Price, Patricia - Curtin University - School of Biomedical Sciences

研究领域

I assisted with the MOU with UWA and am now an Adjunct Professor of UI. I deliver lectures on each visit to UI and have advised on restructuring the Clinical PhD programme. With the head of Neurology at Cipto Mangunkusomo Hospital (Dr Darma Imran) and Dr Evy Yunihastuti, I ran a study of HIV neuropathy in 2006 (publications 137, 139). Dr Evy now co-ordinates clinical care of ~5000 patients at the Pokdisus HIV Clinic. Our research into HCV co-infection has generated 3 PhD projects based at UI (Dr Evy passed 2010, Dr Rino passed 2011 and Henny Saraswati, passed 2014). For Henny’s work we created a laboratory enabled to run most assays operational at UWA, with QC carefully maintained across the two sites. This is a significant achievement. We have now archived samples for a second prospective cohort (n=82). These patients have expert clinical characterization, so the project has a name (JakCCANDO) and has received funding from the Goodeve foundation, Abbot Pharmaceuticals and University of Indonesia. By engaging the workforce and skills of several clinical departments of the Cipto Mangunkusomo Hospital (Neurology, Parasitology, Cardiology, Ophthalmology and Oral Medicine), this project recapitulates the achievements of a major clinical trial on a minimal budget. JakCCANDO is powering 5 PhD projects at UI. The clinical work is juxtapositioned with high level immunology performed locally following advanced and precise training at UWA. It is a significant undertaking by any metric. A satellite study of JakCCANDO extends our work on HIV neuropathy with 2 more PhD projects beginning at UI in 2014. The work will address the role of co-infections (CMV and TB) in neuropathy and will parallel studies ongoing at University of Witwatersrand.

近期论文

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Brunt, S., L. Cysique, S. Lee, S. Burrows, B. Brew, and P. Price. 2016.“Short communication: Do cytomegalovirus antibody levels associate with age-related syndromes in HIV patients stable on antiretroviral therapy?.”AIDS Research and Human Retroviruses 32 (6): 567-572. Tan, D., F. Amran, T. Teo, P. Price, and Y. Moodley. 2016.“Levels of CMV-reactive antibodies correlate with the induction of CD28(null) T cells and systemic inflammation in chronic obstructive pulmonary disease (COPD).”Cellular and Molecular Immunology 26 January 2015: 1-3. Saraswati, H., S. Lee, D. Tan, E. Yunihastuti, R. Gani, and P. Price. 2016.“Increased proportions of dendritic cells and recovery of IFN? responses in HIV/HCV co-infected patients receiving ART.”Human Immunology In Press. In press. Amran, F., K. Kim, A. Lim, R. Thomson, S. Lee, G. Waterer, and P. Price. 2016.“Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus?.”Journal of Clinical Immunology 36. In press. Goullee, H., A. Wadley, C. Cherry, R. Allcock, M. Black, P. Kamerman, and P. Price. 2016.“Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients.”Journal of NeuroVirology 22 (4). In press. Tanaskovic, S., S. Fernandez, H. Saraswati, E. Yunihastuti, R. Gani, S. Djauzi, and P. Price. 2016.“Naive and Memory CD4⁺ T Cells Are Differentially Affected in Indonesian HIV Patients Responding to ART.”Viral Immunology 29 (3): 176-183. Affandi, J., J. Montgomery, S. Lee, and P. Price. 2015.“HIV patients stable on ART retain evidence of a high CMV load but changes to Natural Killer cell phenotypes reflect both HIV and CMV.”AIDS Research and Therapy 12 (1): 1-7. Cysique, L., T. Hewitt, J. Croitoru-Lamoury, K. Taddei, R. Martins, C. Chew, N. Davies, P. Price, and B. Brew. 2015.“APOE e4 moderates abnormal CSF-abeta-42 levels, while neurocognitive impairment is associated with abnormal CSF tau levels in HIV+ individuals - A cross-sectional observational study.”BMC Neurology 15 (1): 1-8. Wadley, A., L. Hendry, P. Kamerman, C. Chew, P. Price, C. Cherry, and Z. Lombard. 2015.“Role of TNF block genetic variants in HIV-associated sensory neuropathy in black Southern Africans.”European Journal of Human Genetics 23 (3): 363-368. Affandi, J., J. Montgomery, S. Brunt, D. Nolan, and P. Price. 2015.“The immunological footprint of CMV in HIV-1 patients stable on long-term ART.”Immunity & Ageing 12: 14-14. Zhou, J., F. Amran, M. Kramski, T. Angelovich, J. Elliott, A. Hearps, P. Price, and A. Jaworowski. 2015.“An NK cell population lacking FcR? is expanded in chronically infected HIV patient.”Journal of Immunology 194 (10): 4688-4697. Estiasari, R., J. Imran, D. Lastri, P. Prawiro-Hardjo, and P. Price. 2015.“Cognitive impairment among Indonesia HIV naïve patients.”Neurology Asia 20 (2): 155-160. Susufi, Y., E. Krisnuhoni, R. Gani, E. Yunihastuti, S. Lee, and P. Price. 2015.“CD56 + lymphocyte counts remain low in the livers of human immunodeficiency virus/hepatitis C virus patients commencing ART.”Pathology International 65 (6): 335-337. Conference Articles (Research) Adams, L., A. Wree, P. Melton, G. Jeffrey, H. Ching, B. de Boer, J. Olynyk, O. Ayonrinde, T. Mori, L. Beilin et al. 2015.“Serum marker of inflammasome activity correlates with liver injury in nonalcoholic fatty liver disease and is influenced by genetic polymorphisms.” In 66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD). Tanaskovic, S., S. Fernandez, P. Price, and M. A. French. 2014.“Interleukin-7 signalling defects in naive CD4+ T cells of HIV patients with CD4+ T-cell deficiency on antiretroviral therapy are associated with T-cell activation and senescence.”AIDS 28: 821-830. Tan, D., S. Fernandez, P. Price, M. A. French, P. J. Thompson, and Y. P. Moodley. 2014.“Impaired CTLA-4 responses in COPD are associated with systemic inflammation.”Cellular and Molecular Immunology 11 (6): 606-608. Lee, S., H. Saraswati, E. Yunihastuti, R. Gani, and P. Price. 2014.“Patients co-infected with hepatitis C virus (HCV) and human immunodeficiency virus recover genotype cross-reactive neutralising antibodies to HCV during antiretroviral therapy.”Clinical Immunology 155 (2): 149-159. Kim, K., G. Waterer, R. Thomson, I. A. Yang, N. Nashi, D. Tan, and P. Price. 2014.“Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria.”Cytokine 66 (2): 160-163. Brunt, S., S. Lee, L. D'Orsogna, C. S. Bundell, S. Burrows, and P. Price. 2014.“The Use of Humoral Responses as a Marker of CMV Burden in HIV Patients on ART Requires Consideration of T-Cell Recovery and Persistent B-Cell Activation.”Disease Markers 2014.