Mancera, Ricardo - Curtin University - School of Biomedical Sciences

研究领域

Prof. Mancera's research makes use of molecular modelling, computational chemistry and structural bioinformatics to investigate a number of areas of biophysical, biomedical and pharmaceutical importance, such as protein folding, denaturation and aggregation; structure and dynamics of biological membranes; the mechanism of solvent cryoprotection; ligand-protein and protein-protein interactions; structure- and ligand-based drug design; protein flexibility and solvation in drug design; biopolymeric materials for drug delivery; hydrophobic and hydrophilic interactions. In addition, Prof. Mancera undertakes research in biophysics and biochemistry of membrane and protein strucure and interactions using approaches such as small-angle X-ray and neutron scattering (SAXS/WAXS/SANS), surface plasmon resonance (SPR), mass spectrometry methods.

近期论文

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Anggayasti, W., R. L. Mancera, S. Bottomley, and E. Helmerhorst. 2016.“Optimization of surface plasmon resonance experiments: Case of high mobility group box 1 (HMGB1) interactions.”Analytical Biochemistry 499. In press. Funnekotter, B., A. Sortey, E. Bunn, S. Turner, and R. L. Mancera. 2016.“Influence of abiotic stress preconditioning on antioxidant enzymes in shoot tips of Lomandra sonderi (Asparagaceae) prior to cryostorage.”Australian Journal of Botany 64 (3): 260-268. Anggayasti, W., R. L. Mancera, S. Bottomley, and L. Xie. 2016.“The effect of physicochemical factors on the self-association of HMGB1: A surface plasmon resonance study.”Biochimica et Biophysica Acta - Proteins and Proteomics 1864 (11). In press. Garvey, C., B. Kent, T. Hauss, R. Georgii, K. Seemann, R. L. Mancera, and G. Bryant. 2016.“Distribution of Solute Molecules in Bilayer Stacks by Medium Angle Diffraction.”Biophysical Journal 110 (3): 81A-81A. Arooj, M., N. S. Gandhi, C. Kreck, D. W. Arrigan, and R. L. Mancera. 2016.“Adsorption and Unfolding of Lysozyme at a Polarized Aqueous-Organic Liquid Interface.”Journal of Physical Chemistry B 120 (12): 3100-3112. Whiteley, S., E. Bunn, A. Menon, R. L. Mancera, and S. Turner. 2016.“Ex situ conservation of the endangered species Androcalva perlaria (Malvaceae) by micropropagation and cryopreservation.”Plant Cell, Tissue and Organ Culture 125 (2). In press. Zamanipoor, M., and R. L. Mancera. 2016.“Corrigendum to "The emerging application of ultrasound in lactose crystallisation" [Trends in Food Science & Technology 38/1 (2014) 47-59] doi 10.1016/j.tifs.2014.04.005.”Trends in Food Science and Technology 50: 264-264. Gandhi, N. S., I. Landrieu, C. Byrne, P. Kukic, L. Amniai, F. Cantrelle, J. Wieruszeski, R. L. Mancera, Y. Jacquot, and G. Lippens. 2015.“A Phosphorylation-Induced Turn Defines the Alzheimer’s Disease AT8 Antibody Epitope on the Tau Protein.”Angewandte Chemie - International Edition 54 (23): 6819-6823. Funnekotter, B., S. Whiteley, S. Turner, E. Bunn, and R. L. Mancera. 2015.“Evaluation of the new vacuum infiltration vitrification (viv) cryopreservation technique for native Australian plant shoot tips.”Cryo-Letters 36 (2): 104-113. Hughes, Z. E., and R. L. Mancera. 2014.“Molecular mechanism of the synergistic effects of vitrification solutions on the stability of phospholipid bilayers.”Biophysical Journal 106: 2617-2624. Hou, B., P. Yi, Z. Wang, S. Zhang, J. Zhao, R. L. Mancera, Y. Cheng, and Z. .. Zuo. 2014.“Assignment of aromaticity of the classic heterobenzenes by three aromatic criteria.”Computational and Theoretical Chemistry 1046: 20-24. Agostino, M., N. S. Gandhi, and R. L. Mancera. 2014.“Development and application of site mapping methods for the design of glycosaminoglycans.”Glycobiology 24: 840-851. Zhuo, Z. L., L. Guo, and R. L. Mancera. 2014.“Free energy of binding of coiled-coil complexes with different electrostatic environments: the influence of force field polarisation and capping.”Natural Products and Bioprospecting 4: 285-295. Namjoshi, S., I. Toth, J. T. Blanchfield, N. Trotter, R. L. Mancera, and H. A. Benson. 2014.“Enhanced Transdermal Peptide Delivery and Stability by Lipid Conjugation: Epidermal Permeation, Stereoselectivity and Mechanistic Insights.”Pharmaceutical Research 31: 3304-3312. Namjoshi, S., I. Toth, J. Blanchfield, N. Trotter, R. L. Mancera, and H. A. Benson. 2014.“Enhanced transdermal peptide delivery and stability by lipid conjugation: Epidermal permeation, stereoselectivity and mechanistic insights.”Pharmaceutical Research 31 (12): 3304-3312. Menon, A., B. Funnekotter, A. Kaczmarczyk, E. Bunn, S. Turner, and R. L. Mancera. 2014.“Cold-induced changes affect survival after exposure to vitrification solution during cryopreservation in the south-west Australian Mediterranean climate species Lomandra sonderi (Asparagaceae).”Plant Cell, Tissue and Organ Culture 119 (2): 347-358. Lyons, A. J., N. S. Gandhi, and R. L. Mancera. 2014.“Molecular dynamics simulation of the phosphorylation-induced conformational changes of a tau peptide fragment.”Proteins: Function, Structure, and Bioinformatics 82: 1907-1923. Kreck, C. A., and R. L. Mancera. 2014.“Characterization of the Glass Transition of Water Predicted by Molecular Dynamics Simulations Using Nonpolarizable Intermolecular Potentials.”The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical 118 (7): 1867-1880. Sassi, M., D. J. Carter, B. P. Uberuaga, C. R. Stanek, R. L. Mancera, and N. A. Marks. 2014.“Hydrogen Bond Disruption in DNA Base Pairs from 14C Transmutation.”The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical 118: 10430-10435. Zamanipoor, M. H., and R. L. Mancera. 2014.“The emerging application of ultrasound in lactose crystallisation.”Trends in Food Science and Technology 38: 47-59.