Hu, Tony Ye - Tulane University - School of Medicine

个人简介

Weatherhead Presidential Chair in Biotechnology Innovation Professor, Biochemistry and Molecular Biology Professor, Division of Microbiology, Tulane National Primate Research Center Professor, Department of Biomedical Engineering

研究领域

We employ biomarker function, sequence, and expression (stage-specificity and abundance) information to design assays to comprehensively profile the pathological status of an individual. We focus on diseases with unmet diagnostic/prognostic needs, and utilize nanomaterial properties to address issues that limit conventional assays. We also consider the feasibility of translating an assay into a clinical application early in the design process to improve its potential for subsequent translation. My group utilizes nanomaterials, which offer multiple properties that can be exploited to allow disease diagnosis with biomarkers, samples, and/or methods that would not otherwise be feasible, particularly in clinical applications. We have developed several integrated procedures that utilize nanomaterials to improve the sensitivity and reliability of biomarker quantification, most of which can be readily repurposed to assay different biomarkers, including biomarkers for emerging diseases, by altering their surface properties or affinity, to reduce assay development and clinical translation effort. We have used this platform flexibility to produce TB and HIV-1 assays and to develop assays for non-tuberculous mycobacteria (NTM) and Ebolavirus species responsible for human disease.

近期论文

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Bao, D., Maity, S., Zelanzny, A., Lyon, C.,Fan, J. Improving Targeted Mass Spectrometry Data Analysis with Nested Active Machine Learning. 2024, 2300773. Li, L., Henkle, E., Youngquist, B., Seo, S., Hamed, K., Melnick, D., Lyon, C., Jiang, L., Zelazny, A.,Hu, T., Winthrop, K., Ning, B. Serum cell-free DNA-based detection of Mycobacterium avium complex infection. Am. J. Respir. Crit. Care Med. 2024, 209(10):1246-1254.. Das, S., Lyon, C., Hu, T. A Panorama of Extracellular Vesicle Applications: From Biomarker Detection to Therapeutics. ACS Nano. 2024, 18(14): 9784–9797. Liao, H., Lyon, C., Ying, B., Hu, T. Climate change, its impact on emerging microbial infectious diseases and new technologies to combat the challenge. Emerging Microbes & Infections. 2024, 13(1):2356143. Huang G., Zheng, W., Wan, M., Hu, T. Recent Advances to Address Challenges in Extracellular Vesicles-Based Application for Lung Cancer. Acta Pharmaceutica Sinica B. 2024. Li, L., Lyon, C. J., LaCourse, S. M., Zheng, W., Stern, J., Escudero, J. N., Murithi, W., Njagi, L., John-Stewart, G., Hawn, T., Nduba, V., Abdelgaliel, W., Tombler, T., Horne. D., Jiang, L., Hu, T.Sensitive detection of HIV-1 and Mycobacterium tuberculosis peptides in blood for rapid diagnosis of co-infected individuals by immuno-affinity liquid chromatography tandem mass spectrometry. Clinical Chemistry. 2023, 69(12):1409-1419. Huang, Z., Lyon, C., Wang, J., Lu, S., Hu, T. CRISPR assays for disease diagnosis: progress to and barriers remaining for clinical applications. Advanced Science. 2023, e2301697. Huang, Z., Zhang, G., Lyon, C., Hu, T., Lu, S. Outlook for CRISPR-based tuberculosis assays now in their infancy. Frontier in Immunology. 2023, 14:1172035. Li, L., Wu, J., Lyon, C., Jiang, L., Hu, T. Clinical Peptidomics: Advances in Instrumentation, Analyses, and Applications. BME Frontiers. 2023. 4:0019. Li, C.Z. and Hu, T. (2022) Nanotechnology Powered CRISPR-Cas Systems for Point of Care Diagnosis and Therapeutic. Research. 2023. 2022:9810237. Monk, C., Youngquist, B., Brady, A., Shaffer, J., Hu, T., Ning, B., Zwezdaryk, K. Development of a CRISPR-Cas12a rapid diagnostic for human cytomegalovirus. Antiviral Research. 2023. 215:105624. Toraih, E.A., Fawzy, M.S., Ning, B., Zerfaoui, M., Errami, Y., Ruiz, E.M., Hussein, M.H., Haidari, M., Bratton, M., Tortelote, G.G., Hilliard, S., Nilubol, N., Russell, J.O., Shama, M.A., El-Dahr, S.S., Moroz, K., Hu, T., and Kandil E. A miRNA-Based Prognostic Model to Trace Thyroid Cancer Recurrence. Cancers. 2023. 14(17):4128. Maity, S., Mayer, M., Shu, Q., Bao, D., Blair, R., He, Y., Lyon, C., Hu, T., Fischer, T., Fan, J.Cerebrospinal fluid protein markers indicate neuro-damage in SARS-CoV-2-infected non-human primates. Molecular and Cellular Proteomics. 2023, 22(4):100523. Huang, Z., Lyon, C., Hu, T. CRISPR-based assays for low-resource settings. Nature Reviews Bioengineering. 2023. Li, L., Zhang, L., Montgomery, K., Lyon, C., Hu, T. Advanced Technologies for Molecular Diagnosis of Cancer: State of Pre-Clinical Tumor-Derived Exosome Liquid Biopsies. Materials Today Bio. 2023, 100538. Wu, J., Lin, Z., Zou, Z., Wu, M., Hu, T.*, Zhang, Y.* Identifying the Phenotypes of Tumor-Derived Extracellular Vesicles using Size-coded Affinity Microbeads. Journal of the American Chemical Society. 2022, 144(51):23483-91. Wang, S., Zheng, W., Zhang, L., Yang, L., Wang, T., Saliba, J., Chandra, S., Chandra, S., Li, C., Lyon, C., Hu, T. Monocrystalline labeling enables stable plasmonic enhancement for isolation-free extracellular vesicle analysis. Small. 2022. 2204298. Yang, L., Liang T., Pierson, L., Wang, H., Fletcher, J., Wang, S., Bao, D., Zhang, L., Huang, Z., Zheng, W., Zhang, X., Park, H., Li, Y., Robinson, J., Feehan, A., Lyon, C., Cao, J., Morici, L., Li, C., Roy, C., Yu, X., Hu, T. SARS-CoV-2 epitopes following infection and vaccination overlap known neutralizing antibody sites. Research. 2022. 9769803. Wei, X., Wang, X., Zhang1, Z., Luo, Y., Wang, Z., Xiong, W., Jain, P., Monnier, J., Wang, H., Hu, T., Tang, C., Albrecht, H., Liu, C. A Click Chemistry Amplified Nanopore (CAN) Assay for Ultrasensitive Quantification of HIV p24 Antigen in Clinical Samples. Nature Communications. 2022. 6852. Chandra, S., Hu, T. From Prevention to Therapy- A Roadmap of Nanotechnologies to Stay Ahead of Future Pandemics. ACS Nano. 2022, 16, 7, 9985–9993. Liu, S., Wu, X., Sutapa, C., Lyon, C., Ning, B., jiang, L., Fan, J., Hu, T. Extracellular vesicles: emerging tools as therapeutic agent carriers. Acta Pharmaceutica Sinica B. 2022. Hu, T., Chen, X. Nano for CRISPR. ACS Nano. 2022, 16, 6, 8505–8506. Huang, Z., Zhang, L., Lyon, C. J., Ning, B., Youngquist, B. M., Niu, A., Beddingfield, B. J., Maness, N. J., Saba, N. S., Li, C., Roy, C. J., Hu, T. CRISPR-based Assay Reveals SARS-CoV-2 RNA Dynamic Changes and Redistribution Patterns in Non-Human Primate Models. Emerging Microbe & Infections. 2022. 11(1):629-638. Rutkai, I., Mayer. M., Hellmers, L., Ning, B., Huang, Z., Monjure, C., Coyne, C., Silvestri, R., Golden, N., Hensley, K., Chandler, K., Lehmicke, G., Bix, G., Maness, N., Russell-Lodrigue, K., Hu, T., Roy, C., Blair, R., Bohm, R., Doyle-Meyers, L., Rappaport, J., Fisher, T. Neuropathology and Virus in Brain of SARS-CoV-2 Infected Non-Human Primates. Nature Communications. 2022. 13:1745. Alwarappan, S., Nesakumar, N., Sun, D., Hu, T.*, Li, C.* 2D metal carbides and nitrides (MXenes) for Sensors and Biosensors. Biosensors and Bioelectronics. 2022. 205:113943. Shu, Q., Rajagopal, M., Fan, J., Zhan L., Kong X, He Y., Rotcheewaphan, S., Lyon, C. J., Sha, W., Adrian M. Zelazny, A. M., Hu, T. Peptidomic Analysis of Mycobacterial Secreted Proteins Enables Species Identification. View. 2022, 3:20210019. Shu, Q., Liu, S., Alonzi, T., LaCourse, S. M., Singh, D., Bao, D., Wamalwa, D., Jiang, L., Lyon, C. J., John-Stewart, G., Kaushal, D., Goletti, D., Hu, T. Assay Design for Unambiguous Identification and Quantification of Circulating Pathogen-derived Peptide Biomarkers. Theranostics. 2022. 12(6):2948-2962. Toraih, E.A., Fawzy, M.S., Ning, B., Zerfaoui, M., Errami, Y., Ruiz, E.M., Hussein, M.H., Haidari, M., Bratton, M., Tortelote, G.G., Hilliard, S., Nilubol, N., Russell, J.O., Shama, M.A., El-Dahr, S.S., Moroz, K., Hu, T., Kandil, E. A miRNA-Based Prognostic Model to Trace Thyroid Cancer Recurrence. Cancers. 2022, 14, 4128. Oguntoye, I., Simone, B., Padmanabha, S., Hartfield, G., Amrollahi, P., Hu, T., Ollanik, A., Escarra, M. Silicon Nanodisk Huygens Metasurfaces for Portable and Low-Cost Refractive Index and Biomarker Sensing. ACS Applied Nano Materials. 2022. 5(3): 3983-3991. Hu, Q., Zhang, S., Yang, Y., Yao, J., Tang, W., Lyon, C., Hu, T., Wan, M. Extracellular vesicles in the pathogenesis and treatment of acute lung injury. Military Medical Research. 2022. Sun, D., Zhao, Z., Spiegel, S., Liu, Y., Fan, J., Amrollahi, P., Lyon, C. J., Wan, M., Hu, T. Dye-free spectrophotometric measurement of nucleic acid-to-protein ratio for cell selective extracellular vesicle discrimination. Biosensors and Bioelectronics. 2021. 179: 113058. Shu, Q., Kenny, T., Fan, J., Lyon, C., Cazares, L., Hu. T. Species-specific Quantification of Circulating Ebolavirus Burden using VP40-derived Peptide Variants. PLOS Pathogens. 2021. 17(11): e1010039. Nakao, Y., Amrollahi, P., Parthasarathy, G., Mauer, A. S., Sehrawat, T. S., Vanderboom, P., Nair, S., Nakao, K., Allen, A. M., Hu, T.*, Malhi, H.* Circulating extracellular vesicles are a biomarker for NAFLD resolution and response to weight loss surgery. Nanomedicine: BME. 2021. 36:102430. Rao, J., Hu, T., Teck, L., Han, D. Mechanics of cancer and cancer cells – a 4th dimension? Frontier in Cell and Development Biology. 2021, 9:775012. Liu, W., Zhu, X., Mozneb, M., Nagahara, L., Hu, T., Li, C. Lighting up ATP in cells and tissues using a simple aptamer-based fluorescent probe. Microchimica Acta. 2021, 188(10):352. Amrollahi, P., Zheng, W., Monk, C., Li, C., Hu, T. Nanoplasmonic sensor approaches for sensitive detection of disease-associated exosomes. ACS Applied Bio Materials. 2021, 4 (9): 6589–6603.