马梅 - 中国科学院大学 - 资源与环境学院

个人简介

招生专业 083001-环境科学招生方向水生态毒理学教育背景 1996-09--中科院生态环境研究中心博士 1986-09--北京大学医学部药学院化学与生物学系理学学士工作简历 2008-03~现在, 中科院生态环境研究中心, 研究员 2001-12~现在, 中科院生态环境研究中心, 副研究员 1996-09~现在, 中科院生态环境研究中心, 博士 1996-07~现在, 中科院生态环境研究中心, 助理研究员 1991-07~现在, 中科院生态环境研究中心, 研究实习员 1986-09~现在, 北京大学医学部药学院化学与生物学系, 理学学士教授课程环境水质学奖励信息（1）基于鱼法的生物预警关键技术研究及在北京市南水北调工程中的应用，2016年度北京水务科学技术奖，三等奖，2016。, 三等奖, 其他, 2016 （2）基于人核受体超家族监测环境内分泌干扰物的新技术及应用, 二等奖, 部委级, 2013 专利成果（ 1 ）检测类/抗甲状腺激素化合物的双杂交酵母及检测方法, 2011, 第 3 作者, 专利号: 200710308507.3 （ 2 ）检测类/抗维甲酸化合物的双杂交酵母以及生物测试方法, 2011, 第 3 作者, 专利号: 200710308511.X 科研项目（ 1 ）化学品毒性的高通量生物测试与评价技术, 主持, 国家级, 2012-01--2014-12 （ 2 ）水环境中有机磷阻燃剂的环境暴露、生态风险和毒理机制, 参与, 国家级, 2015-01--2019-12 （ 3 ）饮用水复合污染风险因子识别与控制原理, 参与, 部委级, 2017-01--2021-12 （ 4 ）南水北调水质健康效应评估体系标准化研究及应用, 参与, 省级, 2017-04--2019-03 （ 5 ）基于离体生物测试指导的地表水复合污染诊断方法研究, 主持, 国家级, 2020-01--2023-12 参与会议（1）有机磷酸酯阻燃剂的线粒体损伤与神经毒性作用机制研究第五届生态毒理学学术研讨会马梅，黄超，王子健 2018-04-25

近期论文

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（1） Tricresyl phosphate isomers exert estrogenic effects via G proteincoupled estrogen receptor-mediated pathways, Environmental Pollution, 2020, 通讯作者（2） In vitro estrogen-disrupting effects of organophosphate flame retardants, Science of the Total Environment, 2020, 通讯作者（3） In vitro oxidative stress, mitochondrial impairment and G1 phase cell cycle arrest induced by alkyl-phosphorus-containing flame retardants, Chemosphere, 2020, 通讯作者（4） In Vitro Immunotoxicity of Organophosphate Flame Retardants in human THP-1-Derived Macrophages, Environ. Sci. Technol., 2020, 通讯作者（5）壬基酚雌激素受体介导的共激活因子招募的新的分子事件研究, The steroid receptor coactivator 1 (SRC1) and 3 (SRC3) recruitment as a novel molecular initiating event of 4-n-nonylphenol in estrogen receptor αmediated pathways, Ecotoxicology and Environmental Safety, 2020, 通讯作者（6） Comparative toxicity study of a novel non-ionic surfactant, vanillin ethoxylates, and nonylphenol ethoxylates in Chinese hamster ovary cells in vitro, Journal of environmental sciences, 2019, 通讯作者（7） A comparison of endocrine disruption potential of nonylphenol ethoxylate, vanillin ethoxylate, 4-n-nonylphenol and vanillin in vitro, Ecotoxicology and Environmental Safety, 2019, 通讯作者（8） Aryl-phosphorus-containing flame retardants induce oxidative stress, the p53-dependent DNA damage response and mitochondrial impairments in A549 cells, Environmental Pollution, 2019, 通讯作者（9） Insight into the generation of toxic products during chloramination of carbamazepine: Kinetics, transformation pathway and toxicity, Science of the Total Environment, 2019, 通讯作者（10） Simultaneous passive sampling of hydrophilic and hydrophobic emerging organic contaminants in water, Ecotoxicology and Environmental Safety, 2019, 通讯作者（11） Triple functional small-molecule-protein conjugate mediated optical biosensor for quantification of estrogenic activities in water, Environment International, 2019, 第 5 作者（12） The Molecular Mechanism of the Antagonistic Activity of Hydroxylated Polybrominated Biphenyl (OH-BB80) toward Thyroid Recepto, Science of the Total Environment, 2019, 第 5 作者（13）加氯，氯胺和臭氧消毒卡马西平的毒性, Chlorination, chloramination and ozonation of carbamazepine enhance cytotoxicity and genotoxicity: Multi-endpoint evaluation and identification of its genotoxic transformation products, Journal of Hazardous Materials, 2018, 通讯作者（14）氯代多环芳烃的Ah受体效应和DNA损伤效应, The aryl hydrocarbon receptor (AhR) activity and DNA-damaging effects of chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs), Chemosphere, 2018, 通讯作者（15）多种雌激素污染物对MCF-7细胞增殖联合效应的预测及相关基因分析, Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression, Ecotoxicology and Environmental Safety, 2018, 通讯作者（16）十种皮革化学品的细胞和遗传毒性的高内涵分析, In vitro Cytotoxicity and Genotoxicity Analysis of Ten Tannery Chemicals Using SOS/umu Tests and High-content In vitro Micronucleus Tests, Combinatorial Chemistry & High Throughput Screening,, 2018, 通讯作者（17）双酚S的甲状腺受体作用，离体，活体和分子动力模拟研究, Thyroid Disruption by Bisphenol S Analogues via Thyroid Hormone Receptor β: in Vitro, in Vivo, and Molecular Dynamics Simulation Study, Environ. Sci. Technol, 2018, 第 3 作者（18）黄超，李娜，袁圣武，季晓亚，马梅*，饶凯锋，王子健，有机磷阻燃剂诱导的CHO细胞线粒体损伤和死亡机制研究，环境污染，2017，2307,775, Chao Huang, Na Li, Shengwu Yuan, Xiaoya Ji, Mei Ma *, Kaifeng Rao, Zijian Wang，Aryl- and alkyl-phosphorus-containing flame retardants induced mitochondrial impairment and cell death in Chinese hamster ovary (CHO-k1) cells，Environmental Pollution 230 (2017) 775-786, Environmental Pollution, 2017, 通讯作者（19）季晓亚，李娜，袁圣武，黄超，饶凯锋，马梅* ，王子健，环境雌激素生物效应的作用机制研究进展，生态毒理学报，2017,12（1）38-51, Ji Xiaoya , Li Na , Yuan Shengwu , Huang Chao , Rao Kaifeng , Ma Mei* , Wang Zijian，Ｒesearch Progress in the Mechanisms for Biological Effects of Environmental Estrogens，Asian Journal of Ecotoxicology， 2017 Vol. 12, No.1, 38-51, 生态毒理学报, 2017, 通讯作者（20）环境污染物导致氧化应激的关键信号通路及其检测方法, Yuan Shengwu1，Huang Chao1， Ji Xiaoya1，Ma Mei，Main Signaling Pathways and Detection Methods of Oxidative Stress Caused by Environmental Pollutants，Asian Journal of Ecotoxicology， 2017，12, No.1, 25-37, 生态毒理学报, 2017, 通讯作者（21） Development of a data-processing method based on Bayesian k-means clustering to discriminate aneugens and clastogens in a high-content micronucleus assay,, Human and Experimental Toxicology, 2017, 通讯作者（22） 59. Na Li, Weiwei Jiang, Mei Ma*, Donghong Wang, Zijian Wang，Chlorination by-products of bisphenol A enhanced retinoid X receptordisrupting effects, Journal of Hazardous Materials, 2016, 通讯作者（23） Evaluation of genotoxic effects of surface waters using a battery of Bioassays indicating different mode of action, Ecotoxicology and Environmental Safety, 2016, 通讯作者（24） Combined action of estrogen receptor agonists and antagonists in two-hybrid recombinant yeast in vitro, Ecotoxicol. Environ. Saf. 2015, 111(1):228-235, 2015, 通讯作者（25） Combined effects of estrogenic chemicals with the same mode of action using an estrogen receptor binding bioassay, Environmental Toxicology and Pharmacology, 2014, 通讯作者（26） Application of the SOS/umu test and high-content in vitro micronucleus test to determine genotoxicity and cytotoxicity of nine benzothiazoles, Journal of Applied Toxicology, 2014, 通讯作者（27） Liu Nannan, Ma Mei, Xu Yiping, Zha Ji nmiao, Rao Kaifeng, Wang Zijian. 2013. Susceptibility of male and female Japanese medaka (Oryzias latipes) to 2,4,6-trichlorophenol-induced micronuclei in peripheral erythrocytes, Frontiers of Environmental Science ＆Engineering., 2013, 通讯作者（28） Assessment of source water contamination by estrogenic disrupting compounds in China. Journal of Environmental Sciences, Journal of Environmental Sciences (China),, 2012, 通讯作者（29） Retinoid X receptor activities of source waters in China and their removal efficiencies of drinking water treatment processes. , Chinese Science Bulletin, 2012, 通讯作者（30） 45. Jianping Luo a,b, Bingli Lei a, Mei Maa, Jinmiao Zha a, Zijian Wang，Identification of estrogen receptor agonists in sediments from Wenyu River, Beijing, China，, water re search, 2011, 第 3 作者（31） In vitro assay for human thyroid hormone receptor ？ agonist and antagonist effects of individual polychlorinated naphthalenes and Halowas mixtures, , Chinese Science Bulletin , 2011, 第 2 作者（32） Dibutyl Phthalate Contributes to the Thyroid Receptor Antagonistic Activity in Drinking Water Processes, Environmental Science and Technology, 2010, 第 4 作者（33） Analysis of Environmental Endocrine Disrupting Activities Using Recombinant Yeast Assay in Wastewater Treatment Plant Effluents. , Bulletin of Environmental Contamination and Toxicology,, 2010, 第 3 作者（34） Jian Li, Mei Ma, Zijian Wang, In vitro profiling of endocrine disrupting effects of phenols, Toxicology in Vitro , 2010, 第 2 作者（35） Luo, J. P.; Ma, M.; Liu, C.; Zha, J. M.; Wang, Z. J. 2009. Impacts of particulate organic carbon and dissolved organic carbon on removal of polycyclic aromatic hydrocarbons, organochlorine pesticides, and nonylphenols in a wetland., J SOIL SEDIMENT, 2009, 第 2 作者（36） Luo, J. P.; Ma, M.; Zha, J. M.; Wang, Z. J. 2009. Characterization of aryl hydrocarbon receptor agonists in sediments of Wenyu River, Beijing, China., WATER RES., 2009, 第 2 作者（37） Jian Li, Mei Ma, Zijian Wang. 2008. A two-hybrid yeast assay to quantify the effects of xenobiotics on thyroid hormone-mediated gene expression., Environmental Toxicology and Chemistry., 2008, 第 2 作者（38） Jian Li, Mei Ma, and Zijian Wang, A Two-hybrid Yeast Assay to Quantify the Effects of Xenobiotics on Retinoid X Receptor -mediated Gene Expression. , Toxicology Letters. , 2008, 第 2 作者