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Chemical Sciences Biologically Active Molecules Molecular Medicine Organic Chemical Synthesis Medical and Health Sciences Pharmaceutical Sciences

Glycogen synthase kinase-3ß inhibitors as stimulators of steroidogenesis Antitubercular drugs for tuberculosis-HIV co-infection

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Makhathini, S., S. Das, T. Singh, P. Arvidsson, H. Kruger, H. Gunosewoyo, T. Govender, and T. Naicker. 2016.“Stereoselective synthesis towards unnatural proline-based amino acids.”Arkivoc 2016 (3): 134-144. Sun, H., M. Shi, W. Zhang, Y. Zheng, Y. Xu, J. Shi, T. Liu, H. Gunosewoyo, T. Pang, Z. Gao et al. 2016.“Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.”Journal of Medicinal Chemistry 59 (13): 6329-6343. Cheng, ., P. Giguère, O. Onajole, W. Lv, A. Gaisin, H. Gunosewoyo, C. Schmerberg, V. Pogorelov, R. Rodriguiz, G. Vistoli et al. 2015.“Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.”Journal of Medicinal Chemistry 58 (4): 1992-2002. Wilkinson, S. M., H. Gunosewoyo, M. L. Barron, A. Boucher, M. McDonnell, P. Turner, D. E. Morrison, M. R. Bennett, I. S. McGregor, L. M. Rendina et al. 2014.“The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity.”ACS Chemical Neuroscience 5: 335-339. Pal, K., Y. Cao, I. N. Gaisina, S. Bhattacharya, S. K. Dutta, E. Wang, H. Gunosewoyo, A. Kozikowski, D. D. Billadeau, and D. Mukhopadhyay. 2014.“Inhibition of GSK-3 Induces Differentiation and Impaired Glucose Metabolism in Renal Cancer.”Molecular Cancer Therapeutics 13 (2): 285-296. Gunosewoyo, H., S. Tipparaju, M. Pieroni, Y. .. Wang, B. Doctor, M. P. Nambiar, and A. Kozikowski. 2013.“Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.”Bioorganic & Medicinal Chemistry Letters 23 (5): 1544-1547. Gunosewoyo, H., A. Midzak, I. N. Gaisina, E. V. Sabath, A. Fedolak, T. Hanania, D. Brunner, V. Papadopoulos, and A. Kozikowski. 2013.“Characterization of Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitors as Stimulators of Steroidogenesis.”Journal of Medicinal Chemistry 56: 5115-5129. Onajole, O. K., M. Pieroni, S. Tipparaju, S. Lun, J. Stec, G. .. Chen, H. Gunosewoyo, H. Guo, N. C. Ammerman, W. Bishai et al. 2013.“Preliminary Structure-Activity Relationships and Biological Evaluation of Novel Antitubercular Indolecarboxamide Derivatives Against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains.”Journal of Medicinal Chemistry 56: 4093-4103. Lun, S., H. Guo, O. K. Onajole, M. Pieroni, H. Gunosewoyo, G. .. Chen, S. Tipparaju, N. C. Ammerman, A. Kozikowski, and W. Bishai. 2013.“Indoleamides are active against drug-resistant Mycobacterium tuberculosis.”Nature Communications 4: 1-8. Yu, L., H. Zhang, H. Gunosewoyo, and A. Kozikowski. 2012.“From [alpha]4[beta]2 Nicotinic Ligands to the Discovery of [sigma]1 Receptor Ligands: Pharmacophore Analysis and Rational Design.”ACS Medicinal Chemistry Letters 3: 1054-1058. Kozikowski, A., H. Gunosewoyo, S. Guo, I. N. Gaisina, R. L. Walter, A. Ketcherside, C. A. McClung, A. D. Mesecar, and B. Caldarone. 2011.“Identification of a Glycogen Synthase Kinase-3[beta] Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice.”ChemMedChem 6 (9): 1593-1602. Chen, W., I. N. Gaisina, H. Gunosewoyo, S. A. Malekiani, T. Hanania, and A. Kozikowski. 2011.“Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3[beta] Inhibitor: a Superior Neuroprotective Pyrazolone Showing Antimania Effects.”ChemMedChem 6 (9): 1587-1592. Gunosewoyo, H., and M. Kassiou. 2010.“P2X purinergic receptor ligands: recently patented compounds.”Expert Opinion on Therapeutic Patents 20 (5): 625-646. Gunosewoyo, H., J. L. Guo, M. R. Bennett, M. J. Coster, and M. Kassiou. 2008.“Cubyl amides: Novel P2X7 receptor antagonists.”Bioorganic & Medicinal Chemistry Letters 18 (13): 3720-3723. Gunosewoyo, H., M. J. Coster, and M. Kassiou. 2007.“Molecular Probes for P2X7 Receptor Studies.”Current Medicinal Chemistry 14 (14): 1505-1523.