Schwaneberg, Ulrich - RWTH Aachen University

个人简介

EDUCATION 1996 - 1999 Dr. rer. nat. (PhD) Faculty of Chemistry, Institute of Technical Biochemistry, University Stuttgart, Germany (Group of Prof. R. D. Schmid) 1990 - 1996 Diploma in Chemistry Faculty of Chemistry, Institute of Technical Biochemistry, University Stuttgart, Germany (Group of Prof. R. D. Schmid) PREVIOUS POSITIONS 1999 – 2001 Postdoc at the California Institute of Technology (CalTech Fellowship), Division of Chemistry & Chemical Engineering, Pasadena, USA (Group of Prof. F. Arnold; Nobel prize winner 2018 in chemistry) 2002 - 2008 Professorship at the Jacobs University Bremen (renamed in 2006; International University Bremen), Faculty of Science, Bremen, Germany CURRENT POSITION(S) Since 01/2009 Head of the Institute of Biotechnology; (since 1/2014 reduced to a 50 % appointment); Faculty of Natural Science, Mathematics and Informatics, RWTH Aachen University, Germany Since 01/2014 Member of the Board of Scientific Directors at DWI-Leibniz Institute for Interactive Materials (50 % appointment; located at the RWTH Aachen Campus Melaten), Leibniz Gemeinschaft, Germany

研究领域

Research is organized in 5 divisions with the general goal to advance directed evolution methodologies to discover fundamental design principles of proteins, and to perform translational research within the areas of interactive materials (focus on plant health, medicine), biocatalysis, and circular bioeconomy. Developed protein engineering strategies such as KnowVolution are used to combine computational and experimental efforts and thereby to ensure efficient protein design with minimal experimental efforts and a molecular understanding of improved properties. Hybrid Catalysis & High Throughput Screening Molecular Bioeconomy Biohybrid Systems Next Generation Biocatalysis Computational Biology

近期论文

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Flexibility Regulation of Loops Surrounding the Tunnel Entrance in Cytochrome P450 Enhanced Substrate Access Substantially In: ACS catalysis, 12 (20), 12800-12808, 2022 [DOI: 10.1021/acscatal.2c02258]Li, Zhongyu Structure protects function - An enabler for the functionalization of component surfaces by biohybrid coatings In: Procedia CIRP, 110, 133-138, 2022 Using a bio-economic farm model to evaluate the economic potential and pesticide load reduction of the greenRelease technology In: Agricultural systems, 201, 103454, 2022 [DOI: 10.1016/j.agsy.2022.103454 Kuhn, Tuba (Corresponding author) Möhring, N. Töpel, Tobias Alexander. Jakob, Felix. Britz, W. High-Yield Synthesis of Enantiopure 1,2-Amino Alcohols from l-Phenylalanine via Linear and Divergent Enzymatic Cascades In: Organic process research & development, 26 (7), 2085-2095, 2022 [DOI: 10.1021/acs.oprd.1c00490]Corrado, Maria L. Knaus, Tanja (Corresponding author) Schwaneberg, Ulrich Mutti, Francesco G. (Corresponding author) Rational Design Yields Molecular Insights on Leaf-Binding of Anchor Peptides In: ACS applied materials & interfaces, 14 (25), 28412-28426, 2022 [DOI: 10.1021/acsami.2c00648] Dittrich, Jonas Brethauer, Christin. Goncharenko, Liudmyla. Bührmann, Jens. Zeisler-Diehl, Viktoria Structure protects function - An enabler for the functionalization of component surfaces by biohybrid coatings In: Procedia CIRP, 110, 133-138, 2022 [DOI: 10.1016/j.procir.2022.06.025] Bergs, Thomas. Schwaneberg, Ulrich. Apelt, Sebastian (Corresponding author) Jakob, Felix. Rodriguez-Emmenegger, Cesar BioAdhere: tailor-made bioadhesives for epiretinal visual prostheses In: Biomaterials science, 10 (12), 3282-3295, 2022[DOI: 10.1039/D1BM01946E] Hintzen, Kai-Wolfgang. Simons, Christian. Schaffrath, Kim Katharina. Rößler, Gernot F. Johnen, Sandra Combinatorial InVitroFlow-assisted mutagenesis (CombIMut) yields a 41-fold improved CelA2 cellulase In: Biotechnology & bioengineering, 10 (8), 2076-2087, 2022 [DOI: 10.1002/bit.28110] Körfer, Georgette Dorothea Johanna. Besirlioglu, Volkan. Davari, Mehdi D. Martinez, Ronny. Vojcic, Ljubica Conditioning of Feed Material Prior to Feeding: Approaches for a Sustainable Phosphorus Utilization In: Sustainability, 14 (7), 3998, 2022 [DOI: 10.3390/su14073998] Widderich, Niklas (Corresponding author) Mayer, Natalie. Ruff, Anna Joelle. Reckels, Bernd. Lohkamp, Florian Preparative Production of Functionalized (N- and O-Heterocyclic) Polycyclic Aromatic Hydrocarbons by Human Cytochrome P450 3A4 in a Bioreactor In: Biomolecules : open access journal, 12 (2), 153, 2022 [DOI: 10.3390/biom12020153]Srdič, Matic. Fessner, Nico D. Yildiz, Deniz. Glieder, Anton. Spiertz, Markus (Corresponding author) How Does Surface Charge Engineering of Bacillus subtilis Lipase A Improve Ionic Liquid Resistance? Lessons Learned from Molecular Dynamics Simulations In: ACS sustainable chemistry & engineering, 10 (8), 2689-2698, 2022 [DOI: 10.1021/acssuschemeng.1c07332] Pramanik, Subrata. Cui, Haiyang. Dhoke, Gaurao V. Yildiz, Can Bora. Vedder, Markus In Silico and Experimental ADAM17 Kinetic Modeling as Basis for Future Screening System for Modulators In: International journal of molecular sciences, 23 (3), 1368, 2022 [DOI: 10.3390/ijms23031368] Bienstein, Marian. Minond, Dmitriy. Schwaneberg, Ulrich. Davari, Mehdi D. (Corresponding author) Yildiz, Daniela (Corresponding author) Polar Substitutions on the Surface of a Lipase Substantially Improve Tolerance in Organic Solvents In: ChemSusChem : chemistry & sustainability, energy & materials, 15 (9), e202102551, 2022 [DOI: 10.1002/cssc.202102551] Cui, Haiyang. Vedder, Markus. Zhang, Lingling. Jaeger, Karl-Erich. Schwaneberg, Ulrich (Corresponding author) Optimized Hemolysin Type 1 Secretion System in Escherichia coli by Directed Evolution of the Hly Enhancer Fragment and Including a Terminator Region In: ChemBioChem : a European journal of chemical biology, 23 (6), e202100702, 2022 [DOI: 10.1002/cbic.202100702] Pourhassan, Zohreh N. Cui, Haiyang. Khosa, Sakshi. Davari, Mehdi D. Jaeger, Karl-Erich Critical assessment of structure-based approaches to improve protein resistance in aqueous ionic liquids by enzyme-wide saturation mutagenesis In: Computational and structural biotechnology journal, 20, 399-409, 2022 [DOI: 10.1016/j.csbj.2021.12.018] El Harrar, Till Davari, Mehdi D. Jaeger, Karl-Erich. Schwaneberg, Ulrich. Gohlke, Holger (Corresponding author) Phytase blends for enhanced phosphorous mobilization of deoiled seeds In: Enzyme and microbial technology, 153, 109953, 2021 [DOI: 10.1016/j.enzmictec.2021.109953] Infanzón, Belén. Herrmann, Kevin Rico. Hofmann, Isabell. Willbold, Sabine. Ruff, Anna Joelle (Corresponding author) Progress toward a bicarbonate-based microalgae production system In: Trends in biotechnology : TIBTECH, 40 (2), 180-193, 2022 [DOI: 10.1016/j.tibtech.2021.06.005] Zhu, Chenba. Chen, Shulin. Ji, Yu. Schwaneberg, Ulrich. Chi, Zhanyou (Corresponding author) Structure and Cooperativity in Substrate-Enzyme Interactions : Perspectives on Enzyme Engineering and Inhibitor Design In: ACS chemical biology, 17 (2), 266-280, 2022 [DOI: 10.1021/acschembio.1c00500] Rajakumara, Eerappa (Corresponding author) Abhishek, Suman. Nitin, Kulhar. Saniya, Dubey. Bajaj, Priyanka