Tirnitz-Parker, Nina - Curtin University - School of Biomedical Sciences

研究领域

Our research focuses on liver progenitor cells / liver stem cells and their role in hepatic regeneration vs. hepatocarcinogenesis.

近期论文

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Köhn-Gaone, J., J. Gogoi-Tiwari, G. Ramm, J. Olynyk, and J. E. Tirnitz-Parker. 2016.“The role of liver progenitor cells during liver regeneration, fibrogenesis and carcinogenesis.”Am J Physiol Gastrointest Liver Physiol Pre Press. In press. Köhn-Gaone, J., B. Dwyer, C. Grzelak, G. Miller, N. Shackel, G. Ramm, G. McCaughan, C. Elsegood, J. Olynyk, and J. E. Tirnitz-Parker. 2016.“Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury.”American Journal of Pathology 186 (7): 1762-1774. Woo, K., S. Stewart, G. Kong, M. Finch-Edmondson, B. Dwyer, S. Yeung, L. Abraham, S. Kampmann, L. Diepeveen, A. Passman et al. 2016.“Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib.”European Journal of Medicinal Chemistry 120. In press. Müller, M., S. Wetzel, J. Köhn-Gaone, K. Chalupsky, R. Lüllmann-Rauch, R. Barikbin, J. Bergmann, B. Wöhner, O. Zbodakova, I. Leuschner et al. 2016.“A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis.”Oncotarget 7 (14): 17431-17441. Dwyer, B. J., J. Olynyk, G. A. Ramm, and J. E. Tirnitz-Parker. 2014.“TWEAK and LTß Signaling during Chronic Liver Disease.”Frontiers in Immunology 5 (39): 1-7. Tirnitz-Parker, J. E., J. Olynyk, and G. A. Ramm. 2014.“Role of TWEAK in coregulating liver progenitor cell and fibrogenic responses.”Hepatology 59 (3): 1198-1201. Grzelak, C. A., L. G. Martelotto, N. D. Sigglekow, B. Patkunanathan, K. Ajami, S. R. Calabro, B. J. Dwyer, J. E. Tirnitz-Parker, D. N. Watkins, F. J. Warner et al. 2014.“The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury.”Journal of Hepatology 60 (1): 143-151. Prakoso, E., J. E. Tirnitz-Parker, A. D. Clouston, Z. Kayali, A. Lee, E. Gan, G. A. Ramm, J. G. Kench, D. G. Bowen, J. Olynyk et al. 2014.“Analysis of the Intrahepatic Ductular Reaction and Progenitor Cell Responses in Hepatitis C Virus Recurrence After Liver Transplantation.”Liver Transplantation 20 (12): 1508-1519. Tirnitz-Parker, J. E., A. Glanfield, J. Olynyk, and G. A. Ramm. 2013.“Iron and Hepatic Carcinogenesis.”Critical Reviews in Oncogenesis 18 (5): 391-407. Tirnitz-Parker, J. E., G. Yeoh, and J. Olynyk. 2012. “Liver Progenitor Cells, Cancer Stem Cells and Hepatocellular Carcinoma.” In Liver Regeneration, ed. PhD. Pedro Baptista, 17-42. Rijeka, Croatia: InTech. Delima, R., A. Chua, J. E. Tirnitz-Parker, E. Gan, K. D. Croft, R. M. Graham, J. Olynyk, and D. Trinder. 2012.“Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice.”Hepatology 56 (2): 585-593. Forster, N., J. A. Palmer, G. C. Yeoh, W. Ong, G. Mitchell, J. Slavin, J. E. Tirnitz-Parker, and W. A. Morrison. 2011.“Expansion and Hepatocytic Differentiation of Liver Progenitor Cells In Vivo Using a Vascularized Tissue Engineering Chamber in Mice.”Tissue Engineering Part C: Methods 17 (3): 359-366. Tirnitz-Parker, J. E., C. Viebahn, A. Jakubowski, B. Klopcic, J. Olynyk, G. Yeoh, and B. Knight. 2010.“Tumor Necrosis Factor–Like Weak Inducer of Apoptosis Is a Mitogen for Liver Progenitor Cells.”Hepatology 52: 291-302. Chua, A., R. D. Delima, E. Morgan, C. E. Herbison, J. E. Tirnitz-Parker, R. M. Graham, R. E. Fleming, R. S. Britton, B. R. Bacon, J. Olynyk et al. 2010.“Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis.”Journal of Hepatology 52: 425-431. Tirnitz-Parker, J. E., E. Gan, M. Trimzi, Z. Kayali, and J. Olynyk. 2010.“CO-REGULATION OF FIBROGENIC AND LIVER PROGENITOR CELL RESPONSES IN BOTH PRE- AND POST-LIVER TRANSPLANT RECURRENT CHRONIC HEPATITIS C INFECTION.” In 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases: WILEY-BLACKWELL. Delima, R., A. Chua, J. E. Tirnitz-Parker, K. Croft, R. Graham, J. Olynyk, and D. Trinder. 2010.“DISRUPTION OF BOTH HFE AND TFR2 CAUSES IRON-INDUCED LIVER INJURY.” In 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases: WILEY-BLACKWELL. Tirnitz-Parker, J. E., and J. Olynyk. 2009.“Liver carcinogenesis.”Cancer Forum 33: 93-97. Ruddell, R. G., B. Knight, J. E. Tirnitz-Parker, B. Akhurst, L. Summerville, V. N. Subramaniam, J. Olynyk, and G. A. Ramm. 2009.“Lymphotoxin-beta Receptor Signaling Regulates Hepatic Stellate Cell Function and Wound Healing in a Murine Model of Chronic Liver Injury.”Hepatology 49 (1): 227-239. Knight, B., J. E. Tirnitz-Parker, and J. Olynyk. 2008.“C-kit Inhibition by Imatinib Mesylate Attenuates Progenitor Cell Expansion and Inhibits Liver Tumor Formation in Mice.”Gastroenterology 135 (3): 969-9790. Tirnitz-Parker, J. E., J. N. Tonkin, B. Knight, J. Olynyk, and G. C. Yeoh. 2007.“Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet.”International Journal of Biochemistry and Cell Biology 39 (12): 2226-2239.