Harris, Hugh - University of Adelaide - Department of Chemistry

研究领域

Bioinorganic Chemistry/Metals in Biology Metabolism and benefits of dietary selenium Heavy metal toxicology in mammals (As, Se, Hg, Cd) Metalloprotein active site structures and mechanisms Application of X-ray absorption and X-ray fluorescence techniques to intact tissues

近期论文

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Distribution and speciation of bromine in mammalian tissue and fluids by X-ray fluorescence imaging and X-ray absorption spectroscopy.Ceko MJ, Hummitzsch K, Hatzirodos N, Bonner WM, James SA, Kirby JK, Rodgers RJ and Harris HH*. Metallomics. 2015. http://dx.doi.org/10.1039/C4MT00338A X-Ray fluorescence imaging and other analyses identify selenium and GPX1 as important in female reproductive function.Ceko MJ, Hummitzsch K, Hatzirodos N, Bonner WM, Aitken JB, Russell DL, Lane M, Rodgers RJ and Harris HH*. Metallomics. 7, 66-77. 2015. XAS and XFM studies of selenium and copper speciation and distribution in the kidneys of selenite-supplemented rats.Weekley CM, Shanu A, Aitken JB, Vogt S, Witting PK, and Harris HH*. Metallomics. 6, 1602-15. 2014. The importance of selenium speciation and metabolism in the prevention and treatment of disease.Weekley CM and Harris HH. Chem. Soc. Rev. 42, 8870-94. 2013. Selenium metabolism in cancer cells: The combined application of XAS and XFM techniques to the problem of selenium speciation in biological systems.Weekley CM, Aitken JB, Finney L, Vogt S, Witting PK and Harris HH*. Nutrients. 5, 1734-56. 2013. Selenium inhibits renal oxidation and inflammation but not acute kidney injury in an animal model of rhabdomyolysis.Shanu A, Groebler L, Kim HB, Wood S, Weekley CM, Aitken JB, Harris HH and Witting PK. Antioxid. Redox Sign. 18, 756-69. 2013. Distinct cellular fates for KP1019 and NAMI-A determined by X-ray fluorescence imaging of single cells.Aitken JB, Antony S, Weekley CM, Lai B, Spiccia L and Harris HH*. Metallomics. 4, 1051-6. 2012. Methylselenocysteine treatment leads to diselenide formation in human cancer cells: Evidence from X-ray absorption spectroscopy studies.Weekley CM, Aitken JB, Musgrave IF and Harris HH*. Biochemistry. 51, 736-738. 2012. Metabolism of selenite in human lung cancer cells: X-ray absorption and fluorescence studies.Weekley CM, Aitken JB, Vogt S, Finney LA, Paterson DJ, De Jonge MD, Howard DL, Witting PK, Musgrave IF and Harris HH*. J. Amer. Chem. Soc. 133, 18272-18279. 2011. The photoreduction kinetics of sodium tetrachloroaurate under synchrotron soft x-ray exposure.Fong Y-Y, Visser B, Gascooke J, Cowie B, Thomsen L, Metha GF, Buntine MA and Harris HH*.Langmuir. 27, 8099-8104, 2011. Uptake, distribution, and speciation of selenoamino acids by human cancer cells: X-ray absorption and fluorescence methods. Weekley CM, Aitken JB, Vogt S, Finney LA, Paterson DJ, De Jonge MD, Howard DL, Musgrave IF and Harris HH*.Biochemistry. 50, 1641- 1650, 2011. Selective aggregation of a Pt- Gd complex within a tumour cell nucleus.Crossley EL, Aitken JB, Vogt S, Harris HH* and Rendina LM*. Angew. Chem. Int. Ed. Engl. 49, 1231-1233, 2010. Multiple protective activities of neuroglobin in cultured neuronal cells exposed to hypoxia re-oxygenation injury.Duong TTH, Witting PK, Antao ST, Parry SN, Kennerson M, Lai B, Vogt S, Lay PA and Harris HH. J. Neurochem. 8, 1143-1154, 2009. Microprobe XRF mapping of the intracellular metabolism of arsenic for understandingarsenic-induced toxicity.Munro KL, Mariana A, Klavins AI, Foster AJ, Lai B, Vogt S, Cai Z, Harris HH and Dillon CT. Chem. Res. Toxicol. 21, 1760-1769, 2008. Migration of mercury from dental amalgam through human teeth.Harris HH*, Vogt S, Eastgate H, Legnini DG, Hornberger B, Cai Z, Lai B and Lay PA*.J. Synchrotron Rad. 15, 123-128, 2008. Structural Studies of the Alzheimer's Amyloid Precursor Protein Copper-binding Domain Reveal How it Binds Copper Ions.Kong GK, Adams JJ, Harris HH, Boas JF, Curtain CC, Galatis D, Masters CL, Barnham KJ, McKinstry WJ, Cappai R and Parker MW.J. Mol. Biol. 367, 148-161, 2007. Biotransformations of Chromium(VI) in Mammalian Cells: X-Ray Absorption and EPR Spectroscopic Studies.Levina A, Harris HH and Lay PA.J. Amer. Chem. Soc. 129, 1065-1075, 2007. Localizing the chemical transformation of arsenic in a hyperaccumulating fern.Pickering IJ, Gumaelius L, Harris HH, Prince RC, Hirsch G, Banks, JA, Salt DE and George GN.Environ. Sci. Tech. 40, 5010-5014, 2006. Charge Distribution in Chromium and Vanadium Catecholato Complexes: X-ray Absorption Spectroscopic and Computational Studies.Millsman C, Levina A, Harris HH, Turner P, Lay PA.Inorg. Chem. 45, 4743-4754, 2006. High-Resolution EXAFS of the Active Site of Human Sulfite Oxidase: Comparison with Density Functional Theory and X-ray Crystallographic Results.Harris HH, George GN and Rajagopalan KV.Inorg. Chem. 45, 493-495, 2006.