Francesco Faiola - 中国科学院大学

个人简介

招生专业 071009-细胞生物学 071010-生物化学与分子生物学 071008-发育生物学招生方向干细胞毒理学分子生物学发育生物学教育背景 2000-08--2006-03 University of California，Riverside 博士后 1989-09--1998-10 University of Rome 学士/硕士工作简历 2014-03~现在, 中国科学院生态环境研究中心, 研究员（干细胞毒理学课题组组长） 2010-07~2014-03,Icahn School of Medicine at Mount Sinai, New York,, Postdoctoral Fellow 2006-07~2010-06,University of California, Riverside, CA, Postdoctoral Fellow 2000-08~2006-03,University of California，Riverside, 博士后 1989-09~1998-10,University of Rome, 学士/硕士教授课程现代生物学技术在环境健康研究中的应用干细胞毒理学环境毒理与健康危害（干细胞毒理基础与进展）奖励信息（1） Best Poster Award, 特等奖, 研究所（学校）, 2006 （2） Outstanding Talk Award, 特等奖, 研究所（学校）, 2004 （3） Best Teaching Assistant Award, 特等奖, 研究所（学校）, 2002 （4） Chancellor Prestigious Fellowship, 特等奖, 研究所（学校）, 2000 专利成果（ 1 ）微孔模具及其制备方法和应用, 2018, 第 2 作者, 专利号: 201811096910.9 （ 2 ）一种微孔模具, 2018, 第 2 作者, 专利号: 201821538823.X 科研项目（ 1 ）中国科学院战略性先导科技专项（典型污染物的环境暴露与健康危害机制项目三）, 主持, 部委级, 2014-07--2019-06 （ 2 ）利用多能干细胞研究环境污染物的健康效应及风险评估, 主持, 国家级, 2016-01--2019-12 （ 3 ）环境小分子与表观遗传的交互作用, 参与, 部委级, 2017-01--2021-12 （ 4 ）基于人胚胎干细胞胰腺分化模型研究全氟化合物与糖尿病发病的相关性, 主持, 国家级, 2019-01--2022-12 参与会议（1）The environmental pollutants PFOS and PFOA disrupt the specification and function of pancreatic and endocrine progenitor cells in vitro. 2018-12-02 （2）Stem cell toxicology is a powerful system to assess the developmental toxicity of environmental pollution. 2018-03-10 （3）Assessment of the developmental toxicity of BPA, BPF and BPS, with a stem cell toxicology system 2017年“香港浸会大学-中国科学院生态环境研究中心伙伴国家重点实验室以及环境科学联合研究所”环境科学论坛 2017-04-16 （4）Stem cell toxicology: a powerful tool to assess pollution effects on human health 国际毒理学学会第56届年会 2017-03-12 （5）The rise of stem cell toxicology 第13届持久性有毒污染物国际研讨会 2016-10-10 （6）Stem Cell Toxicology 2016-06-21 （7）Stem cell toxicology: a powerful tool to assess Bisphenol A (BPA) derivatives- toxicity 第12届持久性有毒污染物国际研讨会 Nuoya Yin, Xinglei Yao, Francesco Faiola 2015-11-15

近期论文

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（1） TBBPA, TBBPS, and TCBPA disrupt hESC hepatic differentiation and promote the proliferation of differentiated cells partly via up-regulation of the FGF10 signaling pathway, Journal of Hazardous Materials, 2021, 通讯作者（2） A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis, Journal of Environmental Sciences, 2020, 通讯作者（3） The short-chain perfluorinated compounds PFBS, PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self- renewal and adipogenic differentiation, Journal of Environmental Sciences, 2020, 通讯作者（4） Non-cytotoxic silvernanoparticlelevelsperturbhumanembryonicstemcelldependent speciﬁcation of the cranial placode in part via FGF signaling, Journal of Hazardous Materials, 2020, 通讯作者（5） Silver nanoparticles (AgNPs) and AgNO3 perturb the specification of human hepatocyte-like cells and cardiomyocytes, Science of the Total Environment, 2020, 通讯作者（6） Tetrabromobisphenol A (TBBPA): A controversial environmental pollutant, Journal of Environmental Sciences, 2020, 通讯作者（7） F-53B and PFOS treatments skew human embryonic stem cell in vitro cardiac differentiation towards epicardial cells by partly disrupting the WNT signaling pathway, Environmental Pollution, 2020, 通讯作者（8） Effects of per- and poly-fluorinated alkyl substances on pancreatic and endocrine differentiation of human pluripotent stem cells, Chemosphere, 2020, 通讯作者（9） Bisphenol A and several derivatives exert neural toxicity in human neuronlike cells by decreasing neurite length, Food and Chemical Toxicology, 2020, 通讯作者（10） Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system, Toxicology and Applied Pharmacology, 2019, 通讯作者（11） Typical halogenated flame retardants affect human neural stem cell gene expression during proliferation and differentiation via glycogen synthase kinase 3 beta and T3 signaling, Ecotoxicology and Environmental Safety, 2019, 通讯作者（12） Environmental and human relevant PFOS and PFOA doses alter human mesenchymal stem cell self-renewal, adipogenesis and osteogenesis., Ecotoxicology and Environmental Safety, 2019, 通讯作者（13） Establishment of a human embryonic stem cell-based liver differentiation model for hepatotoxicity evaluations., Ecotoxicology and Environmental Safety, 2019, 通讯作者（14） 5-fluorouracil-induced neurotoxicity in rat cerebellum granule cells involves oxidative stress and activation of caspase-3 pathway., International Journal of Clinical and Experimental Medicine, 2019, 通讯作者（15） Embryonic stem cell- and transcriptomics- based in vitro analyses reveal that bisphenols A, F and S have similar and very complex potential developmental toxicities., Ecotoxicology and Environmental Safety, 2019, 通讯作者（16） Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo., Toxicology Letters, 2019, 通讯作者（17） Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity., Journal of Hazardous Materials, 2019, 通讯作者（18） Human pluripotent stem cells as tools for predicting developmental neural toxicity of chemicals: strategies, applications and challenges., Stem Cells and Development, 2019, 通讯作者（19） Assessment of the developmental neurotoxicity of silver nanoparticles and silver ions with mouse embryonic stem cells in vitro, Journal of Interdisciplinary Nanomedicine, 2018, 通讯作者（20）干细胞毒理学在大气污染健康风险评估中的应用, 中国科学: 化学, 2018, 通讯作者（21） Non-cytotoxic nanomolar concentrations of bisphenol A induce human mesenchymal stem cell adipogenesis and osteogenesis., Ecotoxicology and Environmental Safety, 2018, 通讯作者（22） DEP and DBP induce cytotoxicity in mouse embryonic stem cells and abnormally enhance neural ectoderm development., Environmental Pollution, 2018, 通讯作者（23） TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways, Environmental Science & Technology, 2018, 通讯作者（24） PFOA and PFOS Disrupt the Generation of Human Pancreatic Progenitor Cells, Environmental Science & Technology Letters, 2018, 通讯作者（25） Evaluation of the early developmental neural toxicity of F-53B, as compared to PFOS, with an in vitro mouse stem cell differentiation model., Chemosphere, 2018, 通讯作者（26） Non-cytotoxic nanomolar concentrations of bisphenol A induce human mesenchymal stem cell adipogenesis and osteogenesis, Ecotoxicology and Environmental Safety, 2018, 通讯作者（27） NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression., Stem Cell Reports, 2017, 通讯作者（28） Prospects and Frontiers of Stem Cell Toxicology., Stem Cells Dev., 2017, 通讯作者（29） Stem cell toxicology: a powerful tool to assess pollution effects on human health., National Science Review, 2016, 通讯作者（30） The rise of stem cell toxicology, Environmental Science & Technology, 2015, 通讯作者（31） Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells, Journal of Environmental Sciences, 2015, 通讯作者（32） Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats, Biochemical and Biophysical Research Communications, 2015, 通讯作者（33） Concise review: pursuing self-renewal and pluripotency with the stem cell factor nanog., Stem Cells, 2013, 第 2 作者（34） NANOG-dependent function of TET1 and TET2 in establishment of pluripotency., Nature, 2013, 第 1 作者（35） Zfp281 mediates Nanogautorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming., Proc Natl Acad Sci U.S.A., 2012, 第 2 作者（36） Oct4 links multiple epigenetic pathways to the pluripotency network., Cell Res., 2011, 第 2 作者（37） Max is acetylated by p300 at several nuclear localization residues., Biochem J., 2007, 第 1 作者（38） Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription., Mol Cell Biol., 2005, 第 1 作者