研究领域

Biological Sciences Cell Metabolism Engineering Biomaterials Technology Nanomedicine Medical and Health Sciences Cancer Cell Biology Chemotherapy Pharmaceutical Sciences

If you are keen on joining my lab, a project in one of these areas will be on offer: Formulation development and testing in vitro and in vivo Development and testing of safer cancer therapeutics Cell biology - specifically metabolism, stress, survival and death Mitochondrial function - how it affects cell viability Finding better ways to deliver insulin in the body Testing of agents that shield normal cells from harmful effects of chemotherapy Development of orthotopic models for cancer Oestrogen regulation of breast cancer Bone tissue regeneration Finding better lipofection reagents

近期论文

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Wong, J., P. Sriamornsak, and C. Dass. 2016.“Doxorubicin: The dogma and the bone.”Asian Journal of Pharmaceutical Sciences 11 (1): 22-23. Manchun, S., C. Dass, and P. Sriamornsak. 2016.“Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin.”Asian Journal of Pharmaceutical Sciences 11 (5). In press. Elahy, M., M. R. Doschak, J. Hughes, . Baindur-Hudson, and C. Dass. 2016.“Alginate bead-encapsulated PEDF induces ectopic bone formation in vivo in the absence of co-administered mesenchymal stem cells.”Curr Drug Targets 2016. Armstrong, J., and C. Dass. 2016.“Doxorubicin action on mitochondria: relevance to osteosarcoma therapy?.”Curr Drug Targets Early Online. In press. Xiao, S., P. Tanalgo, M. Bustos, and C. Dass. 2016.“The Effect of Krill Oil and n-3 Polyunsaturated Fatty Acids on Human Osteosarcoma Cell Proliferation and Migration.”Curr Drug Targets 17 (16). In press. Carnagarin, R., R. Carlessi, P. Newsholme, A. M. Dharmarajan, and C. Dass. 2016.“Pigment epithelium-derived factor stimulates skeletal muscle glycolytic activity through NADPH oxidase-dependent reactive oxygen species production.”International Journal of Biochemistry and Cell Biology 78: 229-236. Saffari, M., H. Moghimi, and C. Dass. 2016.“Barriers to liposomal gene delivery: From application site to the target.”Iranian Journal of Pharmaceutical Research 15. In press. Poon, B., T. Kha, S. Tran, and C. Dass. 2016.“Bone morphogenetic protein-2 and bone therapy: Successes and pitfalls.”Journal of Pharmacy and Pharmacology 68 (2): 139-147. Carnagarin, R., A. M. Dharmarajan, and C. Dass. 2016.“PEDF attenuates insulin-dependent molecular pathways of glucose homeostasis in skeletal myocytes.”Molecular and Cellular Endocrinology 422: 115-124. Chen, Y., R. Carlessi, N. Walz, V. Cruzat, K. Keane, A. John, F. Jiang, R. Carnagarin, C. Dass, and P. Newsholme. 2016.“Pigment epithelium-derived factor (PEDF) regulates metabolism and insulin secretion from a clonal rat pancreatic beta cell line BRIN-BD11 and mouse islets.”Molecular and Cellular Endocrinology 426: 50-60. Lee, P., and C. Dass. 2016.“Potential of pigment epithelium-derived factor (PEDF) as a bone regenerative biopharmaceutical.”Pharmazie 71 (4): 171-174. Lee, P., J. Martinez, and C. Dass. 2016.“Stimulation of bone regeneration with pigment epithelium-derived factor microparticles: Evidence in silico, in vitro and in vivo.”Pharmazie 71 (7): 382-389. Manchun, S., C. Dass, K. Cheewatanakornkool, and P. Sriamornsak. 2015.“Enhanced anti-tumor effect of pH-responsive dextrin nanogels delivering doxorubicin on colorectal cancer.”Carbohydrate Polymers 126: 222-230. Tacar, O., S. Indumathy, M. Tan, S. Baindur-Hudson, A. Friedhuber, and C. Dass. 2015.“Cardiomyocyte apoptosis vs autophagy with prolonged doxorubicin treatment: Comparison with osteosarcoma cells.”Journal of Pharmacy and Pharmacology 67 (2): 231-234. Friedhuber, A., V. Chandolu, S. Manchun, O. Donkor, P. Sriamornsak, and C. Dass. 2015.“Nucleotropic doxorubicin nanoparticles decrease cancer cell viability, destroy mitochondria, induce autophagy and enhance tumour necrosis.”Journal of Pharmacy and Pharmacology 67 (1): 68-77. Carnagarin, R., A. M. Dharmarajan, and C. Dass. 2015.“Molecular aspects of glucose homeostasis in skeletal muscle - A focus on the molecular mechanisms of insulin resistance.”Molecular and Cellular Endocrinology 417: 52-62. Carnagarin, R., A. M. Dharmarajan, and C. Dass. 2015.“PEDF-induced alteration of metabolism leading to insulin resistance.”Molecular and Cellular Endocrinology 401: 98-104. Tan, M. L., P. Shao, A. M. Friedhuber, M. van Moorst, M. Elahy, S. Indumathy, D. E. Dunstan, Y. Z. Wei, and C. Dass. 2014.“The potential role of free chitosan in bone trauma and bone cancer management.”Biomaterials 35: 7828-7838. Ko, S. Y., G. L. Blatch, and C. Dass. 2014.“Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer.”Cancer and Metastasis Reviews 33: 101-113. Manchun, S., C. Dass, and P. Sriamornsak. 2014.“Designing nanoemulsion templates for fabrication of dextrin nanoparticles via emulsion cross-linking technique.”Carbohydrate Polymers 101 (1): 650-655.