Chan Cao - École polytechnique fédérale de Lausanne EPFL

个人简介

Education 09/2013 – 03/2017 Ph.D Key Laboratory for Advanced Materials & Department of Chemistry, East China University of Science and Technology, Shanghai, China. 09/2009 – 06/2013 Bachelor Department of Chemistry, East China University of Science and Technology, Shanghai, China. Academic Positions 12/2020 – now Scientist (PRIMA Group Leader) Institute of Bioengineering, School of Life Science, École Polytechnique Fédérale de Lausanne, Switzerland. 05/2017 – 11/2020 Postdoc Institute of Bioengineering, School of Life Science, École Polytechnique Fédérale de Lausanne, Switzerland. Advisor Prof. Dr. Matteo Dal Peraro Awards 11/2020 Annual Jeffrey Hubbell and Melody Swartz Young Bioengineer Award 09/2020 PRIMA Grant Award 03/2020 Synapsis Career Development Award 10/2019 Postdoc fellowship of the Peter and Traudl Engelhorn Foundation 08/2018 China Adolescents Science & Technology Innovation award 03/2018 Seal of excellence of Marie Sklodowska-Curie Fellowship application 11/2017 Shanghai Mayer Award of Youth Science and Technology Innovation 10/2017 China Association for Instrumental Analysis Award 04/2017 Shanghai Outstanding Member of Youth League 02/2017 EPFL fellows co-funded by Marie Sklodowska-Curie Fellowship 02/2017 Biophysical Society International Travel Award 12/2016 American Chemical Society Outstanding Graduate Student Research Award 12/2016 National Scholarship for PhD Graduate Student 07/2016 Gordon Research Conferences Poster Prize 12/2014 National Scholarship for Master Graduate Student 11/2014 Outstanding student award of East China University of Science and Technology 09/2013 Poster Prize of the 8th National Conference on Chemical Biology 06/2013 Excellent Graduation Thesis Award of Shanghai

研究领域

We are working on various aspects of molecular nanotechnology and bioengineering, particularly focusing on biological nanopore sensing, including engineering and design of biological nanopores, detection of protein biomarkers, single-molecule DNA/protein sequencing, and nanopore-based molecular digital data storage.

近期论文

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12/2020 Chan Cao, Lucien F. Krapp, Abdelaziz Al Ouahabi, Niklas F. König, Nuria Cirauqui, Aleksandra Radenovic*, Jean-François Lutz* and Matteo Dal Peraro*. Aerolysin nanopores decode digital information stored in tailored macromolecular analytes. Science Advance, 2020, 6, eabc2661. https://advances.sciencemag.org/content/6/50/eabc2661 11/2020 Jinming Wu, Chan Cao, Rolf Antonie Loch, Ann Tiiman and Jinghui Luo. Single- molecule studies of amyloid proteins: from biophysical properties to diagnostic perspectives. Quarterly Reviews of Biophysics, 2020, 53, E12. https://doi.org/10.1017/S0033583520000086 10/2019 Chan Cao*, Nuria Cirauqui, Maria Jose Marcaida, Elena Buglakova, Alice Duperrex, Aleksandra Radenovic, Matteo Dal Peraro*. Single-molecule sensing of peptides and nucleic acids by engineered aerolysin nanopores. Nature Communications, 2019, 10, 4918. https://www.nature.com/articles/s41467-019-12690-9#additional-information 01/2019 Shuang Li, Chan Cao*, Jie Yang and Yi-Tao Long*. Detection of peptides with different charges and lengths by using the aerolysin nanopore. ChemElectroChem 2019, 6, 126. https://onlinelibrary.wiley.com/doi/full/10.1002/celc.201800288 11/2018 Bing Zhou, Ya-Qian Wang, Chan Cao, Da-Wei Li*, Yi-Tao Long*. Monitoring disulphide bonds making and breaking in biological nanopore at single molecule level. Science China Chemistry, 2018, 61, 1385. https://link.springer.com/article/10.1007%2Fs11426-018-9231-2 08/2018 Yi-Lun Ying, Zi-Yuan Li, Zheng-Li Hu, Junji Zhang*, Fu-Na Meng, Chan Cao, Yi-Tao Long* and He Tian. Time-resolved single-molecular train based on aerolysin nanopore. Chem, 2018, 4, 1893. https://www.cell.com/chem/fulltext/S2451-9294(18)30213-4 07/2018 Chan Cao, Meng-Yin Li, Nuria Cirauqui, Ya-Qian Wang, Matteo Dal Peraro*, He Tian, Yi-Tao Long*. Mapping the sensing spots of aerolysin for single oligonucleotides analysis. Nature Communications, 2018, 9, 2823. https://www.nature.com/articles/s41467-018-05108-5 06/2018 Ya-Qian Wang, Mengyin Li, Hu Qiu, Chan Cao, Mingbo Wang, Xueyuan Wu, Jin Huang, Yi-Lun Ying*, Yi-Tao Long*. Identification of essential sensitive regions of the aerolysin nanopore for single oligonucleotide analysis. Analytical Chemistry, 2018, 90, 7790. https://pubs.acs.org/doi/10.1021/acs.analchem.8b01473 04/2018 Ya-Qian Wang#, Chan Cao#, Yi-Lun Ying, Shuang Li, Ming-Bo Wang, Jin Huang, and Yi-Tao Long*. Rationally designed sensing selectivity and sensitivity of an aerolysin nanopore via site-directed mutagenesis. ACS Sensors, 2018, 3, 779. https://pubs.acs.org/doi/10.1021/acssensors.8b00021 03/2018 Dong-Fang Liao, Chan Cao, Yi-Lun Ying* and Yi-Tao Long*. A general strategy of aerolysin nanopore detection for oligonucleotides with the secondary structure. Small, 2018, 14, 1704520. https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201704520 03/2018 Zheng-Li Hu, Zi-Yuan Li, Yi-Lun Ying*, Junji Zhang, Chan Cao, Yi-Tao Long and He Tian. Real-time and accurate identification of single oligonucleotide photoisomers via an aerolysin nanopore, Analytical chemistry, 2018, 90, 4268. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.8b00096 02/2018 Yi-Lun Ying, Chan Cao and Yi-Tao Long*. A single biomolecule interface for advancing the sensitivity, selectivity and accuracy of sensors. National Science Review, 2018, 5, 450. https://academic.oup.com/nsr/article/5/4/450/4862477 01/2018 Chan Cao, and Yi-Tao Long*. Biological nanopores: confined apaces for electrochemical single-molecule analysis. Accounts Chemical Research, 2018, 51, 331. https://pubs.acs.org/doi/10.1021/acs.accounts.7b00143 10/2017 Chan Cao, Jie Yu, Meng-Yin Li, Ya-Qian Wang, He Tian and Yi-Tao Long*. Direct readout of single nucleobase variations in an oligonucleotide. Small, 2017, 13, 1702011. https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201702011 10/2017 Jie Yu, Chan Cao, and Yi-Tao Long*. Selective and sensitive detection of methylcytosine in human serum by aerolysin nanopore. Analytical Chemistry, 2017, 21, 11685. https://pubs.acs.org/doi/10.1021/acs.analchem.7b03133 08/2017 Chan Cao#, Dong-Fang Liao#, Jie Yu, He Tian and Yi-Tao Long*. Construction of an aerolysin nanopore in a lipid bilayer for single-oligonucleotide analysis. Nature Protocols, 2017, 12, 1901. https://www.nature.com/articles/nprot.2017.077 11/2016 Jun-Gang Wang, John S Fossey, Meng Li, Da-Wei Li, Wei Ma, Yi-Lun Ying, Ruo-Can Qian, Chan Cao, Yi-Tao Long*. Real-time plasmonic monitoring of electrocatalysis on single nanorods. Journal of Electroanalytical Chemistry, 2016, 781, 257. https://www.sciencedirect.com/science/article/pii/S157266571630529X 08/2016 Chan Cao, Dong-Fang Liao, Yi-Lun Ying and Yi-Tao Long*. Detection of single oligonucleotide by an aerolysin nanopore. Acta Chimica Sinica 2016, 74, 734. http://sioc-journal.cn/Jwk_hxxb/CN/abstract/abstract345663.shtml 04/2016 Chan Cao, Yi-Lun Ying, Zheng-Li Hu, Dong-Fang Liao, He Tian and Yi-Tao Long*. Discrimination of oligonucleotides of different lengths with a wild-type aerolysin nanopore. Nature Nanotechnology, 2016, 11, 713. https://www.nature.com/articles/nnano.2016.66 05/2016 Yong-Xu Hu, Yi-Lun Ying, Zhen Gu, Chan Cao, Bing-Yong Yan, Hui-Feng Wang and Yi-Tao Long*. Single molecule study of initial structural features on the amyloidosis process. Chemical Communications, 2016, 52, 5542. Linkhttps://pubs.rsc.org/en/content/articlelanding/2016/CC/C6CC01292B#!divAbstract 04/2016 Chan Cao, Jie Yu, Ya-Qian Wang, Yi-Lun Ying and Yi-Tao Long*. Driven translocation of polynucleotides through an aerolysin nanopore. Analytical Chemistry, 2016, 88, 5046. https://pubs.acs.org/doi/10.1021/acs.analchem.6b01514 12/2015 Zheng-Li Hu, Chan Cao, Hui-Feng Wang, Bing-Yong Yan*. Alkyl detection facilitated by a DNA conjugate with an α-hemolysin nanopore. RSC Advances, 2016, 6, 105. https://pubs.rsc.org/en/content/articlelanding/2016/ra/c5ra20425a#!divAbstract 07/2015 Bing-Yong Yan, Zhen Gu, Rui Gao, Chan Cao, Yi-Lun Ying, Wei Ma, Yi-Tao Long*. A low noise amplifier system for nanoporebased single molecule analysis. Chinese Journal of Analytical Chemistry, 2015, 43, 971. https://www.sciencedirect.com/science/article/abs/pii/S187220401560843X 12/2014 Chan Cao, Yi-Lun Ying, Zhen Gu and Yi-Tao Long*. Enhanced resolution of low molecular weight poly(Ethylene Glycol) in nanopore analysis. Analytical Chemistry, 2014, 86, 11946. https://pubs.acs.org/doi/10.1021/ac504233s 12/2014 Zhen Gu, Yi-Lun Ying, Chan Cao and Yi-Tao Long*. Accurate data process for nanopore analysis. Analytical Chemistry, 2015, 87, 907. https://pubs.acs.org/doi/10.1021/ac5028758 06/2014 Yi-Lun Ying, Chan Cao and Yi-Tao Long*. Single molecule analysis by biological nanopore sensors. Analyst, 2014,139, 3826. https://pubs.rsc.org/en/content/articlelanding/2014/AN/C4AN00706A#!divAbstract 07/2013 Hai-Yan Wang, Zhen Gu, Chan Cao and Yi-Tao Long*. Analysis of a single α-synuclein fibrillation by the interaction with a protein nanopore. Analytical Chemistry, 2013, 85, 8254. https://pubs.acs.org/doi/10.1021/ac401496x 04/2013 Yu Liu, Yi-Lun Ying, Hai-Yan Wang, Chan Cao, Da-Wei Li, Wen-Qing Zhang and Yi-Tao Long*. Real-time monitoring of the oxidative response of a membrane–channel biomimetic system to free radicals. Chemical Communications, 2013, 49, 6584. https://pubs.rsc.org/en/content/articlelanding/2013/CC/c3cc41763h#!divAbstract 04/2013 Yi-Lun Ying, Junji Zhang, Fu-Na Meng, Chan Cao, Xuyang Yao, Itamar Willner, He Tian* and Yi-Tao Long*. A stimuli-responsive nanopore based on a photoresponsive host-guest system. Scientific Reports, 2013, 3, 16662. https://www.nature.com/articles/srep01662#supplementary-information