Fox, Simon - Curtin University - School of Pharmacy

研究领域

The broad area of my research interest is in cellular signalling and experimental cancer therapeutics. A significant part of our work is studying transcriptional programs (pharmacogenomics) and phenotypic effects of cancer therapeutics targeting the Wnt signalling pathway in mesothelioma and pancreatic cancer. A current focus of our research is the regulation and analysis of mRNA splicing both of Wnt pathway components and by downstream signalling and how this can influence cancer and stem cell biology. Research in our lab can be loosely divided into two areas although there is plenty of overlap: Wnt signalling in stem cell biology, and experimental cancer therapeutics.

近期论文

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Perumal, V., S. Pohl, K. Keane, F. Arfuso, P. Newsholme, S. A. Fox, and A. M. Dharmarajan. 2016.“Therapeutic approach to target mesothelioma cancer cells using the Wnt antagonist, secreted frizzled-related protein 4: Metabolic state of cancer cells.”Experimental Cell Research 341 (2): 218-224. Perumal, V., K. Krishnan, E. Gratton, A. M. Dharmarajan, and S. A. Fox. 2015.“Number and brightness analysis of sFRP4 domains in live cells demonstrates vesicle association signal of the NLD domain and dynamic intracellular responses to Wnt3a.”International Journal of Biochemistry and Cell Biology 64: 91-96. Surana, R., S. Sikka, W. Cai, E. Shin, S. R. Warrier, H. Tan, F. Arfuso, S. A. Fox, A. M. Dharmarajan, and A. Prem Kumar. 2014.“Secreted frizzled related proteins: Implications in cancers.”Biochimica et Biophysica Acta Reviews on Cancer 1845: 53-65. Fox, S. A., A. K. Richards, I. Kusumah, V. Perumal, E. Bolitho, S. Mutsaers, and A. M. Dharmarajan. 2013.“Expression profile and function of Wnt signaling mechanisms in malignant mesothelioma cells.”Biochemical and Biophysical Research Communications 440: 82-87. Cregan, I. L., A. M. Dharmarajan, and S. A. Fox. 2013.“Mechanisms of cisplatin-induced cell death in malignant mesothelioma cells: Role of inhibitor of apoptosis proteins (IAPs) and caspases.”International Journal of Oncology 42 (2): 444-452. Jackaman, C., D. Majewski, S. A. Fox, A. nowak, and D. J. Nelson. 2012.“Chemotherapy broadens the range of tumor antigens seen by cytotoxic CD8+ T cells in vivo.”Cancer Immunology, Immunotherapy 61: 2343-2356. Fox, S. A., S. Loh, S. Mahendran, and M. J. Garlepp. 2012.“Regulated chemokine gene expression in mouse mesothelioma and mesothelial cells: TNF-alpha upregulates both CC and CXC chemokine genes.”Oncology Reports 28 (2): 707-713. Whittell, L. R., K. T. Batty, R. Wong, E. M. Bolitho, S. A. Fox, T. M. Davis, and P. E. Murray. 2011.“Synthesis and antimalarial evaluation of novel isocryptolepine derivatives.”Bioorganic & Medicinal Chemistry 19: 7519-7525. Lareu, R., N. Swanson, and S. A. Fox. 1997.“Rapid and sensitive genotyping of hepatitis C virus by single-strand conformation polymorphism.”Journal of Virological Methods 64 (1): 11-18. Fox, S. A., B. Ward, P. Robbins, F. Mastaglia, and N. Swanson. 1996.“Inclusion body myositis: Investigation of the mumps virus hypothesis by polymerase chain reaction.”Muscle & Nerve 19 (1): 23-28. Fox, S. A., R. Lareu, and N. Swanson. 1995.“Rapid genotyping of hepatitis C virus isolates by dideoxy fingerprinting.”Journal of Virological Methods 53 (1): 1-9. Swanson, N., S. A. Fox, and F. Mastaglia. 1995.“Search for persistent infection with poliovirus or other enteroviruses in amyotrophic lateral sclerosis-motor neurone disease.”Neuromuscular Disorders 5 (6): 457-465. Fox, S. A., E. Finklestone, P. Robbins, F. Mastaglia, and N. Swanson. 1994.“Search for persistent enterovirus infection of muscle in inflammatory myopathies.”Journal of the Neurological Sciences 125 (1): 70-76.