Ward, Natalie - Curtin University - School of Biomedical Sciences

研究领域

Vascular biology - the structure and function of blood vessels, bioavailability and bioactivity of nitric oxide (NO) and the role of vascular dysfunction in CVD. Atherosclerosis - development and pathogenesis of plaque formation. Type 2 diabetes and the metabolic syndrome - effect of diet and nutrition on obesity, glycaemic control and glucose/insulin signalling. Hypertension and stroke - the role of CYP450 metabolites of arachidonic acid (20-HETE, EETs & DiHETEs), as well as the contribution of vascular dysfunction. Nutrition and lifestyle - dietary polyphenols (from tea, coffee, fruit & vegetables), dietary nitrate and lupin and their role in prevention and treatment of CVD. I use laboratory based techniques (in vitro cell culture, ex vivo aortic ring studies), animal studies and human intervention studies to investigate mechanisms involved in the development and pathogenesis of CVD.

近期论文

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Bakker, J., N. Bondonno, T. Gaspari, B. Kemp-Harper, A. McCashney, J. Hodgson, K. Croft, and N. Ward. 2016.“Low dose dietary nitrate improves endothelial dysfunction and plaque stability in the ApoE^-/- mouse fed a high fat diet.”Free Radical Biology and Medicine 99. In press. Wu, J., J. Hodgson, N. Ward, M. Clarke, I. Puddey, and K. Croft. 2005.“Nitration of ?-tocopherol prevents its oxidative metabolism by HepG2 cells.”Free Radical Biology and Medicine 39 (4): 483-494. Ward, N., I. Puddey, J. Hodgson, L. Beilin, and K. Croft. 2005.“Urinary 20-hydroxyeicosatetraenoic acid excretion is associated with oxidative stress in hypertensive subjects.”Free Radical Biology and Medicine 38 (8): 1032-1036. Ward, N., J. Hodgson, K. Croft, V. Burke, L. Beilin, and I. Puddey. 2005.“The combination of vitamin C and grape-seed polyphenols increases blood pressure: A randomized, double-blind, placebo-controlled trial.”Journal of Hypertension 23 (2): 427-434. Hodgson, J., S. Chan, I. Puddey, A. Devine, N. Wattanapenpaiboon, M. Wahlqvist, W. Lukito, V. Burke, N. Ward, R. Prince et al. 2004.“Phenolic acid metabolites as biomarkers for tea- and coffee-derived polyphenol exposure in human subjects.”British Journal of Nutrition 91 (2): 301-305. Ward, N., J. Rivera, J. Hodgson, I. Puddey, L. Beilin, J. Falck, and K. Croft. 2004.“Urinary 20-hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humans.”Circulation 110 (4): 438-443. Rivera, J., N. Ward, J. Hodgson, I. Puddey, J. Falck, and K. Croft. 2004.“Measurement of 20-Hydroxyeicosatetraenoic Acid in Human Urine by Gas Chromatography-Mass Spectrometry.”Clinical Chemistry 50 (1): 224-226. Ward, N., J. Hodgson, I. Puddey, T. Mori, L. Beilin, and K. Croft. 2004.“Oxidative stress in human hypertension: Association with antihypertensive treatment, gender, nutrition, and lifestyle.”Free Radical Biology and Medicine 36 (2): 226-232. Ward, N., K. Croft, I. Puddey, and J. Hodgson. 2004.“Supplementation with grape seed polyphenols results in increased urinary excretion of 3-hydroxyphenylpropionic acid, an important metabolite of proanthocyanidins in humans.”Journal of Agriculture and Food Chemistry 52 (17): 5545-5549. Ward, N., K. Croft, J. Hodgson, L. Rich, L. Beilin, and I. Puddey. 2004.“Brachial artery vasomotor function is inversely associated with 24-h ambulatory blood pressure.”Journal of Hypertension 22 (5): 967-972. Morton, L., N. Ward, K. Croft, and I. Puddey. 2002.“Evidence for the nitration of ?-tocopherol in vivo: 5-nitro-?-tocopherol is elevated in the plasma of subjects with coronary heart disease.”Biochemical Journal 364 (3): 625-628. Watts, G., D. Playford, K. Croft, N. Ward, T. Mori, and V. Burke. 2002.“Coenzyme Q10 improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus.”Diabetologia 45 (3): 420-426. Dogra, G., N. Ward, K. Croft, T. Mori, P. Barrett, S. Herrmann, A. Irish, and G. Watts. 2001.“Oxidant stress in nephrotic syndrome: Comparison of F2-isoprostanes and plasma antioxidant potential.”Nephrology Dialysis Transplantation 16 (8): 1626-1630. R Jiang, JM Hodgson, E Mas, KD Croft, NC Ward. “Chlorogenic acid improves ex vivo vessel function and protects endothelial cells against HOCl-induced oxidative damage via increased production of nitric oxide and induction of Hmox-1.” Journal of Nutritional Biochemistry. 27:53-60;2016. NP Bondonno, JR Lewis, RL Prince, WH Lim, G Wong, JT Schousboe, RJ Woodman, DP Kiel, CP Bondonno, NC Ward, KD Croft, JM Hodgson. "Fruit intake and abdominal aortic calcification in elderly women: a prospective cohort study." Nutrients. 8(159):1-12;2016. JM Hodgson, RL Prince, RJ Woodman, CP Bondonno, KL Ivey, N Bondonno, EB Rimm, NC Ward, KD Croft, JR Lewis. "Apple intake and all-cause mortality in elderly women." British Journal of Nutrition. 115:860-867;2016. NP Bondonno, CP Bondonno, L Rich, E Mas, S Shinde, NC Ward, JM Hodgson, KD Croft. "The acute effects of quercetin-3-O-glucoside on endothelial function and blood pressure: a randomised dose-response study." The American Journal of Clinical Nutrition. 104(1):97-103;2016. NC Ward, JM Hodgson, RJ Woodman, D Zimmermann, L Poquet, A Leveques, L Actis-Goretta, IB Puddey, KD Croft. "Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women." Food & Function. 7:2197-2203;2016. JR Bakker*, NP Bondonno*, TA Gaspari, BK Kemp-Harper, AJ McCashney, JM Hodgson, KD Croft, NC Ward. "Low dose dietary nitrate improves endothelial function and plaque stability in the ApoE-/- mouse fed a high fat diet." Free Radical Biology & Medicine. In Press 2016. NP Bondonno, CP Bondonno, JM Hodgson, NC Ward, KD Croft. “The efficacy of quercetin in cardiovascular health.” Current Nutrition Reports. 4:290-303;2015.