Chen and Minbo Lan*, The influence of conditioning film on antifouling properties of the polyurethane film modified by chondroitin sulfate in urine. Applied Surface Science 426, 587-596, doi:10.1016/j.apsusc.2017.06.314 (2017). (中科院一区Top期刊,影响因子:7.392) Huihui Yuan, Jing Xue, Bin Qian, Huaying Chen, Yonggang Zhu and Minbo Lan*, Preparation and antifouling property of polyurethane film modified by chondroitin sulfate, Applied Surface Science, 2017, 394, 403-413. (中科院一区Top期刊,影响因子:7.392) Sheng Yan, Jun Zhang, Huaying Chen, Dan Yuan, GurselAlici, Haiping Du, Yonggang Zhu, and Weihua Li*, Development of a novel magnetophoresis-assisted hydrophoresis microdevice for rapid particle ordering, Biomedical Microdevices,2016,18,1-9. (JCR 三区,影响因子:3.783) Gleb E. Yakubov, Mauricio R. Bonilla, Huaying Chen, Monika S. Doblin, Antony Bacic, Michael J. Gidley and Jason R. Stokes *, Mapping nano-scale mechanical heterogeneity of primary plant cell walls, Journal of Experimental Botany, 2016, 67(9):2799-2816. (中科院一区Top期刊,影响因子:7.298) Sheng Yan, Jun Zhang, Huaying Chen, Gursel Alici, Haiping Du, Yonggang Zhu, Weihua Li*, Making a hydrophoretic focuser tunable using a diaphragm, Biomicrofluidics, 2015, 8(6):064115. (JCR 二区,影响因子:3.258) Drew M. Titmarsh, Huaying Chen, Nick R. Glass and Justin J. Cooper-White*, Microfluidic technology platforms: poised to accelerate development and translation of stem cell-derived therapies, STEM CELLS Translational Medicine, 2014, 3(1):81-90. (JCR 一区,影响因子:7.655) Drew M. Titmarsh, Huaying Chen, Ernst J. Wolvetang and Justin J. Cooper-White*, Arrayed cellular environments for stem cells and regenerative medicine, Biotechnology Journal, 2013,8 2: 167-179. (JCR 一区,影响因子:5.726)

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