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个人简介

2019.7-至今, 中国科学院心理研究所,副研究员 2016.12-2017.6 美国国立卫生研究院(NIH) 访问学者 2012.7- 2019.7 中国科学院心理研究所,助理研究员 2007.9-2012.7 北京大学生命科学学院,生理学专业,博士 2003.9-2007.7 兰州大学生命科学学院,生物学基地班,学士 获奖及荣誉: 2020年入选中国科学院青年创新促进会会员 北京市科学技术三等奖,病理性成瘾记忆加工的神经环路调控及分子机制 承担科研项目情况: 1.国家自然科学基金面上项目“海马CA1中TET介导的DNA去甲基化调控吗啡成瘾相关记忆形成的机制”,课题编号31871111,2019.01.01-2022.12.31 2.国家自然科学基金青年科学基金项目“杏仁核调控阿片类药物成瘾记忆再巩固的DNA甲基化机制”,课题编号31400880,2015.01.01-2017.12.31(已结题) 3.中国科学院心理健康重点实验室自主研究课题面上项目“岛叶调控吗啡成瘾负性情绪记忆再巩固的DNA甲基化机制”,课题编号KLMH2014ZG02,2014.12.1-2016.12.31(已结题) 4.中科院心理所青年人才科研启动项目“外侧杏仁核调控阿片类药物成瘾行为的电生理机制”,课题编号Y2CQ061005,2013.1-2014.12(已结题)

研究领域

健康与遗传心理学 药物成瘾 健康与遗传心理学 情绪 健康与遗传心理学 记忆、认知表观遗传学

以大鼠为主要动物模型,通过化学遗传学、光遗传学、膜片钳、内窥成像、分子生物学、生物化学及药理学等技术手段,研究药物成瘾及情绪记忆的脑机制,特别是表观遗传与神经环路调控机制。 具体方向: 1. 药物成瘾的表观遗传学调控机制 2. 情绪记忆的神经环路调控机制

近期论文

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1. Jiang F-Z, Zheng W, Wu C, Li Y-H, Shen F, Liang J, Li M, Zhang J.J*, Sui N. *. Double dissociation of inhibitory effects between the hippocampal TET1 and TET3 in the acquisition of morphine self-administration in rats. Addict Biol. 2020, e12875. doi: 10.1111/adb.12875. (*co-Correspondence) 2. Wei, Z. X., Chen, L., Zhang, J. J. *, & Cheng, Y*. Aberrations in peripheral inflammatory cytokine levels in substance use disorders: a meta-analysis of 74 studies. Addiction. 2020, doi:10.1111/add.15160 3. Zhang J.J.#, Jiang F.Z.#, Zheng W., Duan Y., Jin S.B., Shen F., Liang J., Li M., Sui N., DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats. Addict Biol., 2019 (#co-first author) 4. Zhang, J. J. * & Kong, Q, Locomotor activity: A distinctive index in morphine self-administration in rats. Plos One, 2017, 12 (4):e0174272. 5. Zhang, J. J., Liu, X. D., & Yu, L. C. *, Influences of morphine on the spontaneous and evoked excitatory postsynaptic currents in lateral amygdala of rats. Physiol Res., 2016, 65 (1), 165–169. 6. Zhang, J. J., Han, J., & Sui, N, Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats. Neuropharmacology, 2014, 86, 282-293. 7. Zhang, J. J., Ma, X., & Yu, L. C, Repeated paired-testing impairs extinction of morphine-induced conditioned place preference dependent on the inter-test interval in rats. Neurosci Lett, 2012, 516(1), 72-74. 8. Ma, X. #, Zhang, J. J. #, & Yu, L. C, Post-retrieval extinction training enhances or hinders the extinction of morphine-induced conditioned place preference in rats dependent on the retrieval-extinction interval. Psychopharmacology (Berl), 2012, 221(1), 19-26. (#co-first author) 9. Liu, P.#, Zhang, J. J.#, Li, M., & Sui, N.*, Distinctive Roles of 5-Aza-2′-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats. Front Behav Neurosci, 2016, 15;10:50. (#co-first author) 10. Lin, X. J.#, Zhang, J. J.#, & Yu, L. C. *, GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place-Preference in Rats. Neurosci. Bull., 2016, 32 (2), 177–182. (#co-first author) 11. Jiang, X. #, Zhang, J. J. #, Wang, M. Y., & Sui, N, Differential muscarinic modulation of synaptic transmission in dorsal and ventral regions of the rat nucleus accumbens core. Physiol Res, 2014, 63(1), 135-142. (# equal contribution) 12. Li, Xuan.,Carreria, Maria B..,Witonsky, Kailyn R..,Zeric, Tamara.,Lofaro, Olivia M.., Zhang, J. J., ...&Shaham, Yavin. Role of Dorsal Striatum Histone Deacetylase 5 in Incubation of Methamphetamine Craving. Biological psychiatry, 2018, (17),32314-4. 13. Li, Xuan.,Witonsky, Kailyn R..,Lofaro, Olivia M..,Surjono, Felicia.,Zhang, Jianjun.,...&Shaham, Yavin. Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving. JOURNAL OF NEUROSCIENCE, 2018, 38(9),2270-2282. 14. Wang, Xingyue.,Qiao, Yanhua.,Dai, Zhonghua.,Sui, Nan.,Shen, Fang., Zhang, Jianjun., &Liang, Jing.(2019).Medium spiny neurons of the anterior dorsomedial striatum mediate reversal learning in a cell-type-dependent manner. BRAIN STRUCTURE & FUNCTION,224(1),419-434. 15. Liu, Z., Zhang, J. J., Liu, X. D., & Yu, L. C, Inhibition of CaMKII activity in the nucleus accumbens shell blocks the reinstatement of morphine-seeking behavior in rats. Neurosci Lett, 2012, 518(2), 167-171. 16. Liu, X. D., Zhang, J. J., Wang, Y., & Yu, L. C, Inhibitory effects of calcitonin gene-related peptide on long-term potentiation induced in hippocampal slices of rats. Neurosci Lett, 2011, 494(1), 10-13. 17. Li, J., Zhang, J. J., Xu, S. L., & Yu, L. C, Antinociceptive effects induced by injection of the galanin receptor 1 agonist M617 into central nucleus of amygdala in rats. Neurosci Lett, 2012, 526(1), 45-48. 18. Liu, Z., Liu, X. D., Zhang, J. J., & Yu, L. C, Increases in alphaCaMKII phosphorylated on Thr286 in the nucleus accumbens shell but not the core during priming-induced reinstatement of morphine-seeking in rats. Neurosci Lett, 2012, 526(1), 39-44. 19. Xu, S. L., Li, J., Zhang, J. J., & Yu, L. C, Antinociceptive effects of galanin in the nucleus accumbens of rats. Neurosci Lett, 2012, 520(1), 43-46. 20. Liu, X. D., Liu, Z., Kong, Q. Y., Zhang, J. J., Wang, Y., & Yu, L. C, Different physiological properties of spontaneous excitatory postsynaptic currents in nucleus accumbens shell neurons between adult and juvenile rats. Neurosci Lett, 2011, 496(2), 80-83.

学术兼职

中国毒理学会药物依赖性毒理学专业委员会青年委员(2018.12.01-2023.11.30) 中国药物滥用防治协会青年专家委员会委员(2017.05.10-2022.05.09) 担任European Journal of Pharmaceutical Sciences,Aging,Behavioural Brain Research,Brain and Behavior,Current Cancer Drug Targets,心理学报,心理科学进展,生理科学进展等多个重要学术期刊的审稿人

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