Abell, Andrew - University of Adelaide - Department of Chemistry

研究领域

His research interests are concerned with understanding the fundamental link between the chemical structure and shape of key biological molecules and their biological function. While his work is very much driven by fundamental science, he has always had a keen interest in pursuing associated commercial opportunities. The seed for this was sown with a sabbatical leave working as a visiting scientist, consultant and senior Fulbright Fellow with SmithKline Beecham (now GSK) in Philadelphia. In Adelaide he co-founded an Adelaide-based company (Calpain Therapeutics) to develop macrocyclic protease inhibitors as a potential treatment for cataract and other conditions.

近期论文

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2016 Sutton-McDowall,ML, Wu,LL, Purdey,M, Abell,AD, Goldys,EM, MacMillan,KL, Thompson,JG, Robker,RL, 2016, Non-esterified fatty acid-induced endoplasmic reticulum stress in cattle cumulus oocyte complexes alters cell metabolism and developmental competence, Biology of Reproduction, 94, 1, 23 -1-23 -9 10.1095/biolreprod.115.131862 2016 Feng,J, Paparella,AS, Booker,GW, Polyak,SW, Abell,AD, 2016, Biotin Protein Ligase Is a Target for New Antibacterials., Antibiotics (Basel, Switzerland), 5, 3, 26-26 10.3390/antibiotics5030026 2016 Zuber,A, Purdey,M, Schartner,E, Forbes,C, Van Der Hoek,B, Giles,D, Abell,A, Monro,T, Ebendorff-Heidepriem,H, 2016, Detection of gold nanoparticles with different sizes using absorption and fluorescence based method, Sensors and Actuators, B: Chemical, 227, 117-127 10.1016/j.snb.2015.12.044 2016 Heng,S, McDevitt,CA, Kostecki,R, Morey,JR, Eijkelkamp,BA, Ebendorff-Heidepriem,H, Monro,TM, Abell,AD, 2016, Microstructured optical fiber-based biosensors: reversible and nanoliter-scale measurement of zinc ions, ACS Applied Materials and Interfaces, 8, 20, 12727-12732 10.1021/acsami.6b03565 2016 Cottam Jones,JM, Harris,PWR, Scanlon,DB, Forbes,BE, Brimble,MA, Abell,AD, 2016, Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R, Organic and Biomolecular Chemistry, 14, 9, 2698-2705 10.1039/c5ob02110c 2016 Stubing,DB, Heng,S, Abell,AD, 2016, Crowned spiropyran fluoroionophores with a carboxyl moiety for the selective detection of lithium ions, Organic and Biomolecular Chemistry, 14, 15, 3752-3757 10.1039/c6ob00468g 2016 Zhang,X, Bruning,JB, George,JH, Abell,AD, 2016, A mechanistic study on the inhibition of α-chymotrypsin by a macrocyclic peptidomimetic aldehyde, Organic and Biomolecular Chemistry, 14, 29, 6970-6978 10.1039/c6ob01159d 2016 Greenwood,JE, Tan,JL, Choong Tzen Ming,J, Abell,AD, 2016, Alkalis and skin, Journal of Burn Care and Research, 37, 2, 135-141 10.1097/BCR.0000000000000222 2016 Yu,J, Horsley,JR, Abell,AD, 2016, Turning electron transfer 'on-off' in peptides through side-bridge gating, Electrochimica Acta, 209, 65-74 10.1016/j.electacta.2016.05.067 2015 Kumeria,T, Yu,J, Alsawat,M, Kurkuri,MD, Santos,A, Abell,AD, Losic,D, 2015, Photoswitchable membranes based on peptide-modified nanoporous anodic alumina: toward smart membranes for on-demand molecular transport, Advanced Materials, 27, 19, 3019-3024 10.1002/adma.201500473 2015 Kumeria,T, Yu,J, Alsawat,M, Kurkuri,MD, Santos,A, Abell,AD, Losic,D, 2015, Membranes: photoswitchable membranes based on Peptide-modified nanoporous anodic alumina: toward smart membranes for on-demand molecular transport (adv. Mater. 19/2015)., Advanced materials (Deerfield Beach, Fla.), 27, 19, 2950- 10.1002/adma.201570127 2015 Tieu,W, Polyak,SW, Paparella,AS, Yap,MY, Soares Da Costa,TP, Ng,B, Wang,G, Lumb,R, Bell,JM, Turnidge,JD et al, 2015, Improved synthesis of biotinol-5'-AMP: implications for antibacterial discovery, ACS Medicinal Chemistry Letters, 6, 2, 216-220 10.1021/ml500475n 2015 Zhang,X, Heng,S, Abell,AD, 2015, Photoregulation of α-chymotrypsin activity by spiropyran-based inhibitors in solution and attached to an optical fiber, Chemistry, 21, 30, 10703-10713 10.1002/chem.201501488 2015 Purdey,MS, Thompson,JG, Monro,TM, Abell,AD, Schartner,EP, 2015, A dual sensor for pH and hydrogen peroxide using polymer-coated optical fibre tips, Sensors, 15, 12, 31904-31913 10.3390/s151229893 2015 Purdey,MS, Connaughton,HS, Whiting,S, Schartner,EP, Monro,TM, Thompson,JG, John Aitken,R, Abell,AD, 2015, Boronate probes for the detection of hydrogen peroxide release from human spermatozoa, Free Radical Biology & Medicine, 81, 69-76 10.1016/j.freeradbiomed.2015.01.015 2015 Horsley,JR, Yu,J, Abell,AD, 2015, The correlation of electrochemical measurements and molecular junction conductance simulations in β-strand peptides, Chemistry, 21, 15, 5926-5933 10.1002/chem.201406451 2015 Schartner,EP, Tsiminis,G, Fran?ois,A, Kostecki,R, Warren-Smith,SC, Nguyen,LV, Heng,S, Reynolds,T, Klantsataya,E, Rowland,KJ et al, 2015, Taming the light in microstructured optical fibers for sensing, International Journal of Applied Glass Science, 6, 3, 229-239 10.1111/ijag.12128 2015 Sutton-McDowall,ML, Purdey,M, Brown,HM, Abell,AD, Mottershead,DG, Cetica,PD, Dalvit,GC, Goldys,EM, Gilchrist,RB, Gardner,DK et al, 2015, Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone, Molecular Reproduction and Development, 82, 4, 281-294 10.1002/mrd.224