Newsholme, Philip - Curtin University - School of Biomedical Sciences

研究领域

1. Regulation of Insulin Secretion 2. Insulin Action 3. Oxidative stress and Diabetes 4. Oxidative stress and Cystinosis 5. Amino acid metabolism 6. Lipids and Health

近期论文

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Fortes, M., G. Marzuca-Nassr, K. Vitzel, C. Da Justa Pinheiro, P. Newsholme, and R. Curi. 2016.“Housekeeping proteins: How useful are they in skeletal muscle diabetes studies and muscle hypertrophy models?.”Analytical Biochemistry 504: 38-40. Raizel, R., J. Leite, T. Hypólito, A. Coqueiro, P. Newsholme, V. Cruzat, and J. Tirapegui. 2016.“Determination of the anti-inflammatory and cytoprotective effects of l-glutamine and l-alanine, or dipeptide, supplementation in rats submitted to resistance exercise.”British Journal of Nutrition 116 (3): 470-479. Calton, E., K. Pathak, M. J. Soares, H. Alfonso, K. Keane, P. Newsholme, N. Cummings, W. Chan She Ping-Delfos, and A. Hamidi. 2016.“Vitamin D status and insulin sensitivity are novel predictors of resting metabolic rate: a cross-sectional analysis in Australian adults.”European Journal of Nutrition Online 26 August 2015: 1-6. Perumal, V., S. Pohl, K. Keane, F. Arfuso, P. Newsholme, S. A. Fox, and A. M. Dharmarajan. 2016.“Therapeutic approach to target mesothelioma cancer cells using the Wnt antagonist, secreted frizzled-related protein 4: Metabolic state of cancer cells.”Experimental Cell Research 341 (2): 218-224. Carnagarin, R., R. Carlessi, P. Newsholme, A. M. Dharmarajan, and C. Dass. 2016.“Pigment epithelium-derived factor stimulates skeletal muscle glycolytic activity through NADPH oxidase-dependent reactive oxygen species production.”International Journal of Biochemistry and Cell Biology 78: 229-236. Sumayao, R., B. McEvoy, P. Newsholme, and T. McMorrow. 2016.“Lysosomal cystine accumulation promotes mitochondrial depolarization and induction of redox-sensitive genes in human kidney proximal tubular cells.”Journal of Physiology 594 (12): 3353-3370. Langman, C., B. Barshop, G. Deschênes, F. Emma, P. Goodyer, G. Lipkin, J. Midgley, C. Ottolenghi, A. Servais, N. Soliman et al. 2016.“Controversies and research agenda in nephropathic cystinosis: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference.”Kidney International 89 (6): 1192-1203. Chen, Y., V. Cruzat, and P. Newsholme. 2016.“?-cell metabolism, insulin production and secretion: Metabolic failure resulting in diabetes.”Molecular Nutrition and Food research A Volume in the Molecular Nutrition Series: 29-40. Chen, Y., R. Carlessi, N. Walz, V. Cruzat, K. Keane, A. John, F. Jiang, R. Carnagarin, C. Dass, and P. Newsholme. 2016.“Pigment epithelium-derived factor (PEDF) regulates metabolism and insulin secretion from a clonal rat pancreatic beta cell line BRIN-BD11 and mouse islets.”Molecular and Cellular Endocrinology 426: 50-60. Sidarala, V., R. Veluthakal, K. Syeda, C. Vlaar, P. Newsholme, and A. Kowluru. 2015.“Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic ß-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1).”Biochemical Pharmacology 95 (4): 301-310. Keane, K., E. Calton, V. Cruzat, M. J. Soares, and P. Newsholme. 2015.“The impact of cryopreservation on human peripheral blood leucocyte bioenergetics.”Clinical science (London, England : 1979) 128 (10): 723-733. Keane, K., P. Hinchliffe, N. Namdar, J. Conceicao, P. Newsholme, and J. Yovich. 2015.“Novel dehydroepiandrosterone troche supplementation improves the serum androgen profile of women undergoing in vitro fertilization.”Drug Design, Development and Therapy 9: 5569-5578. Cruzat, V., K. Keane, A. Scheinpflug, R. Cordeiro, M. J. Soares, and P. Newsholme. 2015.“Alanyl-glutamine improves pancreatic ß-cell function following ex vivo inflammatory challenge.”Journal of Endocrinology 224 (3): 261-271. Verdile, G., K. Keane, V. Cruzat, S. Medic, M. Sabale, J. Rowles, N. Wijesekara, R. Martins, P. Fraser, and P. Newsholme. 2015.“Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer’s disease.”Mediators of Inflammation 2015. Krause, M., T. Heck, A. Bittencourt, S. Scomazzon, P. Newsholme, R. Curi, and P. Homem De Bittencourt. 2015.“The chaperone balance hypothesis: The importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management.”Mediators of Inflammation 2015. Calton, E., K. Keane, P. Newsholme, and M. J. Soares. 2015.“The Impact of Vitamin D Levels on Inflammatory Status: A Systematic Review of Immune Cell Studies.”PLoS One 10 (11). Visweswaran, M., L. Schiefer, F. Arfuso, R. Dilley, P. Newsholme, and A. M. Dharmarajan. 2015.“Wnt antagonist secreted frizzled-related protein 4 upregulates adipogenic differentiation in human adipose tissue-derived mesenchymal stem cells.”PLoS One 10 (2). McEvoy, B., R. Sumayao, C. Slattery, T. McMorrow, and P. Newsholme. 2015.“Cystine accumulation attenuates insulin release from the pancreatic beta-cell due to elevated oxidative stress and decreased ATP levels.”The Journal of Physiology 593 (23): 5167-5182. Newsholme, P., and M. S. Krause. 2014. “Diet, Obesity, and Reactive Oxygen Species - Implications for Diabetes and Aging.” In Systems Biology of Free Radicals and Anti-Oxidants, ed. Ismail Laher, 3361-3374. Berlin: Springer. Keane, K., and P. Newsholme. 2014. “Metabolic Regulation of Insulin Secretion.” In The Pancreatic Beta Cell, ed. Gerald Litwack, 1-33. London, United Kingdom: Academic Press.