Young, Fiona - Flinders University - Department of Medical Biotechnology

研究领域

Research Overview: Reproductive Toxicology, Environmental Endocrine Disrupters and Fertility Oncology 1.Use of human reproductive cells in vitro (including primary-derived human granulosa cells and spermatozoa from patients of Flinders Reproductive Medicine, embryonic stem cells, and human breast, uterine and ovarian cancer cell lines), as well as in vitro mouse embryo cultures, to assess the toxicity, or the activity, of novel bioactive extracts, nanoparticles, agrichemicals (eg pesticides and herbicides), new pharmaceutical agents or bioremediation products. 2.Endocrine Disrupters - the detection and characterisation of endocrine disrupting compounds (EDCs) in surface and drinking waters, recycled water and wastewater, using SPE-ELISA, HPLC, E-screen, and human cell lines in novel in vitro assays. 3.Development of a preventative anti-cancer therapy for post-menopausal women. 4.Development of a therapy that will prevent breast, uterine and ovarian cancer. 5.Fertility Oncology - anti-cancer radiotherapy and chemotherapy make female cancer patients infertile. This research area is about developing therapies that can preserve the fertility of female cancer survivors.

近期论文

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Benkendorff, K., Rudd, D.A., Nongmaithem, B.D., Liu, L., Young, F.M., Edwards, V.S., et al. (2015). Are the Traditional Medical Uses of Muricidae Molluscs Substantiated by Their Pharmacological Properties and Bioactive Compounds? Marine Drugs, 13 pp. 5237-5275. [10.3390/md13085237] [Scopus] Reid, K., Lang, K.J., Froscio, S.M., Humpage, A.R. and Young, F.M. (2015). Undifferentiated murine embryonic stem cells used to model the effects of the blue-green algal toxin cylindrospermopsin on preimplantation embryonic cell proliferation. Toxicon, 106 pp. 79-88. [10.1016/j.toxicon.2015.09.022] [Scopus] Edwards, V.S., Benkendorff, K. and Young, F. (2014). An in vitro high-throughput assay for screening reproductive and toxic effects of anticancer compounds. Biotechnology and Applied Biochemistry, 61(5) pp. 582-592. [10.1002/bab.1199] [Scopus] Edwards, V., Benkendorff, K. and Young, F. (2012). Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells. Marine Drugs, 10(1) pp. 64-83. [10.3390/md10010064] [Scopus] Young, F., Zebian, D., Froscio, S. and Humpage, A. (2012). Cylindrospermopsin, a blue-green algal toxin, inhibited human luteinised granulosa cell protein synthesis in vitro. Toxicology in Vitro, 26(5) pp. 656-662. [10.1016/j.tiv.2012.03.001] [Scopus] Edwards, V., Markovic, E., Matisons, J.G. and Young, F.M. (2008). Development of an in vitro reproductive screening assay for novel pharmaceutical compounds. Biotechnology and Applied Biochemistry, 51(2) pp. 63-71. [10.1042/BA20070223] [Scopus] Young, F.M., Micklem, J.M. and Humpage, A.R. (2008). Effects of Blue Green Algal Toxin Cylindrospermopsin (CYN) on Human Granulosa Cells in vitro. Reproductive Toxicology, 25(3) pp. 374-380. [10.1016/j.reprotox.2008.02.006] [Scopus] Young, F.M. and Sanderson, B.J. (2005). Modification of MTT assay conditions to examine the cytotoxic effects of amitraz on the human lymphoblastoid cell line, WIL2NS. Toxicology in Vitro, 19(8) pp. 1051-1059. [10.1016/j.tiv.2005.05.001] [Scopus] Young, F.M., Menadue, M.F. and Lavranos, T.C. (2005). Effects of the insecticide amitraz, an alpha(2)-adrenergic receptor agonist, on human luteinized granulosa cells. Human Reproduction, 20(11) pp. 3018-3025. [10.1093/humrep/dei194] [Scopus] Al-Jiffry, B.O., Shaffer, E.A., Woods, C.M., Menadue, M.F., Young, F.M., Oliver, J.R., et al. (2004). Endogenous endothelin increases gallbladder tone and leads to acute cholecystitis in the Australia possum. Neurogastroenterology and Motility, 16(1) pp. 125-133. [10.1046/j.1365-2982.2003.00459.x] [Scopus