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个人简介

张健健,博士,副教授,硕士生导师。2010年本科毕业于中国矿业大学化学工程与工艺系,2013年,2016年分别获兰州大学有机化学硕士学位,师从彭羽教授;和兰州大学分析化学博士学位,师从张海霞教授。2016年至2017年在新加坡南洋理工大学浦侃裔副教授处做博士后研究。2017年8月至今在西北大学化学与材料科学学院任教。迄今为止在Advanced Materials, Chemical Science, Analytical Chemistry, Chemical Communications, Trends in Chemistry等国际著名期刊及分析化学类权威期刊以第一作者或通讯作者身份发表论文10余篇。2017年获中国分析测试协会科学技术奖三等奖(第二名)。入选陕西省(青年项目)。目前主持国家自然科学基金青年项目。担任Research And Application Of Materials Science期刊编委。担任《精细化工》外审专家。

研究领域

1、有机小分子近红外荧光探针的合成与设计 2、激活型分子探针在细胞和动物活体的光声成像分析中的应用 3、设计靶向型诊疗探针在肿瘤早期诊断与治疗评价中的应用

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Xinyue, Zhao; Lulu,Ning; Xiaoman, Zhou; Zhihui,Song; Jianjian, Zhang*; Feng,Guan; Xiaofeng,Yang, An Activatable Near-Infrared Fluorescence Hydrogen Sulfide (H2S) Donor for Imaging H2S Release and Inhibiting Inflammation in Cells, Analytical Chemistry, 2021, DOI.org/10.1021/acs.analchem.0c05081. Jianjian Zhang,* Lulu Ning, Ziling Zeng, Kanyi Pu,* Development of NIR-II Photoacoustic Imaging Agents, Trends in Chemistry, 2021, Doi.org/10.1016/j.trechm.2021.01.002 (Review) 张素雅,张健健* 光气检测用小分子荧光探针的研究进展,《精细化工》, 2020, 37(11), 2229-2237. (综论) Yang Li, Lulu Ning, Fang Yuan, Tian Zhang, Jianjian Zhang,* Zhigang Xu,* and Xiaofeng Yang,* Activatable Formation of Emissive Excimers for Highly Selective Detection of β-Galactosidase. Analytical Chemistry, 2020, 92, 8, 5733–5740. Jianjian Zhang,* Lulu Ning, Jiaguo Huang, Chi Zhang, and Kanyi Pu,* Activatable Molecular Agents for Cancer Theranostics. Chemical Science, 2020, 11, 618-630. [Invited Perspective] Xinli Li, Zhiying Niu, Zhenfeng Lin, Yuan Qin, Jingxi Xu, Huayu Huang* Liancheng Wang, Jianjian Zhang, and Zhigang Xu. A boron nitride electrode modified with a nanocomposite prepared from an ionic liquid and tungsten disulfide for voltammetric sensing of 4-aminophenol, Microchimica Acta, 2019, 186, 614. Tianyi Cheng, Wenming Huang, Di Gao, Zhe Yang, Congjie Zhang, Haixia Zhang, Jianjian Zhang, Hua Li, and Xiao-Feng Yang*, Michael Addition/S,N-Intramolecular Rearrangement Sequence Enables Selective Fluorescence Detection of Cysteine and Homocysteine. Analytical Chemistry, 2019, 91, 10894−10900. Ali Hariri, Eric Zhao, Ananthakrishna Soundaram Jeevarathinam, Jeanne Lemaster, Jianjian Zhang & Jesse V. Jokerst,* Molecular imaging of oxidative stress using an LED-based photoacoustic imaging system. Scientific Reports, 2019, 9, 11378. Haihua Chen, Xueyun Gong, Xiawei Liu, Zheng Li, Jianjian Zhang, Xiao-Feng Yang,* A nitroso-based fluorogenic probe for rapid detection of hydrogen sulfide in living cells.Sensors and Actuators B:Chemical, 2019, 281, 542-548. Jiangjiang Sun, Qin Wang, Jiajun Yang, Jianjian Zhang, Zheng Li, Hua Li, Xiao-Feng Yang,*2,4-Dinitrobenzenesulfonate-functionalized carbon dots as aturn-on fluorescent probe for imaging of biothiols in living cells. Microchimica Acta, 2019, 186, 402. Jianjian Zhang,* Penghui Cheng, Kanyi Pu,* Recent Advances of Molecular Optical Probes in Imaging of β-Galactosidase.Bioconjugate Chemistry, 2019, 30, 8, 2089-2101. (Invited Review) Yuan Liu, Dandan Ren Jianjian Zhang, Hua Li, Xiao-Feng Yang*A fluorescent probe for hydrazine based on anewly developed 1-indanonefused coumarin scaffold. Dyes and Pigments 2019,162,112-119. Biliu Wu,Jiajun Yang, Jianjian Zhang,Zheng Li,Hua Li,Xiao-Feng Yang*A ratiometric fluorescent probe for the detection of endogenous hydroxyl radicals in living cells.Talanta 2019,196,317–324. Shengrui Zhang,Qin Wang,Xiawei Liu,Jianjian Zhang,Xiao-Feng Yang,*Zheng Li and Hua Li,*Sensitive and Selective Fluorescent Probe for Selenol in Living Cells Designed via apKa Shift Strategy.Anal.Chem.,2018,90,4119-4125. Jianjian Zhang, Xu Zhen, Jianfeng Zeng, Kanyi Pu,* A Dual-modal Molecular Probe for Near-infrared Fluorescence and Photoacoustic Imaging of Peroxynitrite. Analytical Chemistry, 2018, 90, 9301-9307. Penghui Cheng, Jianjian Zhang, Jiaguo Huang, Qingqing Miao, Chenjie Xu,Kanyi Pu.* Near-infrared fluorescence probes detect reactive oxygen species for keloid diagnosis. Chemical Science, 2018, 9, 6340-6347. [2018 Chemical Science HOT Article Collection]. Xiaoqian Ma, Xiaoxiao Shi, Shuang Bai, Jianjian Zhang, Meili Hou, Tian Zhang, Bao-sheng Li, Peng Xue, Yuejun Kang and Zhigang Xu.* Water-soluble Fluorescent Unimolecular Micelles:Ultra-small Size,Tunable Fluorescence Emission from Visible to NIR Region and Enhanced Biocompatibility for In Vitro and In Vivo Bioimaging. Chemical Communications, 2018, 54, 6252-6255. Xu Zhen, Jianjian Zhang, Jiaguo Huang, Chen Xie, Qingqing Miao, Kanyi Pu.* Macrotheranostic probe with disease-activated near-infrared fluorescence, photoacoustic and photothermal signals for imaging‐guided therapy. Angewandte Chemie International Edition, 2018, 57, 7804-7808. Qingqing Miao, David Yeo, Christian Wiraja, Jianjian Zhang, Xiaoyu Ning, Chenjie Xu, Kanyi Pu.* Near-infrared fluorescent molecular probe for sensitive imaging of keloid. Angewandte Chemie International Edition, 2018, 57, 1256-1260. Jianjian Zhang, Xu Zhen, Paul Kumar Upputuri, Manojit Pramanik, Peng Chen, Kanyi Pu.* Activatable photoacoustic nanoprobes for in vivo ratiometric imaging of peroxynitrite. Advanced Materials, 2017, 29, 1604764. [Cover] Jianxi Wang, Cheng Zhou, Wei Liu, Jianjian Zhang, Xinyue Zhu, Xiaoyan Liu, Qin Wang and Haixia Zhang,* A near-infrared fluorescent probe based on chloroacetate modified naphthofluorescein for selectively detecting cysteine/homocysteine and its application in living cells. Photochemical & Photobiological Sciences, 2016, 15, 1393-1399. Jianjian Zhang, Chuwen Li, Rui Zhang, Fengyuan Zhang, Wei Liu, Xiaoyan Liu, Simon Ming-Yuen Lee,H aixia Zhang,* A Phosphinate-Based Near-Infrared Fluorescence Probe for Imaging the Superoxide Radical Anion in In Vitro and In Vivo. Chem.Commun., 2016, 52, 2679-2682. (Front Cover) Jianjian Zhang, Lulu Ning, Jiting Liu, Jianxi Wang, Bianfei Yu, Xiaoyan Liu,Xiaojun Yao, Zi-Ping Zhang, Haixia Zhang,* Naked-Eye and Near-Infrared Fluorescence Probe for Hydrazine and Its Applications in In Vitro and In Vivo Bioimaging. Anal.Chem., 2015, 87, 9101-9107. Jianjian Zhang, Jianxi Wang, Jiting Liu, Lulu Ning, Xinyue Zhu, Bianfei Yu, Xiaoyan Liu, Xiaojun Yao, Haixia Zhang,* Near-Infrared and Naked-Eye Fluorescence Probe for Direct and Highly Selective Detection of Cysteine and Its Application in Living Cells. Anal.Chem., 2015, 87, 4856-4863. Jianjian Zhang, Bianfei Yu, Lulu Ning, Xinyue Zhu, Jianxi Wang, Zhenjie Chen, Xiaoyan Liu, Xiaojun Yao, Xiaoyu Zhang, Haixia Zhang,* A Near-Infrared Fluorescence Probe for Thiols Based on Analyte-Specific Cleavage of Carbamate and Its Application in Bioimaging. Eur. J. Org. Chem., 2015, 1711-1718. Jianjian Zhang, Changsong Yan, Yu Peng,* Zhenbiao Luo, Xiaobo Xu, Yawen Wang, Total synthesis of(±)-sacidumlignans Dand Athrough Ueno-Stork radical cyclization reaction. Org.Biomol.Chem., 2013, 11, 2498-2513. Xinyue Zhu, Yan Li, Wenyan Zan, Jianjian Zhang, Zhenjie Chen, Xiaoyan Liu, Fengchao Qi, Xiaojun Yao, Xiaoyu Zhang, Haixia Zhang,* A two-photon off-on fluorescence probe for imaging thiols in live cells and tissues. Photochem.Photobiol.Sci., 2016, 15, 412-419. Xinyue Zhu, Jianxi Wang, Jianjian Zhang, Zhenjie Chen, Haixia Zhang,* Xiaoyu Zhang, Imaging of Fluoride Ion in Living Cells and Tissues with a Two-Photon Ratiometric Fluorescence Probe, Sensors, 2015, 15, 1611-1622. Xinyue Zhu, Hong Gao, Wenyan Zan, Yan Li, Jianjian Zhang, Xiaoyan Liu, Xuan Wei, Fengchao Qi, Xiaojun Yao, Haixia Zhang,* A rational designed thiols fluorescence probe:the positional isomer in PET. Tetrahedron, 2016, 72, 2048-2056. Yan Li, Yanxin Qiu, Jianjian Zhang, Xinyue Zhu, Bin Zhu, Xiaoyan Liu, Xiaoyu Zhang, Haixia Zhang,* Naphthalimide derived fluorescent probes with turn-on response for Au3+and the application for biological visualization, Biosens. Bioelectron., 2016, 83, 334-338. Jianxi Wang,Cheng Zhou,Jianjian Zhang,Xinyue Zhu,Xiaoyan Liu,Qin Wang,Haixia Zhang,*A new fluorescence turn-on probe for biothiols based on photoinduced electron transfer and its application in living cells,Spectrochim Acta A, 2016, 166, 31-37. Long Luo, Jianjian Zhang, Weijian Ling, Yongliang Shao, Yawen Wang, Yu Peng,* Unified Synthesis of(-)-Folicanthine and(-)-Ditryptophenaline Enabled by aRoom Temperature Nickel-Mediated Reductive Dimerization. Synthesis, 2014, 46, 1908-1916. Yu Peng,* Zhenbiao Luo, Jianjian Zhang, long Luo, Yawen Wang, Collective synthesis of several 2,7'-cyclolignans and their correlation by chemical transformations. Org.Biomol.Chem., 2013, 11, 7574-7586. Yu Peng,* Long Luo, Changsong Yan, Jianjian Zhang,Yawen Wang,Ni-Catalyzed Reductive Homocoupling of Unactivated Alkyl Bromides at Room Temperature and Its Synthetic Application. J.Org.Chem., 2013, 78, 10960-10967. Xiaobo Xu, Jian Liu, Jianjian Zhang, Yawen Wang, Yu Peng,* Nickel-Mediated Inter-and Intramolecular C-S Coupling of Thiols and Thioacetates with Aryl Iodides at Room Temperature. Org.Lett., 2013, 15, 550-553.

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