Tee, Lisa - Curtin University - School of Pharmacy

研究领域

Diabetes cause extensive complications in affected individuals and impose a great economic burden. Diabetic retinopathy is the main cause of blindness. Despite extensive basic and clinical research, we are still far from a cure. My primary aim is to understand the mechanism and characterise the pathological changes associated with diabetic retinopathy which progresses to vision loss. We have a transgenic mouse model of neovascularisation which exhibits pathological features similar to clinical diabetic retinopathy. We are currently exploring this model to develop novel therapies including gene therapy with the collaboration with Professor Rakoczy and A/Prof May Lai in the Lion Eye's Institute and, Professor Lyn Beazley and Professor Sarah Dunlop in Animal Biology, UWA. Another area of my research is the characterisation of drug transporters in mammary epithelial cells. Drug transporters in mammary glands are of clinical, toxicological and nutritional importance. P-glycoprotein, an efflux transporter, has been implicated in protecting the body against foreign substances. To date few studies have addressed the importance of such transporters in the transfer of drugs into breast milk. I aim to establish a mammary epithelial cell culture model and examine the role of P-glycoprotein in transporting drugs into breast milk. The model will be a useful tool to study mechanism underpinning drug transporters and more importantly, enable better identification of drugs that may enter breast milk and cause adverse events in breastfed infants.

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Sim, T., J. L. Sherriff, L. Tee, and L. Hattingh. 2015.“The use, perceived effectiveness and safety of herbal galactagogues during breastfeeding: A qualitative study.”International Journal of Environmental Research and Public Health 12 (9): 11050-11071. Sim, T., L. Hattingh, J. L. Sherriff, and L. Tee. 2015.“What do breastfeeding women taking herbal galactagogues perceive of community pharmacists’ role in breastfeeding support? A qualitative study.”International Journal of Environmental Research and Public Health 12 (9): 11132-11145. Tee, L., L. Hattingh, K. Rodgers, S. J. Ferns, V. S. Chang, and S. D. Fyfe. 2015.“MyCourseMap: an interactive visual map to increase curriculum transparency for university students and staff.” In ascilite2015. sim, T., L. Hattingh, J. L. Sherriff, and L. Tee. 2014.“Perspectives and attitudes of breastfeeding women using herbal galactagogues during breastfeeding: a qualitative study.”BMC Complementary and Alternative Medicine 14. Ahmadzai, H., L. Tee, and A. Crowe. 2014.“Pharmacological role of efflux transporters: Clinical implications for medication use during breastfeeding.”World Journal of Pharmacology 3 (4): 153-161. sim, T., J. L. Sherriff, L. Hattingh, R. W. Parsons, and L. Tee. 2013.“The use of herbal medicines during breastfeeding: a population-based survey in Western Australia.”BMC Complementary and Alternative Medicine 13. Taylor, L., J. Howell, S. T. Jones, N. Gasson, L. Tee, and J. Mulcock. 2010.“Mapping Career Development Learning in the Curriculum: Implementation of the Australian Blueprint for Career Development in Higher Education.” In Australian Collaborative Education Network National Conference 2010, Sep 27, 2011, Perth, Western Australia: Australian Collaborative Education Network. Lai, C., M. J. Estcourt, M. Wikstrom, R. P. Himbeck, N. L. Barnett, M. Brankov, L. Tee, S. Dunlop, M. A. Degli-Esposti, and E. P. Rakoczy. 2009.“rAAV.sFlt-1 Gene Therapy Achieves Lasting Reversal of Retinal Neovascularization in the Absence of a Strong Immune Response to the Viral Vector.”Investigative Ophthalmology & Visual Science 50: 4279-4287. Tee, L., M. A. Penrose, J. E. O'Shea, M. Lai Chooi, P. E. Rakocsy, and S. Dunlop. 2008.“VEGF-induced choroidal damage in a murine model of retinal neovascularisation.”British Journal of Ophthalmology 92: 832-838. Dunlop, S., L. Tee, M. Goossens, V. Stirling, L. Hool, J. Rodger, and L. Beazley. 2007.“Regenerating optic axons restore topography after incomplete optic nerve injury.”The Journal of Comparative Neurology 505: 46-57. van Eeden, P. E., L. Tee, S. Lukehurst, C. Lai, E. P. Rakoczy, L. Beazley, and S. Dunlop. 2006.“Early Vascular and Neuronal Changes in a VEGF Transgenic Mouse Model of Retinal Neovascularization.”Investigative Ophthalmology & Visual Science 47: 4638-4645. Rodger, J., P. N. Vitale, L. Tee, C. E. King, C. A. Bartlett, A. Fall, C. Brennan, J. E. O'Shea, S. A. Dunlops, and L. Beazley. 2004.“EphA/ephrin-A interactions during optic nerve regeneration: restoration of topography and regulation of ephrin-A2 expression.”Molecular and Cellular Neuroscience 25 (1): 56-68. Dunlop, S., L. Tee, V. Stirling, A. L. Taylor, G. Kuchling, J. Rodger, J. D. Roberts, A. Harvey, and L. Beazley. 2004.“Failure to restore vision after optic nerve regeneration in reptiles: Interspecies variation in response to axotomy.”The Journal of Comparative Neurology 478 (3): 292-305. Dunlop, S., V. Stirling, J. Rodger, A. C. Symonds, W. J. Bancroft, L. Tee, and L. Beazley. 2003.“Failure to form a stable topographic map during optic nerve regeneration: abnormal activity- dependent mechanisms.”Experimental Neurology 184 (2): 805-815. Beazley, L., J. Rodger, P. Chen, L. Tee, V. Stirling, S. Dunlop, and A. Taylor. 2003.“Training on a visual task improves the outcome of optic nerve regeneration.”Journal of Neurotrauma 20 (11): 1263-1270.