Krchňák, Viktor - University of Notre Dame - Department of Chemistry & Biochemistry

个人简介

Viktor Krchňák studied chemistry at the Faculty of Natural Sciences of the Masaryk University in Brno, Czechoslovakia. He earned his PhD in organic chemistry from the Institute of Organic Chemistry and Biochemistry of the Czechoslovak Academy of Sciences in Prague, under the supervision of Prof. Zdenek Arnold. After holding several industrial positions with small biotech companies in the US, he joined the faculty of the University of Notre Dame as a research professor in May 2003.

研究领域

Research interest covers combinatorial chemistry in general and solid-phase chemistry in particular. His group introduced novel coding technique for the synthesis on modular solid support (lantern necklace coding), new concept for the solid phase synthesis of traceless heterocyclic libraries, cleavage of resin-bound compounds by gaseous reagents, the “split-split” method for the synthesis of sizable combinatorial libraries (up to 60,000 compounds), instrumentation and logistics for high throughput organic synthesis. Numerous inventions resulted in commercially available personal chemistry tools (www.torviq.com). Current focus is design of efficient synthetic routes for stereoselective synthesis of nitrogenous heterocycles with 3D architecture.

近期论文

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Schütznerova, E.; Oliver, A. G.; Zajicek, J.; Krchňák, V. Polymer-Supported Stereoselective Synthesis of (1S,5S)-6-oxa-3,8-diazabicyclo[3.2.1]octanes. Eur. J. Org. Chem. 2013, 3158-3165. La Venia, A.; Lemrova, B.; Krchňák, V. Regioselective Incorporation of Backbone Constrains Compatible with Traditional Solid-Phase Peptide Synthesis. ACS Comb. Sci. 2013, 15, 59-72. La Venia, A.; Dolensky, B.; Krchňák, V. Polymer-Supported Stereoselective Synthesis of Tetrahydro-2H-oxazolo[3,2-a]pyrazin-5(3H)-ones. ACS Comb. Sci. 2013, 15, 162-167. Cankarova, N.; Krchňák, V. Solid-Phase Synthesis Enabling Chemical Diversity. In Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology, Trabocchi, A., Ed.; Wiley: 2013; pp 201-252. Kaplanek, R.; Krchňák, V. Fast and effective reduction of nitroarenes by sodium dithionite under PTC conditions: Application in solid-phase synthesis. Tetrahedron Lett. 2013, 54, 2600-2603. Tiwari, R.; Moraski, G.; Krchňák, V.; Miller, P.; Colon-Martinez, M.; Herrero, E.; Oliver, A.; Miller, M. J. Thiolates Chemically Induce Redox Activation of BTZ043 and Related Potent Nitro Aromatic Anti-Tuberculosis Agents. J. Am. Chem. Soc. 2013, 135, 3539-3549. Krchňákova, A.; Miller, P.; Miller, M. J.; Krchňák, V. Teaching Old Dogs (Fmoc-amine, Azodicarboxylate, and Phosphine) New Tricks (Triazolidinones). Tetrahedron Lett. 2013, 54, 4749-4752.