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个人简介

工作经历 2024.01-至今,郑州大学,公共卫生学院,教授(破格晋升) 2020.01-2023.12,郑州大学,公共卫生学院,副教授(直聘教授) 2015.08-2019.12,郑州大学,公共卫生学院,讲师(直聘副教授) 教育经历 2022.10-2023.07,清华大学访问学者 2010.09-2015.06,湖南大学,分析化学专业,博士 2007.09-2010.06,湖南大学,分析化学专业,硕士 2003.09-2007.06,湖南师范大学,化学专业, 学士

研究领域

肿瘤液体活检作为一种微创诊断技术,能检测肿瘤释放到血液等液体中的生物标志物,对肿瘤的辅助诊断和治疗监测具有重要意义。同时考虑到单细胞水平上原位监测生物标志物在时间与空间上的变化,能更精确地探索标志物表达水平与细胞功能之间的关联。因此,以功能核酸构建及生物分析应用为基础,主要研究方向为:(1)肿瘤液体活检新技术研发及应用;(2)单细胞分析及调控。

近期论文

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Ya Wang, Yamin Xiong, Kangqi Shi, Clement Yaw Effah, Lulu Song, Leiliang He*, Jianbo Liu*. DNA nanostructures for exploring cell–cell communication. Chemical Society Reviews, 2024, DOI: 10.1039/d3cs00944k. (中科院1区) Ya Wang#, Yamin Xiong#, Yanjuan Duan, Kangqi Shi, Chaojie Su, Lihua Ding, Jia Wang, and Leiliang He*. Activatable fluorescence-encoded nanoprobes enable simple multiplexed RNA imaging in live cells. ACS Sensors, 2023, 8, 1918-1928.(中科院1区) Ya Wang, Yamin Xiong, Lulu Song, Sitian He, Feng Yao, Yongjun Wu, Kangqi Shi, and Leiliang He*. Spatial control of receptor dimerization using programmable DNA nanobridge. Biomacromolecules, 2023, 24, 3228-3236.(中科院1区) Leiliang He*, Kangqi Shi, Xinlian Liu, Ya Wang, Lulu Song, Di Wu, Yongjun Wu, Yamin Xiong, Peili Huang*. Engineering supramolecular ensemble for specific distinction of lung adenocarcinoma from inflammation. Sensors and Actuators: B. Chemical, 2023, 393, 134126. (中科院1区) Leiliang He, Jingjing Wang, Zhenzhen Wan, Yamin Xiong, Jin Man, Ya Wang, Guojiang Mao*, Fei Yu*. Biomimetic-compartmented nanoprobe for in-situ imaging of iron storage and release from ferritin in cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 286, 121967.(中科院2区) Ya Wang, Xinlian Liu, Longjie Wu, Lihua Ding, Clement Yaw Effah, Yongjun Wu, Yamin Xiong*, Leiliang He*. Construction and bioapplications of aptamer-based dual recognition strategy. Biosensors and Bioelectronics, 2022, 195,113661.(中科院1区) Xinlian Liu, Ya Wang, Clement Yaw Effah, Longjie Wu, Fei Yu, Jinlan Wei, Guojiang Mao, Yamin Xiong*, Leiliang He*. Endocytosis and intracellular RNAs imaging of nanomaterials-based fluorescence probes. Talanta, 2022, 243, 123377.(中科院1区) Lihua Ding, Yongjun Wu, Yanjuan Duan, Songcheng Yu, Fei Yu, Jia Wang, Yongmei Tian, Zibo Gao, Zhenzhen Wan, Leiliang He*. A novel cell-assisted enhanced chemiluminescence strategy for rapid and label-free detection of tumor cells in whole blood. ACS Sensors, 2020, 5, 440-446.(中科院1区) Leiliang He, Yanjuan Duan, Jiaodi Feng, Zhenzhen Wan, Xinlian Liu, Ya Wang, Fei Yu, Yilin Wang, Yamin Xiong*, Yongjun Wu*. Apoferritin-based tunable nano-indicator for intracellular pH sensing: Regulating response performances and minimizing effects of system fluctuations. Sensors and Actuators: B. Chemical, 2020, 323, 128661.(中科院1区) Yamin Xiong, Lihong Zhou, Xiaoxia Peng, Huiling Li, Hui Wang, Leiliang He*, Peili Huang*. A specific short peptide-assisted enhanced chemiluminescence resonance energy transfer (CRET) for label-free and ratiometric detection of copper ions in complex samples. Sensors and Actuators: B. Chemical, 2020, 320, 128411.(中科院1区) Jiajia Dong#, Leiliang He#, Yilin Wang, Fei Yu, Songcheng Yu, Lie Liu, Jia Wang, Yongmei Tian, Lingbo Qu, Runping Han, Ziling Wang*, Yongjun Wu*. A highly sensitive colorimetric aptasensor for the detection of the vascular endothelial growth factor in human serum. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 226, 117622.(中科院2区) Leiliang He, Lihua Ding, Songcheng Yu, Fei Yu, Yongmei Tian, Xinsheng Xie, Lingbo Qu, Lie Liu*, Yongjun Wu*. Self-assembled poly-HRP dual signal amplification strategy for high-sensitive detection of circulating miR-142-3p in human serum. Sensors and Actuators: B. Chemical, 2019, 279, 440-446.(中科院1区) Lihua Ding, Yongjun Wu, Wei Liu, Lie Liu, Fei Yu, Songcheng Yu, Yongmei Tian, Jiaodi Feng, Leiliang He*. Magnetic-assisted self-assembled aptamer/protein hybrid probes for efficient capture and rapid detection of cancer cells in whole blood. Talanta, 2019, 205, 120129.(中科院1区) Yanhua Mao, Nana Wang, Fei Yu, Songcheng Yu, Lie Liu, Yongmei Tian, Jia Wang, Yilin Wang, Leiliang He*, Yongjun Wu*. Simultaneous detection of carcinoembryonic antigen and neuron-specific enolase in human serum based on time-resolved chemiluminescence immunoassay. Analyst, 2019, 144, 4813-4819.(中科院2区)

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