Benson, Heather - Curtin University

研究领域

Dr Heather Benson leads the Skin Delivery Research Group and has an international reputation for her research in the area of skin biology and drug/peptide delivery. She is invited to and regularly presents research from her group at international conferences; is on the editorial board and acts as a reviewer for many prestigious journals in drug delivery, medicinal chemistry and pharmacology; is a reviewer for national and international grant bodies; and is a member of national committees in peptide research and controlled release delivery. She collaborates with colleagues in industry and university nationally (UWA, UQ, USyd, UniSA) and internationally (Queen's University Belfast, UniBarcelona). Dr Benson's current research areas are in drug targeting to the skin using physical, chemical and formulation enhancement techniques; delivery of therapeutic peptides to the skin by novel formulations/delivery systems including nanosystems, enhancer ligands, peptide shuttles/chaperons and physical enhancement technologies.

近期论文

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Benson, H. A. 2016. “Vesicles for transdermal delivery of peptides and proteins.” In Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Nanocarriers, 297-307. : . Journal Articles (Research) Leite-Silva, V., W. Sanchez, H. Studier, D. Liu, Y. Mohammed, A. Holmes, E. Ryan, I. Haridass, N. Chandrasekaran, W. Becker et al. 2016.“Human skin penetration and local effects of topical nano zinc oxide after occlusion and barrier impairment.”European Journal of Pharmaceutics and Biopharmaceutics 104: 140-147. Benson, H. A. 2016.“Vesicles for transdermal delivery of peptides and proteins.”Nanocarriers 1: 297-307. Leite-Silva, V., D. Liu, W. Sanchez, H. Studier, Y. Mohammed, A. Holmes, W. Becker, J. Grice, H. A. Benson, and M. Roberts. 2016.“Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles.”Nanomedicine 11 (10): 1193-1205. Mohammed, Y., M. Teixido, S. Namjoshi, E. Giralt, and H. A. Benson. 2016.“Cyclic Dipeptide Shuttles as a Novel Skin Penetration Enhancement Approach: Preliminary Evaluation with Diclofenac.”PLoS One 11 (8): e0160973-e0160973. Raphael, A., O. Wright, H. A. Benson, and T. Prow. 2015.“Recent advances in physical delivery enhancement of topical drugs.”Current Pharmaceutical Design 21 (20): 2830-2847. Ng, Y., H. A. Benson, D. H. Brown, and Y. Chen. 2015.“Synthesis and characterization of novel copolymeric resveratrol conjugates.”Journal of Chemistry 2015: na-na. Siddalingappa, ., H. A. Benson, D. H. Brown, K. T. Batty, and Y. Chen. 2015.“Stabilization of resveratrol in blood circulation by conjugation to mPEG and mPEG-PLA polymers: Investigation of conjugate linker and polymer composition on stability, metabolism, antioxidant activity and pharmacokinetic profile.”PLoS One 10 (3). Prow, T. W., Y. H. Mohammed, A. B. Ansaldo, and H. A. Benson. 2014. “Topical Microneedle Drug Delivery Enhanced with Magnetophoresis.” In Advances in Dermatological Sciences, ed. Keith R. Brain and Robert P Chilcott, 169-177. Cambridge, United Kingdom: The Royal Society of Chemistry. Journal Articles (Research) Ali, M., M. Amon, V. Bender, A. Bolte, F. Separovic, H. A. Benson, and N. Manolios. 2014.“Cyclization enhances function of linear anti-arthritic peptides.”Clinical Immunology 150 (1): 121-133. Krishnan, G., M. S. Roberts, J. Grice, Y. Anissimov, H. R. Moghimi, and H. A. Benson. 2014.“Iontophoretic skin permeation of peptides: an investigation into the influence of molecular properties, iontophoretic conditions and formulation parameters.”Drug Delivery and Translational Research 4: 222-232. Slominski, A., T. Kim, H. Z. Shehabi, E. K. Tang, H. A. Benson, I. Semak, Z. Lin, C. R. Yates, J. Wang, W. Li et al. 2014.“In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland.”Molecular and Cellular Endocrinology 383: 181-192. Mohammed, Y. H., M. Yamada, L. L. Lin, J. Grice, M. S. Roberts, A. P. Raphael, H. A. Benson, and T. W. Prow. 2014.“Microneedle Enhanced Delivery of Cosmeceutically Relevant Peptides in Human Skin.”PLoS ONE 9 (7). Namjoshi, S., I. Toth, J. T. Blanchfield, N. Trotter, R. L. Mancera, and H. A. Benson. 2014.“Enhanced Transdermal Peptide Delivery and Stability by Lipid Conjugation: Epidermal Permeation, Stereoselectivity and Mechanistic Insights.”Pharmaceutical Research 31: 3304-3312. Namjoshi, S., I. Toth, J. Blanchfield, N. Trotter, R. L. Mancera, and H. A. Benson. 2014.“Enhanced transdermal peptide delivery and stability by lipid conjugation: Epidermal permeation, stereoselectivity and mechanistic insights.”Pharmaceutical Research 31 (12): 3304-3312. Basavaraj, S., H. A. Benson, D. H. Brown, and Y. Chen. 2013.“Application of Solvent Influenced Fluorescence-quenching and Enhancement to Develop a Highly Sensitive HPLC Methodology for Analysis of Resveratrol-PEG Conjugates.”Current Pharmaceutical Analysis 9 (2): 199-207. Sharma, S., H. A. Benson, T. K. mukkur, P. Rigby, and Y. Chen. 2013.“Preliminary studies on the development of IgA-loaded chitosan-dextran sulphate nanoparticles as a potential nasal delivery system for protein antigens.”Journal of Microencapsulation 30 (3): 283-294. Krishnan, G., J. Grice, M. S. Roberts, H. A. Benson, and T. W. Prow. 2013.“Enhanced sonophoretic delivery of 5-aminolevulinic acid: preliminary human ex vivo permeation data.”Skin Research & Technology 19 (1): 283-289. Benson, H. A., and A. Watkinson. 2012. Preface. : . Books (Research) - Edited Benson, H. A., and A. C. Watkinson. ed. 2012. Topical and Transdermal Drug Delivery: Principles and Practice. USA: John Wiley & Sons.