个人简介
张兴林博士，浙江大学生物系统工程与食品科学学院研究员，博士生导师（浙江大学“百人计划”），2017年入选国家重点人才计划（青年）。荷兰乌特勒支大学（Utrecht University）博士；英国牛津大学（University of Oxford）博士后，Rubicon fellow。
欢迎有微生物学相关专业背景的博士毕业生到实验室进行博士后研究！
其他英文学术出版物(书籍)：
Xinglin Zhang.Functional Genomics of Enterococcus faecium:Antibiotic Resistance and Niche Adaptation.(2013;book;国际标准书号ISBN:978-94-6108-407-1；共52819字)
教学与课程
研究生课程：肠道菌群、食品微生物。
课程内容围绕微生物领域内的最新进展。归纳总结知识要点，展望发展趋势。并带领学生细致分析实际研究案例，提高科研思维能力。
研究与成果
主要从事食源性致病菌的耐药和致病机理研究、微生物技术研发、细菌功能基因组学以及肠道菌群和益生菌研究。近年来以肠球菌、小肠炎耶尔森氏菌和布氏杆菌等为研究对象，结合新一代高通量测序技术和纳米新材料，建立和优化了M-TraM、Tn-seq、Cre-lox和热敏质粒介导的基因重组系统以及纳米颗粒磁性吸附技术等一系列国际领先的细菌微生物学方法，突破了肠球菌等重要细菌的研究瓶颈，搭建了有广泛应用价值的细菌学研究平台。在此基础上，张教授对肠球菌等细菌的耐药性、致病性、糖代谢、胆盐耐受以及遗传进化等方面进行了系统的研究，相关成果已发表在PLoS Genet、J Infect Dis、Environ Microbiol和Nature Nanotechnol等高影响力杂志上，并出版英文学术专著一本。
奖励荣誉
国家优秀（非公派）留学生奖学金（2013）
Chinese Government Award for Outstanding Self-financed Students Abroad
荷兰皇家微生物协会大会最佳报告奖（poster，1st/153）（2012）
Best Poster Presentation Award in Conference of Royal Netherlands Society for Microbiology
美国微生物协会学生旅费奖（2012）
American Society for Microbiology Student Travel Award
Eijkman-Winkler研究所最佳学术成果和最佳会议报告奖（2010）
Eijkman-Winkler Institute Award for excellent scientific achievement and presentation
美国微生物协会学生旅费奖（2010）
American Society for Microbiology Student Travel Award
中国农业大学校级优秀论文（2005）
中国农业大学动物医学院优秀毕业论文(1st/96)（2005）
国际会议报告（口头/展板）
X.Zhang,M.Rogers,et al.Combining enrichment culturing and metagenomic sequencing:characterization of populations of enterococci and Enterobacteriaceae during antibiotic therapy.114th ASM General Conference.第114届美国微生物协会大会美国2014
X.Zhang,D.Bierschenk,et al.Functional genomic analysis of bile salt resistance in Enterococcus faecium.7th International Conference on Gram-positive Microorganisms.第七届国际革兰氏阳性菌大会意大利2013
X.Zhang,J.Top,et al.Identification of a genetic determinant in clinical Enterococcus faecium strains which contributes to intestinal colonization during antibiotic treatment.Gut Day.肠道会议比利时2013
X.Zhang,F.L.Paganelli,D et al.Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium.112th ASM General Conference.第112届美国微生物协会大会美国2012
X.Zhang,F.L.Paganelli,D et al.Ampicillin resistance determinants of Enterococcus faecium.Annual EvoTAR meeting.EvoTAR年会法国2012
X.Zhang,F.L.Paganelli,D et al.Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium.NVMM&NVvM Scientific Spring Meeting.荷兰微生物协会春季大会荷兰2012
X.Zhang,I.Anastasiou,et al.Comprehensive identification of genes required for antibiotic resistance and bile tolerance in the nosocomial pathogen Enterococcus faecium.100th Anniversary NVvM&Scientific Spring Meeting.荷兰微生物协会100周年大会荷兰2011
X.Zhang,I.Anastasiou,et al.Development of Microarray-based Transposon Mapping in Enterococcus faecium and its application in the identification of genes required for bile resistance.ALW Platform Molecular Genetics Annual Meeting.ALW分子遗传学大会荷兰2010
X.Zhang,I.Anastasiou,et al.Development of Microarray-based Transposon Mapping(M-TraM)in Enterococcus faecium and its application in the identification of genes required for bile resistance.3rd International ASM Conference on Enterococci.美国微生物协会第三届肠球菌大会美国2010
X.Zhang,J.E.Vrijenhoek,M et al.A large conjugative plasmid confers the ability to utilizeα-galactoside sugars as carbon source in E.faecium.NVMM&NVvM Scientific Spring Meeting.荷兰微生物协会春季大会荷兰2010
X.Zhang,J.E.Vrijenhoek,M et al.A novel conjugative element from Enterococcus faecium involved inα-galactoside metabolism.ESCMID Conference on Enterococci.欧洲临床微生物与传染病协会肠球菌大会西班牙2009
X.Zhang,J.E.Vrijenhoek et al.A novel conjugative element from Enterococcus faecium involved inα-galactoside metabolism.FEMS.欧洲微生物协会大会瑞典2009
X.Zhang,J.E.Vrijenhoek,et al.Metabolism ofα-galactosides in Enterococcus faecium.NVMM&NVvM Scientific Spring Meeting.荷兰微生物协会春季大会荷兰2009
出版著作
Xinglin Zhang.Functional Genomics of Enterococcus faecium:Antibiotic Resistance and Niche Adaptation.(2013;book;国际标准书号ISBN:978-94-6108-407-1；共52819字)
主持的科研项目
浙江大学“百人计划”启动项目2017年-2020年
青年项目2016年-2022年
欧盟荷兰科研组织（NWO）Rubicon项目
Comprehensive analyses of the essential genome and the virulence determinants of Yersinia enterocolitica
参与申请或实施的重要科研项目
欧盟第六框架计划“预防和控制多重耐药肠球菌”项目
European Union Sixth Framework Programme“Approaches to Control multi-resistant Enterococci(ACE):Studies on molecular ecology,horizontal gene transfer,fitness,and prevention”under contract LSHE-CT-2007-037410.
欧盟第七框架计划“细菌耐药性的进化和传播”项目
European Union Seventh Framework Programme(FP7-HEALTH-2011-single-stage)“Evolution and Transfer of Antibiotic Resistance”(EvoTAR)under grant agreement number 282004.
荷兰科研组织（NWO）VINI项目
Functional genomics of Enterococcus faecium.
荷兰科研组织（NWO）VIDI项目
From harmless gut commensal to antibiotic-resistant hospital bug.
英国Wellcome Trust项目
Bacterial immune evasion.
实验室介绍
实验室每年招收1-2名博士和硕士研究生，欢迎报考和咨询。
面向海内外招收博士后2名，欢迎生物学相关研究领域，已经取得或即将取得博士学位的科研人员发送简历申报或邮件咨询。浙江大学和本课题组将提供不低于15万元的年薪以及租住公寓等福利。合同期限一般为2-6年，期间可以竞聘浙大事业编制的副教授岗位。实验室与牛津大学等国际著名高校保持密切合作关系，鼓励博士后和研究生出国交流深造，学校每年将提供会议专项资金。
近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
B.Peng†,X.Zhang†,D.G.A.L.Aarts and R.Dullens.2017.Superparamagnetic colloidal nickel nanocrystal clusters with antibacterial activity and bacteria binding ability.Nat Nanotechnol(Accepted)（IF：38.9）(†:Co-first author)
X.Zhang,V.de Maat,A.M.Guzmán,T.K.Prajsnar,J.R.Bayjanov,M.de Been,M.R.C.Rogers,M.J.M.Bonten,S.Mesnage,R.J.L.Willems,W.van Schaik.2017.RNA-seq and Tn-seq reveal fitness determinants of vancomycin-resistant Enterococcus faecium during growth in human serum.BMC Genomics(Accepted)（IF：3.7）
A.M.Guzmán,J.Wijngaarden,J.C.Braat,MRC Rogers,Majoor E,E.C.Brouwer,X.Zhang,J.R.Bayjanov,M.J.M.Bonten,R.J.L.Willems,W.van Schaik.2017.The Two-Component System ChtRS Contributes to Chlorhexidine Tolerance in Enterococcus faecium.Antimicrob Agents Chemother 61(5).pii:e02122-16.（IF：4.3）
F.L.Paganelli,J.Huebner,K.V.Singh,X.Zhang,D.Wobser,J.C.Braat,B.E.M.Murray,J.M.Bonten,R.J.L.Willems,H.L.Leavis.2016.Identification of Phosphoenolpyruvate-Phosphotransferase system permease BepA involved in Enterococcus faecium endocarditis and biofilm formation by a genome-wide screening approach.J Infect Dis 15;214(2):189-95..（IF：6.0）
A.M.Guzmán,R.T.Urbanus,X.Zhang,D.Bierschenk,A.Koekman,M.van Luit-Asbroek,J.P.Ouwerkerk,M.Pape,M.Roest,M.J.M.Bonten,R.J.L.Willems,W.van Schaik.2015.The N-terminal domain of the thermo-regulated surface protein PrpA of Enterococcus faecium binds to fibrinogen,fibronectin and platelets.Sci.Rep 17;5:18255..（IF：5.6）
R.Ladjouzi,A.Bizzini,W.van Schaik,X.Zhang,A.Rincé,A.Benachour,A.Hartke.2015.Loss of antibiotic tolerance in Sod-deficient mutants is dependent on the energy source and arginine catabolism in enterococci.J Bacteriol DOI:10.1128/JB.00389-15.（IF：2.8）
X.Zhang*,M.Rogers,D.Bierschenk,M.J.Bonten,R.J.Willems,W.van Schaik.2013.A LacI-family regulator activates maltodextrin metabolism of Enterococcus faecium.PLoS One 8(8):e72285.doi:10.1371/journal.pone.0072285.（IF：4.1；*通讯作者）
X.Zhang*,D.Bierschenk,J.Top,I.Anastasiou,M.J.Bonten,R.J.Willems,and W.van Schaik.2013.Functional genomic analysis of bile salt resistance in Enterococcus faecium.BMC Genomics 14:299 doi:10.1186/1471-2164-14-299.（IF：4.1；*通讯作者）
J.Top,F.L.Paganelli,X.Zhang,W.van Schaik,H.L.Leavis,M.van Luit-Asbroek,T.van der Poll,M.Leendertse,M.J.Bonten,R.J.Willems.2013.The Enterococcus faecium enterococcal biofilm regulator,EbrB,regulates the esp operon and is implicated in biofilm formation and intestinal colonization.PLoS One 8(5),e65224.（IF：4.1）
X.Zhang,J.Top,M.de Been,D.Bierschenk,M.Rogers,M.Leendertse,M.J.Bonten,T.van der Poll,R.J.Willems,W.van Schaik.2013.Identification of a genetic determinant in clinical Enterococcus faecium strains which contributes to intestinal colonization during antibiotic treatment.J Infect Dis 207(11):1780-1786.doi:10.1093/infdis/jit076.（IF：6.4）
F.L.Paganelli,R.J.Willems,P.Jansen,A.Hendrickx,X.Zhang,M.J.Bonten,H.L.Leavis.2013.Enterococcus faecium biofilm formation:identification of major autolysin AtlAEfm,associated Acm surface localization,and AtlAEfm-independent extracellular DNA release.mBio doi:10.1128/mBio.00154-13.（IF：5.3）
X.Zhang,F.L.Paganelli,D.Bierschenk,A.Kuipers,M.J.Bonten,R.J.Willems,and W.van Schaik.2012.Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium.PLoS Genet 8:e1002804.（IF：9.5）
F.Lebreton,W.van Schaik,M.Sanguinetti,B.Posteraro,R.Torelli,F.L.Bras,N.Verneuil,X.Zhang,A.Dhalluin,R.J.Willems,R.Leclercq and V.Cattoir.2012.AsrR is an Oxidative stress sensing regulator modulating Enterococcus faecium opportunistic traits,antimicrobial resistance and pathogenicity.PLoS Pathog 8(8):e1002834.（IF：9.1）
X.Zhang,J.E.Vrijenhoek,M.J.Bonten,R.J.Willems,and W.van Schaik.2011.A genetic element present on megaplasmids allows Enterococcus faecium to use raffinose as carbon source.Environ Microbiol 13:518-28.（IF：5.5）
X.Zhang,J.Ren,N.Li,W.Liu,and Q.Wu.2009.Disruption of the BMEI0066 gene attenuates the virulence of Brucella melitensis and decreases its stress tolerance.Int J Biol Sci 5:570-7.(2014 IF:4.5）
Y.L.Cong,J.Pu,Q.F.Liu,S.Wang,G.Z.Zhang,X.L.Zhang,W.X.Fan,E.G.Brown,and J.H.Liu.2007.Antigenic and genetic characterization of H9N2 swine influenza viruses in China.J Gen Virol 88:2035-41.（IF：3.1）
J.Liu,H.Xiao,F.Lei,Q.Zhu,K.Qin,X.W.Zhang,X.L.Zhang,D.Zhao,G.Wang,Y.Feng,J.Ma,W.Liu,J.Wang,and G.F.Gao.2005.Highly pathogenic H5N1 influenza virus infection in migratory birds.Science 309:1206.（IF：31.9）
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