个人简介

Born 1951; M. Sc. Warsaw University (1974); Ph. D. Southern Illinois University at Carbondale (1980); Research Associate, University of Illinois (1980-82); Associate Faculty Scientist, Lawrence Berkeley National Laboratory; Member, American Chemical Society, Electrochemical Society, and Society for Electroanalytical Chemistry; Joel H. Hildebrand Chair in Chemistry (1982-1984); College of Science Alumni Achievement Award, Southern Illinois University at Carbondale (2002).

研究领域

Bioanalytical Chemistry - Antibody-Antigen Equilibria in a Field of Magnetic Forces: Protein Micro-Array Sensors (link is external) Electrochemistry - Dynamic Properties of Amphiphiles at the Air/Water Interface (link is external) Our research concerns two parallel projects. In the bioanalytical area, our long term goal is the design of reagentless, disposable protein and DNA micro-array sensors capable of performing simultaneous, multi-component immunoassay analysis using smaller samples and requiring less involved procedures than currently existing techniques while providing equal or superior sensitivity. At a fundamental level we ask whether the application of mechanical forces with magnetic tweezers can be used to shift the position of chemical equilibria such as those governing antibody-antigen binding. This question is a central aspect of the sensor array as it provides a driving force in an otherwise unfavorable competitive exchange reaction, increasing the expected sensor sensitivity. We also investigate the effects of spatial confinement on such equilibria. In the area of interfacial chemistry we investigate dynamic behavior of monolayer assemblies at liquid/gas and solid/liquid interfaces. We are interested in understanding how composition and structure of monolayer assemblies affect the dynamics of such processes as long range electron tunneling, lateral molecular diffusion and vectorial proton transport. Our underlying goal is to address issues relevant to the behavior and functioning of biological membrane systems. For example, Langmuir techniques, Brewster angle microscopy (BAM), 2D electrochemical methods, and electron spin resonance spectroscopy are used to study lateral mobility of lipids at the air/water interface in order to understand physical properties of lipid monolayers and to probe the water liquid-vapor interfacial region. We want to learn about the dynamic properties of this important interfacial region and to understand how they differ from the properties of bulk water. Likewise, we want to understand what types of interactions determine phase behavior and the lateral dynamics of lipid monolayer films on the water surface. How does their mobility depend on their immersion depth, surface density and on the physical properties of the interfacial water region?

Bioanalytical Chemistry - Antibody-Antigen Equilibria in a Field of Magnetic Forces: Protein Micro-Array Sensors Electrochemistry - Dynamic Properties of Amphiphiles at the Air/Water Interface Our research concerns two parallel projects. In the bioanalytical area, our long term goal is the design of reagentless, disposable protein and DNA micro-array sensors capable of performing simultaneous, multi-component immunoassay analysis using smaller samples and requiring less involved procedures than currently existing techniques while providing equal or superior sensitivity. At a fundamental level we ask whether the application of mechanical forces with magnetic tweezers can be used to shift the position of chemical equilibria such as those governing antibody-antigen binding. This question is a central aspect of the sensor array as it provides a driving force in an otherwise unfavorable competitive exchange reaction, increasing the expected sensor sensitivity. We also investigate the effects of spatial confinement on such equilibria. In the area of interfacial chemistry we investigate dynamic behavior of monolayer assemblies at liquid/gas and solid/liquid interfaces. We are interested in understanding how composition and structure of monolayer assemblies affect the dynamics of such processes as long range electron tunneling, lateral molecular diffusion and vectorial proton transport. Our underlying goal is to address issues relevant to the behavior and functioning of biological membrane systems. For example, Langmuir techniques, Brewster angle microscopy (BAM), 2D electrochemical methods, and electron spin resonance spectroscopy are used to study lateral mobility of lipids at the air/water interface in order to understand physical properties of lipid monolayers and to probe the water liquid-vapor interfacial region. We want to learn about the dynamic properties of this important interfacial region and to understand how they differ from the properties of bulk water. Likewise, we want to understand what types of interactions determine phase behavior and the lateral dynamics of lipid monolayer films on the water surface. How does their mobility depend on their immersion depth, surface density and on the physical properties of the interfacial water region?

近期论文

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C. F. Monson, L. N. Driscoll, E. Bennion, C. J. Miller and M. Majda, �Antibody-Antigen Exchange Equilibria in a Field of External Force: Design of Reagentless Biosensors�, Anal. Chem. 2009, 81, 7510-7514. C. F. Monson, L. N. Driscoll, S. Khoie, E. Bennion, C. J. Miller and M. Majda, �Antibody-Antigen Equilibria in a Field of Magnetic Forces: Design of Reagentless Biosensors�, ECS Transactions - San Francisco, CA, 2009, 19, (6) 79-91. H. A. Elsen, C. F. Monson and M. Majda. �Effects of Electrodeposition Conditions and Protocol on the Properties of Iridium Oxide pH Sensor Electrodes�. J. Electrochem. Soc. 2009, 56, F1-F6 C. Monson, M. Majda. "Ion Diffusion in Channels Containing Random Arrays of Microspheres: An Electrochemical Time-of-Flight Method". Anal. Chem. 2007, 79, 9315-9320. M. Majda. �Electrochemistry of Monolayer Assemblies at the Air/Water Interface� in Encyclopedia of Electrochemistry, Vol 10, Modified Electrodes, Bard, A.J.; Stratman, M. Eds.; Fujihira, M.; Rubinstein, I.; Rusling, J. F., volume Eds., Chapter 5, 211-235, Wiley-VCH, Weinheim, 2007. H. Elsen, K. Slowinska, E. Hull and M. Majda. �Determination of the Capacitance of Solid-State Potentiometric Sensors: An Electrochemical Time-of-Flight Method�. Anal. Chem. 2006, 78(18), 6356-6363. N. Glandut, C. Monson and M. Majda. �Electrochemistry of TEMPO in the Aqueous Liquid/Vapor Interfacial Region: Measurements of the Lateral Mobility and Kinetics of Surface Partitioning�. Langmuir 2006, 22, 10697�10704. N. Glandut, A. Malec, M. Mirkin, and M. Majda. �Electrochemical Studies of the Lateral Diffusion of TEMPO in the Aqueous Liquid/Vapor Interfacial Region�. J.Phys.Chem B 2006, 110, 6101-6109. D. G. Wu, A. Malec, J. Majewski and M. Majda. "Orientation and Lateral Mobility of Insoluble Tempo Amphiphiles at the Air/Water Interface". Electrochimica Acta, 2005, 51, 2237-46. D. G. Wu, A. Malec, M. Head-Gordon and M. Majda. "Viscosity of the Aqueous Liquid/Vapor Interfacial Region. 2D Electrochemical Measurements with a Piperidine Nitroxy Radical Probe". J. Am. Chem. Soc., 2005, 127(12), 4490-4496. K. Slowinska and M. Majda. “Measurements of the Capacitance and the Response Time of Solid-State Potentiometric Sensors by an Electrochemical Time-of-Flight Method”, J. Solid State Electrochem. 2004, 8, 763-771. A. Malec, D. G. Wu, M. Louie, J. J. Skolimowski, and M. Majda. “Gibbs Monolayers at the Air/Water Interface. Surface Partitioning and Lateral Mobility of an Electrochemically Active Surfactant”, Langmuir, 2004, 20, 1305-1310. K. Slowinska, S. W. Feldberg and M. Majda. “An Electrochemical Time-of-Flight Technique with Galvanostatic Generation and Potentiometric Sensing”, J. Electroanal. Chem. 2003, 554-555, 61-69. M. Galperin, A. Nitzan, S. Sek and M. Majda. “Asymmetric Electron Transmission across Asymmetric Alkanethiol Bilayer Junctions”, J. Electroanal. Chem. 2003, 550-551, 337-351. M. Wittek, G. M�ller, M. J. Johnson and M. Majda. “2D Electrochemical Time-of-Flight and Its Application in the Measurements of the Kinetics of Lateral Electron Hopping in Monolayer Films at the Air/Water Interface ”, Anal. Chem., 2001, 73, 870-877. M. J. Johnson, C. Majmudar, J. J. Skolimowski and M. Majda. “Critical Temperature and LE/G Phase Transitions in Monolayer Films of the Amphiphilic TEMPO Derivatives at the Air/Water Interface”, J. Phys. Chem. B, 2001, 105, 9002-9010. M. J. Johnson, D. J. Anvar, J. J. Skolimowski and M. Majda. “Dynamic Properties of Supercritical C14TEMPO Monolayers at the Air/Water Interface”, J. Phys. Chem. B, 2001, 105, 514-519. K. Slowinska, M. J. Johnson, M. Wittek, G. Miller and M. Majda. “Electrochemical Time-of-Flight Investigations of the Diffusion Processes in Complex 2D and 3D Molecular Systems,” in “Chemical and Biological Sensors and Analytical Methods II”, M. A. Buttler, P. Vanysek, N. Yamazoe Eds.; The Electrochemical Society: 2001, ECS PV 2001-18, 130-137. K. Slowinski and M. Majda. “Mercury-Mercury Tunneling Junctions. II. Structure and Stability of Symmetric Alkanethiolate Bilayers and Their Effect on the Rate of Electron Tunneling”, J. Electroanal Chem. 2000, 491, 139-147. R. J. Forster, T. E. Keyes and M. Majda. “Homogeneous and Heterogeneous Electron Transfer Dynamics in Osmium-Containing Monolayers at the Air/Water Interface”, J.Phys.Chem. B 2000, 104, 4425-4432. Y.-S. Kang and M. Majda. “Head Group Immersion Depth and Its Effect on the Lateral Diffusion of Amphiphiles at the Air/Water Interface”, J.Phys.Chem. B 2000, 104, 2082-2089. R. V. Chamberlain, K. Slowinska, M. Majda, P. Buhlmann, H. Aoki and Y. Umezawa. “Electrostatically Induced Inclusion of Anions in Cyclodextrin Monolayers on Electrodes, Langmuir”, 2000, 16, 1388-1396. K. Slowinski, H. K. Y. Fong and M. Majda. “Mercury-Mercury Tunneling Junctions. I. Electron Tunneling Across Symmetric and Asymmetric Alkanethiolate Bilayers”, J. Am. Chem. Soc. 1999, 121, 7257-7261. K. Slowinski, K. U. Slowinska and M. Majda. “Electron Tunneling Across Hexadecanethiolate Monolayers on Mercury Electrodes. Reorganization Energy, Structure and Permeability of the Alkane/Water Interface”, J.Phys.Chem. B 1999, 103, 8544-8551. W.-Y. Lee, M. Wittek, G. Brezesinski, D. Moebius and M. Majda. “Structure and Lateral Electron Hopping in Osmium-tris-4,7-diphenylphenanthroline Perchlorate Monolayers at the Air/Water Interface”, J.Phys.Chem. B 1999, 103, 6950-6956.