个人简介

B.A., University of Chicago, 1983. PhD, University of California-Berkeley, 1990 (Mel Klein and Ken Sauer). Postdoctoral: Northwestern University (Brian Hoffman). Assistant (1995-01) and Associate (2001-05) Professor of Chemistry, Texas A&M University. Honors and Awards: NIH Postdoctoral fellow, 1991-94; NSF CAREER awardee, 1997; Research Corporation Cottrell Scholar, 1998; Center for Teaching Excellence Montague Scholar,1999; AFS College of Science Teaching Award, 2000. University of Oregon Fund for Faculty Members Excellence Award, 2008. American Association for the Advancement of Science Fellow, 2010. At UO since 2006.

研究领域

Biochemistry/Molecular Biology/Bioorganic/Medicinal Chemistry/Biophysics/Inorganic/Organometallic Chemistry/Optics & Spectroscopy/Organic Synthesis

We are investigating chemical activity and structure in nucleic acids and proteins, with an emphasis on metal interactions. Proteins have long been known to exploit and tune the reactive properties of metals in order to perform reactions that are sometimes unavailable to the benchtop chemist. It has only recently been determined that ribonucleic acid (RNA) also catalyzes chemical reactions in certain biologically important systems. RNA has its own distinctive metallobiochemistry. Our research group examines such systems using tools of biological and bioinorganic chemistry, and spectroscopic methods. These are interdisciplinary studies that lie at the interface of biology and chemistry. RNA is a truly unique biopolymer that displays a rich array of cellular functions, some of which are still being uncovered. RNA structure itself is complex and dynamic, and can be profoundly influenced by ionic conditions. One long-term objective of our research program is to directly measure cation-RNA interactions and understand their importance in function. Catalytic RNAs, or ribozymes, provide model systems for these studies. Since their discovery approximately two decades ago, the mechanisms by which RNA catalyzes reactions have been an area of intense investigation. Biological ribozymes catalyze phosphoryl transfer reactions in RNA processing and splicing events. A growing body of evidence indicates that the aminoacyl transferase activity of the ribosome also is catalyzed in an RNA-formed active site. Cations influence activity in these systems by mechanisms that are not entirely understood, but range from general electrostatic effects to population of very specific ‘sites’ created by the folded RNA. Our current projects include detailed studies of ribozymes such as the hammerhead motif derived from the genomes of plant viroids and other organisms. We are also initiating an investigation of the interactions of metal-based therapeutics, such as the anticancer compound cisplatin, with structured RNAs. In the active sites of metalloenzymes, the properties of metal ions are highly tuned by their protein environments. In order to understand the importance of different ‘spheres of influence’ that the protein exerts on the metal ion, we are designing and investigating small peptides based on the metal-binding cavities of naturally-occurring enzymes. The active sites of blue copper proteins and of mononuclear Fe and Co-containing enzymes are current targets using both rational and combinatorial methods to create appropriate peptide models. These studies require spectroscopic techniques that examine global structure as well as provide a window of observation around the metal ion. EPR, NMR, fluorescence, and other spectroscopic methods are used in these projects. SDSL (site-directed spin labeling) allows tracking of RNA structure by monitoring changes in local dynamics and interprobe distances. ENDOR (electron nuclear double resonance) spectroscopy is a double resonance technique that detects only nuclei that are coupled to a paramagnetic metal ion. When combined, these methods provide unique information about global structure and local environments in the active sites of metalloproteins and ribozymes.

近期论文

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An Alkyne-Appended, Click-Ready Pt(II) Complex with an Unusual Arrangement in the Solid State Jonathan D. White, Lindsay E. Guzman, Dr. Lev N. Zakharov, Prof. Michael M. Haley and Prof. Victoria J. DeRose, Angew. Chem. Int. Ed. 2015 54 (3), 1032-1035 Link Convenient Detection of Metal-DNA, Metal-RNA, and Metal-Protein Adducts With a Click-Modified Pt(II) Complex Alan D. Moghaddam, Jonathan D. White, Rachael M Cunningham, Andrea N Loes, Michael M Haley and Victoria J. DeRose Dalton Transactions 2015, 44, 3536-3539Link Platinum-RNA Modifications Following Drug Treatment in S. cerevisiae Identified by Click Chemistry and Enzymatic Mapping Maire F. Osborn , Jonathan D. White , Michael M. Haley , and Victoria J. DeRose ACS Chem. Bio. 2014, 9 (10), pp 2404–2411 Link Nucleic Acid Catalysis: Metals, Nucleobases, and Other Cofactors W. Luke Ward, Kory Plakos, and Victoria J. DeRose Chem. Rev. 2013, 135 (32), pp 11680–11683 Link Picazoplatin, an Azide-Containing Platinum(II) Derivative for Target Analysis by Click Chemistry White, Jonathan D.; Osborn, Maire F; Moghaddam, Alan D; Guzman, Lindsay E; Haley, Michael M; DeRose, Victoria J J. Am. Chem. Soc. 2013, 135 (32), pp 11680–11683 Link Defect Mechanisms in High Resistivity BaTiO3-Bi(Zn1/2Ti1/2)O3 Ceramics Raengthon, Natthaphon; DeRose, Victoria J.; Brennecka, Geoffrey L.; Cann, David P. Applied Physics Letters 2012, 101(11), 112904/1-112904/5. Link Ground-State Coordination of a Catalytic Metal to the Scissile Phosphate of a Tertiary-Stabilized Hammerhead Ribozyme Ward, W. Luke; DeRose, Victoria J. RNA 2012, 18(1), 16-23.Link Site-Specific Platinum(II) Cross-Linking in a Ribozyme Active Site Chapman, Erich G.; DeRose, Victoria J. JACS 2012, 134(1), 256-262 Link RNA-Pt Adducts Following Cisplatin Treatment of Saccharomyces cerevisiae Hostetter, Alethia A.; Osborn, Maire F.; DeRose, Victoria J. ACS Chemical Biology 2012, 7(1), 218-225 Link Binding of Kinetically Inert Metal Ions to RNA: the Case of Platinum(II) Chapman, Erich G.; Hostetter, Alethia A.; Osborn, Maire F.; Miller, Amanda L.; DeRose, Victoria J. Metal Ions in Life Sciences 2011, 9(Structural and Catalytic Roles of Metal Ions in RNA), 347-377. Link Ru binding to RNA Following Treatment with the Antimetastatic Prodrug NAMI-A in Saccharomyces Cerevisiae and In-Vitro Hostetter, Alethia A.; Miranda, Michelle L.; DeRose, Victoria J.; McFarlane Holman, Karen L. JBIC 2011, 16(8), 1177-1185 Link Precise Mapping of RNA Tertiary Structure via Nanometer Distance Measurements with Double Electron-ElectronResonance Spectroscopy Kim, Nak-Kyoon; Bowman, Michael K.; DeRose, Victoria J. From JACS 2010, 132(26), 8882-8884. Link Enzymatic Processing of Platinated RNAs Chapman, Erich G.; DeRose, Victoria J. JACS 2010, 132(6), 1946-1952. Link The Identity of the Nucleophile Substitution May Influence Metal Interactions with the Cleavage Site of the Minimal Hammerhead Ribozyme Osborne, Edith M.; Ward, W. Luke; Ruehle, Max Z.; DeRose, Victoria J. Biochemistry 2009, 48(44), 10654-10664. Link Rapid Cross-Linking of an RNA Internal Loop by the Anticancer Drug Cisplatin Hostetter, Alethia A.; Chapman, Erich G.; DeRose, Victoria J. From JACS 2009, 131(26), 9250-9257. Link Characterizaation of Nucleic Acid-Metal Ion Binding by Spectroscopic Techniques DeRose, Victoria J. Ribozymes and RNA Catalysis DeRose, Victoria J. JACS 2008, 130(42), 14017. Link Sensing Cellular Magnesium with RNA DeRose, Victoria J. Nature Chemical Biology 2007, 3(11), 693-694. Link Multifrequency Pulsed EPR Studies of Biologically Relevant Manganese(II) Complexes Stich, T. A.; Lahiri, S.; Yeagle, G.; Dicus, M.; Brynda, M.; Gunn, A.; Aznar, C.; DeRose, V. J.; Britt, R. D. Applied Magnetic Resonance 2007, 31(1-2), 321-341. Link Activation of the Binuclear Metal Center through Formation of Phosphotriesterase-Inhibitor Complexes Samples, Cynthia R.; Raushel, Frank M.; DeRose, Victoria J. Biochemistry 2007, 46(11), 3435-3442. Link