研究领域
Allergic inflammatory disease
Metastatic melanoma
Epithelial wound healing
Cell-extracellular matrix interactions
Regenerative medicine and tissue engineering
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Singh, A., W. Kett, I. Severin, I. Agyekum, J. Duan, I. Amster, A. Proudfoot, D. R. Coombe, and R. Woods. 2015.“The interaction of heparin tetrasaccharides with chemokine CCL5 is modulated by sulfation pattern and pH.”Journal of Biological Chemistry 290 (25): 15421-15436.
Chaturvedi, V., D. E. Dye, B. F. Kinnear, T. Van Kuppevelt, M. Grounds, and D. R. Coombe. 2015.“Interactions between skeletal muscle myoblasts and their extracellular matrix revealed by a serum free culture system.”PLoS One 10 (6): 1-27.
Dye, D. E., S. medic, M. Ziman, and D. R. Coombe. 2013.“Melanoma Biomolecules: Independently Identified but Functionally Intertwined.”Frontiers in Oncology 3 (252).
Zhu, C., D. R. Coombe, M. H. Zheng, G. Yeoh, and L. Li. 2013.“Liver progenitor cell interactions with the extracellular matrix.”Journal of Tissue Engineering and Regenerative Medicine 7: 757-766.
Coombe, D. R., and W. Kett. 2012. “Herapin mimetics.” In Handbook of Experimental Pharmacology: Herapin - A Century of Progress, ed. Lever, Rebecca; Mulloy, Barbara; Page, Clive P., 361-383. London: Springer.
Coombe, D. R., and W. Kett. 2012.“Heparin mimetics.”Handbook of Experimental Pharmacology 207: 361-383.
Wong, C. W., D. E. Dye, and D. R. Coombe. 2012.“The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis.”International Journal of Cell Biology 2012.
Tanino, Y., D. R. Coombe, S. E. Gill, W. C. Kett, O. Kajikawa, A. E. Proudfoot, T. N. Wells, W. C. Parks, T. N. Wight, T. R. Martin et al. 2010.“Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs.”Journal of Immunology 184 (5): 2677-2685.
Dye, D. E., S. Karlen, B. Rohrbach, O. Staub, L. R. Braathen, K. A. Eidne, and D. R. Coombe. 2009.“hShroom1 links a membrane bound protein to the actin cytoskeleton.”Cellular and Molecular Life Sciences 66: 681-696.
Gandhi, N. S., D. R. Coombe, and R. L. Mancera. 2008.“Platelet endothelial cell adhesion molecule (PECAM-1) and its interactions with glycosaminoglycans 1. Molecular modelling studies.”Biochemistry 47: 4851-4862.
Coombe, D. R., S. M. Stevenson, B. F. Kinnear, N. S. Gandhi, R. L. Mancera, R. I. Osmond, and W. C. Kett. 2008.“Platelet endothelial cell adhesion molecule (PECAM-1) and its interactions with glycosaminoglycans 2. Biochemical analyses.”Biochemistry 47: 4863-4875.
Coombe, D. R. 2008.“Biological implications of glycosaminoglycan interactions with haemopoietic cytokines.”Immunology and Cell Biology 86: 589-607.
Kett, W. C., R. I. Osmond, S. M. Stevenson, L. Moe, and D. R. Coombe. 2005.“Direct detection of the binding of avidin and lactoferrin fluorescent probes to heparinized surfaces.”Analytical Biochemistry 339: 206-215.
Coombe, D. R., and W. C. Kett. 2005.“Heparan sulfate-protein interactions: therapeutic potential through structure-function insights.”Cellular and Molecular Life Sciences 62: 410-424.
Kett, W. C., and D. R. Coombe. 2004.“A structural analysis of heparin-like glycosaminoglycans using MALDI-TOF mass spectrometry.”Spectroscopy 18: 185-201.
Kett, W. C., R. I. Osmond, L. Moe, S. E. Skett, B. F. Kinnear, and D. R. Coombe. 2003.“Avidin is a heparin-binding protein. Affinity, specificity and structural analysis.”Biochimica et Biophysica Acta - General Subjects 1620: 225-234.
Cochran, S., C. Li, J. Fairweather, W. C. Kett, D. R. Coombe, and V. Ferro. 2003.“Probing the interactions of phosphosulfomannans with angiogenic growth factors by surface plasmon resonance.”Journal of Medicinal Chemistry 46 (21): 4601-4608.
Osmond, R. I., W. C. Kett, S. E. Skett, and D. R. Coombe. 2002.“Protein-heparin interactions measured by BIAcore 2000 are affectd by the method of heparin immobilization.”Analytical Biochemistry 310: 199-207.
Coombe, D. R., A. Nakhoul, S. Stevenson, S. Peroni, and C. J. Sanderson. 1998.“Expressed luciferase viability assay (ELVA) for the measurement of cell growth and viability.”Journal of Immunological Methods 215 (1-2): 145-150.
Lipscombe, R., A. Nakhoul, C. J. Sanderson, and D. R. Coombe. 1998.“Interleukin-5 binds to heparin/heparan sulfate. A model for an interaction with extracellular matrix.”Journal of Leukocyte Biology 63 (3): 342-350.