Polyak, Steven - University of Adelaide - School of Biological Sciences

研究领域

Protein structure and function Small molecule drug discovery Biotin (vitamin B7 or H) Antibiotics

近期论文

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van Marrewijk, L.M., Hijnen, M., Polyak, S.W., Shin, Y., Kamenecka, T.M., Griffin, P.R. & Bruning, J.B. (2016) Structural and Kinetic Mechanism of a Non-Acid PPAR? Partial Agonist: SR2067. ACS Chem. Biol. 11(1):273-83 Azhar, A., Booker G.W. & Polyak, S.W. (2015) Mechanisms of biotin transport. Biochem. Anal Biochem. 4 (4):210 Salaemae, W., Yap, M.Y., Wegener, K.L., Booker, G.W., Wilce, M.C.J & Polyak, S.W. (2015) Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis Dethiobiotin Synthetase. Tuberculosis. 95(3):259-66 Tieu, W., Polyak, S.W., Paparella, A.S., Yap, M., Soares da Costa, T., Ng, B., Wang, G., Lumb, R., Bell, J., Turnidge, J.D., Wilce, M.C.J., Booker, G.W. & Abell, A.D. (2015) An improved synthesis of biotinol-5’-AMP: Implications for antibacterial discovery. ACS Med Chem Letts. 6(2):216-220 Paparella, A.P., Soares da Costa, T.P., Yap, M.Y., Tieu, W., Wilce, M.C.J., Booker, G.W., Abell, A.D. & Polyak, S.W. (2014) Structure guided design of biotin protein ligase inhibitors for antibiotic discovery. Curr. Top. Med. Chem., 14(1): 4-20 Soares da Costa, T.P., Yap, M.Y., Perugini. M.A., Wallace, J.C., Abell, A.D., Wilce, M.C.J., Polyak, S.W. & Booker, G.W. (2014) Dual roles for F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus. Mol Microbiol. 91(1):110-120. Tieu, W., Soares Da Costa, T.P., Yap, M.Y., Keeling, K.L., Wilce, M.C.J., Wallace, J.C., Booker, G.W., Polyak, S. W. & Abell, A.D. (2013) Optimising in situ click chemistry: the screening and identification of biotin protein ligase inhibitors. Chem. Sci. 4, 3533-353. Pendini, N.R., Yap, M.Y., Polyak, S. W., Cowieson, N.P., Booker, G.W., Wallace, J.C., Abell, A.D., Wilce, J.A. & Wilce, M.C.J. (2013) Structural characterisation of Staphylocococcus aureus biotin protein ligase: An antibiotic target. Prot. Sci. 22(6): 762-73 Soares da Costa, T.P. Tieu, W., Yap, M.Y., Zvarec, O., Bell, J., Turnidge, J.D., Wallace. J.C., Booker, G.W., Wilce, M.C.J., Abell, A.D., Polyak, S. W. (2012) Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase. ACS Med. Chem. Letts. Soares da Costa, T.P., Tieu, W., Yap, M.Y., Pendini, N.R., Polyak, S. W., Sejer Pedersen, D., Morona, R. Turnidge, J.D., Wallace, J.C. Wilce, M.C.J., Booker, G.W. & Abell, A.D. (2012) Selective inhibition of Biotin Protein Ligase from Staphylococcus aureus. J. Biol. Chem. 287(21):17823-32. Mayende, L., Swift, R.D., Bailey, L.M., Soares da Costa, T.P., Wallace, J.C., Booker, G.W. & Polyak, S. W. (2012) A novel molecular mechanism to explain biotin-unresponsive Holocarboxylase synthetase. J Mol. Med. 90(1):81-88 Polyak, S. W., Abell, A.D., Wilce, M.C.J., Zhang, L. & Booker, G.W. (2012) Structure, function and selective inhibition of bacterial acetyl CoA carboxylase. Appl. Micro. Biotech. Salaemae, W., Azhar, A., Booker, G.W. & Polyak, S. W. (2011) Biotin biosynthesis in Mycobacterium tuberculosis: Physiology, biochemistry and molecular intervention. Protein & Cell. 2(9):691-5 Bailey, L. M., Wallace, J.C. & Polyak, S. W. (2010) Holocarboxylase synthetase: Correlation of protein localisation with biological function Arch Biochem Biophys 496(1):45-52 Pendini, N.R., Bailey, L.M., Booker, G.W., Wilce, M., Wallace, J.C. & Polyak, S. W. (2008) Microbial relatives of biotin protein ligase aid in understanding holocarboxylase synthetase deficiency BBA-Proteins and proteomics 784(7-8):973-82 Bailey, L.M., Ivanov,R., Jitrapakdee, S., Wilson, C.J., Wallace, J.C. & Polyak, S. W. (2008) Reduced half-life of holocarboxylase synthetase from patients with severe mutiple carboxylase deficiency Human Mutation Mutation in Brief #1009, 29:E47-57 Ng, B., Polyak, S. W., Bird, D., Bailey, L.M., Wallace, J.C. & Booker, G.W. (2008) Escherichia coli biotin protein ligase: Characterisation and development of a high-throughput assay Anal. Biochem. 376(1): 131-6 Bailey, L.M., Ivanov, R., Wallace, J.C. & Polyak, S. W. (2008) Artifactual detection of biotin on histones by streptavidin Anal. Biochem. 373(1):71-7 Jitrapakdee, S., Surinya, K., Adina-Zada, A., Polyak, S. W., Stojkoski, C., Smyth, R., Booker, G.W., Cleland, C.C., Attwood, P. & Wallace, J.C. (2007) Conserved Glu40 and Glu433?of the biotin carboxylase domain of yeast pyruvate carboxylase I isoenzyme are essential for the association of tetramers Int. J. Biochem. Cell Biol. 39(11):2120-34 Polyak, S. W., Chapman-Smith, A., Mulhern, T.D., Cronan, J.E. Jnr. & Wallace, J.C. (2001) Mutational analysis of protein substrate presentation in the post-translational attachment of biotin to biotin domains. J. Biol. Chem. 276 (5): 3037-3045