Kaur, Pritinder - Curtin University - School of Biomedical Sciences

研究领域

Understanding the specific cellular and molecular interactions between Molecular & cellular characterisation of human epithelial stem cells and their mesenchymal microenvironment (fibroblasts and MSC-like pericytes) of the using model tissues such as skin, ovary and oesophagus that underlie : Stem cell self-renewal and tissue renewal during homeostasis Wound healing and skin regeneration Human epithelial cancer progression to malignancy in ovarian and skin cancer Functional changes in the mesenchymal microenvironment with ageing human skin

近期论文

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Kaur P and McDougall JK. Characterisation of primary human keratinocytes transformed by human papillomavirus type 18. J Virology 62:1917-1924, 1988. Kaur P and McDougall JK. HPV-18 immortalisation of human keratinocytes. Virology 173:302-310, 1989. Carter WG, Wayner EA, Bouchard TS and Kaur P. The role of integrins a2b1 and a3b1 in cell-cell and cell-substrate adhesion of human epidermal cells. J Cell Biol 110:1387-1404, 1990. Carter WG, Kaur P, Gil SG, Gahr PJ and Wayner EA. Distinct functions for integrins a3b1 in focal adhesions and a6b4/Bullous Pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: Relation to hemidesmosomes. J Cell Biol 111:3141-3154, 1990. Hurlin PJ, Kaur P, Smith PP, Perez-Reyes N, Blanton RA and McDougall JK. Progression of human papillomavirus type 18-immortalized human keratinocytes to a malignant phenotype. PNAS-USA 88:570-574, 1991. Kaur P and Carter WG. Integrin expression and differentiation in transformed human epidermal cells is regulated by fibroblasts. Journal Cell Science 103:755-763, 1992. Gamble JR, Matthias LJ, Meyer G, Kaur P, Russ G, Faull R, Berndt M and Vadas MA. Regulation of in vitro capillary tube formation by anti-integrin antibodies. J Cell Biol 121:931-934, 1993. Li A, Simmons PJ & Kaur P. Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype. PNAS-USA 95 : 3902-3907, 1998. Kaur P & Li A. Adhesive properties of human basal epidermal cells: An analysis of keratinocyte stem cells, transit amplifying cells, and postmitotic differentiating cells. Journal of Investigative Dermatology, 114:413-20, 2000. Tani H, Morris RJ & Kaur P. Enrichment for murine keratinocyte stem cells based on cell surface phenotype. PNAS-USA, 97 10960-10965, 2000. Li A, Pouliot N, Redvers R and Kaur P. 2004. Extensive tissue regenerative capacity of neonatal human keratinocyte stem cells and their progeny. J. Clin.Invest. 113:390-400. Gugasyan R, Voss A, Varigos G, Thomas T, Grumont RJ, Kaur P, Grigoriadis G, Gerondakis S. 2004. The Transcription Factors c-rel and RelA Control Epidermal Development and Homeostasis in Embryonic and Adult Skin via Distinct Mechanisms. Mol Cell Biol. 24:5733-45. Adolphe C, Narang M, Ellis T, Wicking C, Kaur P and Wainwright B. 2004. An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development, 131: 5009-5017. Webb A, Li A and Kaur P. 2004. Location and phenotype of adult keratinocyte stem cells of the skin. Differentiation. 72: 387-95. Pouliot N, Redvers RP, Ellis S, Saunders NA and Kaur P. 2005. Optimisation of a transplant model to assess skin reconstitution from stem cell-enriched primary human keratinocyte populations. Exptl Dermatol, 14: 60-69. Ting SB, Caddy J, Hislop N, Wilanowski T, Auden A, Zhao LL, Ellis S, Kaur P, Uchida Y, Holleran WM, Elias PM, Cunningham JM, Jane SM. 2005. A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Science. 308:411-413. Redvers RP, Li A, Kaur P. 2006. The side population in adult murine epidermis exhibits phenotypic and functional characteristics of keratinocyte stem cells. PNAS-USA, 103(35):13168-73. Croagh D, Phillips WA, Redvers R, Thomas RJ, Kaur P. 2007. Identification of candidate murine esophageal stem cells using a combination of cell kinetic studies and cell surface markers. Stem Cells 25 (2): 313-318. Gangatirkar P, Paquet-Fifield S, Li A, Rossi R, Kaur P. 2007. Establishment of 3D organotypic cultures using human neonatal epidermal cells. Nature Protocols. 2(1):178-86. Paquet-Fifield S, Schlüter H, Li A, Aitken T, Gangatirkar P, Blashki D, Koelmeyer R, Pouliot N, Palatsides M, Ellis S, Brouard N, Zannettino A, Saunders N, Thompson N, Li J and Kaur P. 2009. A role for pericytes as microenvironmental regulators of human skin tissue regeneration. J Clin Invest. 119 (9):2795-806.